PDEase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8S7_LEIBR

TriTrypDb:

LbrM.16.1540 , LBRM2903_160023500

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8S7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8S7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008483	transaminase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016769	transferase activity, transferring nitrogenous groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	526	530	PF00656	0.355
CLV_C14_Caspase3-7	76	80	PF00656	0.741
CLV_MEL_PAP_1	590	596	PF00089	0.434
CLV_NRD_NRD_1	202	204	PF00675	0.669
CLV_NRD_NRD_1	231	233	PF00675	0.554
CLV_NRD_NRD_1	249	251	PF00675	0.699
CLV_NRD_NRD_1	37	39	PF00675	0.587
CLV_PCSK_FUR_1	228	232	PF00082	0.580
CLV_PCSK_FUR_1	520	524	PF00082	0.457
CLV_PCSK_KEX2_1	202	204	PF00082	0.665
CLV_PCSK_KEX2_1	230	232	PF00082	0.504
CLV_PCSK_KEX2_1	253	255	PF00082	0.691
CLV_PCSK_KEX2_1	37	39	PF00082	0.566
CLV_PCSK_KEX2_1	522	524	PF00082	0.484
CLV_PCSK_KEX2_1	592	594	PF00082	0.428
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.731
CLV_PCSK_PC1ET2_1	522	524	PF00082	0.484
CLV_PCSK_PC1ET2_1	592	594	PF00082	0.358
CLV_PCSK_SKI1_1	162	166	PF00082	0.746
CLV_PCSK_SKI1_1	361	365	PF00082	0.529
CLV_PCSK_SKI1_1	371	375	PF00082	0.460
CLV_PCSK_SKI1_1	419	423	PF00082	0.412
CLV_PCSK_SKI1_1	441	445	PF00082	0.552
CLV_PCSK_SKI1_1	481	485	PF00082	0.495
CLV_PCSK_SKI1_1	535	539	PF00082	0.333
DEG_APCC_DBOX_1	473	481	PF00400	0.295
DEG_SCF_FBW7_1	278	283	PF00400	0.545
DEG_SIAH_1	273	281	PF03145	0.536
DEG_SPOP_SBC_1	168	172	PF00917	0.465
DOC_MAPK_DCC_7	430	440	PF00069	0.333
DOC_MAPK_gen_1	250	260	PF00069	0.610
DOC_MAPK_gen_1	313	320	PF00069	0.503
DOC_MAPK_gen_1	37	44	PF00069	0.450
DOC_MAPK_MEF2A_6	251	260	PF00069	0.680
DOC_MAPK_MEF2A_6	481	490	PF00069	0.419
DOC_USP7_MATH_1	134	138	PF00917	0.663
DOC_USP7_MATH_1	160	164	PF00917	0.631
DOC_USP7_MATH_1	168	172	PF00917	0.674
DOC_USP7_MATH_1	236	240	PF00917	0.754
DOC_USP7_MATH_1	24	28	PF00917	0.465
DOC_USP7_MATH_1	576	580	PF00917	0.516
DOC_USP7_MATH_1	8	12	PF00917	0.710
DOC_USP7_UBL2_3	419	423	PF12436	0.295
DOC_USP7_UBL2_3	441	445	PF12436	0.508
DOC_USP7_UBL2_3	562	566	PF12436	0.522
DOC_WW_Pin1_4	276	281	PF00397	0.695
DOC_WW_Pin1_4	318	323	PF00397	0.526
DOC_WW_Pin1_4	407	412	PF00397	0.355
DOC_WW_Pin1_4	55	60	PF00397	0.713
LIG_14-3-3_CanoR_1	231	241	PF00244	0.619
LIG_14-3-3_CanoR_1	315	321	PF00244	0.727
LIG_14-3-3_CanoR_1	474	480	PF00244	0.387
LIG_14-3-3_CanoR_1	481	487	PF00244	0.441
LIG_Actin_WH2_2	187	204	PF00022	0.573
LIG_Actin_WH2_2	425	443	PF00022	0.482
LIG_BIR_III_4	65	69	PF00653	0.538
LIG_deltaCOP1_diTrp_1	353	357	PF00928	0.290
LIG_EH1_1	329	337	PF00400	0.281
LIG_eIF4E_1	330	336	PF01652	0.292
LIG_FAT_LD_1	211	219	PF03623	0.507
LIG_FHA_1	168	174	PF00498	0.444
LIG_FHA_1	345	351	PF00498	0.355
LIG_FHA_1	362	368	PF00498	0.217
LIG_FHA_1	386	392	PF00498	0.440
LIG_FHA_1	408	414	PF00498	0.421
LIG_FHA_1	420	426	PF00498	0.269
LIG_FHA_1	442	448	PF00498	0.432
LIG_FHA_1	470	476	PF00498	0.450
LIG_FHA_1	52	58	PF00498	0.500
LIG_FHA_1	529	535	PF00498	0.376
LIG_FHA_1	551	557	PF00498	0.357
LIG_FHA_1	580	586	PF00498	0.409
LIG_FHA_2	140	146	PF00498	0.630
LIG_FHA_2	184	190	PF00498	0.528
LIG_FHA_2	74	80	PF00498	0.614
LIG_FHA_2	82	88	PF00498	0.516
LIG_LIR_Gen_1	353	363	PF02991	0.392
LIG_LIR_LC3C_4	444	449	PF02991	0.467
LIG_LIR_Nem_3	112	118	PF02991	0.627
LIG_LIR_Nem_3	293	297	PF02991	0.530
LIG_LIR_Nem_3	353	358	PF02991	0.378
LIG_LIR_Nem_3	422	427	PF02991	0.305
LIG_PCNA_yPIPBox_3	326	336	PF02747	0.326
LIG_Pex14_2	111	115	PF04695	0.577
LIG_PTB_Apo_2	105	112	PF02174	0.598
LIG_SH2_CRK	433	437	PF00017	0.464
LIG_SH2_PTP2	424	427	PF00017	0.359
LIG_SH2_STAP1	330	334	PF00017	0.511
LIG_SH2_STAT5	180	183	PF00017	0.439
LIG_SH2_STAT5	424	427	PF00017	0.359
LIG_SH2_STAT5	589	592	PF00017	0.396
LIG_SH3_1	282	288	PF00018	0.795
LIG_SH3_3	282	288	PF00018	0.754
LIG_SH3_3	43	49	PF00018	0.544
LIG_SUMO_SIM_anti_2	331	337	PF11976	0.283
LIG_SUMO_SIM_anti_2	476	481	PF11976	0.421
LIG_SUMO_SIM_par_1	500	505	PF11976	0.468
LIG_SUMO_SIM_par_1	514	519	PF11976	0.338
LIG_SUMO_SIM_par_1	552	559	PF11976	0.396
LIG_TYR_ITIM	538	543	PF00017	0.333
LIG_TYR_ITSM	420	427	PF00017	0.285
LIG_UBA3_1	434	441	PF00899	0.483
LIG_WRC_WIRS_1	291	296	PF05994	0.529
LIG_WRC_WIRS_1	398	403	PF05994	0.441
LIG_WRC_WIRS_1	568	573	PF05994	0.344
MOD_CDC14_SPxK_1	58	61	PF00782	0.776
MOD_CDK_SPK_2	407	412	PF00069	0.441
MOD_CDK_SPxK_1	276	282	PF00069	0.576
MOD_CDK_SPxK_1	55	61	PF00069	0.756
MOD_CK1_1	210	216	PF00069	0.328
MOD_CK1_1	28	34	PF00069	0.630
MOD_CK1_1	281	287	PF00069	0.744
MOD_CK1_1	316	322	PF00069	0.721
MOD_CK1_1	359	365	PF00069	0.306
MOD_CK1_1	493	499	PF00069	0.466
MOD_CK1_1	579	585	PF00069	0.501
MOD_CK1_1	78	84	PF00069	0.591
MOD_CK2_1	139	145	PF00069	0.623
MOD_CK2_1	377	383	PF00069	0.352
MOD_GlcNHglycan	234	237	PF01048	0.690
MOD_GlcNHglycan	238	241	PF01048	0.759
MOD_GlcNHglycan	301	305	PF01048	0.654
MOD_GlcNHglycan	361	364	PF01048	0.462
MOD_GlcNHglycan	73	76	PF01048	0.728
MOD_GlcNHglycan	93	97	PF01048	0.443
MOD_GSK3_1	107	114	PF00069	0.559
MOD_GSK3_1	201	208	PF00069	0.599
MOD_GSK3_1	232	239	PF00069	0.776
MOD_GSK3_1	24	31	PF00069	0.544
MOD_GSK3_1	274	281	PF00069	0.731
MOD_GSK3_1	286	293	PF00069	0.576
MOD_GSK3_1	305	312	PF00069	0.622
MOD_GSK3_1	318	325	PF00069	0.630
MOD_GSK3_1	403	410	PF00069	0.497
MOD_GSK3_1	415	422	PF00069	0.548
MOD_GSK3_1	469	476	PF00069	0.496
MOD_GSK3_1	51	58	PF00069	0.594
MOD_GSK3_1	579	586	PF00069	0.424
MOD_GSK3_1	71	78	PF00069	0.747
MOD_GSK3_1	81	88	PF00069	0.607
MOD_N-GLC_1	107	112	PF02516	0.537
MOD_N-GLC_1	149	154	PF02516	0.616
MOD_N-GLC_1	160	165	PF02516	0.653
MOD_N-GLC_1	168	173	PF02516	0.619
MOD_N-GLC_1	242	247	PF02516	0.663
MOD_N-GLC_1	25	30	PF02516	0.588
MOD_N-GLC_1	351	356	PF02516	0.517
MOD_N-GLC_1	396	401	PF02516	0.390
MOD_N-GLC_1	407	412	PF02516	0.427
MOD_N-GLC_1	52	57	PF02516	0.530
MOD_N-GLC_1	550	555	PF02516	0.356
MOD_N-GLC_1	556	561	PF02516	0.399
MOD_N-GLC_1	71	76	PF02516	0.659
MOD_N-GLC_2	71	73	PF02516	0.524
MOD_NEK2_1	102	107	PF00069	0.547
MOD_NEK2_1	109	114	PF00069	0.493
MOD_NEK2_1	144	149	PF00069	0.627
MOD_NEK2_1	155	160	PF00069	0.610
MOD_NEK2_1	267	272	PF00069	0.682
MOD_NEK2_1	309	314	PF00069	0.668
MOD_NEK2_1	32	37	PF00069	0.514
MOD_NEK2_1	377	382	PF00069	0.372
MOD_NEK2_1	473	478	PF00069	0.381
MOD_NEK2_1	482	487	PF00069	0.390
MOD_NEK2_1	502	507	PF00069	0.226
MOD_NEK2_1	518	523	PF00069	0.381
MOD_NEK2_1	556	561	PF00069	0.420
MOD_NEK2_1	85	90	PF00069	0.551
MOD_NEK2_2	25	30	PF00069	0.483
MOD_NMyristoyl	1	7	PF02799	0.534
MOD_PK_1	86	92	PF00069	0.493
MOD_PKA_2	201	207	PF00069	0.603
MOD_PKA_2	249	255	PF00069	0.631
MOD_PKA_2	316	322	PF00069	0.715
MOD_PKA_2	473	479	PF00069	0.492
MOD_PKA_2	60	66	PF00069	0.654
MOD_PKA_2	85	91	PF00069	0.710
MOD_PKB_1	230	238	PF00069	0.580
MOD_Plk_1	107	113	PF00069	0.564
MOD_Plk_1	118	124	PF00069	0.456
MOD_Plk_1	144	150	PF00069	0.574
MOD_Plk_1	155	161	PF00069	0.627
MOD_Plk_1	168	174	PF00069	0.615
MOD_Plk_1	25	31	PF00069	0.584
MOD_Plk_1	267	273	PF00069	0.698
MOD_Plk_1	351	357	PF00069	0.507
MOD_Plk_1	396	402	PF00069	0.398
MOD_Plk_1	469	475	PF00069	0.493
MOD_Plk_1	52	58	PF00069	0.525
MOD_Plk_1	550	556	PF00069	0.354
MOD_Plk_1	78	84	PF00069	0.558
MOD_Plk_1	86	92	PF00069	0.584
MOD_Plk_2-3	351	357	PF00069	0.448
MOD_Plk_4	139	145	PF00069	0.598
MOD_Plk_4	169	175	PF00069	0.668
MOD_Plk_4	210	216	PF00069	0.459
MOD_Plk_4	305	311	PF00069	0.729
MOD_Plk_4	475	481	PF00069	0.416
MOD_Plk_4	550	556	PF00069	0.374
MOD_ProDKin_1	276	282	PF00069	0.698
MOD_ProDKin_1	318	324	PF00069	0.515
MOD_ProDKin_1	407	413	PF00069	0.350
MOD_ProDKin_1	55	61	PF00069	0.719
MOD_SUMO_rev_2	414	421	PF00179	0.352
MOD_SUMO_rev_2	460	464	PF00179	0.570
TRG_DiLeu_BaEn_1	196	201	PF01217	0.372
TRG_DiLeu_BaEn_1	331	336	PF01217	0.345
TRG_DiLeu_LyEn_5	196	201	PF01217	0.372
TRG_ENDOCYTIC_2	330	333	PF00928	0.394
TRG_ENDOCYTIC_2	424	427	PF00928	0.359
TRG_ENDOCYTIC_2	540	543	PF00928	0.338
TRG_ENDOCYTIC_2	99	102	PF00928	0.605
TRG_ER_diArg_1	201	203	PF00400	0.673
TRG_ER_diArg_1	227	230	PF00400	0.455
TRG_ER_diArg_1	231	233	PF00400	0.549
TRG_ER_diArg_1	315	318	PF00400	0.603
TRG_ER_diArg_1	37	39	PF00400	0.377
TRG_NLS_MonoExtC_3	249	254	PF00514	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX36	Leptomonas seymouri	54%	98%
A0A1X0P052	Trypanosomatidae	39%	100%
A0A3R7K490	Trypanosoma rangeli	35%	100%
A0A3S7WU54	Leishmania donovani	74%	94%
A4HX46	Leishmania infantum	74%	94%
C9ZVU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AQW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	94%
Q4QEL7	Leishmania major	73%	100%
V5BS91	Trypanosoma cruzi	38%	100%