LeishMANIAdb
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Sm domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Sm domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H8Q3_LEIBR
TriTrypDb:
LbrM.16.1300 , LBRM2903_160020500 *
Length:
148

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 1
GO:1990904 ribonucleoprotein complex 2 1

Expansion

Sequence features

A4H8Q3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8Q3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 126 130 PF00656 0.521
CLV_NRD_NRD_1 57 59 PF00675 0.504
CLV_NRD_NRD_1 91 93 PF00675 0.593
CLV_PCSK_KEX2_1 57 59 PF00082 0.508
DOC_CYCLIN_RxL_1 114 126 PF00134 0.482
DOC_MAPK_gen_1 92 100 PF00069 0.566
DOC_PP1_RVXF_1 117 124 PF00149 0.422
DOC_USP7_MATH_1 76 80 PF00917 0.694
DOC_WW_Pin1_4 69 74 PF00397 0.676
DOC_WW_Pin1_4 98 103 PF00397 0.311
LIG_BIR_II_1 1 5 PF00653 0.618
LIG_Clathr_ClatBox_1 21 25 PF01394 0.367
LIG_Clathr_ClatBox_1 36 40 PF01394 0.386
LIG_FHA_1 28 34 PF00498 0.358
LIG_FHA_1 41 47 PF00498 0.378
LIG_LIR_Gen_1 132 141 PF02991 0.569
LIG_LIR_Nem_3 132 137 PF02991 0.525
LIG_LIR_Nem_3 52 56 PF02991 0.280
LIG_SH2_SRC 134 137 PF00017 0.312
LIG_SH2_STAP1 134 138 PF00017 0.314
LIG_SH2_STAT5 120 123 PF00017 0.502
LIG_SH3_2 73 78 PF14604 0.485
LIG_SH3_3 70 76 PF00018 0.491
LIG_TYR_ITSM 130 137 PF00017 0.543
MOD_CK1_1 4 10 PF00069 0.528
MOD_CK1_1 79 85 PF00069 0.679
MOD_CK2_1 130 136 PF00069 0.563
MOD_GlcNHglycan 81 84 PF01048 0.633
MOD_N-GLC_1 27 32 PF02516 0.466
MOD_N-GLC_1 79 84 PF02516 0.625
MOD_NEK2_1 1 6 PF00069 0.623
MOD_Plk_4 107 113 PF00069 0.395
MOD_Plk_4 27 33 PF00069 0.399
MOD_ProDKin_1 69 75 PF00069 0.674
MOD_ProDKin_1 98 104 PF00069 0.316
TRG_DiLeu_BaLyEn_6 32 37 PF01217 0.456
TRG_ENDOCYTIC_2 120 123 PF00928 0.414
TRG_ENDOCYTIC_2 134 137 PF00928 0.345
TRG_ER_diArg_1 56 58 PF00400 0.476
TRG_Pf-PMV_PEXEL_1 35 40 PF00026 0.423

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I4W6 Leptomonas seymouri 60% 100%
A0A0S4IMH1 Bodo saltans 29% 92%
A0A1X0NYY2 Trypanosomatidae 44% 95%
A0A3R7LUA9 Trypanosoma rangeli 44% 100%
A0A3S7WU38 Leishmania donovani 79% 100%
A4HX22 Leishmania infantum 79% 100%
C9ZVX7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9AQT6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 99%
Q4QEP2 Leishmania major 79% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS