Putative U1 small nuclear ribonucleoprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

u1 small nuclear ribonucleoprotein 70 kDa

Species:

Leishmania braziliensis

UniProt:

A4H8T7_LEIBR

TriTrypDb:

LbrM.16.1650 , LBRM2903_160024500

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005634	nucleus	5	1
GO:0005681	spliceosomal complex	3	1
GO:0005685	U1 snRNP	5	1
GO:0005689	U12-type spliceosomal complex	4	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H8T7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8T7

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045292	mRNA cis splicing, via spliceosome	9	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003729	mRNA binding	5	1
GO:0017069	snRNA binding	5	1
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0044877	protein-containing complex binding	2	1
GO:0070990	snRNP binding	4	1
GO:1990446	U1 snRNP binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.432
CLV_NRD_NRD_1	175	177	PF00675	0.230
CLV_NRD_NRD_1	188	190	PF00675	0.255
CLV_NRD_NRD_1	195	197	PF00675	0.160
CLV_NRD_NRD_1	45	47	PF00675	0.588
CLV_PCSK_FUR_1	196	200	PF00082	0.288
CLV_PCSK_KEX2_1	119	121	PF00082	0.476
CLV_PCSK_KEX2_1	175	177	PF00082	0.243
CLV_PCSK_KEX2_1	198	200	PF00082	0.265
CLV_PCSK_KEX2_1	221	223	PF00082	0.411
CLV_PCSK_KEX2_1	249	251	PF00082	0.524
CLV_PCSK_KEX2_1	27	29	PF00082	0.404
CLV_PCSK_KEX2_1	45	47	PF00082	0.582
CLV_PCSK_KEX2_1	67	69	PF00082	0.484
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.265
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.411
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.524
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.427
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.402
CLV_PCSK_SKI1_1	176	180	PF00082	0.310
CLV_PCSK_SKI1_1	198	202	PF00082	0.365
CLV_PCSK_SKI1_1	276	280	PF00082	0.418
CLV_PCSK_SKI1_1	28	32	PF00082	0.481
DEG_Nend_UBRbox_2	1	3	PF02207	0.492
DOC_MAPK_gen_1	173	182	PF00069	0.464
DOC_MAPK_gen_1	196	207	PF00069	0.482
DOC_PP1_RVXF_1	188	195	PF00149	0.528
DOC_USP7_MATH_1	225	229	PF00917	0.446
DOC_USP7_MATH_1	239	243	PF00917	0.462
DOC_USP7_MATH_1	263	267	PF00917	0.554
DOC_USP7_UBL2_3	197	201	PF12436	0.475
DOC_WW_Pin1_4	229	234	PF00397	0.511
DOC_WW_Pin1_4	235	240	PF00397	0.544
LIG_14-3-3_CanoR_1	120	128	PF00244	0.492
LIG_AP2alpha_1	153	157	PF02296	0.528
LIG_EH_1	120	124	PF12763	0.491
LIG_FHA_2	143	149	PF00498	0.446
LIG_LIR_Apic_2	228	233	PF02991	0.498
LIG_LIR_Gen_1	174	185	PF02991	0.528
LIG_LIR_Nem_3	155	160	PF02991	0.433
LIG_LIR_Nem_3	174	180	PF02991	0.449
LIG_LIR_Nem_3	181	185	PF02991	0.433
LIG_NRBOX	84	90	PF00104	0.446
LIG_Pex14_1	26	30	PF04695	0.431
LIG_Pex14_2	153	157	PF04695	0.433
LIG_REV1ctd_RIR_1	28	34	PF16727	0.458
LIG_RPA_C_Fungi	8	20	PF08784	0.345
LIG_SH2_CRK	203	207	PF00017	0.412
LIG_SH2_STAP1	203	207	PF00017	0.412
LIG_SH3_1	262	268	PF00018	0.670
LIG_SH3_3	262	268	PF00018	0.690
LIG_SH3_3	32	38	PF00018	0.462
LIG_SUMO_SIM_par_1	86	94	PF11976	0.443
LIG_TRAF2_1	104	107	PF00917	0.493
LIG_TRAF2_1	145	148	PF00917	0.266
LIG_TRAF2_1	70	73	PF00917	0.554
MOD_CK1_1	228	234	PF00069	0.561
MOD_CK1_1	238	244	PF00069	0.549
MOD_CK1_1	84	90	PF00069	0.597
MOD_CK2_1	101	107	PF00069	0.553
MOD_CK2_1	142	148	PF00069	0.284
MOD_CK2_1	238	244	PF00069	0.589
MOD_CK2_1	263	269	PF00069	0.587
MOD_GlcNHglycan	252	255	PF01048	0.740
MOD_GlcNHglycan	93	96	PF01048	0.674
MOD_GSK3_1	225	232	PF00069	0.506
MOD_GSK3_1	235	242	PF00069	0.560
MOD_GSK3_1	48	55	PF00069	0.651
MOD_GSK3_1	83	90	PF00069	0.640
MOD_NEK2_1	89	94	PF00069	0.556
MOD_NEK2_2	26	31	PF00069	0.552
MOD_PIKK_1	102	108	PF00454	0.431
MOD_PK_1	201	207	PF00069	0.418
MOD_Plk_1	4	10	PF00069	0.557
MOD_Plk_1	81	87	PF00069	0.734
MOD_Plk_4	201	207	PF00069	0.418
MOD_Plk_4	225	231	PF00069	0.529
MOD_Plk_4	84	90	PF00069	0.446
MOD_ProDKin_1	229	235	PF00069	0.518
MOD_SUMO_rev_2	241	251	PF00179	0.483
MOD_SUMO_rev_2	72	81	PF00179	0.556
TRG_DiLeu_BaEn_4	4	10	PF01217	0.562
TRG_ENDOCYTIC_2	177	180	PF00928	0.266
TRG_ENDOCYTIC_2	203	206	PF00928	0.421
TRG_ER_diArg_1	175	177	PF00400	0.262
TRG_NLS_MonoCore_2	195	200	PF00514	0.344
TRG_NLS_MonoExtC_3	196	201	PF00514	0.399
TRG_NLS_MonoExtN_4	196	202	PF00514	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T1	Leptomonas seymouri	60%	95%
A0A0S4J1P9	Bodo saltans	28%	100%
A0A1X0NYS6	Trypanosomatidae	42%	100%
A0A3Q8IAQ7	Leishmania donovani	80%	100%
A4HX57	Leishmania infantum	80%	75%
C9ZVT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AQX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QEK6	Leishmania major	80%	100%
V5B2N5	Trypanosoma cruzi	39%	100%