Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8S9_LEIBR

TriTrypDb:

LbrM.16.1560 , LBRM2903_160023700

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8S9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8S9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.562
CLV_C14_Caspase3-7	418	422	PF00656	0.563
CLV_C14_Caspase3-7	450	454	PF00656	0.655
CLV_C14_Caspase3-7	461	465	PF00656	0.452
CLV_MEL_PAP_1	404	410	PF00089	0.301
CLV_NRD_NRD_1	139	141	PF00675	0.420
CLV_NRD_NRD_1	3	5	PF00675	0.632
CLV_NRD_NRD_1	477	479	PF00675	0.531
CLV_NRD_NRD_1	48	50	PF00675	0.441
CLV_NRD_NRD_1	558	560	PF00675	0.505
CLV_NRD_NRD_1	569	571	PF00675	0.504
CLV_PCSK_KEX2_1	11	13	PF00082	0.513
CLV_PCSK_KEX2_1	139	141	PF00082	0.522
CLV_PCSK_KEX2_1	3	5	PF00082	0.592
CLV_PCSK_KEX2_1	31	33	PF00082	0.377
CLV_PCSK_KEX2_1	477	479	PF00082	0.531
CLV_PCSK_KEX2_1	48	50	PF00082	0.427
CLV_PCSK_KEX2_1	558	560	PF00082	0.505
CLV_PCSK_KEX2_1	569	571	PF00082	0.504
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.559
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.377
CLV_PCSK_SKI1_1	268	272	PF00082	0.409
CLV_PCSK_SKI1_1	309	313	PF00082	0.410
CLV_PCSK_SKI1_1	477	481	PF00082	0.482
CLV_PCSK_SKI1_1	547	551	PF00082	0.570
CLV_PCSK_SKI1_1	66	70	PF00082	0.497
CLV_PCSK_SKI1_1	74	78	PF00082	0.456
DEG_APCC_DBOX_1	476	484	PF00400	0.510
DEG_Nend_Nbox_1	1	3	PF02207	0.558
DOC_ANK_TNKS_1	326	333	PF00023	0.391
DOC_ANK_TNKS_1	38	45	PF00023	0.332
DOC_CYCLIN_RxL_1	306	316	PF00134	0.288
DOC_CYCLIN_RxL_1	61	72	PF00134	0.564
DOC_MAPK_MEF2A_6	111	120	PF00069	0.273
DOC_MAPK_MEF2A_6	124	133	PF00069	0.264
DOC_MAPK_MEF2A_6	293	302	PF00069	0.532
DOC_SPAK_OSR1_1	215	219	PF12202	0.297
DOC_USP7_MATH_1	189	193	PF00917	0.393
DOC_USP7_MATH_1	398	402	PF00917	0.592
DOC_WW_Pin1_4	10	15	PF00397	0.539
DOC_WW_Pin1_4	173	178	PF00397	0.472
DOC_WW_Pin1_4	315	320	PF00397	0.430
DOC_WW_Pin1_4	345	350	PF00397	0.689
DOC_WW_Pin1_4	365	370	PF00397	0.669
DOC_WW_Pin1_4	381	386	PF00397	0.613
LIG_14-3-3_CanoR_1	170	180	PF00244	0.559
LIG_14-3-3_CanoR_1	20	25	PF00244	0.453
LIG_14-3-3_CanoR_1	283	289	PF00244	0.421
LIG_14-3-3_CanoR_1	293	299	PF00244	0.463
LIG_14-3-3_CanoR_1	3	9	PF00244	0.616
LIG_14-3-3_CanoR_1	558	568	PF00244	0.568
LIG_14-3-3_CanoR_1	84	89	PF00244	0.444
LIG_APCC_ABBA_1	326	331	PF00400	0.416
LIG_APCC_ABBA_1	436	441	PF00400	0.522
LIG_BIR_III_4	453	457	PF00653	0.510
LIG_BRCT_BRCA1_1	313	317	PF00533	0.516
LIG_CtBP_PxDLS_1	177	181	PF00389	0.434
LIG_DLG_GKlike_1	20	27	PF00625	0.635
LIG_FHA_1	179	185	PF00498	0.508
LIG_FHA_1	196	202	PF00498	0.440
LIG_FHA_1	204	210	PF00498	0.423
LIG_FHA_1	283	289	PF00498	0.497
LIG_FHA_1	293	299	PF00498	0.549
LIG_FHA_1	346	352	PF00498	0.705
LIG_FHA_1	360	366	PF00498	0.600
LIG_FHA_1	397	403	PF00498	0.406
LIG_FHA_1	491	497	PF00498	0.573
LIG_FHA_1	526	532	PF00498	0.561
LIG_FHA_1	560	566	PF00498	0.561
LIG_FHA_1	75	81	PF00498	0.489
LIG_FHA_2	159	165	PF00498	0.469
LIG_FHA_2	174	180	PF00498	0.414
LIG_FHA_2	23	29	PF00498	0.540
LIG_FHA_2	316	322	PF00498	0.410
LIG_GBD_Chelix_1	298	306	PF00786	0.532
LIG_LIR_Gen_1	115	125	PF02991	0.502
LIG_LIR_Gen_1	143	154	PF02991	0.321
LIG_LIR_Gen_1	205	214	PF02991	0.502
LIG_LIR_Gen_1	424	433	PF02991	0.515
LIG_LIR_Nem_3	115	120	PF02991	0.484
LIG_LIR_Nem_3	143	149	PF02991	0.424
LIG_LIR_Nem_3	205	210	PF02991	0.496
LIG_LIR_Nem_3	424	429	PF02991	0.540
LIG_LIR_Nem_3	72	76	PF02991	0.406
LIG_LYPXL_SIV_4	425	433	PF13949	0.561
LIG_MYND_1	349	353	PF01753	0.464
LIG_NRBOX	495	501	PF00104	0.446
LIG_PCNA_PIPBox_1	432	441	PF02747	0.495
LIG_PCNA_yPIPBox_3	267	279	PF02747	0.304
LIG_Pex14_2	100	104	PF04695	0.411
LIG_SH2_CRK	146	150	PF00017	0.464
LIG_SH2_CRK	245	249	PF00017	0.395
LIG_SH2_SRC	329	332	PF00017	0.446
LIG_SH2_STAT5	16	19	PF00017	0.534
LIG_SH2_STAT5	245	248	PF00017	0.392
LIG_SH2_STAT5	329	332	PF00017	0.401
LIG_SH2_STAT5	34	37	PF00017	0.554
LIG_SH2_STAT5	426	429	PF00017	0.470
LIG_SH2_STAT5	75	78	PF00017	0.488
LIG_SH3_3	130	136	PF00018	0.255
LIG_SH3_3	152	158	PF00018	0.537
LIG_SH3_3	372	378	PF00018	0.641
LIG_SUMO_SIM_anti_2	240	246	PF11976	0.449
LIG_SUMO_SIM_anti_2	321	327	PF11976	0.472
LIG_SUMO_SIM_anti_2	335	340	PF11976	0.329
LIG_SUMO_SIM_anti_2	401	406	PF11976	0.438
LIG_SUMO_SIM_anti_2	431	437	PF11976	0.515
LIG_SUMO_SIM_anti_2	90	96	PF11976	0.477
LIG_SUMO_SIM_par_1	331	337	PF11976	0.435
LIG_SUMO_SIM_par_1	492	498	PF11976	0.467
LIG_TRAF2_1	161	164	PF00917	0.484
LIG_TRAF2_1	522	525	PF00917	0.416
LIG_TYR_ITIM	243	248	PF00017	0.389
LIG_UBA3_1	116	124	PF00899	0.390
LIG_UBA3_1	487	492	PF00899	0.557
MOD_CK1_1	10	16	PF00069	0.540
MOD_CK1_1	22	28	PF00069	0.490
MOD_CK1_1	259	265	PF00069	0.494
MOD_CK1_1	337	343	PF00069	0.508
MOD_CK1_1	368	374	PF00069	0.699
MOD_CK1_1	428	434	PF00069	0.472
MOD_CK1_1	447	453	PF00069	0.441
MOD_CK2_1	158	164	PF00069	0.418
MOD_CK2_1	173	179	PF00069	0.435
MOD_CK2_1	20	26	PF00069	0.535
MOD_CK2_1	315	321	PF00069	0.402
MOD_CK2_1	428	434	PF00069	0.517
MOD_CK2_1	492	498	PF00069	0.458
MOD_CK2_1	52	58	PF00069	0.574
MOD_GlcNHglycan	105	108	PF01048	0.297
MOD_GlcNHglycan	289	292	PF01048	0.483
MOD_GlcNHglycan	339	342	PF01048	0.459
MOD_GlcNHglycan	370	373	PF01048	0.727
MOD_GlcNHglycan	385	388	PF01048	0.523
MOD_GlcNHglycan	4	7	PF01048	0.442
MOD_GlcNHglycan	410	415	PF01048	0.449
MOD_GlcNHglycan	421	424	PF01048	0.460
MOD_GlcNHglycan	446	449	PF01048	0.521
MOD_GlcNHglycan	460	463	PF01048	0.638
MOD_GlcNHglycan	483	486	PF01048	0.327
MOD_GlcNHglycan	510	513	PF01048	0.560
MOD_GlcNHglycan	537	540	PF01048	0.505
MOD_GSK3_1	189	196	PF00069	0.432
MOD_GSK3_1	277	284	PF00069	0.397
MOD_GSK3_1	311	318	PF00069	0.466
MOD_GSK3_1	379	386	PF00069	0.679
MOD_GSK3_1	396	403	PF00069	0.474
MOD_GSK3_1	421	428	PF00069	0.542
MOD_GSK3_1	444	451	PF00069	0.517
MOD_LATS_1	556	562	PF00433	0.551
MOD_N-GLC_1	365	370	PF02516	0.482
MOD_NEK2_1	103	108	PF00069	0.316
MOD_NEK2_1	180	185	PF00069	0.466
MOD_NEK2_1	2	7	PF00069	0.546
MOD_NEK2_1	27	32	PF00069	0.559
MOD_NEK2_1	287	292	PF00069	0.468
MOD_NEK2_1	343	348	PF00069	0.554
MOD_NEK2_1	419	424	PF00069	0.536
MOD_NEK2_1	508	513	PF00069	0.453
MOD_PIKK_1	195	201	PF00454	0.450
MOD_PIKK_1	396	402	PF00454	0.506
MOD_PIKK_1	428	434	PF00454	0.483
MOD_PKA_1	558	564	PF00069	0.578
MOD_PKA_2	19	25	PF00069	0.475
MOD_PKA_2	2	8	PF00069	0.581
MOD_PKA_2	218	224	PF00069	0.393
MOD_PKA_2	274	280	PF00069	0.464
MOD_PKA_2	282	288	PF00069	0.416
MOD_PKA_2	292	298	PF00069	0.439
MOD_PKA_2	558	564	PF00069	0.557
MOD_PKB_1	545	553	PF00069	0.587
MOD_Plk_1	193	199	PF00069	0.302
MOD_Plk_2-3	159	165	PF00069	0.538
MOD_Plk_4	180	186	PF00069	0.418
MOD_Plk_4	256	262	PF00069	0.384
MOD_Plk_4	334	340	PF00069	0.358
MOD_Plk_4	354	360	PF00069	0.728
MOD_Plk_4	400	406	PF00069	0.425
MOD_ProDKin_1	10	16	PF00069	0.539
MOD_ProDKin_1	173	179	PF00069	0.476
MOD_ProDKin_1	315	321	PF00069	0.423
MOD_ProDKin_1	345	351	PF00069	0.696
MOD_ProDKin_1	365	371	PF00069	0.671
MOD_ProDKin_1	381	387	PF00069	0.606
MOD_SUMO_rev_2	121	126	PF00179	0.306
TRG_DiLeu_BaEn_1	498	503	PF01217	0.432
TRG_DiLeu_BaEn_2	503	509	PF01217	0.438
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.479
TRG_ENDOCYTIC_2	146	149	PF00928	0.420
TRG_ENDOCYTIC_2	245	248	PF00928	0.392
TRG_ENDOCYTIC_2	426	429	PF00928	0.508
TRG_ENDOCYTIC_2	73	76	PF00928	0.403
TRG_ER_diArg_1	138	140	PF00400	0.507
TRG_ER_diArg_1	2	4	PF00400	0.612
TRG_ER_diArg_1	216	219	PF00400	0.533
TRG_ER_diArg_1	225	228	PF00400	0.519
TRG_ER_diArg_1	389	392	PF00400	0.646
TRG_ER_diArg_1	48	50	PF00400	0.427
TRG_ER_diArg_1	558	560	PF00400	0.493
TRG_ER_diArg_1	568	570	PF00400	0.444
TRG_NES_CRM1_1	321	331	PF08389	0.376
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.354
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	391	396	PF00026	0.633
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5T4	Leptomonas seymouri	64%	98%
A0A0S4IMI7	Bodo saltans	30%	98%
A0A1X0NYU8	Trypanosomatidae	43%	100%
A0A3Q8ICN8	Leishmania donovani	82%	100%
A0A422N437	Trypanosoma rangeli	39%	100%
A4HX48	Leishmania infantum	82%	100%
C9ZVU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AQW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QEL5	Leishmania major	84%	99%
V5B2M3	Trypanosoma cruzi	39%	100%