LeishMANIAdb
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LSM14 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
LSM14 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H8R5_LEIBR
TriTrypDb:
LbrM.16.1420 , LBRM2903_160021800
Length:
108

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8R5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8R5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 28 32 PF00656 0.597
CLV_NRD_NRD_1 84 86 PF00675 0.464
CLV_PCSK_KEX2_1 84 86 PF00082 0.460
CLV_PCSK_SKI1_1 57 61 PF00082 0.457
CLV_PCSK_SKI1_1 77 81 PF00082 0.428
DOC_CYCLIN_yCln2_LP_2 72 78 PF00134 0.474
DOC_MAPK_DCC_7 84 94 PF00069 0.639
DOC_MAPK_HePTP_8 64 76 PF00069 0.441
DOC_MAPK_MEF2A_6 101 108 PF00069 0.628
DOC_MAPK_MEF2A_6 67 76 PF00069 0.439
DOC_PP2B_LxvP_1 72 75 PF13499 0.457
DOC_WW_Pin1_4 100 105 PF00397 0.748
LIG_Actin_WH2_2 75 92 PF00022 0.391
LIG_BIR_II_1 1 5 PF00653 0.768
LIG_FHA_1 101 107 PF00498 0.628
LIG_FHA_2 50 56 PF00498 0.320
LIG_FHA_2 93 99 PF00498 0.634
LIG_MYND_1 87 91 PF01753 0.610
LIG_PDZ_Class_2 103 108 PF00595 0.608
LIG_SUMO_SIM_par_1 90 95 PF11976 0.621
LIG_UBA3_1 71 77 PF00899 0.437
MOD_CK2_1 49 55 PF00069 0.319
MOD_CK2_1 92 98 PF00069 0.687
MOD_GlcNHglycan 43 47 PF01048 0.581
MOD_NEK2_1 49 54 PF00069 0.322
MOD_NEK2_2 62 67 PF00069 0.555
MOD_Plk_1 62 68 PF00069 0.461
MOD_Plk_4 35 41 PF00069 0.371
MOD_ProDKin_1 100 106 PF00069 0.749
TRG_DiLeu_BaEn_1 102 107 PF01217 0.734
TRG_DiLeu_BaEn_2 15 21 PF01217 0.575
TRG_Pf-PMV_PEXEL_1 23 28 PF00026 0.462

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWX0 Leptomonas seymouri 75% 100%
A0A1X0NZ50 Trypanosomatidae 57% 86%
A0A3R7N3A0 Trypanosoma rangeli 68% 86%
A0A3S7WU53 Leishmania donovani 85% 100%
A4HX33 Leishmania infantum 85% 100%
C9ZVW0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 83%
E9AQU8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QEN0 Leishmania major 87% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS