Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8T5_LEIBR

TriTrypDb:

LbrM.16.1620 , LBRM2903_160024200

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8T5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.676
CLV_C14_Caspase3-7	391	395	PF00656	0.462
CLV_C14_Caspase3-7	510	514	PF00656	0.537
CLV_NRD_NRD_1	659	661	PF00675	0.463
CLV_PCSK_KEX2_1	121	123	PF00082	0.428
CLV_PCSK_KEX2_1	364	366	PF00082	0.528
CLV_PCSK_KEX2_1	659	661	PF00082	0.463
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.428
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.528
CLV_PCSK_SKI1_1	144	148	PF00082	0.393
CLV_PCSK_SKI1_1	292	296	PF00082	0.326
CLV_PCSK_SKI1_1	38	42	PF00082	0.564
CLV_PCSK_SKI1_1	432	436	PF00082	0.435
CLV_PCSK_SKI1_1	51	55	PF00082	0.362
CLV_PCSK_SKI1_1	547	551	PF00082	0.401
CLV_PCSK_SKI1_1	643	647	PF00082	0.568
CLV_PCSK_SKI1_1	67	71	PF00082	0.451
DEG_APCC_DBOX_1	168	176	PF00400	0.507
DEG_Nend_Nbox_1	1	3	PF02207	0.638
DEG_SCF_FBW7_1	470	477	PF00400	0.334
DEG_SPOP_SBC_1	69	73	PF00917	0.567
DOC_CKS1_1	139	144	PF01111	0.428
DOC_CKS1_1	635	640	PF01111	0.585
DOC_MAPK_gen_1	121	129	PF00069	0.409
DOC_MAPK_gen_1	166	174	PF00069	0.521
DOC_MAPK_MEF2A_6	577	586	PF00069	0.540
DOC_PP2B_LxvP_1	380	383	PF13499	0.533
DOC_PP2B_LxvP_1	582	585	PF13499	0.514
DOC_USP7_MATH_1	15	19	PF00917	0.471
DOC_USP7_MATH_1	157	161	PF00917	0.405
DOC_USP7_MATH_1	285	289	PF00917	0.486
DOC_USP7_MATH_1	309	313	PF00917	0.711
DOC_USP7_MATH_1	531	535	PF00917	0.405
DOC_USP7_MATH_1	620	624	PF00917	0.633
DOC_WW_Pin1_4	103	108	PF00397	0.579
DOC_WW_Pin1_4	138	143	PF00397	0.419
DOC_WW_Pin1_4	327	332	PF00397	0.755
DOC_WW_Pin1_4	470	475	PF00397	0.382
DOC_WW_Pin1_4	634	639	PF00397	0.587
DOC_WW_Pin1_4	683	688	PF00397	0.517
LIG_14-3-3_CanoR_1	144	151	PF00244	0.396
LIG_14-3-3_CanoR_1	180	185	PF00244	0.424
LIG_14-3-3_CanoR_1	365	373	PF00244	0.409
LIG_14-3-3_CanoR_1	375	380	PF00244	0.391
LIG_14-3-3_CanoR_1	399	403	PF00244	0.451
LIG_14-3-3_CanoR_1	432	441	PF00244	0.491
LIG_14-3-3_CanoR_1	552	558	PF00244	0.369
LIG_14-3-3_CanoR_1	577	582	PF00244	0.481
LIG_14-3-3_CanoR_1	643	649	PF00244	0.374
LIG_14-3-3_CanoR_1	67	77	PF00244	0.542
LIG_14-3-3_CanoR_1	9	15	PF00244	0.557
LIG_APCC_ABBA_1	464	469	PF00400	0.515
LIG_BIR_III_4	599	603	PF00653	0.484
LIG_BRCT_BRCA1_1	310	314	PF00533	0.712
LIG_BRCT_BRCA1_1	569	573	PF00533	0.307
LIG_Clathr_ClatBox_1	126	130	PF01394	0.456
LIG_deltaCOP1_diTrp_1	177	184	PF00928	0.431
LIG_deltaCOP1_diTrp_1	221	226	PF00928	0.500
LIG_deltaCOP1_diTrp_1	353	360	PF00928	0.375
LIG_FHA_1	145	151	PF00498	0.389
LIG_FHA_1	249	255	PF00498	0.443
LIG_FHA_1	291	297	PF00498	0.499
LIG_FHA_1	352	358	PF00498	0.424
LIG_FHA_1	382	388	PF00498	0.500
LIG_FHA_1	441	447	PF00498	0.344
LIG_FHA_1	48	54	PF00498	0.535
LIG_FHA_1	548	554	PF00498	0.390
LIG_FHA_1	570	576	PF00498	0.403
LIG_FHA_1	630	636	PF00498	0.649
LIG_FHA_2	206	212	PF00498	0.385
LIG_FHA_2	27	33	PF00498	0.600
LIG_FHA_2	483	489	PF00498	0.538
LIG_FHA_2	50	56	PF00498	0.421
LIG_FHA_2	601	607	PF00498	0.492
LIG_FHA_2	623	629	PF00498	0.580
LIG_GBD_Chelix_1	275	283	PF00786	0.295
LIG_LIR_Apic_2	544	548	PF02991	0.545
LIG_LIR_Gen_1	148	157	PF02991	0.395
LIG_LIR_Gen_1	177	184	PF02991	0.479
LIG_LIR_Gen_1	188	199	PF02991	0.335
LIG_LIR_Gen_1	252	263	PF02991	0.351
LIG_LIR_Gen_1	371	380	PF02991	0.434
LIG_LIR_Gen_1	424	434	PF02991	0.332
LIG_LIR_Gen_1	435	446	PF02991	0.372
LIG_LIR_Gen_1	533	543	PF02991	0.339
LIG_LIR_Gen_1	576	586	PF02991	0.309
LIG_LIR_Nem_3	115	120	PF02991	0.473
LIG_LIR_Nem_3	148	154	PF02991	0.399
LIG_LIR_Nem_3	177	181	PF02991	0.519
LIG_LIR_Nem_3	223	229	PF02991	0.405
LIG_LIR_Nem_3	252	258	PF02991	0.346
LIG_LIR_Nem_3	343	347	PF02991	0.500
LIG_LIR_Nem_3	353	358	PF02991	0.303
LIG_LIR_Nem_3	359	363	PF02991	0.292
LIG_LIR_Nem_3	424	429	PF02991	0.317
LIG_LIR_Nem_3	435	441	PF02991	0.363
LIG_LIR_Nem_3	533	539	PF02991	0.476
LIG_LIR_Nem_3	576	582	PF02991	0.502
LIG_LIR_Nem_3	59	65	PF02991	0.445
LIG_NRBOX	553	559	PF00104	0.407
LIG_NRBOX	577	583	PF00104	0.403
LIG_PCNA_yPIPBox_3	137	150	PF02747	0.509
LIG_Pex14_2	441	445	PF04695	0.374
LIG_SH2_CRK	151	155	PF00017	0.437
LIG_SH2_CRK	255	259	PF00017	0.488
LIG_SH2_CRK	536	540	PF00017	0.516
LIG_SH2_CRK	545	549	PF00017	0.532
LIG_SH2_CRK	579	583	PF00017	0.588
LIG_SH2_SRC	465	468	PF00017	0.433
LIG_SH2_STAP1	255	259	PF00017	0.488
LIG_SH2_STAP1	461	465	PF00017	0.438
LIG_SH2_STAP1	519	523	PF00017	0.353
LIG_SH2_STAT5	114	117	PF00017	0.424
LIG_SH2_STAT5	119	122	PF00017	0.409
LIG_SH2_STAT5	229	232	PF00017	0.448
LIG_SH2_STAT5	253	256	PF00017	0.383
LIG_SH2_STAT5	347	350	PF00017	0.535
LIG_SH2_STAT5	421	424	PF00017	0.397
LIG_SH2_STAT5	438	441	PF00017	0.420
LIG_SH2_STAT5	465	468	PF00017	0.414
LIG_SH3_3	151	157	PF00018	0.425
LIG_SH3_3	632	638	PF00018	0.584
LIG_SH3_3	91	97	PF00018	0.437
LIG_SUMO_SIM_anti_2	170	177	PF11976	0.540
LIG_SUMO_SIM_par_1	125	130	PF11976	0.404
LIG_SUMO_SIM_par_1	383	388	PF11976	0.465
LIG_SxIP_EBH_1	674	685	PF03271	0.539
LIG_TRAF2_1	300	303	PF00917	0.551
LIG_UBA3_1	126	131	PF00899	0.413
LIG_UBA3_1	641	646	PF00899	0.342
LIG_WRC_WIRS_1	181	186	PF05994	0.543
LIG_WRC_WIRS_1	607	612	PF05994	0.547
MOD_CDK_SPxK_1	138	144	PF00069	0.432
MOD_CDK_SPxxK_3	103	110	PF00069	0.573
MOD_CDK_SPxxK_3	683	690	PF00069	0.564
MOD_CK1_1	288	294	PF00069	0.281
MOD_CK1_1	316	322	PF00069	0.734
MOD_CK1_1	324	330	PF00069	0.711
MOD_CK1_1	335	341	PF00069	0.638
MOD_CK1_1	534	540	PF00069	0.307
MOD_CK2_1	205	211	PF00069	0.391
MOD_CK2_1	26	32	PF00069	0.467
MOD_CK2_1	482	488	PF00069	0.350
MOD_CK2_1	49	55	PF00069	0.415
MOD_CK2_1	600	606	PF00069	0.547
MOD_CK2_1	622	628	PF00069	0.607
MOD_CK2_1	683	689	PF00069	0.505
MOD_GlcNHglycan	17	20	PF01048	0.507
MOD_GlcNHglycan	311	314	PF01048	0.729
MOD_GlcNHglycan	315	318	PF01048	0.739
MOD_GlcNHglycan	327	330	PF01048	0.754
MOD_GlcNHglycan	533	536	PF01048	0.412
MOD_GlcNHglycan	58	61	PF01048	0.542
MOD_GlcNHglycan	603	606	PF01048	0.531
MOD_GlcNHglycan	622	625	PF01048	0.380
MOD_GlcNHglycan	72	75	PF01048	0.534
MOD_GSK3_1	288	295	PF00069	0.539
MOD_GSK3_1	304	311	PF00069	0.591
MOD_GSK3_1	321	328	PF00069	0.634
MOD_GSK3_1	359	366	PF00069	0.544
MOD_GSK3_1	43	50	PF00069	0.538
MOD_GSK3_1	470	477	PF00069	0.306
MOD_GSK3_1	530	537	PF00069	0.358
MOD_GSK3_1	561	568	PF00069	0.435
MOD_GSK3_1	569	576	PF00069	0.383
MOD_GSK3_1	672	679	PF00069	0.514
MOD_N-GLC_1	103	108	PF02516	0.457
MOD_N-GLC_1	324	329	PF02516	0.773
MOD_NEK2_1	1	6	PF00069	0.617
MOD_NEK2_1	112	117	PF00069	0.520
MOD_NEK2_1	194	199	PF00069	0.430
MOD_NEK2_1	248	253	PF00069	0.476
MOD_NEK2_1	290	295	PF00069	0.507
MOD_NEK2_1	304	309	PF00069	0.614
MOD_NEK2_1	439	444	PF00069	0.430
MOD_NEK2_1	573	578	PF00069	0.545
MOD_NEK2_1	676	681	PF00069	0.505
MOD_NEK2_1	70	75	PF00069	0.551
MOD_NEK2_2	408	413	PF00069	0.492
MOD_NEK2_2	49	54	PF00069	0.356
MOD_PIKK_1	427	433	PF00454	0.420
MOD_PKA_1	364	370	PF00069	0.514
MOD_PKA_2	112	118	PF00069	0.488
MOD_PKA_2	285	291	PF00069	0.429
MOD_PKA_2	364	370	PF00069	0.390
MOD_PKA_2	398	404	PF00069	0.395
MOD_PKA_2	653	659	PF00069	0.533
MOD_Plk_1	474	480	PF00069	0.327
MOD_Plk_1	573	579	PF00069	0.289
MOD_Plk_1	587	593	PF00069	0.512
MOD_Plk_2-3	353	359	PF00069	0.457
MOD_Plk_2-3	388	394	PF00069	0.474
MOD_Plk_4	170	176	PF00069	0.459
MOD_Plk_4	249	255	PF00069	0.388
MOD_Plk_4	285	291	PF00069	0.435
MOD_Plk_4	292	298	PF00069	0.401
MOD_Plk_4	375	381	PF00069	0.412
MOD_Plk_4	474	480	PF00069	0.321
MOD_Plk_4	507	513	PF00069	0.490
MOD_Plk_4	553	559	PF00069	0.372
MOD_Plk_4	577	583	PF00069	0.570
MOD_Plk_4	644	650	PF00069	0.610
MOD_Plk_4	653	659	PF00069	0.560
MOD_Plk_4	672	678	PF00069	0.595
MOD_ProDKin_1	103	109	PF00069	0.575
MOD_ProDKin_1	138	144	PF00069	0.426
MOD_ProDKin_1	327	333	PF00069	0.752
MOD_ProDKin_1	470	476	PF00069	0.378
MOD_ProDKin_1	634	640	PF00069	0.586
MOD_ProDKin_1	683	689	PF00069	0.518
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.386
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.387
TRG_ENDOCYTIC_2	117	120	PF00928	0.409
TRG_ENDOCYTIC_2	151	154	PF00928	0.430
TRG_ENDOCYTIC_2	255	258	PF00928	0.488
TRG_ENDOCYTIC_2	373	376	PF00928	0.373
TRG_ENDOCYTIC_2	438	441	PF00928	0.428
TRG_ENDOCYTIC_2	461	464	PF00928	0.525
TRG_ENDOCYTIC_2	536	539	PF00928	0.511
TRG_ENDOCYTIC_2	579	582	PF00928	0.568
TRG_ENDOCYTIC_2	62	65	PF00928	0.439
TRG_ER_diArg_1	283	286	PF00400	0.427
TRG_ER_diArg_1	651	654	PF00400	0.481
TRG_ER_diArg_1	658	660	PF00400	0.428
TRG_ER_diArg_1	667	670	PF00400	0.492
TRG_NES_CRM1_1	455	469	PF08389	0.494
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	432	437	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T2	Leptomonas seymouri	74%	100%
A0A0S4IYN7	Bodo saltans	39%	100%
A0A1X0NYU0	Trypanosomatidae	56%	100%
A0A3S5H6Z3	Leishmania donovani	89%	100%
A0A422NE62	Trypanosoma rangeli	57%	100%
A4HX54	Leishmania infantum	90%	100%
C9ZVT7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AQW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QEK9	Leishmania major	89%	100%
V5BMQ0	Trypanosoma cruzi	57%	97%