Paraflagellar rod protein 2C

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod protein 2C

Species:

Leishmania braziliensis

UniProt:

A4H8S1_LEIBR

TriTrypDb:

LbrM.16.1480 , LBRM2903_160022600

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 45
NetGPI	no	yes: 0, no: 45

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	46
GO:0031514	motile cilium	5	46
GO:0042995	cell projection	2	46
GO:0043226	organelle	2	46
GO:0043227	membrane-bounded organelle	3	46
GO:0110165	cellular anatomical entity	1	46
GO:0120025	plasma membrane bounded cell projection	3	46
GO:0005737	cytoplasm	2	3
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0043233	organelle lumen	3	3
GO:0070013	intracellular organelle lumen	4	3
GO:0097014	ciliary plasm	5	3
GO:0099568	cytoplasmic region	3	3
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4H8S1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8S1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	46
GO:0005515	protein binding	2	46
GO:0005516	calmodulin binding	3	46

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.437
CLV_NRD_NRD_1	287	289	PF00675	0.337
CLV_NRD_NRD_1	30	32	PF00675	0.540
CLV_NRD_NRD_1	340	342	PF00675	0.342
CLV_NRD_NRD_1	363	365	PF00675	0.349
CLV_NRD_NRD_1	374	376	PF00675	0.325
CLV_NRD_NRD_1	447	449	PF00675	0.311
CLV_NRD_NRD_1	552	554	PF00675	0.336
CLV_PCSK_KEX2_1	273	275	PF00082	0.488
CLV_PCSK_KEX2_1	286	288	PF00082	0.298
CLV_PCSK_KEX2_1	316	318	PF00082	0.332
CLV_PCSK_KEX2_1	362	364	PF00082	0.342
CLV_PCSK_KEX2_1	373	375	PF00082	0.350
CLV_PCSK_KEX2_1	447	449	PF00082	0.328
CLV_PCSK_KEX2_1	462	464	PF00082	0.323
CLV_PCSK_KEX2_1	552	554	PF00082	0.338
CLV_PCSK_KEX2_1	579	581	PF00082	0.518
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.509
CLV_PCSK_PC1ET2_1	286	288	PF00082	0.303
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.338
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.336
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.326
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.518
CLV_PCSK_PC7_1	370	376	PF00082	0.374
CLV_PCSK_PC7_1	575	581	PF00082	0.517
CLV_PCSK_SKI1_1	273	277	PF00082	0.483
CLV_PCSK_SKI1_1	283	287	PF00082	0.328
CLV_PCSK_SKI1_1	317	321	PF00082	0.420
CLV_PCSK_SKI1_1	389	393	PF00082	0.342
CLV_PCSK_SKI1_1	579	583	PF00082	0.420
CLV_PCSK_SKI1_1	86	90	PF00082	0.658
DOC_CYCLIN_RxL_1	386	395	PF00134	0.345
DOC_MAPK_gen_1	31	40	PF00069	0.510
DOC_MAPK_gen_1	389	396	PF00069	0.332
DOC_MAPK_gen_1	469	478	PF00069	0.335
DOC_MAPK_MEF2A_6	389	396	PF00069	0.333
DOC_MAPK_MEF2A_6	472	480	PF00069	0.345
DOC_MAPK_NFAT4_5	389	397	PF00069	0.338
DOC_PP4_FxxP_1	538	541	PF00568	0.330
DOC_USP7_MATH_1	419	423	PF00917	0.293
DOC_USP7_MATH_1	80	84	PF00917	0.600
DOC_USP7_UBL2_3	113	117	PF12436	0.497
DOC_USP7_UBL2_3	286	290	PF12436	0.305
DOC_USP7_UBL2_3	497	501	PF12436	0.307
LIG_14-3-3_CanoR_1	141	146	PF00244	0.499
LIG_14-3-3_CanoR_1	335	343	PF00244	0.393
LIG_14-3-3_CanoR_1	448	454	PF00244	0.325
LIG_14-3-3_CanoR_1	469	478	PF00244	0.308
LIG_14-3-3_CanoR_1	590	595	PF00244	0.576
LIG_Actin_WH2_2	389	406	PF00022	0.454
LIG_APCC_ABBA_1	436	441	PF00400	0.345
LIG_APCC_ABBAyCdc20_2	435	441	PF00400	0.345
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_CtBP_PxDLS_1	103	109	PF00389	0.486
LIG_EH1_1	92	100	PF00400	0.462
LIG_eIF4E_1	235	241	PF01652	0.405
LIG_eIF4E_1	93	99	PF01652	0.469
LIG_FHA_1	138	144	PF00498	0.540
LIG_FHA_1	277	283	PF00498	0.358
LIG_FHA_1	40	46	PF00498	0.485
LIG_FHA_1	404	410	PF00498	0.327
LIG_FHA_1	471	477	PF00498	0.291
LIG_FHA_2	127	133	PF00498	0.467
LIG_FHA_2	256	262	PF00498	0.446
LIG_FHA_2	318	324	PF00498	0.339
LIG_FHA_2	493	499	PF00498	0.370
LIG_GBD_Chelix_1	180	188	PF00786	0.255
LIG_LIR_Apic_2	537	541	PF02991	0.329
LIG_LIR_Gen_1	355	365	PF02991	0.344
LIG_LIR_Gen_1	377	384	PF02991	0.287
LIG_LIR_Nem_3	250	255	PF02991	0.393
LIG_LIR_Nem_3	337	343	PF02991	0.335
LIG_LIR_Nem_3	355	361	PF02991	0.345
LIG_LIR_Nem_3	377	381	PF02991	0.287
LIG_LIR_Nem_3	444	449	PF02991	0.320
LIG_PTB_Apo_2	44	51	PF02174	0.465
LIG_SH2_CRK	450	454	PF00017	0.351
LIG_SH2_NCK_1	9	13	PF00017	0.431
LIG_SH2_SRC	442	445	PF00017	0.370
LIG_SH2_STAP1	9	13	PF00017	0.628
LIG_SH2_STAT3	318	321	PF00017	0.427
LIG_SH2_STAT3	93	96	PF00017	0.535
LIG_SH2_STAT5	235	238	PF00017	0.372
LIG_SH2_STAT5	442	445	PF00017	0.323
LIG_SH3_3	173	179	PF00018	0.521
LIG_SH3_4	113	120	PF00018	0.483
LIG_SUMO_SIM_anti_2	242	250	PF11976	0.229
LIG_SUMO_SIM_par_1	140	146	PF11976	0.625
LIG_SUMO_SIM_par_1	390	395	PF11976	0.345
LIG_TRAF2_1	159	162	PF00917	0.498
LIG_TRAF2_1	275	278	PF00917	0.466
LIG_TRAF2_1	46	49	PF00917	0.477
LIG_TRAF2_1	541	544	PF00917	0.323
LIG_TRAF2_1	564	567	PF00917	0.493
LIG_WRC_WIRS_1	482	487	PF05994	0.314
MOD_CK1_1	551	557	PF00069	0.351
MOD_CK1_1	57	63	PF00069	0.541
MOD_CK2_1	104	110	PF00069	0.478
MOD_CK2_1	126	132	PF00069	0.442
MOD_CK2_1	255	261	PF00069	0.410
MOD_CK2_1	317	323	PF00069	0.360
MOD_CK2_1	43	49	PF00069	0.482
MOD_CK2_1	492	498	PF00069	0.291
MOD_GlcNHglycan	150	153	PF01048	0.502
MOD_GlcNHglycan	2	5	PF01048	0.515
MOD_GlcNHglycan	417	420	PF01048	0.284
MOD_GlcNHglycan	82	85	PF01048	0.558
MOD_GSK3_1	137	144	PF00069	0.529
MOD_GSK3_1	39	46	PF00069	0.475
MOD_GSK3_1	415	422	PF00069	0.358
MOD_N-GLC_1	137	142	PF02516	0.541
MOD_N-GLC_1	188	193	PF02516	0.444
MOD_N-GLC_1	548	553	PF02516	0.392
MOD_NEK2_1	104	109	PF00069	0.471
MOD_NEK2_1	126	131	PF00069	0.446
MOD_NEK2_1	163	168	PF00069	0.444
MOD_NEK2_1	188	193	PF00069	0.431
MOD_NEK2_1	276	281	PF00069	0.351
MOD_NEK2_1	392	397	PF00069	0.318
MOD_NEK2_1	403	408	PF00069	0.314
MOD_NEK2_1	449	454	PF00069	0.310
MOD_PIKK_1	163	169	PF00454	0.452
MOD_PIKK_1	268	274	PF00454	0.525
MOD_PIKK_1	317	323	PF00454	0.355
MOD_PIKK_1	583	589	PF00454	0.561
MOD_PIKK_1	59	65	PF00454	0.549
MOD_PKA_1	490	496	PF00069	0.351
MOD_PKA_2	163	169	PF00069	0.450
MOD_PKA_2	334	340	PF00069	0.448
MOD_PKA_2	403	409	PF00069	0.355
MOD_PKA_2	471	477	PF00069	0.316
MOD_PKA_2	551	557	PF00069	0.328
MOD_Plk_1	104	110	PF00069	0.523
MOD_Plk_1	188	194	PF00069	0.457
MOD_Plk_1	23	29	PF00069	0.561
MOD_Plk_1	392	398	PF00069	0.345
MOD_Plk_2-3	296	302	PF00069	0.417
MOD_Plk_4	188	194	PF00069	0.476
MOD_Plk_4	392	398	PF00069	0.329
MOD_SUMO_for_1	154	157	PF00179	0.475
MOD_SUMO_for_1	564	567	PF00179	0.499
MOD_SUMO_rev_2	110	118	PF00179	0.483
MOD_SUMO_rev_2	2	10	PF00179	0.420
MOD_SUMO_rev_2	567	572	PF00179	0.463
MOD_SUMO_rev_2	574	581	PF00179	0.436
TRG_DiLeu_BaEn_2	376	382	PF01217	0.345
TRG_DiLeu_BaEn_3	507	513	PF01217	0.345
TRG_DiLeu_BaEn_4	429	435	PF01217	0.387
TRG_DiLeu_BaEn_4	508	514	PF01217	0.345
TRG_ENDOCYTIC_2	378	381	PF00928	0.281
TRG_ENDOCYTIC_2	450	453	PF00928	0.320
TRG_ER_diArg_1	287	289	PF00400	0.332
TRG_ER_diArg_1	363	365	PF00400	0.343
TRG_ER_diArg_1	373	375	PF00400	0.345
TRG_ER_diArg_1	446	448	PF00400	0.344
TRG_NES_CRM1_1	242	257	PF08389	0.419
TRG_NES_CRM1_1	425	440	PF08389	0.392
TRG_NES_CRM1_1	96	110	PF08389	0.543
TRG_NLS_Bipartite_1	273	290	PF00514	0.351
TRG_NLS_MonoExtC_3	285	290	PF00514	0.345
TRG_NLS_MonoExtN_4	283	290	PF00514	0.345
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.327
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	462	466	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I5	Leptomonas seymouri	66%	100%
A0A0N0P5J5	Leptomonas seymouri	26%	75%
A0A0N1IFZ5	Leptomonas seymouri	93%	100%
A0A0S4IZY8	Bodo saltans	84%	100%
A0A0S4J193	Bodo saltans	28%	97%
A0A0S4J561	Bodo saltans	29%	85%
A0A0S4JS20	Bodo saltans	69%	100%
A0A1X0NKG2	Trypanosomatidae	28%	82%
A0A1X0NR57	Trypanosomatidae	25%	76%
A0A1X0NYU4	Trypanosomatidae	85%	100%
A0A1X0P0B7	Trypanosomatidae	68%	100%
A0A381MH18	Leishmania infantum	94%	100%
A0A381MN58	Leishmania infantum	66%	100%
A0A3Q8IAP5	Leishmania donovani	94%	100%
A0A3Q8IEH2	Leishmania donovani	66%	100%
A0A3R7KDB9	Trypanosoma rangeli	85%	100%
A0A3R7NHV7	Trypanosoma rangeli	28%	93%
A0A3S5IRI8	Trypanosoma rangeli	68%	100%
A0A3S7X0V5	Leishmania donovani	24%	77%
A0A3S7X2K1	Leishmania donovani	66%	100%
A0A422NJR9	Trypanosoma rangeli	25%	81%
A4H5W0	Leishmania braziliensis	22%	99%
A4HFV9	Leishmania braziliensis	24%	77%
A4HIY0	Leishmania braziliensis	66%	100%
A4HX40	Leishmania infantum	95%	100%
A4I2Z1	Leishmania infantum	24%	77%
C9ZJD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	79%
C9ZLC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
C9ZLC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
C9ZU76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	87%
C9ZVV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	84%	100%
E9ADG3	Leishmania major	25%	100%
E9AE36	Leishmania major	66%	100%
E9AE37	Leishmania major	66%	100%
E9AHJ2	Leishmania infantum	66%	100%
E9ALP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
E9ALP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
E9AMY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	99%
E9AQV6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	90%
E9AZ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	77%
P22225	Trypanosoma brucei brucei	84%	100%
Q26789	Trypanosoma brucei brucei	66%	100%
Q4QEM2	Leishmania major	94%	100%
V5ARJ3	Trypanosoma cruzi	28%	86%
V5BDW8	Trypanosoma cruzi	68%	100%
V5BIN9	Trypanosoma cruzi	26%	81%