Diacylglycerol kinase (ATP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

diacylglycerol kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H8Q7_LEIBR

TriTrypDb:

LbrM.16.1340 , LBRM2903_160021000

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8Q7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Q7

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0007165	signal transduction	2	11
GO:0007186	G protein-coupled receptor signaling pathway	3	11
GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	4	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0044237	cellular metabolic process	2	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0065007	biological regulation	1	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004143	diacylglycerol kinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	322	326	PF00656	0.465
CLV_C14_Caspase3-7	501	505	PF00656	0.292
CLV_NRD_NRD_1	140	142	PF00675	0.217
CLV_NRD_NRD_1	164	166	PF00675	0.355
CLV_NRD_NRD_1	366	368	PF00675	0.309
CLV_NRD_NRD_1	37	39	PF00675	0.567
CLV_NRD_NRD_1	602	604	PF00675	0.381
CLV_PCSK_FUR_1	138	142	PF00082	0.197
CLV_PCSK_KEX2_1	103	105	PF00082	0.432
CLV_PCSK_KEX2_1	140	142	PF00082	0.217
CLV_PCSK_KEX2_1	164	166	PF00082	0.355
CLV_PCSK_KEX2_1	366	368	PF00082	0.338
CLV_PCSK_KEX2_1	37	39	PF00082	0.567
CLV_PCSK_KEX2_1	602	604	PF00082	0.381
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.410
CLV_PCSK_SKI1_1	389	393	PF00082	0.260
CLV_PCSK_SKI1_1	467	471	PF00082	0.355
CLV_PCSK_SKI1_1	498	502	PF00082	0.292
CLV_PCSK_SKI1_1	97	101	PF00082	0.277
DEG_APCC_DBOX_1	407	415	PF00400	0.348
DEG_COP1_1	13	24	PF00400	0.619
DEG_Kelch_Keap1_1	80	85	PF01344	0.292
DEG_SPOP_SBC_1	190	194	PF00917	0.300
DEG_SPOP_SBC_1	480	484	PF00917	0.197
DOC_CKS1_1	25	30	PF01111	0.510
DOC_CKS1_1	494	499	PF01111	0.348
DOC_CKS1_1	542	547	PF01111	0.537
DOC_CYCLIN_RxL_1	437	445	PF00134	0.355
DOC_MAPK_DCC_7	272	282	PF00069	0.456
DOC_MAPK_DCC_7	396	406	PF00069	0.366
DOC_MAPK_MEF2A_6	428	435	PF00069	0.410
DOC_MAPK_MEF2A_6	578	585	PF00069	0.456
DOC_PP2B_LxvP_1	433	436	PF13499	0.410
DOC_PP2B_LxvP_1	492	495	PF13499	0.297
DOC_PP4_FxxP_1	113	116	PF00568	0.279
DOC_PP4_FxxP_1	205	208	PF00568	0.357
DOC_USP7_MATH_1	266	270	PF00917	0.430
DOC_USP7_MATH_1	371	375	PF00917	0.318
DOC_USP7_UBL2_3	560	564	PF12436	0.694
DOC_WW_Pin1_4	129	134	PF00397	0.282
DOC_WW_Pin1_4	229	234	PF00397	0.413
DOC_WW_Pin1_4	24	29	PF00397	0.574
DOC_WW_Pin1_4	308	313	PF00397	0.646
DOC_WW_Pin1_4	49	54	PF00397	0.562
DOC_WW_Pin1_4	493	498	PF00397	0.324
DOC_WW_Pin1_4	541	546	PF00397	0.457
DOC_WW_Pin1_4	612	617	PF00397	0.495
LIG_14-3-3_CanoR_1	319	324	PF00244	0.335
LIG_14-3-3_CanoR_1	423	431	PF00244	0.197
LIG_14-3-3_CanoR_1	578	582	PF00244	0.516
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_BRCT_BRCA1_1	350	354	PF00533	0.215
LIG_FHA_1	191	197	PF00498	0.433
LIG_FHA_1	341	347	PF00498	0.489
LIG_FHA_1	437	443	PF00498	0.216
LIG_FHA_1	489	495	PF00498	0.292
LIG_FHA_1	527	533	PF00498	0.419
LIG_FHA_2	156	162	PF00498	0.486
LIG_FHA_2	215	221	PF00498	0.279
LIG_FHA_2	499	505	PF00498	0.197
LIG_FHA_2	542	548	PF00498	0.519
LIG_LIR_Apic_2	111	116	PF02991	0.322
LIG_LIR_Apic_2	463	468	PF02991	0.292
LIG_LIR_Gen_1	331	337	PF02991	0.381
LIG_LIR_Gen_1	427	438	PF02991	0.417
LIG_LIR_Gen_1	535	545	PF02991	0.393
LIG_LIR_Gen_1	556	563	PF02991	0.557
LIG_LIR_Gen_1	69	79	PF02991	0.415
LIG_LIR_Nem_3	168	174	PF02991	0.373
LIG_LIR_Nem_3	331	335	PF02991	0.369
LIG_LIR_Nem_3	351	357	PF02991	0.150
LIG_LIR_Nem_3	427	433	PF02991	0.417
LIG_LIR_Nem_3	463	469	PF02991	0.292
LIG_LIR_Nem_3	535	541	PF02991	0.327
LIG_LIR_Nem_3	556	561	PF02991	0.562
LIG_LIR_Nem_3	58	63	PF02991	0.489
LIG_MAD2	608	616	PF02301	0.277
LIG_MYND_1	208	212	PF01753	0.410
LIG_PAM2_1	229	241	PF00658	0.372
LIG_PCNA_yPIPBox_3	376	386	PF02747	0.405
LIG_Pex14_2	227	231	PF04695	0.485
LIG_SH2_CRK	130	134	PF00017	0.288
LIG_SH2_CRK	466	470	PF00017	0.410
LIG_SH2_CRK	518	522	PF00017	0.410
LIG_SH2_CRK	558	562	PF00017	0.624
LIG_SH2_GRB2like	221	224	PF00017	0.322
LIG_SH2_STAP1	221	225	PF00017	0.322
LIG_SH2_STAP1	558	562	PF00017	0.661
LIG_SH2_STAP1	567	571	PF00017	0.571
LIG_SH2_STAP1	64	68	PF00017	0.413
LIG_SH2_STAT5	204	207	PF00017	0.410
LIG_SH2_STAT5	349	352	PF00017	0.286
LIG_SH2_STAT5	357	360	PF00017	0.409
LIG_SH2_STAT5	518	521	PF00017	0.482
LIG_SH2_STAT5	558	561	PF00017	0.621
LIG_SH3_3	19	25	PF00018	0.703
LIG_SH3_3	401	407	PF00018	0.373
LIG_SH3_3	43	49	PF00018	0.624
LIG_SH3_3	453	459	PF00018	0.412
LIG_SH3_CIN85_PxpxPR_1	493	498	PF14604	0.383
LIG_SUMO_SIM_anti_2	158	164	PF11976	0.402
LIG_SUMO_SIM_par_1	498	504	PF11976	0.410
LIG_TRAF2_2	53	58	PF00917	0.439
LIG_TYR_ITIM	347	352	PF00017	0.297
LIG_TYR_ITIM	464	469	PF00017	0.410
LIG_TYR_ITIM	516	521	PF00017	0.410
MOD_CDC14_SPxK_1	132	135	PF00782	0.197
MOD_CDK_SPK_2	133	138	PF00069	0.197
MOD_CDK_SPK_2	493	498	PF00069	0.282
MOD_CDK_SPxK_1	129	135	PF00069	0.282
MOD_CDK_SPxxK_3	133	140	PF00069	0.197
MOD_CDK_SPxxK_3	229	236	PF00069	0.336
MOD_CK1_1	186	192	PF00069	0.461
MOD_CK1_1	289	295	PF00069	0.621
MOD_CK1_1	422	428	PF00069	0.303
MOD_CK1_1	451	457	PF00069	0.386
MOD_CK1_1	479	485	PF00069	0.228
MOD_CK1_1	526	532	PF00069	0.463
MOD_CK1_1	556	562	PF00069	0.579
MOD_CK1_1	83	89	PF00069	0.357
MOD_CK2_1	566	572	PF00069	0.590
MOD_CK2_1	63	69	PF00069	0.521
MOD_GlcNHglycan	247	250	PF01048	0.597
MOD_GlcNHglycan	304	307	PF01048	0.617
MOD_GlcNHglycan	316	319	PF01048	0.645
MOD_GlcNHglycan	337	340	PF01048	0.513
MOD_GlcNHglycan	363	366	PF01048	0.197
MOD_GlcNHglycan	43	46	PF01048	0.661
MOD_GlcNHglycan	450	453	PF01048	0.397
MOD_GlcNHglycan	460	463	PF01048	0.306
MOD_GlcNHglycan	484	487	PF01048	0.355
MOD_GlcNHglycan	551	554	PF01048	0.613
MOD_GlcNHglycan	82	85	PF01048	0.284
MOD_GSK3_1	10	17	PF00069	0.719
MOD_GSK3_1	111	118	PF00069	0.197
MOD_GSK3_1	129	136	PF00069	0.276
MOD_GSK3_1	151	158	PF00069	0.342
MOD_GSK3_1	186	193	PF00069	0.439
MOD_GSK3_1	20	27	PF00069	0.587
MOD_GSK3_1	418	425	PF00069	0.234
MOD_GSK3_1	476	483	PF00069	0.363
MOD_GSK3_1	549	556	PF00069	0.546
MOD_GSK3_1	566	573	PF00069	0.593
MOD_GSK3_1	63	70	PF00069	0.339
MOD_N-GLC_1	314	319	PF02516	0.393
MOD_N-GLC_1	526	531	PF02516	0.228
MOD_NEK2_1	1	6	PF00069	0.639
MOD_NEK2_1	155	160	PF00069	0.329
MOD_NEK2_1	174	179	PF00069	0.287
MOD_NEK2_1	191	196	PF00069	0.355
MOD_NEK2_1	288	293	PF00069	0.577
MOD_NEK2_1	442	447	PF00069	0.313
MOD_NEK2_1	516	521	PF00069	0.414
MOD_NEK2_1	525	530	PF00069	0.410
MOD_NEK2_2	197	202	PF00069	0.216
MOD_PIKK_1	155	161	PF00454	0.347
MOD_PIKK_1	175	181	PF00454	0.173
MOD_PIKK_1	289	295	PF00454	0.577
MOD_PK_1	319	325	PF00069	0.334
MOD_PK_1	614	620	PF00069	0.529
MOD_PKA_1	140	146	PF00069	0.239
MOD_PKA_2	10	16	PF00069	0.656
MOD_PKA_2	140	146	PF00069	0.279
MOD_PKA_2	422	428	PF00069	0.265
MOD_PKA_2	476	482	PF00069	0.270
MOD_PKA_2	577	583	PF00069	0.519
MOD_PKB_1	138	146	PF00069	0.197
MOD_PKB_1	612	620	PF00069	0.514
MOD_Plk_1	186	192	PF00069	0.355
MOD_Plk_1	197	203	PF00069	0.211
MOD_Plk_1	273	279	PF00069	0.447
MOD_Plk_1	594	600	PF00069	0.464
MOD_Plk_1	68	74	PF00069	0.485
MOD_Plk_2-3	14	20	PF00069	0.588
MOD_Plk_4	1	7	PF00069	0.719
MOD_Plk_4	140	146	PF00069	0.302
MOD_Plk_4	151	157	PF00069	0.346
MOD_Plk_4	186	192	PF00069	0.197
MOD_Plk_4	273	279	PF00069	0.442
MOD_Plk_4	594	600	PF00069	0.458
MOD_Plk_4	614	620	PF00069	0.529
MOD_ProDKin_1	129	135	PF00069	0.282
MOD_ProDKin_1	229	235	PF00069	0.422
MOD_ProDKin_1	24	30	PF00069	0.571
MOD_ProDKin_1	308	314	PF00069	0.631
MOD_ProDKin_1	49	55	PF00069	0.560
MOD_ProDKin_1	493	499	PF00069	0.324
MOD_ProDKin_1	541	547	PF00069	0.461
MOD_ProDKin_1	612	618	PF00069	0.491
TRG_DiLeu_BaEn_2	169	175	PF01217	0.402
TRG_DiLeu_BaEn_2	535	541	PF01217	0.322
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.362
TRG_ENDOCYTIC_2	204	207	PF00928	0.410
TRG_ENDOCYTIC_2	349	352	PF00928	0.280
TRG_ENDOCYTIC_2	383	386	PF00928	0.322
TRG_ENDOCYTIC_2	466	469	PF00928	0.410
TRG_ENDOCYTIC_2	518	521	PF00928	0.410
TRG_ENDOCYTIC_2	558	561	PF00928	0.624
TRG_ENDOCYTIC_2	72	75	PF00928	0.426
TRG_ER_diArg_1	137	140	PF00400	0.197
TRG_ER_diArg_1	163	165	PF00400	0.355
TRG_ER_diArg_1	37	39	PF00400	0.571
TRG_ER_diArg_1	601	603	PF00400	0.320
TRG_ER_diArg_1	611	614	PF00400	0.377
TRG_Pf-PMV_PEXEL_1	120	125	PF00026	0.281
TRG_Pf-PMV_PEXEL_1	165	170	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRI7	Leptomonas seymouri	52%	83%
A0A0S4JFM6	Bodo saltans	26%	79%
A0A3Q8IAN3	Leishmania donovani	72%	85%
A0A3R7MJ80	Trypanosoma rangeli	33%	94%
A4HX26	Leishmania infantum	72%	85%
C9ZVX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AQU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	85%
Q4QEN8	Leishmania major	70%	100%
V5DJ39	Trypanosoma cruzi	31%	94%