Putative endoplasmic reticulum oxidoreductin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endoplasmic reticulum oxidoreductin, putative

Species:

Leishmania braziliensis

UniProt:

A4H8T2_LEIBR

TriTrypDb:

LbrM.16.1590 , LBRM2903_160023900

Length:

429

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 4
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	13
GO:0016020	membrane	2	13
GO:0031090	organelle membrane	3	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4H8T2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8T2

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	13
GO:0009987	cellular process	1	13
GO:0034975	protein folding in endoplasmic reticulum	3	13

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	13
GO:0015035	protein-disulfide reductase activity	3	13
GO:0015036	disulfide oxidoreductase activity	4	13
GO:0016491	oxidoreductase activity	2	13
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	13
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	4	13
GO:0016972	thiol oxidase activity	5	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0050660	flavin adenine dinucleotide binding	4	13
GO:0071949	FAD binding	5	13
GO:0097159	organic cyclic compound binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0003756	protein disulfide isomerase activity	3	1
GO:0016853	isomerase activity	2	1
GO:0016860	intramolecular oxidoreductase activity	3	1
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	261	263	PF00082	0.319
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.410
CLV_PCSK_SKI1_1	211	215	PF00082	0.383
CLV_PCSK_SKI1_1	288	292	PF00082	0.315
CLV_PCSK_SKI1_1	31	35	PF00082	0.450
CLV_PCSK_SKI1_1	318	322	PF00082	0.320
CLV_PCSK_SKI1_1	43	47	PF00082	0.550
CLV_PCSK_SKI1_1	84	88	PF00082	0.225
DEG_APCC_DBOX_1	210	218	PF00400	0.410
DEG_Nend_UBRbox_3	1	3	PF02207	0.395
DEG_SCF_FBW7_1	133	139	PF00400	0.386
DOC_CKS1_1	133	138	PF01111	0.412
DOC_CYCLIN_RxL_1	208	215	PF00134	0.418
DOC_CYCLIN_RxL_1	406	414	PF00134	0.340
DOC_CYCLIN_yClb5_NLxxxL_5	402	411	PF00134	0.316
DOC_PP1_RVXF_1	407	414	PF00149	0.410
DOC_PP1_SILK_1	207	212	PF00149	0.386
DOC_USP7_MATH_1	136	140	PF00917	0.390
DOC_USP7_MATH_1	238	242	PF00917	0.306
DOC_USP7_UBL2_3	373	377	PF12436	0.410
DOC_WW_Pin1_4	132	137	PF00397	0.384
DOC_WW_Pin1_4	234	239	PF00397	0.281
DOC_WW_Pin1_4	325	330	PF00397	0.310
DOC_WW_Pin1_4	56	61	PF00397	0.563
LIG_14-3-3_CanoR_1	31	38	PF00244	0.457
LIG_14-3-3_CanoR_1	393	397	PF00244	0.441
LIG_14-3-3_CanoR_1	76	86	PF00244	0.400
LIG_BRCT_BRCA1_1	327	331	PF00533	0.273
LIG_BRCT_BRCA1_1	79	83	PF00533	0.319
LIG_deltaCOP1_diTrp_1	151	156	PF00928	0.316
LIG_eIF4E_1	96	102	PF01652	0.297
LIG_FHA_1	107	113	PF00498	0.410
LIG_FHA_1	290	296	PF00498	0.424
LIG_FHA_1	33	39	PF00498	0.710
LIG_FHA_1	374	380	PF00498	0.289
LIG_FHA_1	46	52	PF00498	0.524
LIG_FHA_1	65	71	PF00498	0.246
LIG_FHA_2	102	108	PF00498	0.343
LIG_FHA_2	305	311	PF00498	0.297
LIG_FHA_2	328	334	PF00498	0.281
LIG_LIR_Apic_2	176	181	PF02991	0.295
LIG_LIR_Apic_2	227	233	PF02991	0.413
LIG_LIR_Gen_1	155	163	PF02991	0.179
LIG_LIR_Gen_1	164	172	PF02991	0.287
LIG_LIR_Nem_3	164	168	PF02991	0.287
LIG_LIR_Nem_3	80	86	PF02991	0.300
LIG_MLH1_MIPbox_1	79	83	PF16413	0.371
LIG_NRBOX	209	215	PF00104	0.371
LIG_PDZ_Class_3	424	429	PF00595	0.342
LIG_Pex14_1	187	191	PF04695	0.268
LIG_Rb_pABgroove_1	315	323	PF01858	0.179
LIG_SH2_CRK	178	182	PF00017	0.297
LIG_SH2_CRK	245	249	PF00017	0.415
LIG_SH2_CRK	277	281	PF00017	0.177
LIG_SH2_NCK_1	245	249	PF00017	0.386
LIG_SH2_PTP2	165	168	PF00017	0.281
LIG_SH2_STAT5	165	168	PF00017	0.276
LIG_SH2_STAT5	274	277	PF00017	0.325
LIG_SH2_STAT5	55	58	PF00017	0.521
LIG_SH2_STAT5	82	85	PF00017	0.344
LIG_SH3_3	141	147	PF00018	0.441
LIG_SH3_3	166	172	PF00018	0.259
LIG_SUMO_SIM_anti_2	164	170	PF11976	0.219
LIG_SUMO_SIM_anti_2	206	212	PF11976	0.410
LIG_SUMO_SIM_anti_2	399	406	PF11976	0.272
LIG_SUMO_SIM_anti_2	67	75	PF11976	0.369
LIG_SxIP_EBH_1	341	352	PF03271	0.386
LIG_TRAF2_1	203	206	PF00917	0.422
LIG_TYR_ITIM	275	280	PF00017	0.186
LIG_UBA3_1	280	286	PF00899	0.219
MOD_CK2_1	101	107	PF00069	0.343
MOD_CK2_1	167	173	PF00069	0.446
MOD_CK2_1	327	333	PF00069	0.283
MOD_CK2_1	66	72	PF00069	0.429
MOD_CMANNOS	153	156	PF00535	0.316
MOD_GlcNHglycan	11	14	PF01048	0.445
MOD_GlcNHglycan	178	181	PF01048	0.299
MOD_GlcNHglycan	214	217	PF01048	0.268
MOD_GlcNHglycan	240	243	PF01048	0.371
MOD_GlcNHglycan	38	41	PF01048	0.624
MOD_GlcNHglycan	89	92	PF01048	0.420
MOD_GSK3_1	128	135	PF00069	0.308
MOD_GSK3_1	205	212	PF00069	0.329
MOD_GSK3_1	234	241	PF00069	0.317
MOD_GSK3_1	248	255	PF00069	0.444
MOD_GSK3_1	289	296	PF00069	0.363
MOD_GSK3_1	32	39	PF00069	0.586
MOD_GSK3_1	392	399	PF00069	0.457
MOD_GSK3_1	97	104	PF00069	0.352
MOD_N-GLC_1	248	253	PF02516	0.296
MOD_N-GLC_1	354	359	PF02516	0.268
MOD_N-GLC_1	36	41	PF02516	0.474
MOD_N-GLC_2	108	110	PF02516	0.316
MOD_NEK2_1	101	106	PF00069	0.372
MOD_NEK2_1	217	222	PF00069	0.268
MOD_NEK2_1	32	37	PF00069	0.574
MOD_NEK2_1	320	325	PF00069	0.294
MOD_NEK2_1	354	359	PF00069	0.410
MOD_NEK2_1	411	416	PF00069	0.317
MOD_NEK2_1	46	51	PF00069	0.508
MOD_NEK2_2	248	253	PF00069	0.410
MOD_NEK2_2	26	31	PF00069	0.435
MOD_OFUCOSY	103	110	PF10250	0.301
MOD_PKA_2	392	398	PF00069	0.386
MOD_PKA_2	75	81	PF00069	0.400
MOD_Plk_1	205	211	PF00069	0.386
MOD_Plk_1	248	254	PF00069	0.300
MOD_Plk_1	293	299	PF00069	0.339
MOD_Plk_1	304	310	PF00069	0.289
MOD_Plk_1	354	360	PF00069	0.271
MOD_Plk_2-3	392	398	PF00069	0.386
MOD_Plk_4	136	142	PF00069	0.231
MOD_Plk_4	2	8	PF00069	0.478
MOD_Plk_4	205	211	PF00069	0.383
MOD_Plk_4	225	231	PF00069	0.115
MOD_Plk_4	293	299	PF00069	0.368
MOD_Plk_4	348	354	PF00069	0.200
MOD_Plk_4	400	406	PF00069	0.322
MOD_Plk_4	66	72	PF00069	0.421
MOD_Plk_4	78	84	PF00069	0.322
MOD_Plk_4	97	103	PF00069	0.398
MOD_ProDKin_1	132	138	PF00069	0.384
MOD_ProDKin_1	234	240	PF00069	0.281
MOD_ProDKin_1	325	331	PF00069	0.310
MOD_ProDKin_1	56	62	PF00069	0.558
TRG_DiLeu_BaEn_1	164	169	PF01217	0.311
TRG_DiLeu_BaEn_1	400	405	PF01217	0.268
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.371
TRG_ENDOCYTIC_2	165	168	PF00928	0.281
TRG_ENDOCYTIC_2	277	280	PF00928	0.177
TRG_ENDOCYTIC_2	85	88	PF00928	0.309
TRG_ENDOCYTIC_2	96	99	PF00928	0.241
TRG_Pf-PMV_PEXEL_1	343	348	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYQ4	Leptomonas seymouri	73%	100%
A0A0S4JAH9	Bodo saltans	33%	89%
A0A0S4JHX0	Bodo saltans	37%	86%
A0A1X0P0B6	Trypanosomatidae	51%	96%
A0A3S7WU69	Leishmania donovani	86%	97%
A0A422NE38	Trypanosoma rangeli	52%	93%
A4HX51	Leishmania infantum	86%	97%
A5PJN2	Bos taurus	31%	92%
B1H1F9	Xenopus tropicalis	31%	91%
B6CVD7	Sus scrofa	31%	92%
C9ZVU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	97%
E9AQW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O74401	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	92%
Q03103	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	76%
Q4QEL2	Leishmania major	85%	100%
Q6DD71	Xenopus laevis	30%	92%
Q75BB5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	79%
Q7T3D1	Danio rerio	29%	88%
Q7X9I4	Arabidopsis thaliana	31%	91%
Q7YTU4	Caenorhabditis elegans	28%	90%
Q86YB8	Homo sapiens	30%	92%
Q8NIP5	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	27%	76%
Q8R180	Mus musculus	32%	92%
Q8R2E9	Mus musculus	30%	92%
Q8R4A1	Rattus norvegicus	31%	92%
Q96HE7	Homo sapiens	30%	92%
Q9C7S7	Arabidopsis thaliana	32%	91%
Q9V3A6	Drosophila melanogaster	28%	89%
Q9Y7P1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	76%
V5BI75	Trypanosoma cruzi	48%	97%