Coatomer subunit delta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

delta-coat protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8P5_LEIBR

TriTrypDb:

LbrM.16.1220 , LBRM2903_160019800

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	12
GO:0016020	membrane	2	12
GO:0030117	membrane coat	3	12
GO:0030120	vesicle coat	4	12
GO:0030126	COPI vesicle coat	5	12
GO:0031090	organelle membrane	3	12
GO:0032991	protein-containing complex	1	12
GO:0098588	bounding membrane of organelle	4	12
GO:0098796	membrane protein complex	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H8P5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8P5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016192	vesicle-mediated transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0048193	Golgi vesicle transport	5	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051640	organelle localization	2	1
GO:0051645	Golgi localization	3	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	370	374	PF00656	0.320
CLV_C14_Caspase3-7	461	465	PF00656	0.444
CLV_C14_Caspase3-7	49	53	PF00656	0.403
CLV_NRD_NRD_1	166	168	PF00675	0.480
CLV_NRD_NRD_1	172	174	PF00675	0.561
CLV_NRD_NRD_1	250	252	PF00675	0.684
CLV_PCSK_FUR_1	170	174	PF00082	0.527
CLV_PCSK_KEX2_1	124	126	PF00082	0.403
CLV_PCSK_KEX2_1	172	174	PF00082	0.539
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.419
CLV_PCSK_SKI1_1	14	18	PF00082	0.411
CLV_PCSK_SKI1_1	145	149	PF00082	0.579
CLV_PCSK_SKI1_1	159	163	PF00082	0.532
CLV_PCSK_SKI1_1	19	23	PF00082	0.432
CLV_PCSK_SKI1_1	340	344	PF00082	0.298
CLV_PCSK_SKI1_1	360	364	PF00082	0.173
CLV_PCSK_SKI1_1	46	50	PF00082	0.459
DEG_SPOP_SBC_1	405	409	PF00917	0.353
DOC_CYCLIN_RxL_1	355	366	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	488	494	PF00134	0.486
DOC_MAPK_MEF2A_6	284	292	PF00069	0.463
DOC_MAPK_MEF2A_6	324	331	PF00069	0.313
DOC_PP2B_LxvP_1	429	432	PF13499	0.440
DOC_USP7_MATH_1	203	207	PF00917	0.671
DOC_USP7_MATH_1	221	225	PF00917	0.683
DOC_USP7_MATH_1	405	409	PF00917	0.440
DOC_USP7_MATH_1	495	499	PF00917	0.433
DOC_WW_Pin1_4	434	439	PF00397	0.342
LIG_14-3-3_CanoR_1	19	27	PF00244	0.472
LIG_14-3-3_CanoR_1	387	393	PF00244	0.368
LIG_14-3-3_CanoR_1	526	534	PF00244	0.417
LIG_BRCT_BRCA1_1	346	350	PF00533	0.313
LIG_FHA_1	326	332	PF00498	0.388
LIG_FHA_1	394	400	PF00498	0.378
LIG_FHA_1	445	451	PF00498	0.265
LIG_FHA_1	457	463	PF00498	0.329
LIG_FHA_1	82	88	PF00498	0.349
LIG_FHA_2	301	307	PF00498	0.429
LIG_FHA_2	317	323	PF00498	0.298
LIG_FHA_2	368	374	PF00498	0.355
LIG_FHA_2	47	53	PF00498	0.408
LIG_LIR_Apic_2	217	223	PF02991	0.738
LIG_LIR_Gen_1	109	116	PF02991	0.500
LIG_LIR_Gen_1	445	456	PF02991	0.446
LIG_LIR_Gen_1	64	71	PF02991	0.379
LIG_LIR_Nem_3	109	113	PF02991	0.486
LIG_LIR_Nem_3	191	197	PF02991	0.618
LIG_LIR_Nem_3	34	39	PF02991	0.474
LIG_LIR_Nem_3	445	451	PF02991	0.446
LIG_LIR_Nem_3	486	492	PF02991	0.372
LIG_LIR_Nem_3	64	70	PF02991	0.383
LIG_Pex14_2	110	114	PF04695	0.367
LIG_SH2_CRK	184	188	PF00017	0.582
LIG_SH2_NCK_1	414	418	PF00017	0.440
LIG_SH2_SRC	50	53	PF00017	0.378
LIG_SH2_SRC	60	63	PF00017	0.497
LIG_SH2_STAP1	142	146	PF00017	0.580
LIG_SH2_STAT3	58	61	PF00017	0.328
LIG_SH2_STAT5	136	139	PF00017	0.425
LIG_SH2_STAT5	50	53	PF00017	0.378
LIG_SH2_STAT5	58	61	PF00017	0.365
LIG_SH2_STAT5	95	98	PF00017	0.446
LIG_SH3_2	423	428	PF14604	0.440
LIG_SH3_3	268	274	PF00018	0.674
LIG_SH3_3	328	334	PF00018	0.313
LIG_SH3_3	376	382	PF00018	0.380
LIG_SH3_3	420	426	PF00018	0.411
LIG_SH3_3	56	62	PF00018	0.339
LIG_SUMO_SIM_anti_2	326	331	PF11976	0.315
LIG_SUMO_SIM_anti_2	459	464	PF11976	0.395
LIG_SUMO_SIM_par_1	326	333	PF11976	0.440
LIG_SUMO_SIM_par_1	458	464	PF11976	0.401
LIG_SUMO_SIM_par_1	67	74	PF11976	0.353
LIG_TRAF2_1	141	144	PF00917	0.434
LIG_TRAF2_1	147	150	PF00917	0.436
LIG_TRAF2_1	303	306	PF00917	0.440
LIG_TRAF2_1	62	65	PF00917	0.445
LIG_UBA3_1	66	75	PF00899	0.355
MOD_CK1_1	229	235	PF00069	0.674
MOD_CK1_1	391	397	PF00069	0.378
MOD_CK1_1	408	414	PF00069	0.340
MOD_CK1_1	444	450	PF00069	0.305
MOD_CK1_1	512	518	PF00069	0.370
MOD_CK1_1	522	528	PF00069	0.256
MOD_CK2_1	125	131	PF00069	0.405
MOD_CK2_1	138	144	PF00069	0.427
MOD_CK2_1	300	306	PF00069	0.440
MOD_Cter_Amidation	122	125	PF01082	0.392
MOD_GlcNHglycan	174	177	PF01048	0.570
MOD_GlcNHglycan	179	182	PF01048	0.537
MOD_GlcNHglycan	223	226	PF01048	0.665
MOD_GlcNHglycan	231	234	PF01048	0.646
MOD_GlcNHglycan	242	245	PF01048	0.640
MOD_GlcNHglycan	308	311	PF01048	0.310
MOD_GlcNHglycan	33	36	PF01048	0.350
MOD_GlcNHglycan	4	7	PF01048	0.414
MOD_GSK3_1	236	243	PF00069	0.693
MOD_GSK3_1	344	351	PF00069	0.386
MOD_GSK3_1	358	365	PF00069	0.356
MOD_GSK3_1	393	400	PF00069	0.249
MOD_GSK3_1	404	411	PF00069	0.450
MOD_GSK3_1	522	529	PF00069	0.403
MOD_GSK3_1	69	76	PF00069	0.343
MOD_N-GLC_1	126	131	PF02516	0.418
MOD_N-GLC_1	300	305	PF02516	0.440
MOD_N-GLC_1	358	363	PF02516	0.378
MOD_NEK2_1	197	202	PF00069	0.639
MOD_NEK2_1	216	221	PF00069	0.682
MOD_NEK2_1	235	240	PF00069	0.671
MOD_NEK2_1	245	250	PF00069	0.715
MOD_NEK2_1	39	44	PF00069	0.443
MOD_NEK2_1	70	75	PF00069	0.349
MOD_PIKK_1	265	271	PF00454	0.796
MOD_PIKK_1	495	501	PF00454	0.417
MOD_PIKK_1	510	516	PF00454	0.451
MOD_PIKK_1	519	525	PF00454	0.352
MOD_PKA_1	159	165	PF00069	0.603
MOD_PKA_1	172	178	PF00069	0.687
MOD_PKA_2	172	178	PF00069	0.462
MOD_PKA_2	388	394	PF00069	0.459
MOD_PKB_1	170	178	PF00069	0.590
MOD_Plk_1	101	107	PF00069	0.396
MOD_Plk_1	125	131	PF00069	0.434
MOD_Plk_1	216	222	PF00069	0.596
MOD_Plk_1	22	28	PF00069	0.389
MOD_Plk_1	300	306	PF00069	0.400
MOD_Plk_1	316	322	PF00069	0.238
MOD_Plk_1	325	331	PF00069	0.304
MOD_Plk_1	358	364	PF00069	0.414
MOD_Plk_1	40	46	PF00069	0.527
MOD_Plk_1	405	411	PF00069	0.216
MOD_Plk_1	473	479	PF00069	0.244
MOD_Plk_2-3	106	112	PF00069	0.514
MOD_Plk_2-3	126	132	PF00069	0.420
MOD_Plk_2-3	317	323	PF00069	0.327
MOD_Plk_4	325	331	PF00069	0.315
MOD_Plk_4	358	364	PF00069	0.378
MOD_Plk_4	381	387	PF00069	0.343
MOD_Plk_4	46	52	PF00069	0.439
MOD_Plk_4	528	534	PF00069	0.357
MOD_ProDKin_1	434	440	PF00069	0.342
MOD_SUMO_for_1	323	326	PF00179	0.440
TRG_DiLeu_BaEn_1	326	331	PF01217	0.333
TRG_DiLeu_BaEn_1	64	69	PF01217	0.366
TRG_DiLeu_BaEn_4	143	149	PF01217	0.580
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.401
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.361
TRG_ENDOCYTIC_2	136	139	PF00928	0.425
TRG_ENDOCYTIC_2	184	187	PF00928	0.592
TRG_ENDOCYTIC_2	194	197	PF00928	0.622
TRG_ENDOCYTIC_2	448	451	PF00928	0.378
TRG_ENDOCYTIC_2	60	63	PF00928	0.388
TRG_ER_diArg_1	172	174	PF00400	0.694
TRG_ER_diArg_1	26	29	PF00400	0.390
TRG_NES_CRM1_1	254	269	PF08389	0.716
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I039	Leptomonas seymouri	75%	100%
A0A0S4KK09	Bodo saltans	44%	100%
A0A1X0NYY5	Trypanosomatidae	50%	97%
A0A3Q8IAE4	Leishmania donovani	87%	100%
A0A422N6V7	Trypanosoma rangeli	49%	100%
A4HX15	Leishmania infantum	87%	100%
C9ZVY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AQS9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
P43621	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	98%
P48444	Homo sapiens	31%	100%
P49661	Oryza sativa subsp. japonica	33%	100%
P53619	Bos taurus	31%	100%
Q09236	Caenorhabditis elegans	32%	100%
Q0DJ99	Oryza sativa subsp. japonica	33%	100%
Q0DJA0	Oryza sativa subsp. japonica	32%	100%
Q4QEP9	Leishmania major	86%	100%
Q55EZ6	Dictyostelium discoideum	30%	99%
Q5RA77	Pongo abelii	31%	100%
Q5XJY5	Mus musculus	31%	100%
Q5ZL57	Gallus gallus	30%	100%
Q66H80	Rattus norvegicus	31%	100%
Q93Y22	Arabidopsis thaliana	31%	100%
V5BI39	Trypanosoma cruzi	50%	99%