Trafficking protein particle complex subunit

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

trafficking protein particle complex subunit- like protein

Species:

Leishmania braziliensis

UniProt:

A4H8R9_LEIBR

TriTrypDb:

LbrM.16.1460 , LBRM2903_160022300

Length:

195

Annotations

LeishMANIAdb annotations

A conserved eukarytotic protein involved in ER-Golgi transport with no TM segment. Associated to the membrane from the cytoplasmic side.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	10
GO:0005794	Golgi apparatus	5	9
GO:0030008	TRAPP complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0099023	vesicle tethering complex	2	11
GO:0110165	cellular anatomical entity	1	10
GO:0140535	intracellular protein-containing complex	2	11
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	4
GO:0031090	organelle membrane	3	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0033106	cis-Golgi network membrane	5	1
GO:0097014	ciliary plasm	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4H8R9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8R9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0016192	vesicle-mediated transport	4	11
GO:0048193	Golgi vesicle transport	5	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0009987	cellular process	1	1
GO:0046907	intracellular transport	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	130	134	PF00656	0.478
CLV_PCSK_SKI1_1	97	101	PF00082	0.280
DEG_SPOP_SBC_1	4	8	PF00917	0.716
DOC_MAPK_MEF2A_6	175	182	PF00069	0.370
DOC_MAPK_NFAT4_5	175	183	PF00069	0.375
DOC_USP7_MATH_1	4	8	PF00917	0.676
LIG_14-3-3_CanoR_1	5	13	PF00244	0.588
LIG_14-3-3_CanoR_1	82	91	PF00244	0.532
LIG_APCC_ABBA_1	125	130	PF00400	0.452
LIG_BIR_II_1	1	5	PF00653	0.681
LIG_BRCT_BRCA1_1	112	116	PF00533	0.409
LIG_BRCT_BRCA1_1	24	28	PF00533	0.516
LIG_CaM_IQ_9	156	171	PF13499	0.450
LIG_FHA_1	113	119	PF00498	0.466
LIG_FHA_1	149	155	PF00498	0.450
LIG_FHA_1	187	193	PF00498	0.407
LIG_GBD_Chelix_1	36	44	PF00786	0.175
LIG_Integrin_RGD_1	171	173	PF01839	0.452
LIG_LIR_Gen_1	25	36	PF02991	0.557
LIG_LIR_Nem_3	25	31	PF02991	0.514
LIG_LIR_Nem_3	32	36	PF02991	0.452
LIG_Pex14_2	116	120	PF04695	0.466
LIG_SH2_CRK	142	146	PF00017	0.452
LIG_SH2_CRK	33	37	PF00017	0.452
LIG_SH2_GRB2like	142	145	PF00017	0.452
LIG_SH2_STAP1	142	146	PF00017	0.452
LIG_SH3_2	132	137	PF14604	0.504
LIG_SH3_3	126	132	PF00018	0.452
LIG_SUMO_SIM_anti_2	89	95	PF11976	0.483
LIG_TYR_ITIM	140	145	PF00017	0.452
LIG_TYR_ITIM	31	36	PF00017	0.445
MOD_CK1_1	3	9	PF00069	0.679
MOD_CK1_1	73	79	PF00069	0.483
MOD_CK2_1	171	177	PF00069	0.332
MOD_GlcNHglycan	2	5	PF01048	0.478
MOD_GlcNHglycan	24	27	PF01048	0.333
MOD_GlcNHglycan	75	78	PF01048	0.256
MOD_GlcNHglycan	8	11	PF01048	0.443
MOD_GSK3_1	112	119	PF00069	0.489
MOD_GSK3_1	148	155	PF00069	0.421
MOD_N-GLC_1	102	107	PF02516	0.223
MOD_NEK2_1	116	121	PF00069	0.483
MOD_NEK2_1	140	145	PF00069	0.455
MOD_NEK2_1	29	34	PF00069	0.442
MOD_PIKK_1	104	110	PF00454	0.492
MOD_PIKK_1	82	88	PF00454	0.532
MOD_PKA_2	163	169	PF00069	0.291
MOD_PKA_2	186	192	PF00069	0.455
MOD_PKA_2	4	10	PF00069	0.597
MOD_Plk_1	102	108	PF00069	0.484
MOD_Plk_1	70	76	PF00069	0.504
MOD_Plk_4	152	158	PF00069	0.355
TRG_DiLeu_BaEn_1	89	94	PF01217	0.504
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.504
TRG_ENDOCYTIC_2	142	145	PF00928	0.452
TRG_ENDOCYTIC_2	33	36	PF00928	0.444
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P6	Leptomonas seymouri	84%	99%
A0A0S4IZC2	Bodo saltans	49%	82%
A0A1X0NYV5	Trypanosomatidae	61%	100%
A0A3R7N8V3	Trypanosoma rangeli	66%	99%
A0A3S5H6Y9	Leishmania donovani	92%	99%
C9ZVV4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	100%
E9AGP3	Leishmania infantum	92%	99%
E9AQV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
O43617	Homo sapiens	44%	100%
O55013	Mus musculus	44%	100%
P34605	Caenorhabditis elegans	30%	100%
P36149	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
Q4KL14	Mus musculus	42%	100%
Q4QEM6	Leishmania major	92%	100%
Q5T215	Homo sapiens	40%	100%
Q5U1Z2	Rattus norvegicus	44%	100%
Q5ZI57	Gallus gallus	42%	100%
Q61IU9	Caenorhabditis briggsae	30%	100%
Q86K94	Dictyostelium discoideum	44%	100%
Q9P6P5	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%