Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8S0_LEIBR

TriTrypDb:

LbrM.16.1470 , LBRM2903_160022500

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8S0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8S0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.688
CLV_NRD_NRD_1	312	314	PF00675	0.484
CLV_NRD_NRD_1	51	53	PF00675	0.482
CLV_NRD_NRD_1	96	98	PF00675	0.608
CLV_PCSK_KEX2_1	12	14	PF00082	0.688
CLV_PCSK_KEX2_1	120	122	PF00082	0.503
CLV_PCSK_KEX2_1	187	189	PF00082	0.381
CLV_PCSK_KEX2_1	50	52	PF00082	0.477
CLV_PCSK_KEX2_1	95	97	PF00082	0.512
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.503
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.411
CLV_PCSK_SKI1_1	150	154	PF00082	0.441
CLV_PCSK_SKI1_1	191	195	PF00082	0.497
CLV_PCSK_SKI1_1	299	303	PF00082	0.487
CLV_PCSK_SKI1_1	313	317	PF00082	0.402
CLV_PCSK_SKI1_1	346	350	PF00082	0.383
CLV_PCSK_SKI1_1	43	47	PF00082	0.418
DOC_CYCLIN_RxL_1	146	154	PF00134	0.440
DOC_MAPK_DCC_7	158	166	PF00069	0.387
DOC_MAPK_gen_1	146	155	PF00069	0.605
DOC_MAPK_gen_1	95	103	PF00069	0.384
DOC_MAPK_MEF2A_6	158	166	PF00069	0.512
DOC_MAPK_MEF2A_6	236	244	PF00069	0.547
DOC_PP1_RVXF_1	297	304	PF00149	0.508
DOC_USP7_MATH_1	192	196	PF00917	0.496
DOC_USP7_MATH_1	39	43	PF00917	0.647
DOC_USP7_MATH_1	4	8	PF00917	0.622
DOC_USP7_MATH_1	77	81	PF00917	0.338
DOC_USP7_UBL2_3	120	124	PF12436	0.640
DOC_USP7_UBL2_3	146	150	PF12436	0.644
DOC_USP7_UBL2_3	187	191	PF12436	0.513
DOC_WW_Pin1_4	245	250	PF00397	0.438
DOC_WW_Pin1_4	317	322	PF00397	0.588
LIG_14-3-3_CanoR_1	139	145	PF00244	0.579
LIG_14-3-3_CanoR_1	148	153	PF00244	0.469
LIG_14-3-3_CanoR_1	3	9	PF00244	0.722
LIG_BRCT_BRCA1_1	19	23	PF00533	0.693
LIG_EH1_1	223	231	PF00400	0.410
LIG_FHA_1	61	67	PF00498	0.538
LIG_FHA_2	139	145	PF00498	0.665
LIG_FHA_2	246	252	PF00498	0.565
LIG_IRF3_LxIS_1	87	93	PF10401	0.349
LIG_LIR_Gen_1	281	291	PF02991	0.357
LIG_LIR_Gen_1	33	41	PF02991	0.548
LIG_LIR_Gen_1	334	343	PF02991	0.423
LIG_LIR_Nem_3	33	37	PF02991	0.612
LIG_LIR_Nem_3	88	92	PF02991	0.571
LIG_NRBOX	148	154	PF00104	0.441
LIG_PDZ_Class_1	353	358	PF00595	0.420
LIG_RPA_C_Fungi	47	59	PF08784	0.400
LIG_SH2_CRK	298	302	PF00017	0.515
LIG_SH2_STAP1	78	82	PF00017	0.547
LIG_SH2_STAT5	283	286	PF00017	0.609
LIG_SH2_STAT5	34	37	PF00017	0.594
LIG_SH2_STAT5	44	47	PF00017	0.477
LIG_SH3_3	285	291	PF00018	0.535
LIG_SH3_3	298	304	PF00018	0.430
LIG_SUMO_SIM_anti_2	328	334	PF11976	0.469
LIG_SUMO_SIM_par_1	253	259	PF11976	0.461
LIG_SUMO_SIM_par_1	328	334	PF11976	0.463
LIG_UBA3_1	152	158	PF00899	0.471
LIG_UBA3_1	178	187	PF00899	0.484
MOD_CDK_SPxxK_3	245	252	PF00069	0.432
MOD_CK1_1	17	23	PF00069	0.707
MOD_CK1_1	336	342	PF00069	0.444
MOD_CK2_1	138	144	PF00069	0.647
MOD_CK2_1	331	337	PF00069	0.419
MOD_GlcNHglycan	16	19	PF01048	0.594
MOD_GlcNHglycan	226	229	PF01048	0.542
MOD_GlcNHglycan	271	274	PF01048	0.615
MOD_GSK3_1	220	227	PF00069	0.500
MOD_GSK3_1	333	340	PF00069	0.495
MOD_LATS_1	94	100	PF00433	0.373
MOD_N-GLC_1	199	204	PF02516	0.620
MOD_N-GLC_1	224	229	PF02516	0.532
MOD_NEK2_1	224	229	PF00069	0.501
MOD_NEK2_1	90	95	PF00069	0.553
MOD_PIKK_1	65	71	PF00454	0.568
MOD_PKA_1	96	102	PF00069	0.383
MOD_PKA_2	11	17	PF00069	0.645
MOD_PKA_2	138	144	PF00069	0.671
MOD_PKA_2	235	241	PF00069	0.431
MOD_PKA_2	96	102	PF00069	0.383
MOD_Plk_1	224	230	PF00069	0.552
MOD_Plk_1	32	38	PF00069	0.599
MOD_Plk_1	346	352	PF00069	0.377
MOD_Plk_4	148	154	PF00069	0.676
MOD_Plk_4	235	241	PF00069	0.507
MOD_Plk_4	77	83	PF00069	0.337
MOD_ProDKin_1	245	251	PF00069	0.432
MOD_ProDKin_1	317	323	PF00069	0.586
MOD_SUMO_for_1	230	233	PF00179	0.455
MOD_SUMO_for_1	286	289	PF00179	0.616
MOD_SUMO_rev_2	98	103	PF00179	0.495
TRG_DiLeu_BaEn_2	84	90	PF01217	0.596
TRG_DiLeu_BaEn_4	53	59	PF01217	0.414
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.428
TRG_ENDOCYTIC_2	283	286	PF00928	0.359
TRG_ENDOCYTIC_2	298	301	PF00928	0.519
TRG_ENDOCYTIC_2	335	338	PF00928	0.536
TRG_ENDOCYTIC_2	34	37	PF00928	0.418
TRG_ENDOCYTIC_2	78	81	PF00928	0.550
TRG_ER_diArg_1	49	52	PF00400	0.485
TRG_ER_diArg_1	95	97	PF00400	0.606
TRG_NES_CRM1_1	144	156	PF08389	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL8	Leptomonas seymouri	64%	69%
A0A1X0NYW3	Trypanosomatidae	41%	100%
A0A3R7JY16	Trypanosoma rangeli	37%	94%
A0A3S7WU51	Leishmania donovani	81%	100%
A4HX38	Leishmania infantum	81%	100%
E9AQV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QEM4	Leishmania major	79%	100%
V5BMN4	Trypanosoma cruzi	38%	96%