Putative cytochrome c

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c, putative

Species:

Leishmania braziliensis

UniProt:

A4H8R0_LEIBR

TriTrypDb:

LbrM.16.1370 , LBRM2903_160021300

Length:

113

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005758	mitochondrial intermembrane space	6	8
GO:0031970	organelle envelope lumen	5	8
GO:0031974	membrane-enclosed lumen	2	8
GO:0043233	organelle lumen	3	8
GO:0070013	intracellular organelle lumen	4	8
GO:0070469	respirasome	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H8R0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8R0

PDB structure(s): 4dy9_A , 4ged_B

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	1
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	7	1
GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	7	1
GO:0008152	metabolic process	1	1
GO:0009060	aerobic respiration	6	1
GO:0009987	cellular process	1	1
GO:0015980	energy derivation by oxidation of organic compounds	4	1
GO:0019646	aerobic electron transport chain	6	1
GO:0022900	electron transport chain	4	1
GO:0022904	respiratory electron transport chain	5	1
GO:0044237	cellular metabolic process	2	1
GO:0045333	cellular respiration	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	8
GO:0009055	electron transfer activity	3	8
GO:0016491	oxidoreductase activity	2	8
GO:0020037	heme binding	4	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0046906	tetrapyrrole binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	48	50	PF00675	0.311
CLV_PCSK_SKI1_1	19	23	PF00082	0.544
DEG_SCF_TRCP1_1	65	71	PF00400	0.346
DOC_CKS1_1	69	74	PF01111	0.544
DOC_WW_Pin1_4	68	73	PF00397	0.544
LIG_APCC_ABBA_1	75	80	PF00400	0.544
LIG_CSL_BTD_1	69	72	PF09270	0.544
LIG_FHA_1	69	75	PF00498	0.544
LIG_KLC1_Yacidic_2	76	80	PF13176	0.544
LIG_LIR_Nem_3	92	96	PF02991	0.544
LIG_SH2_NCK_1	59	63	PF00017	0.544
LIG_SH2_STAT5	108	111	PF00017	0.544
LIG_SH2_STAT5	78	81	PF00017	0.544
LIG_SH3_3	5	11	PF00018	0.743
LIG_UBA3_1	43	50	PF00899	0.311
MOD_GlcNHglycan	50	53	PF01048	0.544
MOD_GlcNHglycan	65	68	PF01048	0.299
MOD_GSK3_1	29	36	PF00069	0.451
MOD_NEK2_1	57	62	PF00069	0.544
MOD_PKA_2	48	54	PF00069	0.544
MOD_ProDKin_1	68	74	PF00069	0.544

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JRR5	Bodo saltans	74%	99%
A0A0S4JTE8	Bodo saltans	83%	100%
A0A0S4JVW5	Bodo saltans	81%	97%
A0A1X0NYU2	Trypanosomatidae	87%	99%
A0A3S7WU26	Leishmania donovani	93%	100%
A0A3S7WU28	Leishmania donovani	94%	100%
A0A422NDC5	Trypanosoma rangeli	82%	100%
A2Y4S9	Oryza sativa subsp. indica	56%	100%
A4H8Q9	Leishmania braziliensis	98%	100%
A4HX29	Leishmania infantum	93%	100%
A8WQY3	Caenorhabditis briggsae	55%	100%
A8X769	Caenorhabditis briggsae	46%	84%
B4USV4	Otolemur garnettii	54%	100%
C9ZVW7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	88%	99%
D5QVH0	Methylosinus trichosporium	37%	86%
E9AQU2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O13393	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	50%	100%
O22642	Fritillaria agrestis	56%	100%
O23138	Arabidopsis thaliana	53%	99%
O93863	Pachysolen tannophilus	49%	100%
P00002	Macaca mulatta	55%	100%
P00003	Ateles sp.	56%	100%
P00004	Equus caballus	58%	100%
P00007	Hippopotamus amphibius	59%	100%
P00008	Oryctolagus cuniculus	58%	100%
P00011	Canis lupus familiaris	59%	100%
P00012	Mirounga leonina	59%	100%
P00013	Miniopterus schreibersii	58%	100%
P00014	Macropus giganteus	60%	100%
P00015	Mus musculus	58%	100%
P00017	Aptenodytes patagonicus	58%	100%
P00018	Dromaius novaehollandiae	57%	100%
P00019	Struthio camelus	57%	100%
P00020	Anas platyrhynchos	58%	100%
P00021	Columba livia	57%	100%
P00022	Chelydra serpentina	60%	100%
P00024	Lithobates catesbeianus	57%	100%
P00025	Katsuwonus pelamis	53%	100%
P00026	Cyprinus carpio	56%	100%
P00027	Squalus suckleyi	56%	100%
P00028	Entosphenus tridentatus	57%	100%
P00029	Asterias rubens	58%	100%
P00030	Eisenia fetida	57%	100%
P00031	Macrobrachium malcolmsonii	55%	100%
P00032	Cornu aspersum	49%	100%
P00035	Haematobia irritans	56%	100%
P00036	Lucilia cuprina	56%	100%
P00037	Samia cynthia	56%	100%
P00038	Apis mellifera	56%	100%
P00039	Manduca sexta	58%	100%
P00040	Schistocerca gregaria	57%	100%
P00041	Pichia kudriavzevii	50%	100%
P00042	Wickerhamomyces anomalus	50%	100%
P00043	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	52%	100%
P00044	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	100%
P00045	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	48%	100%
P00046	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	59%	100%
P00047	Thermomyces lanuginosus	52%	100%
P00048	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	48%	100%
P00049	Ustilago sphaerogena	52%	100%
P00051	Cucurbita maxima	56%	100%
P00052	Vigna radiata var. radiata	56%	100%
P00053	Cannabis sativa	52%	100%
P00054	Sesamum indicum	58%	100%
P00056	Zea mays	54%	100%
P00057	Ricinus communis	56%	100%
P00058	Gossypium barbadense	55%	100%
P00059	Abutilon theophrasti	55%	100%
P00060	Solanum lycopersicum	56%	100%
P00061	Solanum tuberosum	56%	100%
P00062	Sambucus nigra	54%	100%
P00063	Acer negundo	55%	100%
P00064	Allium porrum	54%	100%
P00065	Arum maculatum	55%	100%
P00066	Nigella damascena	50%	100%
P00067	Tropaeolum majus	54%	100%
P00068	Triticum aestivum	53%	100%
P00069	Guizotia abyssinica	53%	100%
P00070	Helianthus annuus	55%	100%
P00071	Pastinaca sativa	53%	100%
P00072	Fagopyrum esculentum	56%	100%
P00073	Spinacia oleracea	53%	100%
P00074	Ginkgo biloba	52%	100%
P00075	Ulva intestinalis	50%	100%
P00076	Euglena gracilis	56%	100%
P00077	Strigomonas oncopelti	88%	100%
P00078	Crithidia fasciculata	88%	99%
P00079	Tetrahymena pyriformis	41%	100%
P00080	Rhodopila globiformis	54%	100%
P00081	Agrobacterium tumefaciens (strain II Chrys)	46%	100%
P00082	Rhodomicrobium vannielii (strain ATCC 17100 / ATH 3.1.1 / DSM 162 / LMG 4299)	49%	90%
P00083	Blastochloris viridis	51%	89%
P00084	Rhodoblastus acidophilus	45%	100%
P00085	Nitrobacter winogradskyi	44%	100%
P00086	Magnetospirillum fulvum	45%	100%
P00087	Magnetospirillum molischianum	45%	100%
P00088	Magnetospirillum molischianum	48%	100%
P00089	Magnetospirillum fulvum	48%	100%
P00090	Rhodopseudomonas palustris	41%	99%
P00091	Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)	40%	81%
P00093	Pararhodospirillum photometricum	37%	100%
P00096	Paracoccus denitrificans	33%	73%
P04657	Drosophila melanogaster	54%	100%
P0C189	Rhodospirillum rubrum	38%	100%
P10715	Rattus norvegicus	59%	100%
P12831	Sarcophaga peregrina	56%	100%
P12832	Novispirillum itersonii	42%	100%
P15451	Chlamydomonas reinhardtii	61%	100%
P18822	Trypanosoma brucei brucei	73%	100%
P19681	Schwanniomyces occidentalis	53%	100%
P19974	Caenorhabditis elegans	53%	100%
P21665	Varanus varius	56%	100%
P22342	Euglena viridis	55%	100%
P23021	Starkeya novella	47%	100%
P25400	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	53%	100%
P29380	Arabidopsis thaliana	50%	100%
P32556	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	47%	100%
P38091	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	55%	100%
P53698	Candida albicans (strain SC5314 / ATCC MYA-2876)	53%	100%
P56205	Aspergillus niger	56%	100%
P59218	Rosellinia necatrix	53%	100%
P62772	Brassica napus	55%	100%
P62773	Brassica oleracea	55%	100%
P62894	Bos taurus	58%	100%
P62895	Sus scrofa	58%	100%
P62896	Ovis aries	58%	100%
P62897	Mus musculus	58%	100%
P62898	Rattus norvegicus	58%	100%
P67881	Gallus gallus	56%	100%
P67882	Meleagris gallopavo	56%	100%
P68096	Equus quagga burchellii	58%	100%
P68097	Equus asinus	58%	100%
P68098	Lama guanicoe	59%	100%
P68099	Camelus dromedarius	59%	100%
P68100	Eschrichtius robustus	59%	100%
P68517	Crotalus adamanteus	50%	100%
P68518	Crotalus atrox	50%	100%
P68519	Crotalus viridis viridis	50%	100%
P80288	Paracoccus pantotrophus	34%	84%
P81153	Rhodospirillum centenum	37%	94%
P81154	Rhodospirillum centenum	37%	93%
P81280	Alligator mississippiensis	59%	100%
P81459	Thunnus alalunga	53%	100%
P84029	Drosophila melanogaster	57%	100%
P84030	Ceratitis capitata	57%	100%
P86317	Rhodopseudomonas palustris	39%	99%
P86318	Rhodopseudomonas palustris	38%	99%
P86320	Rhodovulum adriaticum	32%	90%
P86321	Afifella marina	39%	91%
P86322	Rhodoplanes tepidamans	47%	100%
P86323	Rhodoplanes tepidamans	46%	100%
P86324	Rhodoplanes tepidamans	43%	100%
P92504	Ascaris suum	55%	100%
P92505	Ascaris suum	46%	100%
P99998	Pan troglodytes	56%	100%
P99999	Homo sapiens	56%	100%
Q00499	Paracoccus versutus	33%	73%
Q0DI31	Oryza sativa subsp. japonica	56%	100%
Q1KKS2	Takifugu rubripes	58%	100%
Q1KL06	Takifugu rubripes	55%	100%
Q23240	Caenorhabditis elegans	49%	92%
Q2RVM4	Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)	36%	84%
Q3SZT9	Bos taurus	54%	100%
Q41346	Stellaria longipes	49%	100%
Q45233	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	38%	83%
Q4HVX7	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	53%	100%
Q4N594	Theileria parva	55%	98%
Q4QEN5	Leishmania major	96%	100%
Q4SG99	Tetraodon nigroviridis	55%	100%
Q4UEA0	Theileria annulata	56%	98%
Q52V08	Macaca sylvanus	55%	100%
Q52V09	Cephalopachus bancanus	57%	100%
Q52V10	Saimiri sciureus	55%	100%
Q5RFH4	Pongo abelii	56%	100%
Q640U4	Xenopus tropicalis	57%	100%
Q6C9Q0	Yarrowia lipolytica (strain CLIB 122 / E 150)	55%	100%
Q6DKE1	Xenopus laevis	58%	100%
Q6GQE4	Xenopus laevis	55%	100%
Q6IQM2	Danio rerio	57%	100%
Q6NTN0	Xenopus laevis	55%	100%
Q6PBF4	Xenopus tropicalis	56%	100%
Q6Q4H8	Komagataella pastoris	50%	100%
Q6QLW4	Pectinaria gouldii	56%	100%
Q6WUX8	Gorilla gorilla gorilla	56%	100%
Q753F4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	49%	100%
Q7YR71	Trachypithecus cristatus	53%	100%
Q869N1	Dictyostelium discoideum	54%	100%
Q96VP3	Cochliobolus lunatus	49%	100%
Q9T0G2	Arabidopsis thaliana	54%	100%