SMP-LTD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8T6_LEIBR

TriTrypDb:

LbrM.16.1630 , LBRM2903_160024300

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032865	ERMES complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0098796	membrane protein complex	2	12
GO:0098798	mitochondrial protein-containing complex	2	12
GO:0098799	outer mitochondrial membrane protein complex	3	12
GO:0140534	endoplasmic reticulum protein-containing complex	2	12

Expansion

Sequence features

A4H8T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8T6

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0007005	mitochondrion organization	5	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0071840	cellular component organization or biogenesis	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.757
CLV_C14_Caspase3-7	243	247	PF00656	0.729
CLV_NRD_NRD_1	213	215	PF00675	0.642
CLV_NRD_NRD_1	285	287	PF00675	0.473
CLV_PCSK_KEX2_1	213	215	PF00082	0.630
CLV_PCSK_KEX2_1	278	280	PF00082	0.525
CLV_PCSK_KEX2_1	284	286	PF00082	0.463
CLV_PCSK_KEX2_1	297	299	PF00082	0.356
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.545
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.489
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.384
CLV_PCSK_SKI1_1	19	23	PF00082	0.529
CLV_PCSK_SKI1_1	285	289	PF00082	0.421
DEG_APCC_DBOX_1	268	276	PF00400	0.610
DEG_Nend_Nbox_1	1	3	PF02207	0.472
DOC_ANK_TNKS_1	328	335	PF00023	0.581
DOC_MAPK_gen_1	283	291	PF00069	0.434
DOC_MAPK_gen_1	36	46	PF00069	0.564
DOC_MAPK_gen_1	84	92	PF00069	0.472
DOC_MAPK_MEF2A_6	15	22	PF00069	0.487
DOC_MAPK_MEF2A_6	283	291	PF00069	0.449
DOC_MAPK_MEF2A_6	39	46	PF00069	0.557
DOC_MAPK_MEF2A_6	84	92	PF00069	0.430
DOC_PP2B_LxvP_1	107	110	PF13499	0.626
DOC_PP4_FxxP_1	111	114	PF00568	0.446
DOC_PP4_FxxP_1	234	237	PF00568	0.653
DOC_PP4_FxxP_1	292	295	PF00568	0.448
DOC_PP4_MxPP_1	216	219	PF00568	0.656
DOC_USP7_MATH_1	185	189	PF00917	0.692
DOC_USP7_MATH_1	250	254	PF00917	0.644
DOC_USP7_MATH_1	263	267	PF00917	0.596
DOC_USP7_MATH_1	268	272	PF00917	0.538
DOC_USP7_UBL2_3	284	288	PF12436	0.468
DOC_USP7_UBL2_3	32	36	PF12436	0.621
DOC_WW_Pin1_4	146	151	PF00397	0.635
DOC_WW_Pin1_4	177	182	PF00397	0.548
DOC_WW_Pin1_4	233	238	PF00397	0.727
DOC_WW_Pin1_4	49	54	PF00397	0.530
LIG_14-3-3_CanoR_1	173	179	PF00244	0.678
LIG_14-3-3_CanoR_1	213	217	PF00244	0.660
LIG_14-3-3_CanoR_1	256	262	PF00244	0.660
LIG_14-3-3_CanoR_1	269	273	PF00244	0.544
LIG_APCC_ABBA_1	130	135	PF00400	0.447
LIG_APCC_ABBA_1	289	294	PF00400	0.440
LIG_APCC_ABBAyCdc20_2	288	294	PF00400	0.453
LIG_APCC_ABBAyCdc20_2	39	45	PF00400	0.584
LIG_BRCT_BRCA1_1	148	152	PF00533	0.619
LIG_Clathr_ClatBox_1	41	45	PF01394	0.572
LIG_CtBP_PxDLS_1	114	118	PF00389	0.525
LIG_deltaCOP1_diTrp_1	5	10	PF00928	0.467
LIG_FHA_1	334	340	PF00498	0.534
LIG_FHA_1	7	13	PF00498	0.590
LIG_FHA_2	116	122	PF00498	0.413
LIG_FHA_2	241	247	PF00498	0.518
LIG_LIR_Gen_1	131	140	PF02991	0.473
LIG_LIR_Nem_3	131	136	PF02991	0.465
LIG_LIR_Nem_3	201	207	PF02991	0.642
LIG_SH2_CRK	204	208	PF00017	0.602
LIG_SH2_STAT5	112	115	PF00017	0.526
LIG_SH3_3	225	231	PF00018	0.767
LIG_SH3_3	262	268	PF00018	0.701
LIG_SH3_3	303	309	PF00018	0.627
LIG_SH3_3	41	47	PF00018	0.542
LIG_SUMO_SIM_anti_2	167	172	PF11976	0.500
LIG_SUMO_SIM_par_1	271	277	PF11976	0.634
LIG_SUMO_SIM_par_1	335	340	PF11976	0.588
LIG_UBA3_1	272	278	PF00899	0.613
MOD_CDK_SPxxK_3	146	153	PF00069	0.473
MOD_CK1_1	146	152	PF00069	0.660
MOD_CK1_1	159	165	PF00069	0.737
MOD_CK1_1	177	183	PF00069	0.661
MOD_CK1_1	193	199	PF00069	0.656
MOD_CK1_1	241	247	PF00069	0.686
MOD_CK1_1	252	258	PF00069	0.560
MOD_CK1_1	99	105	PF00069	0.689
MOD_Cter_Amidation	211	214	PF01082	0.619
MOD_Cter_Amidation	311	314	PF01082	0.621
MOD_GlcNHglycan	176	179	PF01048	0.726
MOD_GlcNHglycan	183	186	PF01048	0.721
MOD_GlcNHglycan	192	195	PF01048	0.565
MOD_GlcNHglycan	201	204	PF01048	0.571
MOD_GlcNHglycan	252	255	PF01048	0.693
MOD_GlcNHglycan	257	260	PF01048	0.679
MOD_GSK3_1	139	146	PF00069	0.601
MOD_GSK3_1	177	184	PF00069	0.734
MOD_GSK3_1	186	193	PF00069	0.597
MOD_GSK3_1	238	245	PF00069	0.680
MOD_GSK3_1	250	257	PF00069	0.580
MOD_GSK3_1	333	340	PF00069	0.575
MOD_GSK3_1	62	69	PF00069	0.420
MOD_GSK3_1	96	103	PF00069	0.616
MOD_N-GLC_1	238	243	PF02516	0.514
MOD_N-GLC_1	97	102	PF02516	0.576
MOD_NEK2_1	115	120	PF00069	0.378
MOD_NEK2_1	156	161	PF00069	0.706
MOD_NEK2_1	66	71	PF00069	0.512
MOD_NEK2_2	212	217	PF00069	0.505
MOD_NEK2_2	79	84	PF00069	0.426
MOD_PIKK_1	263	269	PF00454	0.686
MOD_PKA_2	212	218	PF00069	0.738
MOD_PKA_2	255	261	PF00069	0.631
MOD_PKA_2	268	274	PF00069	0.537
MOD_Plk_1	115	121	PF00069	0.411
MOD_Plk_1	143	149	PF00069	0.667
MOD_Plk_1	238	244	PF00069	0.763
MOD_Plk_1	245	251	PF00069	0.749
MOD_Plk_1	62	68	PF00069	0.460
MOD_Plk_1	79	85	PF00069	0.404
MOD_Plk_1	97	103	PF00069	0.560
MOD_Plk_2-3	333	339	PF00069	0.577
MOD_Plk_4	143	149	PF00069	0.592
MOD_Plk_4	166	172	PF00069	0.662
MOD_Plk_4	268	274	PF00069	0.574
MOD_ProDKin_1	146	152	PF00069	0.638
MOD_ProDKin_1	177	183	PF00069	0.552
MOD_ProDKin_1	233	239	PF00069	0.726
MOD_ProDKin_1	49	55	PF00069	0.533
MOD_SUMO_for_1	31	34	PF00179	0.615
MOD_SUMO_rev_2	146	154	PF00179	0.615
TRG_DiLeu_BaEn_1	143	148	PF01217	0.717
TRG_DiLeu_BaEn_1	67	72	PF01217	0.536
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.496
TRG_DiLeu_BaLyEn_6	322	327	PF01217	0.584
TRG_ENDOCYTIC_2	112	115	PF00928	0.512
TRG_ENDOCYTIC_2	204	207	PF00928	0.602
TRG_ER_diArg_1	285	287	PF00400	0.475
TRG_NES_CRM1_1	55	67	PF08389	0.556
TRG_NLS_Bipartite_1	283	301	PF00514	0.558
TRG_NLS_MonoCore_2	282	287	PF00514	0.560
TRG_NLS_MonoExtC_3	283	288	PF00514	0.561
TRG_NLS_MonoExtC_3	296	302	PF00514	0.563
TRG_NLS_MonoExtN_4	283	288	PF00514	0.546
TRG_NLS_MonoExtN_4	295	301	PF00514	0.479
TRG_Pf-PMV_PEXEL_1	62	67	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY6	Leptomonas seymouri	64%	100%
A0A0S4IYB8	Bodo saltans	35%	93%
A0A1X0NYR1	Trypanosomatidae	42%	100%
A0A3R7LUZ6	Trypanosoma rangeli	40%	100%
A0A3S7WU79	Leishmania donovani	86%	100%
A4HX55	Leishmania infantum	86%	100%
C9ZVT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AQX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QEK8	Leishmania major	86%	100%
V5BSA1	Trypanosoma cruzi	40%	100%