Putative cyclophilin 13

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclophilin 13, putative

Species:

Leishmania braziliensis

UniProt:

A4H8P7_LEIBR

TriTrypDb:

LbrM.16.1240 , LBRM2903_160020000

Length:

349

Annotations

LeishMANIAdb annotations

A large collection of conserved eukaryotic peptidyl-prolyl cis-trans isomerases. Some members of this group are secreted (into the ER).. Localization: Cytoplasmic (by homology) / ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 25
NetGPI	no	yes: 0, no: 25

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	4
GO:0110165	cellular anatomical entity	1	4
GO:0005930	axoneme	2	2
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H8P7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8P7

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	26
GO:0006807	nitrogen compound metabolic process	2	26
GO:0008152	metabolic process	1	26
GO:0018193	peptidyl-amino acid modification	5	26
GO:0018208	peptidyl-proline modification	6	26
GO:0019538	protein metabolic process	3	26
GO:0036211	protein modification process	4	26
GO:0043170	macromolecule metabolic process	3	26
GO:0043412	macromolecule modification	4	26
GO:0044238	primary metabolic process	2	26
GO:0071704	organic substance metabolic process	2	26
GO:1901564	organonitrogen compound metabolic process	3	26
GO:0006457	protein folding	2	9
GO:0009987	cellular process	1	9

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	26
GO:0003824	catalytic activity	1	26
GO:0016853	isomerase activity	2	26
GO:0016859	cis-trans isomerase activity	3	26
GO:0140096	catalytic activity, acting on a protein	2	26
GO:0005488	binding	1	4
GO:0016018	cyclosporin A binding	4	4
GO:0033218	amide binding	2	4
GO:0042277	peptide binding	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.238
CLV_NRD_NRD_1	297	299	PF00675	0.528
CLV_NRD_NRD_1	97	99	PF00675	0.314
CLV_PCSK_KEX2_1	166	168	PF00082	0.240
CLV_PCSK_KEX2_1	297	299	PF00082	0.530
CLV_PCSK_KEX2_1	329	331	PF00082	0.500
CLV_PCSK_KEX2_1	97	99	PF00082	0.394
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.234
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.498
CLV_PCSK_SKI1_1	282	286	PF00082	0.563
CLV_PCSK_SKI1_1	340	344	PF00082	0.728
DEG_Nend_UBRbox_3	1	3	PF02207	0.549
DEG_SPOP_SBC_1	252	256	PF00917	0.523
DOC_CDC14_PxL_1	46	54	PF14671	0.422
DOC_MAPK_gen_1	165	174	PF00069	0.263
DOC_PP2B_LxvP_1	221	224	PF13499	0.359
DOC_USP7_MATH_1	252	256	PF00917	0.497
DOC_USP7_MATH_1	258	262	PF00917	0.464
DOC_USP7_MATH_1	313	317	PF00917	0.655
DOC_USP7_MATH_1	322	326	PF00917	0.765
DOC_USP7_MATH_2	72	78	PF00917	0.347
DOC_USP7_UBL2_3	324	328	PF12436	0.656
DOC_WW_Pin1_4	11	16	PF00397	0.546
DOC_WW_Pin1_4	115	120	PF00397	0.301
DOC_WW_Pin1_4	273	278	PF00397	0.700
DOC_WW_Pin1_4	315	320	PF00397	0.576
LIG_14-3-3_CanoR_1	282	287	PF00244	0.780
LIG_14-3-3_CanoR_1	297	301	PF00244	0.520
LIG_14-3-3_CanoR_1	30	40	PF00244	0.332
LIG_APCC_ABBA_1	222	227	PF00400	0.196
LIG_APCC_ABBA_1	82	87	PF00400	0.331
LIG_BRCT_BRCA1_1	186	190	PF00533	0.312
LIG_FHA_1	139	145	PF00498	0.270
LIG_FHA_1	156	162	PF00498	0.389
LIG_FHA_2	283	289	PF00498	0.518
LIG_GBD_Chelix_1	211	219	PF00786	0.196
LIG_Integrin_isoDGR_2	202	204	PF01839	0.238
LIG_LIR_Gen_1	124	133	PF02991	0.288
LIG_LIR_Gen_1	216	225	PF02991	0.350
LIG_LIR_Gen_1	233	239	PF02991	0.189
LIG_LIR_Gen_1	34	43	PF02991	0.289
LIG_LIR_Nem_3	124	129	PF02991	0.305
LIG_LIR_Nem_3	216	221	PF02991	0.361
LIG_LIR_Nem_3	233	238	PF02991	0.189
LIG_LIR_Nem_3	34	40	PF02991	0.290
LIG_MLH1_MIPbox_1	186	190	PF16413	0.304
LIG_PDZ_Class_2	344	349	PF00595	0.500
LIG_SH2_CRK	114	118	PF00017	0.232
LIG_SH2_CRK	235	239	PF00017	0.239
LIG_SH2_NCK_1	152	156	PF00017	0.359
LIG_SH2_STAP1	235	239	PF00017	0.239
LIG_SH2_STAP1	24	28	PF00017	0.577
LIG_SH2_STAT3	112	115	PF00017	0.238
LIG_SH2_STAT3	133	136	PF00017	0.395
LIG_SH2_STAT5	112	115	PF00017	0.256
LIG_SH2_STAT5	121	124	PF00017	0.363
LIG_SH2_STAT5	125	128	PF00017	0.277
LIG_SH2_STAT5	133	136	PF00017	0.291
LIG_SH3_1	298	304	PF00018	0.501
LIG_SH3_3	298	304	PF00018	0.663
LIG_SH3_3	44	50	PF00018	0.375
LIG_TRAF2_1	72	75	PF00917	0.536
MOD_CK1_1	151	157	PF00069	0.359
MOD_CK1_1	17	23	PF00069	0.491
MOD_CK1_1	184	190	PF00069	0.238
MOD_CK1_1	251	257	PF00069	0.690
MOD_CK1_1	26	32	PF00069	0.508
MOD_CK1_1	261	267	PF00069	0.549
MOD_CK1_1	296	302	PF00069	0.510
MOD_CK1_1	315	321	PF00069	0.596
MOD_CK1_1	331	337	PF00069	0.529
MOD_CK1_1	5	11	PF00069	0.518
MOD_CK2_1	265	271	PF00069	0.513
MOD_CK2_1	282	288	PF00069	0.663
MOD_GlcNHglycan	153	156	PF01048	0.402
MOD_GlcNHglycan	16	19	PF01048	0.470
MOD_GlcNHglycan	193	196	PF01048	0.289
MOD_GlcNHglycan	250	253	PF01048	0.481
MOD_GlcNHglycan	255	258	PF01048	0.469
MOD_GlcNHglycan	267	270	PF01048	0.465
MOD_GlcNHglycan	282	285	PF01048	0.686
MOD_GlcNHglycan	52	55	PF01048	0.401
MOD_GSK3_1	117	124	PF00069	0.313
MOD_GSK3_1	146	153	PF00069	0.388
MOD_GSK3_1	248	255	PF00069	0.507
MOD_GSK3_1	261	268	PF00069	0.513
MOD_GSK3_1	278	285	PF00069	0.737
MOD_GSK3_1	328	335	PF00069	0.686
MOD_GSK3_1	48	55	PF00069	0.440
MOD_GSK3_1	5	12	PF00069	0.478
MOD_N-GLC_1	184	189	PF02516	0.326
MOD_NEK2_1	189	194	PF00069	0.315
MOD_NEK2_1	265	270	PF00069	0.539
MOD_NEK2_1	323	328	PF00069	0.655
MOD_NEK2_1	52	57	PF00069	0.485
MOD_NEK2_1	63	68	PF00069	0.510
MOD_NEK2_1	9	14	PF00069	0.488
MOD_NEK2_2	138	143	PF00069	0.274
MOD_PIKK_1	184	190	PF00454	0.304
MOD_PIKK_1	258	264	PF00454	0.460
MOD_PIKK_1	41	47	PF00454	0.317
MOD_PIKK_1	52	58	PF00454	0.584
MOD_PKA_1	328	334	PF00069	0.501
MOD_PKA_2	248	254	PF00069	0.670
MOD_PKA_2	296	302	PF00069	0.510
MOD_PKA_2	329	335	PF00069	0.545
MOD_Plk_1	138	144	PF00069	0.241
MOD_Plk_1	73	79	PF00069	0.541
MOD_Plk_4	121	127	PF00069	0.261
MOD_ProDKin_1	11	17	PF00069	0.546
MOD_ProDKin_1	115	121	PF00069	0.301
MOD_ProDKin_1	273	279	PF00069	0.702
MOD_ProDKin_1	315	321	PF00069	0.577
TRG_ENDOCYTIC_2	114	117	PF00928	0.258
TRG_ENDOCYTIC_2	235	238	PF00928	0.323
TRG_ER_diArg_1	96	98	PF00400	0.379
TRG_NLS_MonoCore_2	164	169	PF00514	0.232
TRG_NLS_MonoExtC_3	165	171	PF00514	0.347
TRG_NLS_MonoExtN_4	165	170	PF00514	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJB8	Leptomonas seymouri	62%	96%
A0A0S4KGS8	Bodo saltans	41%	100%
A0A1X0P0F8	Trypanosomatidae	64%	100%
A0A3Q8IDR1	Leishmania donovani	87%	100%
A0A3Q8IIG9	Leishmania donovani	33%	99%
A0A3R7MER6	Trypanosoma rangeli	62%	100%
A0A3S7WXF4	Leishmania donovani	33%	100%
A0A3S7X325	Leishmania donovani	30%	100%
A0A3S7XB52	Leishmania donovani	34%	100%
A4HHU7	Leishmania braziliensis	29%	100%
A4HX17	Leishmania infantum	78%	95%
A4I042	Leishmania infantum	33%	100%
A4I4Z7	Leishmania infantum	30%	100%
A4IC14	Leishmania infantum	33%	99%
A4IDA1	Leishmania infantum	34%	100%
C9ZVY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AQT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	97%
E9AW05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B0C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
Q4Q1A6	Leishmania major	34%	100%
Q4Q7V7	Leishmania major	30%	100%
Q4QBH1	Leishmania major	33%	100%
Q4QEP7	Leishmania major	77%	100%
V5DJ29	Trypanosoma cruzi	61%	100%