Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8T4_LEIBR

TriTrypDb:

LbrM.16.1610 , LBRM2903_160024100

Length:

1079

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4H8T4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8T4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.583
CLV_C14_Caspase3-7	365	369	PF00656	0.532
CLV_C14_Caspase3-7	45	49	PF00656	0.518
CLV_C14_Caspase3-7	708	712	PF00656	0.612
CLV_C14_Caspase3-7	787	791	PF00656	0.348
CLV_NRD_NRD_1	1013	1015	PF00675	0.479
CLV_NRD_NRD_1	140	142	PF00675	0.392
CLV_NRD_NRD_1	408	410	PF00675	0.431
CLV_NRD_NRD_1	549	551	PF00675	0.526
CLV_NRD_NRD_1	687	689	PF00675	0.448
CLV_NRD_NRD_1	815	817	PF00675	0.523
CLV_NRD_NRD_1	837	839	PF00675	0.638
CLV_PCSK_FUR_1	813	817	PF00082	0.402
CLV_PCSK_FUR_1	884	888	PF00082	0.593
CLV_PCSK_KEX2_1	301	303	PF00082	0.484
CLV_PCSK_KEX2_1	549	551	PF00082	0.533
CLV_PCSK_KEX2_1	686	688	PF00082	0.464
CLV_PCSK_KEX2_1	738	740	PF00082	0.490
CLV_PCSK_KEX2_1	815	817	PF00082	0.507
CLV_PCSK_KEX2_1	837	839	PF00082	0.638
CLV_PCSK_KEX2_1	886	888	PF00082	0.591
CLV_PCSK_KEX2_1	929	931	PF00082	0.557
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.484
CLV_PCSK_PC1ET2_1	686	688	PF00082	0.521
CLV_PCSK_PC1ET2_1	738	740	PF00082	0.490
CLV_PCSK_PC1ET2_1	837	839	PF00082	0.638
CLV_PCSK_PC1ET2_1	886	888	PF00082	0.591
CLV_PCSK_PC1ET2_1	929	931	PF00082	0.593
CLV_PCSK_SKI1_1	174	178	PF00082	0.511
CLV_PCSK_SKI1_1	18	22	PF00082	0.523
CLV_PCSK_SKI1_1	433	437	PF00082	0.457
CLV_PCSK_SKI1_1	442	446	PF00082	0.388
CLV_PCSK_SKI1_1	482	486	PF00082	0.614
CLV_PCSK_SKI1_1	560	564	PF00082	0.461
CLV_PCSK_SKI1_1	657	661	PF00082	0.633
CLV_PCSK_SKI1_1	671	675	PF00082	0.660
CLV_PCSK_SKI1_1	831	835	PF00082	0.587
CLV_PCSK_SKI1_1	839	843	PF00082	0.522
CLV_PCSK_SKI1_1	929	933	PF00082	0.473
CLV_PCSK_SKI1_1	958	962	PF00082	0.649
CLV_PCSK_SKI1_1	983	987	PF00082	0.579
DEG_Nend_Nbox_1	1	3	PF02207	0.425
DOC_ANK_TNKS_1	146	153	PF00023	0.506
DOC_ANK_TNKS_1	470	477	PF00023	0.475
DOC_CYCLIN_RxL_1	1067	1078	PF00134	0.667
DOC_CYCLIN_RxL_1	345	358	PF00134	0.551
DOC_CYCLIN_RxL_1	652	664	PF00134	0.623
DOC_CYCLIN_RxL_1	667	677	PF00134	0.655
DOC_MAPK_gen_1	1068	1076	PF00069	0.576
DOC_MAPK_gen_1	601	608	PF00069	0.420
DOC_MAPK_gen_1	923	933	PF00069	0.445
DOC_MAPK_MEF2A_6	1068	1076	PF00069	0.573
DOC_PP1_RVXF_1	348	355	PF00149	0.440
DOC_PP1_RVXF_1	440	446	PF00149	0.438
DOC_PP2B_LxvP_1	1072	1075	PF13499	0.582
DOC_PP2B_LxvP_1	199	202	PF13499	0.432
DOC_PP4_FxxP_1	178	181	PF00568	0.523
DOC_PP4_FxxP_1	354	357	PF00568	0.446
DOC_USP7_MATH_1	111	115	PF00917	0.459
DOC_USP7_MATH_1	428	432	PF00917	0.468
DOC_USP7_MATH_1	7	11	PF00917	0.663
DOC_USP7_MATH_1	847	851	PF00917	0.430
DOC_USP7_MATH_1	864	868	PF00917	0.481
DOC_USP7_UBL2_3	932	936	PF12436	0.460
DOC_USP7_UBL2_3	983	987	PF12436	0.387
DOC_WW_Pin1_4	176	181	PF00397	0.396
DOC_WW_Pin1_4	23	28	PF00397	0.494
DOC_WW_Pin1_4	99	104	PF00397	0.426
LIG_14-3-3_CanoR_1	141	147	PF00244	0.411
LIG_14-3-3_CanoR_1	174	179	PF00244	0.509
LIG_14-3-3_CanoR_1	306	311	PF00244	0.383
LIG_14-3-3_CanoR_1	312	320	PF00244	0.352
LIG_14-3-3_CanoR_1	350	355	PF00244	0.490
LIG_14-3-3_CanoR_1	454	460	PF00244	0.376
LIG_14-3-3_CanoR_1	482	487	PF00244	0.430
LIG_14-3-3_CanoR_1	560	569	PF00244	0.529
LIG_14-3-3_CanoR_1	619	627	PF00244	0.537
LIG_14-3-3_CanoR_1	636	642	PF00244	0.564
LIG_14-3-3_CanoR_1	77	87	PF00244	0.374
LIG_14-3-3_CanoR_1	958	967	PF00244	0.682
LIG_14-3-3_CanoR_1	998	1007	PF00244	0.499
LIG_Actin_WH2_2	620	638	PF00022	0.444
LIG_APCC_ABBA_1	1035	1040	PF00400	0.658
LIG_APCC_ABBA_1	522	527	PF00400	0.532
LIG_BRCT_BRCA1_1	350	354	PF00533	0.471
LIG_BRCT_BRCA1_1	48	52	PF00533	0.494
LIG_Clathr_ClatBox_1	87	91	PF01394	0.358
LIG_eIF4E_1	46	52	PF01652	0.525
LIG_eIF4E_1	541	547	PF01652	0.467
LIG_FHA_1	191	197	PF00498	0.376
LIG_FHA_1	221	227	PF00498	0.471
LIG_FHA_1	252	258	PF00498	0.381
LIG_FHA_1	282	288	PF00498	0.303
LIG_FHA_1	333	339	PF00498	0.402
LIG_FHA_1	358	364	PF00498	0.446
LIG_FHA_1	450	456	PF00498	0.359
LIG_FHA_1	497	503	PF00498	0.424
LIG_FHA_1	540	546	PF00498	0.499
LIG_FHA_1	561	567	PF00498	0.465
LIG_FHA_1	67	73	PF00498	0.401
LIG_FHA_1	725	731	PF00498	0.578
LIG_FHA_1	745	751	PF00498	0.291
LIG_FHA_1	774	780	PF00498	0.583
LIG_FHA_1	798	804	PF00498	0.590
LIG_FHA_1	959	965	PF00498	0.709
LIG_FHA_1	999	1005	PF00498	0.503
LIG_FHA_2	11	17	PF00498	0.568
LIG_FHA_2	127	133	PF00498	0.442
LIG_FHA_2	205	211	PF00498	0.589
LIG_FHA_2	4	10	PF00498	0.682
LIG_FHA_2	514	520	PF00498	0.453
LIG_FHA_2	636	642	PF00498	0.470
LIG_FHA_2	841	847	PF00498	0.673
LIG_FHA_2	916	922	PF00498	0.571
LIG_FHA_2	957	963	PF00498	0.582
LIG_FHA_2	984	990	PF00498	0.389
LIG_GBD_Chelix_1	1059	1067	PF00786	0.607
LIG_LIR_Apic_2	177	181	PF02991	0.525
LIG_LIR_Apic_2	351	357	PF02991	0.457
LIG_LIR_Apic_2	422	428	PF02991	0.531
LIG_LIR_Gen_1	378	386	PF02991	0.377
LIG_LIR_Gen_1	692	699	PF02991	0.620
LIG_LIR_LC3C_4	75	80	PF02991	0.479
LIG_LIR_Nem_3	138	143	PF02991	0.429
LIG_LIR_Nem_3	151	157	PF02991	0.488
LIG_LIR_Nem_3	211	217	PF02991	0.452
LIG_LIR_Nem_3	299	303	PF02991	0.374
LIG_LIR_Nem_3	378	382	PF02991	0.383
LIG_LIR_Nem_3	692	696	PF02991	0.588
LIG_LIR_Nem_3	828	833	PF02991	0.529
LIG_LIR_Nem_3	916	922	PF02991	0.503
LIG_NRBOX	655	661	PF00104	0.644
LIG_PDZ_Class_1	1074	1079	PF00595	0.698
LIG_PTB_Apo_2	200	207	PF02174	0.451
LIG_SH2_CRK	140	144	PF00017	0.417
LIG_SH2_CRK	154	158	PF00017	0.506
LIG_SH2_CRK	425	429	PF00017	0.482
LIG_SH2_NCK_1	425	429	PF00017	0.545
LIG_SH2_SRC	46	49	PF00017	0.435
LIG_SH2_STAP1	1038	1042	PF00017	0.652
LIG_SH2_STAP1	197	201	PF00017	0.364
LIG_SH2_STAP1	28	32	PF00017	0.529
LIG_SH2_STAP1	293	297	PF00017	0.512
LIG_SH2_STAP1	334	338	PF00017	0.391
LIG_SH2_STAP1	541	545	PF00017	0.359
LIG_SH2_STAP1	736	740	PF00017	0.594
LIG_SH2_STAT5	115	118	PF00017	0.463
LIG_SH2_STAT5	262	265	PF00017	0.286
LIG_SH2_STAT5	319	322	PF00017	0.375
LIG_SH2_STAT5	332	335	PF00017	0.277
LIG_SH2_STAT5	393	396	PF00017	0.230
LIG_SH2_STAT5	459	462	PF00017	0.424
LIG_SH2_STAT5	541	544	PF00017	0.417
LIG_SH2_STAT5	65	68	PF00017	0.356
LIG_SH3_3	1023	1029	PF00018	0.677
LIG_SH3_3	214	220	PF00018	0.398
LIG_SH3_3	230	236	PF00018	0.383
LIG_SH3_3	525	531	PF00018	0.535
LIG_SH3_3	97	103	PF00018	0.421
LIG_SUMO_SIM_anti_2	1000	1009	PF11976	0.466
LIG_SUMO_SIM_anti_2	604	610	PF11976	0.358
LIG_SUMO_SIM_par_1	1000	1009	PF11976	0.466
LIG_SUMO_SIM_par_1	126	132	PF11976	0.383
LIG_SUMO_SIM_par_1	225	231	PF11976	0.447
LIG_TRAF2_1	182	185	PF00917	0.439
LIG_UBA3_1	1006	1015	PF00899	0.523
LIG_UBA3_1	186	194	PF00899	0.483
LIG_UBA3_1	558	567	PF00899	0.585
LIG_WRC_WIRS_1	143	148	PF05994	0.417
MOD_CK1_1	10	16	PF00069	0.678
MOD_CK1_1	494	500	PF00069	0.387
MOD_CK1_1	648	654	PF00069	0.607
MOD_CK1_1	850	856	PF00069	0.492
MOD_CK1_1	956	962	PF00069	0.644
MOD_CK2_1	126	132	PF00069	0.383
MOD_CK2_1	204	210	PF00069	0.585
MOD_CK2_1	3	9	PF00069	0.656
MOD_CK2_1	513	519	PF00069	0.302
MOD_CK2_1	761	767	PF00069	0.558
MOD_CK2_1	840	846	PF00069	0.670
MOD_CK2_1	864	870	PF00069	0.614
MOD_CK2_1	983	989	PF00069	0.389
MOD_GlcNHglycan	274	277	PF01048	0.329
MOD_GlcNHglycan	364	367	PF01048	0.411
MOD_GlcNHglycan	54	57	PF01048	0.381
MOD_GlcNHglycan	630	633	PF01048	0.449
MOD_GlcNHglycan	790	793	PF01048	0.569
MOD_GlcNHglycan	851	855	PF01048	0.646
MOD_GlcNHglycan	9	12	PF01048	0.624
MOD_GlcNHglycan	943	946	PF01048	0.528
MOD_GlcNHglycan	955	958	PF01048	0.711
MOD_GSK3_1	107	114	PF00069	0.409
MOD_GSK3_1	155	162	PF00069	0.569
MOD_GSK3_1	3	10	PF00069	0.624
MOD_GSK3_1	344	351	PF00069	0.362
MOD_GSK3_1	357	364	PF00069	0.220
MOD_GSK3_1	415	422	PF00069	0.558
MOD_GSK3_1	42	49	PF00069	0.410
MOD_GSK3_1	496	503	PF00069	0.191
MOD_GSK3_1	784	791	PF00069	0.516
MOD_GSK3_1	864	871	PF00069	0.545
MOD_GSK3_1	952	959	PF00069	0.676
MOD_LATS_1	19	25	PF00433	0.566
MOD_N-GLC_1	306	311	PF02516	0.517
MOD_N-GLC_1	323	328	PF02516	0.422
MOD_N-GLC_1	560	565	PF02516	0.582
MOD_N-GLC_1	724	729	PF02516	0.577
MOD_N-GLC_1	761	766	PF02516	0.546
MOD_N-GLC_1	940	945	PF02516	0.600
MOD_NEK2_1	131	136	PF00069	0.516
MOD_NEK2_1	189	194	PF00069	0.428
MOD_NEK2_1	237	242	PF00069	0.362
MOD_NEK2_1	249	254	PF00069	0.363
MOD_NEK2_1	283	288	PF00069	0.428
MOD_NEK2_1	362	367	PF00069	0.400
MOD_NEK2_1	372	377	PF00069	0.393
MOD_NEK2_1	435	440	PF00069	0.361
MOD_NEK2_1	491	496	PF00069	0.370
MOD_NEK2_1	513	518	PF00069	0.298
MOD_NEK2_1	552	557	PF00069	0.458
MOD_NEK2_1	66	71	PF00069	0.459
MOD_NEK2_1	749	754	PF00069	0.551
MOD_NEK2_1	934	939	PF00069	0.406
MOD_NEK2_2	126	131	PF00069	0.380
MOD_NEK2_2	243	248	PF00069	0.237
MOD_NEK2_2	428	433	PF00069	0.525
MOD_PIKK_1	435	441	PF00454	0.521
MOD_PIKK_1	561	567	PF00454	0.564
MOD_PIKK_1	586	592	PF00454	0.589
MOD_PIKK_1	677	683	PF00454	0.681
MOD_PIKK_1	840	846	PF00454	0.539
MOD_PIKK_1	864	870	PF00454	0.601
MOD_PK_1	1044	1050	PF00069	0.633
MOD_PK_1	21	27	PF00069	0.516
MOD_PKA_1	983	989	PF00069	0.389
MOD_PKA_2	1027	1033	PF00069	0.599
MOD_PKA_2	311	317	PF00069	0.305
MOD_PKA_2	382	388	PF00069	0.276
MOD_PKA_2	415	421	PF00069	0.555
MOD_PKA_2	618	624	PF00069	0.549
MOD_PKA_2	635	641	PF00069	0.399
MOD_PKA_2	922	928	PF00069	0.376
MOD_PKA_2	997	1003	PF00069	0.504
MOD_Plk_1	1044	1050	PF00069	0.600
MOD_Plk_1	131	137	PF00069	0.555
MOD_Plk_1	28	34	PF00069	0.425
MOD_Plk_1	306	312	PF00069	0.507
MOD_Plk_1	323	329	PF00069	0.453
MOD_Plk_1	357	363	PF00069	0.314
MOD_Plk_1	372	378	PF00069	0.361
MOD_Plk_1	552	558	PF00069	0.554
MOD_Plk_1	73	79	PF00069	0.440
MOD_Plk_1	744	750	PF00069	0.402
MOD_Plk_1	864	870	PF00069	0.601
MOD_Plk_4	1033	1039	PF00069	0.663
MOD_Plk_4	243	249	PF00069	0.439
MOD_Plk_4	28	34	PF00069	0.401
MOD_Plk_4	323	329	PF00069	0.382
MOD_Plk_4	350	356	PF00069	0.363
MOD_Plk_4	398	404	PF00069	0.351
MOD_Plk_4	415	421	PF00069	0.435
MOD_Plk_4	455	461	PF00069	0.372
MOD_Plk_4	66	72	PF00069	0.469
MOD_Plk_4	934	940	PF00069	0.356
MOD_ProDKin_1	176	182	PF00069	0.408
MOD_ProDKin_1	23	29	PF00069	0.495
MOD_ProDKin_1	99	105	PF00069	0.431
MOD_SUMO_for_1	578	581	PF00179	0.573
MOD_SUMO_for_1	612	615	PF00179	0.485
MOD_SUMO_for_1	857	860	PF00179	0.649
MOD_SUMO_rev_2	294	303	PF00179	0.404
MOD_SUMO_rev_2	622	632	PF00179	0.557
MOD_SUMO_rev_2	764	773	PF00179	0.552
MOD_SUMO_rev_2	835	843	PF00179	0.520
MOD_SUMO_rev_2	921	931	PF00179	0.555
TRG_DiLeu_BaEn_1	1002	1007	PF01217	0.461
TRG_DiLeu_BaEn_1	74	79	PF01217	0.467
TRG_DiLeu_BaEn_1	745	750	PF01217	0.367
TRG_DiLeu_BaEn_2	827	833	PF01217	0.528
TRG_DiLeu_BaEn_3	184	190	PF01217	0.390
TRG_DiLeu_BaEn_4	745	751	PF01217	0.490
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.419
TRG_ENDOCYTIC_2	140	143	PF00928	0.405
TRG_ENDOCYTIC_2	154	157	PF00928	0.480
TRG_ENDOCYTIC_2	319	322	PF00928	0.445
TRG_ER_diArg_1	815	817	PF00400	0.523
TRG_NLS_MonoExtN_4	926	933	PF00514	0.596
TRG_Pf-PMV_PEXEL_1	1057	1061	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	133	138	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	560	565	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	657	662	PF00026	0.564
TRG_Pf-PMV_PEXEL_1	738	742	PF00026	0.612
TRG_Pf-PMV_PEXEL_1	815	819	PF00026	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6X2	Leptomonas seymouri	76%	88%
A0A0S4IXQ4	Bodo saltans	46%	88%
A0A0S4JD05	Bodo saltans	24%	76%
A0A1X0NR39	Trypanosomatidae	26%	80%
A0A1X0NYM6	Trypanosomatidae	21%	100%
A0A1X0NZ74	Trypanosomatidae	54%	90%
A0A3Q8IJ84	Leishmania donovani	88%	88%
A0A3R7K981	Trypanosoma rangeli	53%	89%
A0A3S7X0Y9	Leishmania donovani	24%	68%
A0A422N7Y3	Trypanosoma rangeli	27%	80%
A4HFZ4	Leishmania braziliensis	24%	68%
A4HX53	Leishmania infantum	88%	88%
A4I313	Leishmania infantum	24%	68%
C9ZJI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	81%
C9ZVT8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	90%
E9ADJ7	Leishmania major	25%	68%
E9AQW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	87%
E9AZC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	67%
Q4QEL0	Leishmania major	87%	100%
Q96MR6	Homo sapiens	30%	86%
Q9D180	Mus musculus	30%	86%
V5BE61	Trypanosoma cruzi	26%	80%
V5DJ68	Trypanosoma cruzi	51%	89%