Clu domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Clustered mitochondria, putative

Species:

Leishmania braziliensis

UniProt:

A4H8U2_LEIBR

TriTrypDb:

LbrM.16.1710 , LBRM2903_160025700

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8U2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8U2

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0071840	cellular component organization or biogenesis	2	9

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003743	translation initiation factor activity	4	1
GO:0005488	binding	1	1
GO:0008135	translation factor activity, RNA binding	3	1
GO:0045182	translation regulator activity	1	1
GO:0090079	translation regulator activity, nucleic acid binding	2	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.499
CLV_MEL_PAP_1	378	384	PF00089	0.406
CLV_NRD_NRD_1	253	255	PF00675	0.411
CLV_NRD_NRD_1	348	350	PF00675	0.315
CLV_NRD_NRD_1	371	373	PF00675	0.472
CLV_NRD_NRD_1	400	402	PF00675	0.467
CLV_PCSK_KEX2_1	209	211	PF00082	0.403
CLV_PCSK_KEX2_1	253	255	PF00082	0.404
CLV_PCSK_KEX2_1	314	316	PF00082	0.469
CLV_PCSK_KEX2_1	371	373	PF00082	0.413
CLV_PCSK_KEX2_1	400	402	PF00082	0.481
CLV_PCSK_KEX2_1	649	651	PF00082	0.488
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.403
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.482
CLV_PCSK_PC1ET2_1	649	651	PF00082	0.488
CLV_PCSK_SKI1_1	104	108	PF00082	0.275
CLV_PCSK_SKI1_1	301	305	PF00082	0.339
CLV_PCSK_SKI1_1	332	336	PF00082	0.526
CLV_PCSK_SKI1_1	365	369	PF00082	0.461
CLV_PCSK_SKI1_1	492	496	PF00082	0.424
CLV_PCSK_SKI1_1	61	65	PF00082	0.330
CLV_PCSK_SKI1_1	646	650	PF00082	0.404
CLV_PCSK_SKI1_1	75	79	PF00082	0.265
CLV_Separin_Metazoa	43	47	PF03568	0.394
DEG_Nend_UBRbox_2	1	3	PF02207	0.456
DOC_ANK_TNKS_1	87	94	PF00023	0.499
DOC_CDC14_PxL_1	124	132	PF14671	0.394
DOC_CDC14_PxL_1	494	502	PF14671	0.433
DOC_CKS1_1	166	171	PF01111	0.466
DOC_CYCLIN_RxL_1	359	369	PF00134	0.326
DOC_CYCLIN_RxL_1	488	499	PF00134	0.431
DOC_CYCLIN_RxL_1	71	82	PF00134	0.499
DOC_MAPK_gen_1	209	216	PF00069	0.424
DOC_MAPK_gen_1	253	261	PF00069	0.272
DOC_MAPK_gen_1	340	348	PF00069	0.342
DOC_MAPK_gen_1	526	533	PF00069	0.370
DOC_MAPK_gen_1	649	658	PF00069	0.441
DOC_MAPK_JIP1_4	210	216	PF00069	0.451
DOC_MAPK_MEF2A_6	110	118	PF00069	0.517
DOC_MAPK_MEF2A_6	289	298	PF00069	0.449
DOC_MAPK_MEF2A_6	488	495	PF00069	0.422
DOC_MAPK_NFAT4_5	488	496	PF00069	0.426
DOC_PP1_RVXF_1	379	385	PF00149	0.401
DOC_PP1_RVXF_1	399	406	PF00149	0.515
DOC_PP1_RVXF_1	490	496	PF00149	0.416
DOC_PP2B_LxvP_1	114	117	PF13499	0.475
DOC_PP4_FxxP_1	495	498	PF00568	0.439
DOC_USP7_MATH_1	11	15	PF00917	0.301
DOC_USP7_MATH_1	117	121	PF00917	0.517
DOC_USP7_MATH_1	334	338	PF00917	0.455
DOC_WW_Pin1_4	165	170	PF00397	0.460
DOC_WW_Pin1_4	203	208	PF00397	0.390
DOC_WW_Pin1_4	411	416	PF00397	0.427
LIG_14-3-3_CanoR_1	110	115	PF00244	0.449
LIG_14-3-3_CanoR_1	253	262	PF00244	0.398
LIG_14-3-3_CanoR_1	289	296	PF00244	0.259
LIG_14-3-3_CanoR_1	342	348	PF00244	0.366
LIG_14-3-3_CanoR_1	374	382	PF00244	0.429
LIG_14-3-3_CanoR_1	400	404	PF00244	0.625
LIG_14-3-3_CanoR_1	431	441	PF00244	0.430
LIG_14-3-3_CanoR_1	475	484	PF00244	0.305
LIG_14-3-3_CanoR_1	539	547	PF00244	0.271
LIG_14-3-3_CanoR_1	61	66	PF00244	0.499
LIG_14-3-3_CanoR_1	667	674	PF00244	0.477
LIG_APCC_ABBA_1	142	147	PF00400	0.462
LIG_APCC_ABBA_1	514	519	PF00400	0.332
LIG_APCC_ABBA_1	666	671	PF00400	0.386
LIG_APCC_ABBAyCdc20_2	332	338	PF00400	0.431
LIG_Clathr_ClatBox_1	44	48	PF01394	0.394
LIG_FHA_1	113	119	PF00498	0.481
LIG_FHA_1	137	143	PF00498	0.605
LIG_FHA_1	193	199	PF00498	0.489
LIG_FHA_1	225	231	PF00498	0.442
LIG_FHA_1	289	295	PF00498	0.412
LIG_FHA_1	31	37	PF00498	0.517
LIG_FHA_1	412	418	PF00498	0.399
LIG_FHA_1	509	515	PF00498	0.441
LIG_FHA_1	616	622	PF00498	0.411
LIG_FHA_1	663	669	PF00498	0.440
LIG_FHA_2	221	227	PF00498	0.517
LIG_FHA_2	465	471	PF00498	0.425
LIG_FHA_2	652	658	PF00498	0.489
LIG_GBD_Chelix_1	99	107	PF00786	0.317
LIG_LIR_Gen_1	306	316	PF02991	0.400
LIG_LIR_Gen_1	341	351	PF02991	0.459
LIG_LIR_Gen_1	402	413	PF02991	0.445
LIG_LIR_Gen_1	489	498	PF02991	0.436
LIG_LIR_Gen_1	532	543	PF02991	0.463
LIG_LIR_Gen_1	618	628	PF02991	0.237
LIG_LIR_Nem_3	177	182	PF02991	0.337
LIG_LIR_Nem_3	238	244	PF02991	0.311
LIG_LIR_Nem_3	258	264	PF02991	0.366
LIG_LIR_Nem_3	306	311	PF02991	0.344
LIG_LIR_Nem_3	341	346	PF02991	0.413
LIG_LIR_Nem_3	402	408	PF02991	0.433
LIG_LIR_Nem_3	489	493	PF02991	0.375
LIG_LIR_Nem_3	532	538	PF02991	0.442
LIG_LIR_Nem_3	618	623	PF02991	0.260
LIG_LIR_Nem_3	675	680	PF02991	0.471
LIG_LYPXL_SIV_4	506	514	PF13949	0.391
LIG_NRBOX	363	369	PF00104	0.544
LIG_NRBOX	40	46	PF00104	0.394
LIG_PCNA_PIPBox_1	559	568	PF02747	0.271
LIG_PCNA_yPIPBox_3	552	566	PF02747	0.258
LIG_Pex14_1	19	23	PF04695	0.475
LIG_SH2_CRK	124	128	PF00017	0.542
LIG_SH2_CRK	535	539	PF00017	0.254
LIG_SH2_CRK	87	91	PF00017	0.499
LIG_SH2_NCK_1	308	312	PF00017	0.408
LIG_SH2_NCK_1	507	511	PF00017	0.455
LIG_SH2_SRC	308	311	PF00017	0.276
LIG_SH2_SRC	634	637	PF00017	0.385
LIG_SH2_STAP1	327	331	PF00017	0.482
LIG_SH2_STAP1	634	638	PF00017	0.267
LIG_SH2_STAT3	445	448	PF00017	0.418
LIG_SH2_STAT5	187	190	PF00017	0.333
LIG_SH2_STAT5	5	8	PF00017	0.428
LIG_SH2_STAT5	535	538	PF00017	0.314
LIG_SH2_STAT5	575	578	PF00017	0.346
LIG_SH2_STAT5	606	609	PF00017	0.426
LIG_SH2_STAT5	616	619	PF00017	0.283
LIG_SH2_STAT5	620	623	PF00017	0.240
LIG_SH2_STAT5	680	683	PF00017	0.425
LIG_SH3_3	64	70	PF00018	0.499
LIG_SUMO_SIM_anti_2	158	164	PF11976	0.442
LIG_SUMO_SIM_anti_2	225	232	PF11976	0.377
LIG_SUMO_SIM_anti_2	558	564	PF11976	0.495
LIG_SUMO_SIM_par_1	194	201	PF11976	0.538
LIG_SUMO_SIM_par_1	291	297	PF11976	0.363
LIG_TRAF2_1	50	53	PF00917	0.490
LIG_TYR_ITIM	122	127	PF00017	0.394
LIG_TYR_ITIM	533	538	PF00017	0.234
LIG_TYR_ITIM	85	90	PF00017	0.499
LIG_TYR_ITSM	616	623	PF00017	0.239
MOD_CDC14_SPxK_1	206	209	PF00782	0.362
MOD_CDK_SPxK_1	203	209	PF00069	0.386
MOD_CDK_SPxxK_3	203	210	PF00069	0.376
MOD_CK1_1	10	16	PF00069	0.418
MOD_CK1_1	390	396	PF00069	0.520
MOD_CK1_1	399	405	PF00069	0.331
MOD_CK1_1	432	438	PF00069	0.424
MOD_CK1_1	508	514	PF00069	0.397
MOD_CK2_1	148	154	PF00069	0.382
MOD_CK2_1	464	470	PF00069	0.444
MOD_GlcNHglycan	110	113	PF01048	0.275
MOD_GlcNHglycan	13	16	PF01048	0.314
MOD_GlcNHglycan	356	359	PF01048	0.386
MOD_GlcNHglycan	375	378	PF01048	0.519
MOD_GlcNHglycan	389	392	PF01048	0.419
MOD_GlcNHglycan	540	543	PF01048	0.422
MOD_GlcNHglycan	636	639	PF01048	0.266
MOD_GlcNHglycan	9	12	PF01048	0.289
MOD_GlcNHglycan	94	97	PF01048	0.275
MOD_GSK3_1	106	113	PF00069	0.494
MOD_GSK3_1	188	195	PF00069	0.350
MOD_GSK3_1	220	227	PF00069	0.550
MOD_GSK3_1	7	14	PF00069	0.336
MOD_N-GLC_1	191	196	PF02516	0.360
MOD_N-GLC_1	354	359	PF02516	0.379
MOD_N-GLC_1	477	482	PF02516	0.292
MOD_N-GLC_2	265	267	PF02516	0.399
MOD_N-GLC_2	324	326	PF02516	0.437
MOD_NEK2_1	186	191	PF00069	0.444
MOD_NEK2_1	198	203	PF00069	0.476
MOD_NEK2_1	255	260	PF00069	0.372
MOD_NEK2_1	29	34	PF00069	0.463
MOD_NEK2_1	429	434	PF00069	0.486
MOD_NEK2_1	464	469	PF00069	0.383
MOD_NEK2_1	493	498	PF00069	0.439
MOD_NEK2_1	538	543	PF00069	0.392
MOD_NEK2_1	565	570	PF00069	0.435
MOD_NEK2_1	605	610	PF00069	0.419
MOD_NEK2_2	322	327	PF00069	0.255
MOD_NEK2_2	477	482	PF00069	0.438
MOD_OFUCOSY	217	224	PF10250	0.487
MOD_PIKK_1	341	347	PF00454	0.387
MOD_PIKK_1	648	654	PF00454	0.459
MOD_PKA_1	253	259	PF00069	0.298
MOD_PKA_2	253	259	PF00069	0.331
MOD_PKA_2	288	294	PF00069	0.403
MOD_PKA_2	341	347	PF00069	0.387
MOD_PKA_2	373	379	PF00069	0.437
MOD_PKA_2	380	386	PF00069	0.470
MOD_PKA_2	399	405	PF00069	0.340
MOD_PKA_2	538	544	PF00069	0.266
MOD_PKA_2	566	572	PF00069	0.423
MOD_Plk_1	191	197	PF00069	0.375
MOD_Plk_1	198	204	PF00069	0.499
MOD_Plk_1	224	230	PF00069	0.455
MOD_Plk_1	30	36	PF00069	0.517
MOD_Plk_1	477	483	PF00069	0.578
MOD_Plk_4	117	123	PF00069	0.506
MOD_Plk_4	198	204	PF00069	0.550
MOD_Plk_4	226	232	PF00069	0.372
MOD_Plk_4	380	386	PF00069	0.338
MOD_ProDKin_1	165	171	PF00069	0.460
MOD_ProDKin_1	203	209	PF00069	0.386
MOD_ProDKin_1	411	417	PF00069	0.426
MOD_SUMO_for_1	303	306	PF00179	0.337
TRG_DiLeu_BaEn_1	558	563	PF01217	0.280
TRG_ENDOCYTIC_2	124	127	PF00928	0.425
TRG_ENDOCYTIC_2	179	182	PF00928	0.342
TRG_ENDOCYTIC_2	308	311	PF00928	0.342
TRG_ENDOCYTIC_2	535	538	PF00928	0.473
TRG_ENDOCYTIC_2	620	623	PF00928	0.230
TRG_ENDOCYTIC_2	80	83	PF00928	0.462
TRG_ENDOCYTIC_2	87	90	PF00928	0.488
TRG_ER_diArg_1	253	255	PF00400	0.322
TRG_ER_diArg_1	370	372	PF00400	0.424
TRG_ER_diArg_1	583	586	PF00400	0.411
TRG_ER_diArg_1	653	656	PF00400	0.342
TRG_NES_CRM1_1	226	238	PF08389	0.294
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.527
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.311
TRG_Pf-PMV_PEXEL_1	586	590	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR4	Leptomonas seymouri	65%	99%
A0A1X0NZ67	Trypanosomatidae	39%	98%
A0A3S7WUD5	Leishmania donovani	79%	100%
A4HX63	Leishmania infantum	79%	100%
E9AQX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QEK0	Leishmania major	77%	100%
V5BI85	Trypanosoma cruzi	33%	100%