Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8S8_LEIBR

TriTrypDb:

LbrM.16.1550 , LBRM2903_160023600

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8S8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8S8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016853	isomerase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	272	276	PF00656	0.571
CLV_NRD_NRD_1	214	216	PF00675	0.447
CLV_PCSK_KEX2_1	263	265	PF00082	0.617
CLV_PCSK_KEX2_1	76	78	PF00082	0.542
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.400
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.574
CLV_PCSK_SKI1_1	329	333	PF00082	0.608
CLV_PCSK_SKI1_1	348	352	PF00082	0.404
CLV_Separin_Metazoa	352	356	PF03568	0.480
DOC_CDC14_PxL_1	50	58	PF14671	0.369
DOC_CYCLIN_yClb1_LxF_4	327	332	PF00134	0.641
DOC_MAPK_gen_1	22	31	PF00069	0.556
DOC_MAPK_gen_1	263	271	PF00069	0.466
DOC_MAPK_gen_1	76	85	PF00069	0.468
DOC_MAPK_HePTP_8	19	31	PF00069	0.501
DOC_MAPK_MEF2A_6	22	31	PF00069	0.556
DOC_PP1_RVXF_1	327	333	PF00149	0.637
DOC_PP2B_PxIxI_1	47	53	PF00149	0.498
DOC_PP4_FxxP_1	344	347	PF00568	0.557
DOC_USP7_MATH_1	276	280	PF00917	0.718
DOC_USP7_MATH_1	289	293	PF00917	0.805
DOC_USP7_MATH_1	312	316	PF00917	0.551
DOC_WW_Pin1_4	123	128	PF00397	0.543
DOC_WW_Pin1_4	287	292	PF00397	0.777
DOC_WW_Pin1_4	296	301	PF00397	0.783
DOC_WW_Pin1_4	323	328	PF00397	0.727
LIG_14-3-3_CanoR_1	112	116	PF00244	0.537
LIG_14-3-3_CanoR_1	7	13	PF00244	0.624
LIG_BIR_II_1	1	5	PF00653	0.736
LIG_Clathr_ClatBox_1	330	334	PF01394	0.556
LIG_EH1_1	178	186	PF00400	0.527
LIG_FHA_1	148	154	PF00498	0.391
LIG_FHA_1	22	28	PF00498	0.494
LIG_FHA_1	249	255	PF00498	0.536
LIG_FHA_1	47	53	PF00498	0.397
LIG_FHA_1	79	85	PF00498	0.473
LIG_FHA_2	236	242	PF00498	0.553
LIG_LIR_Apic_2	155	160	PF02991	0.374
LIG_LIR_Gen_1	11	19	PF02991	0.476
LIG_LIR_Gen_1	138	147	PF02991	0.472
LIG_LIR_Gen_1	21	31	PF02991	0.356
LIG_LIR_Gen_1	336	347	PF02991	0.563
LIG_LIR_LC3C_4	14	18	PF02991	0.592
LIG_LIR_Nem_3	101	105	PF02991	0.432
LIG_LIR_Nem_3	11	16	PF02991	0.477
LIG_LIR_Nem_3	138	144	PF02991	0.469
LIG_LIR_Nem_3	21	26	PF02991	0.331
LIG_LIR_Nem_3	210	214	PF02991	0.508
LIG_LIR_Nem_3	336	342	PF02991	0.575
LIG_LIR_Nem_3	349	354	PF02991	0.423
LIG_PCNA_yPIPBox_3	5	13	PF02747	0.420
LIG_SH2_CRK	102	106	PF00017	0.313
LIG_SH2_CRK	141	145	PF00017	0.319
LIG_SH2_CRK	64	68	PF00017	0.370
LIG_SH2_SRC	70	73	PF00017	0.524
LIG_SH2_STAP1	13	17	PF00017	0.585
LIG_SH2_STAP1	64	68	PF00017	0.370
LIG_SH2_STAT5	157	160	PF00017	0.360
LIG_SH2_STAT5	248	251	PF00017	0.552
LIG_SH2_STAT5	257	260	PF00017	0.512
LIG_SH2_STAT5	70	73	PF00017	0.491
LIG_SH3_3	239	245	PF00018	0.386
LIG_SH3_3	294	300	PF00018	0.566
LIG_SH3_3	33	39	PF00018	0.654
LIG_SUMO_SIM_anti_2	14	21	PF11976	0.527
LIG_SUMO_SIM_anti_2	49	55	PF11976	0.258
LIG_SUMO_SIM_anti_2	80	86	PF11976	0.388
LIG_SUMO_SIM_par_1	14	21	PF11976	0.546
LIG_SUMO_SIM_par_1	24	30	PF11976	0.392
LIG_SUMO_SIM_par_1	80	86	PF11976	0.388
LIG_TYR_ITIM	139	144	PF00017	0.432
LIG_UBA3_1	254	263	PF00899	0.531
LIG_WW_3	326	330	PF00397	0.686
MOD_CDC14_SPxK_1	326	329	PF00782	0.460
MOD_CDK_SPxK_1	323	329	PF00069	0.524
MOD_CK1_1	146	152	PF00069	0.526
MOD_CK1_1	21	27	PF00069	0.379
MOD_CK1_1	279	285	PF00069	0.772
MOD_CK2_1	235	241	PF00069	0.571
MOD_DYRK1A_RPxSP_1	296	300	PF00069	0.563
MOD_GlcNHglycan	282	285	PF01048	0.736
MOD_GSK3_1	143	150	PF00069	0.510
MOD_GSK3_1	199	206	PF00069	0.549
MOD_GSK3_1	275	282	PF00069	0.755
MOD_GSK3_1	48	55	PF00069	0.370
MOD_NEK2_1	1	6	PF00069	0.655
MOD_NEK2_1	111	116	PF00069	0.498
MOD_NEK2_1	147	152	PF00069	0.478
MOD_NEK2_1	228	233	PF00069	0.461
MOD_NEK2_1	27	32	PF00069	0.313
MOD_NEK2_1	280	285	PF00069	0.551
MOD_NEK2_1	8	13	PF00069	0.551
MOD_PIKK_1	203	209	PF00454	0.530
MOD_PKA_2	111	117	PF00069	0.530
MOD_PKA_2	21	27	PF00069	0.421
MOD_Plk_1	120	126	PF00069	0.440
MOD_Plk_1	147	153	PF00069	0.515
MOD_Plk_1	186	192	PF00069	0.575
MOD_Plk_2-3	235	241	PF00069	0.580
MOD_Plk_4	111	117	PF00069	0.443
MOD_Plk_4	120	126	PF00069	0.375
MOD_Plk_4	78	84	PF00069	0.506
MOD_ProDKin_1	123	129	PF00069	0.542
MOD_ProDKin_1	287	293	PF00069	0.779
MOD_ProDKin_1	296	302	PF00069	0.783
MOD_ProDKin_1	323	329	PF00069	0.718
TRG_DiLeu_BaEn_1	180	185	PF01217	0.469
TRG_DiLeu_BaEn_4	187	193	PF01217	0.552
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.529
TRG_DiLeu_LyEn_5	180	185	PF01217	0.469
TRG_ENDOCYTIC_2	102	105	PF00928	0.424
TRG_ENDOCYTIC_2	13	16	PF00928	0.513
TRG_ENDOCYTIC_2	141	144	PF00928	0.431
TRG_ENDOCYTIC_2	64	67	PF00928	0.373
TRG_ER_diArg_1	5	8	PF00400	0.578
TRG_NES_CRM1_1	128	142	PF08389	0.470
TRG_Pf-PMV_PEXEL_1	103	107	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.575

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P676	Leptomonas seymouri	64%	100%
A0A1X0NZ85	Trypanosomatidae	49%	100%
A0A3Q8I9J9	Leishmania donovani	83%	100%
A0A3R7KS20	Trypanosoma rangeli	45%	100%
A4HX47	Leishmania infantum	83%	100%
C9ZVU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AQW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QEL6	Leishmania major	81%	100%
V5BI68	Trypanosoma cruzi	46%	100%