Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 41

Species:

Leishmania braziliensis

UniProt:

A4H8Q8_LEIBR

TriTrypDb:

LbrM.16.1350 , LBRM2903_160021100

Length:

1020

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8Q8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Q8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.581
CLV_C14_Caspase3-7	475	479	PF00656	0.564
CLV_C14_Caspase3-7	546	550	PF00656	0.591
CLV_C14_Caspase3-7	752	756	PF00656	0.525
CLV_NRD_NRD_1	295	297	PF00675	0.849
CLV_NRD_NRD_1	408	410	PF00675	0.577
CLV_NRD_NRD_1	462	464	PF00675	0.678
CLV_NRD_NRD_1	693	695	PF00675	0.562
CLV_NRD_NRD_1	723	725	PF00675	0.534
CLV_NRD_NRD_1	807	809	PF00675	0.674
CLV_NRD_NRD_1	930	932	PF00675	0.820
CLV_PCSK_FUR_1	805	809	PF00082	0.728
CLV_PCSK_KEX2_1	295	297	PF00082	0.849
CLV_PCSK_KEX2_1	408	410	PF00082	0.674
CLV_PCSK_KEX2_1	462	464	PF00082	0.678
CLV_PCSK_KEX2_1	723	725	PF00082	0.534
CLV_PCSK_KEX2_1	807	809	PF00082	0.674
CLV_PCSK_KEX2_1	930	932	PF00082	0.832
CLV_PCSK_SKI1_1	33	37	PF00082	0.782
CLV_PCSK_SKI1_1	40	44	PF00082	0.672
CLV_PCSK_SKI1_1	648	652	PF00082	0.697
CLV_PCSK_SKI1_1	672	676	PF00082	0.652
CLV_PCSK_SKI1_1	681	685	PF00082	0.497
CLV_PCSK_SKI1_1	772	776	PF00082	0.485
CLV_PCSK_SKI1_1	959	963	PF00082	0.671
DEG_APCC_DBOX_1	742	750	PF00400	0.540
DEG_APCC_DBOX_1	860	868	PF00400	0.684
DEG_ODPH_VHL_1	185	197	PF01847	0.562
DEG_SCF_FBW7_1	936	943	PF00400	0.832
DEG_SPOP_SBC_1	189	193	PF00917	0.793
DEG_SPOP_SBC_1	728	732	PF00917	0.585
DEG_SPOP_SBC_1	903	907	PF00917	0.560
DEG_SPOP_SBC_1	917	921	PF00917	0.529
DOC_CKS1_1	114	119	PF01111	0.711
DOC_CKS1_1	942	947	PF01111	0.820
DOC_CYCLIN_RxL_1	708	716	PF00134	0.353
DOC_CYCLIN_yClb3_PxF_3	764	772	PF00134	0.676
DOC_MAPK_gen_1	1007	1015	PF00069	0.644
DOC_MAPK_gen_1	408	416	PF00069	0.560
DOC_MAPK_gen_1	679	687	PF00069	0.549
DOC_MAPK_gen_1	692	701	PF00069	0.548
DOC_MAPK_gen_1	741	749	PF00069	0.523
DOC_MAPK_gen_1	930	936	PF00069	0.610
DOC_MAPK_gen_1	954	962	PF00069	0.535
DOC_MAPK_MEF2A_6	409	418	PF00069	0.562
DOC_MAPK_MEF2A_6	681	689	PF00069	0.632
DOC_PP1_RVXF_1	19	26	PF00149	0.562
DOC_PP1_RVXF_1	709	716	PF00149	0.354
DOC_PP4_FxxP_1	942	945	PF00568	0.567
DOC_USP7_MATH_1	231	235	PF00917	0.738
DOC_USP7_MATH_1	27	31	PF00917	0.524
DOC_USP7_MATH_1	315	319	PF00917	0.607
DOC_USP7_MATH_1	339	343	PF00917	0.848
DOC_USP7_MATH_1	511	515	PF00917	0.822
DOC_USP7_MATH_1	609	613	PF00917	0.729
DOC_USP7_MATH_1	670	674	PF00917	0.729
DOC_USP7_MATH_1	728	732	PF00917	0.585
DOC_USP7_MATH_1	840	844	PF00917	0.675
DOC_USP7_MATH_1	857	861	PF00917	0.641
DOC_USP7_MATH_1	899	903	PF00917	0.624
DOC_USP7_MATH_1	917	921	PF00917	0.526
DOC_USP7_MATH_1	946	950	PF00917	0.621
DOC_WW_Pin1_4	109	114	PF00397	0.712
DOC_WW_Pin1_4	13	18	PF00397	0.673
DOC_WW_Pin1_4	158	163	PF00397	0.756
DOC_WW_Pin1_4	174	179	PF00397	0.603
DOC_WW_Pin1_4	215	220	PF00397	0.787
DOC_WW_Pin1_4	229	234	PF00397	0.775
DOC_WW_Pin1_4	289	294	PF00397	0.580
DOC_WW_Pin1_4	323	328	PF00397	0.724
DOC_WW_Pin1_4	370	375	PF00397	0.792
DOC_WW_Pin1_4	416	421	PF00397	0.578
DOC_WW_Pin1_4	538	543	PF00397	0.601
DOC_WW_Pin1_4	563	568	PF00397	0.712
DOC_WW_Pin1_4	572	577	PF00397	0.815
DOC_WW_Pin1_4	579	584	PF00397	0.742
DOC_WW_Pin1_4	587	592	PF00397	0.669
DOC_WW_Pin1_4	605	610	PF00397	0.663
DOC_WW_Pin1_4	672	677	PF00397	0.559
DOC_WW_Pin1_4	936	941	PF00397	0.632
DOC_WW_Pin1_4	944	949	PF00397	0.751
LIG_14-3-3_CanoR_1	213	219	PF00244	0.566
LIG_14-3-3_CanoR_1	341	348	PF00244	0.721
LIG_14-3-3_CanoR_1	436	446	PF00244	0.662
LIG_14-3-3_CanoR_1	462	470	PF00244	0.648
LIG_14-3-3_CanoR_1	772	782	PF00244	0.566
LIG_Actin_WH2_1	861	878	PF00022	0.521
LIG_Actin_WH2_2	8	23	PF00022	0.563
LIG_Actin_WH2_2	860	878	PF00022	0.521
LIG_BIR_II_1	1	5	PF00653	0.649
LIG_BRCT_BRCA1_1	729	733	PF00533	0.503
LIG_deltaCOP1_diTrp_1	1010	1015	PF00928	0.629
LIG_deltaCOP1_diTrp_1	641	645	PF00928	0.693
LIG_deltaCOP1_diTrp_1	655	659	PF00928	0.544
LIG_eIF4E_1	396	402	PF01652	0.443
LIG_FHA_1	137	143	PF00498	0.560
LIG_FHA_1	175	181	PF00498	0.562
LIG_FHA_1	198	204	PF00498	0.704
LIG_FHA_1	269	275	PF00498	0.487
LIG_FHA_1	356	362	PF00498	0.548
LIG_FHA_1	409	415	PF00498	0.638
LIG_FHA_1	422	428	PF00498	0.611
LIG_FHA_1	632	638	PF00498	0.523
LIG_FHA_1	779	785	PF00498	0.545
LIG_FHA_1	948	954	PF00498	0.671
LIG_FHA_1	989	995	PF00498	0.508
LIG_FHA_2	159	165	PF00498	0.816
LIG_FHA_2	219	225	PF00498	0.578
LIG_FHA_2	464	470	PF00498	0.656
LIG_FHA_2	560	566	PF00498	0.584
LIG_FHA_2	606	612	PF00498	0.706
LIG_FHA_2	651	657	PF00498	0.614
LIG_FHA_2	750	756	PF00498	0.545
LIG_LIR_Apic_2	112	117	PF02991	0.708
LIG_LIR_Apic_2	379	383	PF02991	0.569
LIG_LIR_Apic_2	675	680	PF02991	0.672
LIG_LIR_Apic_2	939	945	PF02991	0.572
LIG_LIR_Gen_1	732	742	PF02991	0.478
LIG_LIR_Gen_1	883	894	PF02991	0.713
LIG_LIR_Nem_3	1010	1014	PF02991	0.639
LIG_LIR_Nem_3	103	108	PF02991	0.791
LIG_LIR_Nem_3	24	28	PF02991	0.607
LIG_LIR_Nem_3	730	736	PF02991	0.516
LIG_LIR_Nem_3	871	875	PF02991	0.664
LIG_LIR_Nem_3	883	889	PF02991	0.657
LIG_Pex14_1	1011	1015	PF04695	0.502
LIG_Pex14_1	642	646	PF04695	0.617
LIG_SH2_CRK	114	118	PF00017	0.558
LIG_SH2_CRK	279	283	PF00017	0.779
LIG_SH2_CRK	396	400	PF00017	0.660
LIG_SH2_CRK	693	697	PF00017	0.608
LIG_SH2_CRK	794	798	PF00017	0.611
LIG_SH2_NCK_1	114	118	PF00017	0.558
LIG_SH2_NCK_1	249	253	PF00017	0.587
LIG_SH2_STAP1	138	142	PF00017	0.768
LIG_SH2_STAP1	3	7	PF00017	0.718
LIG_SH2_STAP1	971	975	PF00017	0.728
LIG_SH2_STAT3	138	141	PF00017	0.563
LIG_SH2_STAT3	62	65	PF00017	0.769
LIG_SH2_STAT3	644	647	PF00017	0.620
LIG_SH2_STAT5	138	141	PF00017	0.563
LIG_SH2_STAT5	433	436	PF00017	0.669
LIG_SH2_STAT5	62	65	PF00017	0.516
LIG_SH2_STAT5	874	877	PF00017	0.670
LIG_SH3_1	580	586	PF00018	0.602
LIG_SH3_1	761	767	PF00018	0.686
LIG_SH3_3	107	113	PF00018	0.654
LIG_SH3_3	32	38	PF00018	0.737
LIG_SH3_3	321	327	PF00018	0.785
LIG_SH3_3	368	374	PF00018	0.815
LIG_SH3_3	573	579	PF00018	0.761
LIG_SH3_3	580	586	PF00018	0.827
LIG_SH3_3	588	594	PF00018	0.695
LIG_SH3_3	634	640	PF00018	0.587
LIG_SH3_3	761	767	PF00018	0.584
LIG_SH3_3	828	834	PF00018	0.525
LIG_SH3_3	87	93	PF00018	0.795
LIG_SH3_3	929	935	PF00018	0.657
LIG_SH3_3	942	948	PF00018	0.728
LIG_SUMO_SIM_par_1	829	835	PF11976	0.527
LIG_TRAF2_1	466	469	PF00917	0.812
LIG_TRAF2_1	543	546	PF00917	0.602
LIG_TRFH_1	13	17	PF08558	0.670
LIG_UBA3_1	1013	1020	PF00899	0.624
LIG_WW_3	292	296	PF00397	0.723
MOD_CDC14_SPxK_1	292	295	PF00782	0.584
MOD_CDK_SPK_2	575	580	PF00069	0.596
MOD_CDK_SPxK_1	289	295	PF00069	0.584
MOD_CDK_SPxxK_3	289	296	PF00069	0.586
MOD_CDK_SPxxK_3	672	679	PF00069	0.611
MOD_CK1_1	100	106	PF00069	0.671
MOD_CK1_1	1002	1008	PF00069	0.767
MOD_CK1_1	109	115	PF00069	0.750
MOD_CK1_1	188	194	PF00069	0.814
MOD_CK1_1	2	8	PF00069	0.613
MOD_CK1_1	232	238	PF00069	0.801
MOD_CK1_1	247	253	PF00069	0.461
MOD_CK1_1	373	379	PF00069	0.771
MOD_CK1_1	472	478	PF00069	0.822
MOD_CK1_1	49	55	PF00069	0.691
MOD_CK1_1	494	500	PF00069	0.558
MOD_CK1_1	514	520	PF00069	0.609
MOD_CK1_1	541	547	PF00069	0.714
MOD_CK1_1	563	569	PF00069	0.654
MOD_CK1_1	575	581	PF00069	0.821
MOD_CK1_1	592	598	PF00069	0.640
MOD_CK1_1	843	849	PF00069	0.718
MOD_CK1_1	880	886	PF00069	0.645
MOD_CK1_1	902	908	PF00069	0.616
MOD_CK2_1	130	136	PF00069	0.551
MOD_CK2_1	158	164	PF00069	0.821
MOD_CK2_1	339	345	PF00069	0.742
MOD_CK2_1	356	362	PF00069	0.775
MOD_CK2_1	463	469	PF00069	0.677
MOD_CK2_1	559	565	PF00069	0.586
MOD_CK2_1	575	581	PF00069	0.528
MOD_CK2_1	609	615	PF00069	0.594
MOD_CK2_1	650	656	PF00069	0.614
MOD_CK2_1	856	862	PF00069	0.715
MOD_CMANNOS	642	645	PF00535	0.717
MOD_Cter_Amidation	460	463	PF01082	0.651
MOD_DYRK1A_RPxSP_1	672	676	PF00069	0.720
MOD_GlcNHglycan	120	123	PF01048	0.678
MOD_GlcNHglycan	187	190	PF01048	0.749
MOD_GlcNHglycan	192	195	PF01048	0.707
MOD_GlcNHglycan	209	212	PF01048	0.612
MOD_GlcNHglycan	224	227	PF01048	0.826
MOD_GlcNHglycan	249	252	PF01048	0.516
MOD_GlcNHglycan	330	333	PF01048	0.757
MOD_GlcNHglycan	348	351	PF01048	0.689
MOD_GlcNHglycan	358	361	PF01048	0.650
MOD_GlcNHglycan	471	474	PF01048	0.818
MOD_GlcNHglycan	478	481	PF01048	0.706
MOD_GlcNHglycan	516	519	PF01048	0.608
MOD_GlcNHglycan	562	565	PF01048	0.643
MOD_GlcNHglycan	568	571	PF01048	0.607
MOD_GlcNHglycan	594	597	PF01048	0.848
MOD_GlcNHglycan	615	619	PF01048	0.826
MOD_GlcNHglycan	672	675	PF01048	0.597
MOD_GlcNHglycan	705	708	PF01048	0.499
MOD_GlcNHglycan	715	718	PF01048	0.487
MOD_GlcNHglycan	77	80	PF01048	0.709
MOD_GlcNHglycan	775	778	PF01048	0.567
MOD_GlcNHglycan	86	89	PF01048	0.599
MOD_GlcNHglycan	883	886	PF01048	0.671
MOD_GlcNHglycan	901	904	PF01048	0.632
MOD_GlcNHglycan	909	912	PF01048	0.738
MOD_GlcNHglycan	936	939	PF01048	0.833
MOD_GlcNHglycan	99	102	PF01048	0.770
MOD_GSK3_1	100	107	PF00069	0.708
MOD_GSK3_1	109	116	PF00069	0.699
MOD_GSK3_1	132	139	PF00069	0.549
MOD_GSK3_1	154	161	PF00069	0.751
MOD_GSK3_1	181	188	PF00069	0.669
MOD_GSK3_1	203	210	PF00069	0.751
MOD_GSK3_1	211	218	PF00069	0.819
MOD_GSK3_1	229	236	PF00069	0.728
MOD_GSK3_1	268	275	PF00069	0.481
MOD_GSK3_1	27	34	PF00069	0.558
MOD_GSK3_1	310	317	PF00069	0.707
MOD_GSK3_1	330	337	PF00069	0.580
MOD_GSK3_1	351	358	PF00069	0.688
MOD_GSK3_1	366	373	PF00069	0.784
MOD_GSK3_1	46	53	PF00069	0.786
MOD_GSK3_1	469	476	PF00069	0.726
MOD_GSK3_1	537	544	PF00069	0.747
MOD_GSK3_1	54	61	PF00069	0.670
MOD_GSK3_1	559	566	PF00069	0.770
MOD_GSK3_1	571	578	PF00069	0.648
MOD_GSK3_1	598	605	PF00069	0.777
MOD_GSK3_1	668	675	PF00069	0.475
MOD_GSK3_1	723	730	PF00069	0.500
MOD_GSK3_1	745	752	PF00069	0.559
MOD_GSK3_1	77	84	PF00069	0.755
MOD_GSK3_1	773	780	PF00069	0.537
MOD_GSK3_1	799	806	PF00069	0.619
MOD_GSK3_1	840	847	PF00069	0.689
MOD_GSK3_1	877	884	PF00069	0.660
MOD_GSK3_1	899	906	PF00069	0.815
MOD_GSK3_1	936	943	PF00069	0.807
MOD_GSK3_1	994	1001	PF00069	0.638
MOD_N-GLC_1	335	340	PF02516	0.729
MOD_N-GLC_1	631	636	PF02516	0.573
MOD_N-GLC_1	777	782	PF02516	0.584
MOD_N-GLC_1	917	922	PF02516	0.583
MOD_N-GLC_1	994	999	PF02516	0.627
MOD_N-GLC_2	283	285	PF02516	0.560
MOD_NEK2_1	181	186	PF00069	0.812
MOD_NEK2_1	203	208	PF00069	0.545
MOD_NEK2_1	713	718	PF00069	0.478
MOD_NEK2_1	736	741	PF00069	0.539
MOD_NEK2_1	749	754	PF00069	0.563
MOD_NEK2_1	773	778	PF00069	0.662
MOD_NEK2_1	875	880	PF00069	0.679
MOD_NEK2_1	988	993	PF00069	0.624
MOD_NEK2_2	257	262	PF00069	0.578
MOD_NEK2_2	885	890	PF00069	0.760
MOD_NEK2_2	965	970	PF00069	0.643
MOD_PIKK_1	315	321	PF00454	0.591
MOD_PIKK_1	384	390	PF00454	0.753
MOD_PIKK_1	494	500	PF00454	0.766
MOD_PKA_1	408	414	PF00069	0.563
MOD_PKA_1	723	729	PF00069	0.505
MOD_PKA_2	294	300	PF00069	0.842
MOD_PKA_2	340	346	PF00069	0.806
MOD_PKA_2	408	414	PF00069	0.664
MOD_PKA_2	461	467	PF00069	0.668
MOD_PKA_2	598	604	PF00069	0.688
MOD_PKA_2	723	729	PF00069	0.571
MOD_PKA_2	799	805	PF00069	0.706
MOD_Plk_1	366	372	PF00069	0.570
MOD_Plk_1	440	446	PF00069	0.551
MOD_Plk_1	736	742	PF00069	0.489
MOD_Plk_1	843	849	PF00069	0.816
MOD_Plk_1	994	1000	PF00069	0.634
MOD_Plk_4	218	224	PF00069	0.580
MOD_Plk_4	237	243	PF00069	0.685
MOD_Plk_4	257	263	PF00069	0.493
MOD_Plk_4	351	357	PF00069	0.561
MOD_Plk_4	376	382	PF00069	0.572
MOD_Plk_4	440	446	PF00069	0.551
MOD_Plk_4	58	64	PF00069	0.664
MOD_Plk_4	92	98	PF00069	0.662
MOD_ProDKin_1	109	115	PF00069	0.712
MOD_ProDKin_1	13	19	PF00069	0.669
MOD_ProDKin_1	158	164	PF00069	0.756
MOD_ProDKin_1	174	180	PF00069	0.604
MOD_ProDKin_1	215	221	PF00069	0.789
MOD_ProDKin_1	229	235	PF00069	0.774
MOD_ProDKin_1	289	295	PF00069	0.584
MOD_ProDKin_1	323	329	PF00069	0.725
MOD_ProDKin_1	370	376	PF00069	0.794
MOD_ProDKin_1	416	422	PF00069	0.588
MOD_ProDKin_1	538	544	PF00069	0.600
MOD_ProDKin_1	563	569	PF00069	0.715
MOD_ProDKin_1	572	578	PF00069	0.818
MOD_ProDKin_1	579	585	PF00069	0.738
MOD_ProDKin_1	587	593	PF00069	0.670
MOD_ProDKin_1	605	611	PF00069	0.662
MOD_ProDKin_1	672	678	PF00069	0.557
MOD_ProDKin_1	936	942	PF00069	0.632
MOD_ProDKin_1	944	950	PF00069	0.751
MOD_SUMO_for_1	300	303	PF00179	0.823
TRG_ENDOCYTIC_2	279	282	PF00928	0.771
TRG_ENDOCYTIC_2	396	399	PF00928	0.668
TRG_ENDOCYTIC_2	794	797	PF00928	0.609
TRG_ER_diArg_1	294	296	PF00400	0.850
TRG_ER_diArg_1	408	410	PF00400	0.674
TRG_ER_diArg_1	462	465	PF00400	0.786
TRG_ER_diArg_1	597	600	PF00400	0.613
TRG_ER_diArg_1	722	724	PF00400	0.552
TRG_ER_diArg_1	740	743	PF00400	0.497
TRG_ER_diArg_1	804	807	PF00400	0.640
TRG_ER_diArg_1	929	931	PF00400	0.835
TRG_NLS_MonoCore_2	693	698	PF00514	0.595
TRG_NLS_MonoExtN_4	692	698	PF00514	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G9	Leptomonas seymouri	40%	100%
A0A3Q8IAI0	Leishmania donovani	71%	100%
A4HX27	Leishmania infantum	71%	100%
E9AQU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QEN7	Leishmania major	70%	97%