Paraflagellar rod protein 2C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein 2C

Species:

Leishmania braziliensis

UniProt:

A4H8S2_LEIBR

TriTrypDb:

LbrM.16.1480 , LBRM2903_160022600

Length:

345

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	4
GO:0031514	motile cilium	5	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4

Expansion

Sequence features

A4H8S2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8S2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0005515	protein binding	2	4
GO:0005516	calmodulin binding	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.449
CLV_NRD_NRD_1	120	122	PF00675	0.426
CLV_NRD_NRD_1	193	195	PF00675	0.502
CLV_NRD_NRD_1	298	300	PF00675	0.449
CLV_NRD_NRD_1	33	35	PF00675	0.449
CLV_NRD_NRD_1	4	6	PF00675	0.764
CLV_NRD_NRD_1	86	88	PF00675	0.496
CLV_PCSK_KEX2_1	108	110	PF00082	0.403
CLV_PCSK_KEX2_1	119	121	PF00082	0.419
CLV_PCSK_KEX2_1	19	21	PF00082	0.597
CLV_PCSK_KEX2_1	193	195	PF00082	0.442
CLV_PCSK_KEX2_1	208	210	PF00082	0.325
CLV_PCSK_KEX2_1	298	300	PF00082	0.449
CLV_PCSK_KEX2_1	3	5	PF00082	0.768
CLV_PCSK_KEX2_1	32	34	PF00082	0.360
CLV_PCSK_KEX2_1	325	327	PF00082	0.625
CLV_PCSK_KEX2_1	62	64	PF00082	0.391
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.449
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.735
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.442
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.360
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.625
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.391
CLV_PCSK_PC7_1	116	122	PF00082	0.449
CLV_PCSK_PC7_1	321	327	PF00082	0.624
CLV_PCSK_SKI1_1	135	139	PF00082	0.449
CLV_PCSK_SKI1_1	19	23	PF00082	0.645
CLV_PCSK_SKI1_1	29	33	PF00082	0.346
CLV_PCSK_SKI1_1	325	329	PF00082	0.604
CLV_PCSK_SKI1_1	63	67	PF00082	0.566
DOC_CYCLIN_RxL_1	132	141	PF00134	0.449
DOC_MAPK_gen_1	135	142	PF00069	0.449
DOC_MAPK_gen_1	215	224	PF00069	0.449
DOC_MAPK_MEF2A_6	135	142	PF00069	0.449
DOC_MAPK_MEF2A_6	218	226	PF00069	0.449
DOC_MAPK_NFAT4_5	135	143	PF00069	0.449
DOC_PP4_FxxP_1	284	287	PF00568	0.449
DOC_USP7_MATH_1	165	169	PF00917	0.449
DOC_USP7_UBL2_3	243	247	PF12436	0.566
DOC_USP7_UBL2_3	32	36	PF12436	0.449
LIG_14-3-3_CanoR_1	194	200	PF00244	0.462
LIG_14-3-3_CanoR_1	215	224	PF00244	0.449
LIG_14-3-3_CanoR_1	336	341	PF00244	0.726
LIG_14-3-3_CanoR_1	81	89	PF00244	0.449
LIG_Actin_WH2_2	135	152	PF00022	0.566
LIG_APCC_ABBA_1	182	187	PF00400	0.449
LIG_APCC_ABBAyCdc20_2	181	187	PF00400	0.449
LIG_FHA_1	150	156	PF00498	0.416
LIG_FHA_1	217	223	PF00498	0.413
LIG_FHA_1	23	29	PF00498	0.453
LIG_FHA_2	239	245	PF00498	0.449
LIG_FHA_2	64	70	PF00498	0.566
LIG_LIR_Apic_2	283	287	PF02991	0.391
LIG_LIR_Gen_1	101	111	PF02991	0.449
LIG_LIR_Gen_1	123	130	PF02991	0.449
LIG_LIR_Nem_3	101	107	PF02991	0.449
LIG_LIR_Nem_3	123	127	PF02991	0.449
LIG_LIR_Nem_3	190	195	PF02991	0.398
LIG_LIR_Nem_3	83	89	PF02991	0.393
LIG_SH2_CRK	196	200	PF00017	0.566
LIG_SH2_SRC	188	191	PF00017	0.566
LIG_SH2_STAT3	64	67	PF00017	0.566
LIG_SH2_STAT5	188	191	PF00017	0.419
LIG_SUMO_SIM_par_1	136	141	PF11976	0.449
LIG_TRAF2_1	21	24	PF00917	0.649
LIG_TRAF2_1	287	290	PF00917	0.566
LIG_TRAF2_1	310	313	PF00917	0.609
LIG_WRC_WIRS_1	228	233	PF05994	0.449
MOD_CK1_1	297	303	PF00069	0.471
MOD_CK2_1	238	244	PF00069	0.449
MOD_CK2_1	63	69	PF00069	0.566
MOD_Cter_Amidation	1	4	PF01082	0.754
MOD_GlcNHglycan	163	166	PF01048	0.496
MOD_GSK3_1	161	168	PF00069	0.566
MOD_N-GLC_1	294	299	PF02516	0.449
MOD_NEK2_1	138	143	PF00069	0.449
MOD_NEK2_1	149	154	PF00069	0.449
MOD_NEK2_1	195	200	PF00069	0.449
MOD_NEK2_1	22	27	PF00069	0.566
MOD_PIKK_1	14	20	PF00454	0.729
MOD_PIKK_1	329	335	PF00454	0.711
MOD_PIKK_1	63	69	PF00454	0.566
MOD_PKA_1	236	242	PF00069	0.566
MOD_PKA_1	3	9	PF00069	0.740
MOD_PKA_2	149	155	PF00069	0.449
MOD_PKA_2	217	223	PF00069	0.449
MOD_PKA_2	297	303	PF00069	0.391
MOD_PKA_2	3	9	PF00069	0.731
MOD_PKA_2	80	86	PF00069	0.449
MOD_PKB_1	3	11	PF00069	0.737
MOD_Plk_1	138	144	PF00069	0.534
MOD_Plk_2-3	42	48	PF00069	0.566
MOD_Plk_4	138	144	PF00069	0.449
MOD_SUMO_for_1	310	313	PF00179	0.726
MOD_SUMO_rev_2	313	318	PF00179	0.576
MOD_SUMO_rev_2	320	327	PF00179	0.554
TRG_DiLeu_BaEn_2	122	128	PF01217	0.449
TRG_DiLeu_BaEn_3	253	259	PF01217	0.449
TRG_DiLeu_BaEn_4	175	181	PF01217	0.566
TRG_DiLeu_BaEn_4	254	260	PF01217	0.449
TRG_ENDOCYTIC_2	124	127	PF00928	0.449
TRG_ENDOCYTIC_2	196	199	PF00928	0.405
TRG_ER_diArg_1	109	111	PF00400	0.410
TRG_ER_diArg_1	119	121	PF00400	0.435
TRG_ER_diArg_1	192	194	PF00400	0.534
TRG_ER_diArg_1	3	5	PF00400	0.765
TRG_ER_diArg_1	33	35	PF00400	0.449
TRG_NES_CRM1_1	171	186	PF08389	0.449
TRG_NLS_Bipartite_1	19	36	PF00514	0.566
TRG_NLS_MonoExtC_3	31	36	PF00514	0.449
TRG_NLS_MonoExtN_4	29	36	PF00514	0.449
TRG_Pf-PMV_PEXEL_1	109	113	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HX40	Leishmania infantum	93%	78%
C9ZLC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	68%