Amidase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amidase, putative

Species:

Leishmania braziliensis

UniProt:

A4H8R4_LEIBR

TriTrypDb:

LbrM.16.1410 , LBRM2903_160021700

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4H8R4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8R4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2
GO:0016874	ligase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.493
CLV_NRD_NRD_1	165	167	PF00675	0.213
CLV_NRD_NRD_1	536	538	PF00675	0.312
CLV_PCSK_KEX2_1	134	136	PF00082	0.266
CLV_PCSK_KEX2_1	164	166	PF00082	0.216
CLV_PCSK_KEX2_1	465	467	PF00082	0.233
CLV_PCSK_KEX2_1	536	538	PF00082	0.312
CLV_PCSK_KEX2_1	545	547	PF00082	0.289
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.266
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.154
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.233
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.154
CLV_PCSK_SKI1_1	166	170	PF00082	0.193
CLV_PCSK_SKI1_1	322	326	PF00082	0.266
CLV_PCSK_SKI1_1	433	437	PF00082	0.259
CLV_PCSK_SKI1_1	5	9	PF00082	0.264
CLV_PCSK_SKI1_1	580	584	PF00082	0.357
CLV_Separin_Metazoa	430	434	PF03568	0.433
DEG_Nend_UBRbox_3	1	3	PF02207	0.470
DEG_SCF_FBW7_1	375	381	PF00400	0.466
DOC_CKS1_1	375	380	PF01111	0.475
DOC_CYCLIN_RxL_1	430	439	PF00134	0.354
DOC_CYCLIN_yCln2_LP_2	503	509	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	518	524	PF00134	0.436
DOC_MAPK_DCC_7	438	448	PF00069	0.423
DOC_MAPK_gen_1	178	188	PF00069	0.436
DOC_MAPK_gen_1	463	473	PF00069	0.354
DOC_MAPK_gen_1	536	542	PF00069	0.488
DOC_MAPK_gen_1	78	87	PF00069	0.391
DOC_MAPK_MEF2A_6	181	190	PF00069	0.423
DOC_MAPK_MEF2A_6	5	12	PF00069	0.491
DOC_MAPK_NFAT4_5	5	13	PF00069	0.514
DOC_PP2B_LxvP_1	141	144	PF13499	0.423
DOC_PP2B_LxvP_1	456	459	PF13499	0.466
DOC_PP2B_LxvP_1	518	521	PF13499	0.423
DOC_PP4_FxxP_1	554	557	PF00568	0.514
DOC_USP7_MATH_1	276	280	PF00917	0.454
DOC_USP7_MATH_1	378	382	PF00917	0.486
DOC_USP7_MATH_1	408	412	PF00917	0.411
DOC_USP7_MATH_1	51	55	PF00917	0.582
DOC_USP7_UBL2_3	148	152	PF12436	0.354
DOC_USP7_UBL2_3	545	549	PF12436	0.354
DOC_WW_Pin1_4	171	176	PF00397	0.423
DOC_WW_Pin1_4	260	265	PF00397	0.434
DOC_WW_Pin1_4	316	321	PF00397	0.510
DOC_WW_Pin1_4	374	379	PF00397	0.552
LIG_14-3-3_CanoR_1	165	175	PF00244	0.444
LIG_14-3-3_CanoR_1	346	352	PF00244	0.405
LIG_14-3-3_CanoR_1	438	444	PF00244	0.412
LIG_14-3-3_CanoR_1	536	541	PF00244	0.462
LIG_14-3-3_CanoR_1	81	88	PF00244	0.545
LIG_BIR_III_4	581	585	PF00653	0.548
LIG_Clathr_ClatBox_1	480	484	PF01394	0.466
LIG_deltaCOP1_diTrp_1	121	127	PF00928	0.423
LIG_eIF4E_1	214	220	PF01652	0.423
LIG_FHA_1	167	173	PF00498	0.354
LIG_FHA_1	191	197	PF00498	0.436
LIG_FHA_1	214	220	PF00498	0.423
LIG_FHA_1	235	241	PF00498	0.423
LIG_FHA_1	28	34	PF00498	0.298
LIG_FHA_1	284	290	PF00498	0.431
LIG_FHA_1	380	386	PF00498	0.354
LIG_FHA_1	451	457	PF00498	0.480
LIG_FHA_2	144	150	PF00498	0.447
LIG_FHA_2	564	570	PF00498	0.514
LIG_FHA_2	88	94	PF00498	0.469
LIG_GBD_Chelix_1	575	583	PF00786	0.261
LIG_IBAR_NPY_1	212	214	PF08397	0.412
LIG_IBAR_NPY_1	99	101	PF08397	0.423
LIG_LIR_Apic_2	553	557	PF02991	0.425
LIG_LIR_Gen_1	19	29	PF02991	0.395
LIG_LIR_Gen_1	343	352	PF02991	0.406
LIG_LIR_Gen_1	371	378	PF02991	0.503
LIG_LIR_Gen_1	512	522	PF02991	0.423
LIG_LIR_Gen_1	590	599	PF02991	0.594
LIG_LIR_Nem_3	19	25	PF02991	0.324
LIG_LIR_Nem_3	343	347	PF02991	0.464
LIG_LIR_Nem_3	371	375	PF02991	0.475
LIG_LIR_Nem_3	389	393	PF02991	0.455
LIG_LIR_Nem_3	512	518	PF02991	0.414
LIG_LIR_Nem_3	590	594	PF02991	0.533
LIG_MAD2	323	331	PF02301	0.514
LIG_NRBOX	476	482	PF00104	0.423
LIG_Pex14_1	42	46	PF04695	0.571
LIG_Pex14_1	528	532	PF04695	0.371
LIG_PTB_Apo_2	252	259	PF02174	0.412
LIG_PTB_Phospho_1	252	258	PF10480	0.454
LIG_Rb_LxCxE_1	79	97	PF01857	0.479
LIG_SH2_CRK	511	515	PF00017	0.354
LIG_SH2_CRK	586	590	PF00017	0.442
LIG_SH2_GRB2like	101	104	PF00017	0.423
LIG_SH2_GRB2like	372	375	PF00017	0.423
LIG_SH2_NCK_1	511	515	PF00017	0.412
LIG_SH2_PTP2	372	375	PF00017	0.436
LIG_SH2_SRC	372	375	PF00017	0.514
LIG_SH2_STAP1	511	515	PF00017	0.414
LIG_SH2_STAT3	64	67	PF00017	0.436
LIG_SH2_STAT5	24	27	PF00017	0.272
LIG_SH2_STAT5	266	269	PF00017	0.423
LIG_SH2_STAT5	366	369	PF00017	0.441
LIG_SH2_STAT5	372	375	PF00017	0.425
LIG_SH2_STAT5	511	514	PF00017	0.412
LIG_SH2_STAT5	64	67	PF00017	0.468
LIG_SH3_1	55	61	PF00018	0.429
LIG_SH3_2	317	322	PF14604	0.482
LIG_SH3_3	169	175	PF00018	0.466
LIG_SH3_3	310	316	PF00018	0.421
LIG_SH3_3	372	378	PF00018	0.506
LIG_SH3_3	382	388	PF00018	0.409
LIG_SH3_3	487	493	PF00018	0.412
LIG_SH3_3	523	529	PF00018	0.483
LIG_SH3_3	55	61	PF00018	0.429
LIG_SH3_CIN85_PxpxPR_1	493	498	PF14604	0.454
LIG_SUMO_SIM_anti_2	83	90	PF11976	0.514
LIG_TRFH_1	308	312	PF08558	0.514
LIG_TYR_ITIM	370	375	PF00017	0.436
LIG_WRC_WIRS_1	235	240	PF05994	0.423
LIG_WRC_WIRS_1	88	93	PF05994	0.466
MOD_CDC14_SPxK_1	319	322	PF00782	0.449
MOD_CDK_SPxK_1	316	322	PF00069	0.449
MOD_CDK_SPxK_1	374	380	PF00069	0.466
MOD_CDK_SPxxK_3	171	178	PF00069	0.436
MOD_CDK_SPxxK_3	316	323	PF00069	0.509
MOD_CK1_1	236	242	PF00069	0.423
MOD_CK1_1	379	385	PF00069	0.459
MOD_CK1_1	402	408	PF00069	0.447
MOD_CK1_1	411	417	PF00069	0.422
MOD_CK1_1	439	445	PF00069	0.412
MOD_CK2_1	143	149	PF00069	0.423
MOD_CK2_1	221	227	PF00069	0.423
MOD_CK2_1	347	353	PF00069	0.463
MOD_CK2_1	538	544	PF00069	0.454
MOD_CK2_1	66	72	PF00069	0.517
MOD_CK2_1	80	86	PF00069	0.450
MOD_CK2_1	87	93	PF00069	0.488
MOD_CMANNOS	124	127	PF00535	0.223
MOD_GlcNHglycan	124	127	PF01048	0.233
MOD_GlcNHglycan	223	226	PF01048	0.212
MOD_GlcNHglycan	278	281	PF01048	0.293
MOD_GlcNHglycan	401	404	PF01048	0.288
MOD_GlcNHglycan	493	496	PF01048	0.288
MOD_GlcNHglycan	563	566	PF01048	0.314
MOD_GlcNHglycan	68	71	PF01048	0.273
MOD_GSK3_1	143	150	PF00069	0.486
MOD_GSK3_1	167	174	PF00069	0.503
MOD_GSK3_1	283	290	PF00069	0.496
MOD_GSK3_1	374	381	PF00069	0.514
MOD_GSK3_1	391	398	PF00069	0.466
MOD_GSK3_1	402	409	PF00069	0.498
MOD_GSK3_1	411	418	PF00069	0.524
MOD_N-GLC_1	191	196	PF02516	0.236
MOD_NEK2_1	188	193	PF00069	0.428
MOD_NEK2_1	393	398	PF00069	0.445
MOD_NEK2_1	399	404	PF00069	0.464
MOD_NEK2_1	415	420	PF00069	0.514
MOD_NEK2_1	436	441	PF00069	0.463
MOD_NEK2_1	509	514	PF00069	0.431
MOD_NEK2_1	571	576	PF00069	0.473
MOD_NEK2_1	71	76	PF00069	0.496
MOD_PIKK_1	297	303	PF00454	0.423
MOD_PIKK_1	347	353	PF00454	0.424
MOD_PIKK_1	415	421	PF00454	0.466
MOD_PK_1	536	542	PF00069	0.535
MOD_PKA_1	536	542	PF00069	0.514
MOD_PKA_2	345	351	PF00069	0.393
MOD_PKA_2	379	385	PF00069	0.446
MOD_PKA_2	51	57	PF00069	0.599
MOD_PKA_2	536	542	PF00069	0.479
MOD_PKA_2	80	86	PF00069	0.564
MOD_Plk_4	135	141	PF00069	0.423
MOD_Plk_4	340	346	PF00069	0.491
MOD_Plk_4	368	374	PF00069	0.433
MOD_Plk_4	395	401	PF00069	0.500
MOD_Plk_4	476	482	PF00069	0.514
MOD_Plk_4	87	93	PF00069	0.466
MOD_ProDKin_1	171	177	PF00069	0.423
MOD_ProDKin_1	260	266	PF00069	0.434
MOD_ProDKin_1	316	322	PF00069	0.510
MOD_ProDKin_1	374	380	PF00069	0.552
MOD_SUMO_for_1	464	467	PF00179	0.354
MOD_SUMO_rev_2	125	133	PF00179	0.411
MOD_SUMO_rev_2	407	414	PF00179	0.458
TRG_ENDOCYTIC_2	372	375	PF00928	0.423
TRG_ENDOCYTIC_2	511	514	PF00928	0.358
TRG_NLS_MonoExtN_4	163	168	PF00514	0.354
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3K3	Leptomonas seymouri	77%	100%
A0A0S4JR69	Bodo saltans	44%	100%
A0A1X0NYV8	Trypanosomatidae	60%	99%
A0A3R7KJH6	Trypanosoma rangeli	60%	99%
A0A3S7WU46	Leishmania donovani	87%	100%
A4HX32	Leishmania infantum	87%	100%
C9ZVW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AQU7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
P08158	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	100%
Q05AM4	Danio rerio	37%	100%
Q0ACB5	Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1)	25%	100%
Q4QEN1	Leishmania major	85%	100%
Q6DH69	Danio rerio	38%	100%
Q6GMR7	Homo sapiens	36%	100%
V5BS79	Trypanosoma cruzi	60%	100%