WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8U0_LEIBR

TriTrypDb:

LbrM.16.1680 , LBRM2903_160024900

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8U0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.543
CLV_C14_Caspase3-7	400	404	PF00656	0.555
CLV_NRD_NRD_1	111	113	PF00675	0.423
CLV_PCSK_KEX2_1	111	113	PF00082	0.423
CLV_PCSK_SKI1_1	111	115	PF00082	0.445
CLV_PCSK_SKI1_1	275	279	PF00082	0.407
CLV_PCSK_SKI1_1	355	359	PF00082	0.502
CLV_PCSK_SKI1_1	36	40	PF00082	0.426
CLV_PCSK_SKI1_1	439	443	PF00082	0.490
CLV_PCSK_SKI1_1	58	62	PF00082	0.380
DEG_SCF_FBW7_2	410	416	PF00400	0.488
DEG_SCF_FBW7_2	59	65	PF00400	0.355
DOC_CKS1_1	249	254	PF01111	0.557
DOC_CKS1_1	410	415	PF01111	0.489
DOC_CKS1_1	59	64	PF01111	0.499
DOC_MAPK_gen_1	331	341	PF00069	0.492
DOC_MAPK_MEF2A_6	4	12	PF00069	0.607
DOC_PP4_FxxP_1	249	252	PF00568	0.614
DOC_USP7_MATH_1	13	17	PF00917	0.409
DOC_USP7_MATH_1	206	210	PF00917	0.591
DOC_USP7_MATH_1	343	347	PF00917	0.605
DOC_USP7_MATH_1	390	394	PF00917	0.660
DOC_USP7_MATH_1	397	401	PF00917	0.714
DOC_USP7_MATH_1	447	451	PF00917	0.472
DOC_WW_Pin1_4	248	253	PF00397	0.555
DOC_WW_Pin1_4	377	382	PF00397	0.631
DOC_WW_Pin1_4	409	414	PF00397	0.522
DOC_WW_Pin1_4	58	63	PF00397	0.518
LIG_14-3-3_CanoR_1	124	133	PF00244	0.427
LIG_14-3-3_CanoR_1	207	211	PF00244	0.672
LIG_14-3-3_CanoR_1	355	365	PF00244	0.637
LIG_14-3-3_CanoR_1	368	376	PF00244	0.447
LIG_14-3-3_CanoR_1	382	392	PF00244	0.607
LIG_14-3-3_CterR_2	449	451	PF00244	0.526
LIG_APCC_ABBA_1	60	65	PF00400	0.490
LIG_BIR_II_1	1	5	PF00653	0.674
LIG_BRCT_BRCA1_1	269	273	PF00533	0.363
LIG_BRCT_BRCA1_1	385	389	PF00533	0.493
LIG_BRCT_BRCA1_1	92	96	PF00533	0.425
LIG_EH1_1	435	443	PF00400	0.429
LIG_FHA_1	115	121	PF00498	0.421
LIG_FHA_1	25	31	PF00498	0.426
LIG_FHA_1	278	284	PF00498	0.661
LIG_FHA_1	378	384	PF00498	0.689
LIG_FHA_2	279	285	PF00498	0.613
LIG_FHA_2	296	302	PF00498	0.597
LIG_FHA_2	410	416	PF00498	0.696
LIG_Integrin_isoDGR_2	366	368	PF01839	0.589
LIG_LIR_Nem_3	153	159	PF02991	0.293
LIG_LIR_Nem_3	386	392	PF02991	0.496
LIG_LIR_Nem_3	432	438	PF02991	0.349
LIG_LIR_Nem_3	67	73	PF02991	0.290
LIG_Pex14_1	228	232	PF04695	0.492
LIG_REV1ctd_RIR_1	433	443	PF16727	0.344
LIG_SH2_NCK_1	370	374	PF00017	0.569
LIG_SH2_STAP1	370	374	PF00017	0.433
LIG_SH2_STAP1	74	78	PF00017	0.377
LIG_SH2_STAT5	193	196	PF00017	0.462
LIG_SH2_STAT5	370	373	PF00017	0.449
LIG_SH3_3	220	226	PF00018	0.545
LIG_SH3_3	407	413	PF00018	0.584
LIG_SH3_3	56	62	PF00018	0.531
LIG_SH3_CIN85_PxpxPR_1	406	411	PF14604	0.632
LIG_SUMO_SIM_anti_2	27	34	PF11976	0.506
LIG_SUMO_SIM_par_1	140	145	PF11976	0.282
LIG_SUMO_SIM_par_1	15	21	PF11976	0.586
LIG_TRAF2_1	233	236	PF00917	0.549
LIG_TRAF2_1	413	416	PF00917	0.587
LIG_UBA3_1	434	439	PF00899	0.345
MOD_CDK_SPK_2	377	382	PF00069	0.602
MOD_CK1_1	105	111	PF00069	0.551
MOD_CK1_1	179	185	PF00069	0.541
MOD_CK1_1	238	244	PF00069	0.557
MOD_CK1_1	28	34	PF00069	0.527
MOD_CK1_1	356	362	PF00069	0.622
MOD_CK1_1	393	399	PF00069	0.701
MOD_CK1_1	43	49	PF00069	0.564
MOD_CK1_1	64	70	PF00069	0.535
MOD_CK2_1	164	170	PF00069	0.396
MOD_CK2_1	278	284	PF00069	0.674
MOD_CK2_1	295	301	PF00069	0.487
MOD_CK2_1	369	375	PF00069	0.538
MOD_CK2_1	409	415	PF00069	0.576
MOD_CK2_1	49	55	PF00069	0.406
MOD_DYRK1A_RPxSP_1	58	62	PF00069	0.380
MOD_GlcNHglycan	104	107	PF01048	0.623
MOD_GlcNHglycan	147	150	PF01048	0.385
MOD_GlcNHglycan	210	213	PF01048	0.569
MOD_GlcNHglycan	263	266	PF01048	0.625
MOD_GlcNHglycan	269	272	PF01048	0.523
MOD_GlcNHglycan	27	30	PF01048	0.486
MOD_GlcNHglycan	287	290	PF01048	0.529
MOD_GlcNHglycan	341	344	PF01048	0.621
MOD_GlcNHglycan	345	348	PF01048	0.627
MOD_GlcNHglycan	371	374	PF01048	0.476
MOD_GlcNHglycan	406	409	PF01048	0.644
MOD_GSK3_1	124	131	PF00069	0.383
MOD_GSK3_1	164	171	PF00069	0.405
MOD_GSK3_1	189	196	PF00069	0.514
MOD_GSK3_1	206	213	PF00069	0.666
MOD_GSK3_1	238	245	PF00069	0.754
MOD_GSK3_1	24	31	PF00069	0.538
MOD_GSK3_1	295	302	PF00069	0.567
MOD_GSK3_1	339	346	PF00069	0.733
MOD_GSK3_1	349	356	PF00069	0.610
MOD_GSK3_1	39	46	PF00069	0.486
MOD_GSK3_1	393	400	PF00069	0.582
MOD_NEK2_1	159	164	PF00069	0.419
MOD_NEK2_1	168	173	PF00069	0.459
MOD_NEK2_1	210	215	PF00069	0.467
MOD_NEK2_1	278	283	PF00069	0.440
MOD_NEK2_1	357	362	PF00069	0.634
MOD_NEK2_1	49	54	PF00069	0.446
MOD_NEK2_1	83	88	PF00069	0.346
MOD_NEK2_2	390	395	PF00069	0.628
MOD_NEK2_2	97	102	PF00069	0.437
MOD_OFUCOSY	157	163	PF10250	0.451
MOD_PIKK_1	105	111	PF00454	0.414
MOD_PIKK_1	168	174	PF00454	0.459
MOD_PIKK_1	242	248	PF00454	0.494
MOD_PIKK_1	349	355	PF00454	0.517
MOD_PK_1	4	10	PF00069	0.472
MOD_PKA_1	111	117	PF00069	0.443
MOD_PKA_2	102	108	PF00069	0.601
MOD_PKA_2	111	117	PF00069	0.305
MOD_PKA_2	189	195	PF00069	0.460
MOD_PKA_2	206	212	PF00069	0.492
MOD_PKA_2	343	349	PF00069	0.650
MOD_Plk_1	168	174	PF00069	0.421
MOD_Plk_1	238	244	PF00069	0.477
MOD_Plk_1	300	306	PF00069	0.649
MOD_Plk_1	4	10	PF00069	0.598
MOD_Plk_1	64	70	PF00069	0.443
MOD_Plk_1	74	80	PF00069	0.413
MOD_Plk_4	128	134	PF00069	0.374
MOD_Plk_4	13	19	PF00069	0.531
MOD_Plk_4	151	157	PF00069	0.552
MOD_Plk_4	189	195	PF00069	0.476
MOD_Plk_4	390	396	PF00069	0.684
MOD_Plk_4	43	49	PF00069	0.553
MOD_Plk_4	437	443	PF00069	0.481
MOD_Plk_4	97	103	PF00069	0.447
MOD_ProDKin_1	248	254	PF00069	0.542
MOD_ProDKin_1	377	383	PF00069	0.633
MOD_ProDKin_1	409	415	PF00069	0.521
MOD_ProDKin_1	58	64	PF00069	0.509
TRG_DiLeu_BaEn_1	44	49	PF01217	0.350
TRG_DiLeu_BaEn_2	169	175	PF01217	0.379
TRG_ER_diArg_1	111	113	PF00400	0.452
TRG_ER_diArg_1	333	336	PF00400	0.633
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	258	263	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX30	Leptomonas seymouri	46%	97%
A0A3R7KLD2	Trypanosoma rangeli	26%	100%
A0A3S7WU83	Leishmania donovani	76%	100%
A4HX60	Leishmania infantum	76%	100%
E9AQX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QEK3	Leishmania major	77%	100%