Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H8P3_LEIBR

TriTrypDb:

LbrM.16.1200 , LBRM2903_160019700

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8P3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8P3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.559
CLV_NRD_NRD_1	156	158	PF00675	0.705
CLV_NRD_NRD_1	476	478	PF00675	0.636
CLV_PCSK_KEX2_1	156	158	PF00082	0.705
CLV_PCSK_KEX2_1	319	321	PF00082	0.656
CLV_PCSK_KEX2_1	413	415	PF00082	0.489
CLV_PCSK_KEX2_1	431	433	PF00082	0.658
CLV_PCSK_KEX2_1	476	478	PF00082	0.470
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.634
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.485
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.711
CLV_PCSK_PC7_1	152	158	PF00082	0.708
CLV_PCSK_SKI1_1	234	238	PF00082	0.648
CLV_PCSK_SKI1_1	246	250	PF00082	0.487
CLV_PCSK_SKI1_1	396	400	PF00082	0.517
CLV_PCSK_SKI1_1	428	432	PF00082	0.707
CLV_PCSK_SKI1_1	93	97	PF00082	0.510
CLV_Separin_Metazoa	21	25	PF03568	0.571
DEG_APCC_DBOX_1	233	241	PF00400	0.640
DEG_APCC_DBOX_1	245	253	PF00400	0.486
DEG_APCC_DBOX_1	395	403	PF00400	0.504
DEG_SPOP_SBC_1	385	389	PF00917	0.441
DOC_CDC14_PxL_1	299	307	PF14671	0.530
DOC_CKS1_1	211	216	PF01111	0.503
DOC_CYCLIN_RxL_1	231	239	PF00134	0.647
DOC_CYCLIN_yCln2_LP_2	211	217	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	247	253	PF00134	0.447
DOC_MAPK_gen_1	24	32	PF00069	0.537
DOC_MAPK_MEF2A_6	202	211	PF00069	0.548
DOC_MAPK_MEF2A_6	392	399	PF00069	0.599
DOC_MAPK_NFAT4_5	392	400	PF00069	0.601
DOC_MAPK_RevD_3	400	414	PF00069	0.445
DOC_PP2B_LxvP_1	209	212	PF13499	0.682
DOC_PP2B_LxvP_1	247	250	PF13499	0.447
DOC_PP4_FxxP_1	3	6	PF00568	0.637
DOC_PP4_FxxP_1	94	97	PF00568	0.682
DOC_USP7_MATH_1	125	129	PF00917	0.556
DOC_USP7_MATH_1	201	205	PF00917	0.541
DOC_USP7_MATH_1	276	280	PF00917	0.625
DOC_USP7_MATH_1	385	389	PF00917	0.524
DOC_USP7_MATH_1	445	449	PF00917	0.620
DOC_WW_Pin1_4	1	6	PF00397	0.655
DOC_WW_Pin1_4	123	128	PF00397	0.494
DOC_WW_Pin1_4	203	208	PF00397	0.672
DOC_WW_Pin1_4	210	215	PF00397	0.493
DOC_WW_Pin1_4	418	423	PF00397	0.489
DOC_WW_Pin1_4	441	446	PF00397	0.514
DOC_WW_Pin1_4	75	80	PF00397	0.688
LIG_14-3-3_CanoR_1	202	209	PF00244	0.545
LIG_14-3-3_CanoR_1	297	305	PF00244	0.606
LIG_14-3-3_CanoR_1	320	329	PF00244	0.558
LIG_14-3-3_CanoR_1	350	355	PF00244	0.401
LIG_14-3-3_CanoR_1	367	373	PF00244	0.723
LIG_APCC_ABBA_1	23	28	PF00400	0.591
LIG_BIR_II_1	1	5	PF00653	0.632
LIG_BIR_III_4	136	140	PF00653	0.564
LIG_BRCT_BRCA1_1	83	87	PF00533	0.521
LIG_CtBP_PxDLS_1	375	379	PF00389	0.482
LIG_eIF4E_1	112	118	PF01652	0.524
LIG_EVH1_2	178	182	PF00568	0.663
LIG_FHA_1	204	210	PF00498	0.548
LIG_FHA_1	230	236	PF00498	0.676
LIG_FHA_1	311	317	PF00498	0.634
LIG_FHA_1	369	375	PF00498	0.676
LIG_FHA_1	98	104	PF00498	0.486
LIG_FHA_2	406	412	PF00498	0.593
LIG_LIR_Apic_2	2	6	PF02991	0.641
LIG_LIR_Apic_2	91	97	PF02991	0.685
LIG_LIR_Nem_3	242	248	PF02991	0.532
LIG_LIR_Nem_3	338	344	PF02991	0.528
LIG_NRBOX	113	119	PF00104	0.525
LIG_PCNA_yPIPBox_3	19	27	PF02747	0.592
LIG_PTAP_UEV_1	8	13	PF05743	0.529
LIG_SH2_CRK	415	419	PF00017	0.622
LIG_SH2_STAT5	354	357	PF00017	0.649
LIG_SH2_STAT5	415	418	PF00017	0.620
LIG_SH3_3	185	191	PF00018	0.683
LIG_SH3_3	222	228	PF00018	0.583
LIG_SH3_3	3	9	PF00018	0.643
LIG_SH3_3	370	376	PF00018	0.700
LIG_TYR_ITIM	218	223	PF00017	0.660
LIG_UBA3_1	248	257	PF00899	0.614
MOD_CK1_1	194	200	PF00069	0.571
MOD_CK1_1	239	245	PF00069	0.448
MOD_CK1_1	332	338	PF00069	0.648
MOD_CK1_1	340	346	PF00069	0.498
MOD_CK1_1	377	383	PF00069	0.539
MOD_CK1_1	384	390	PF00069	0.623
MOD_CK1_1	4	10	PF00069	0.515
MOD_CK1_1	78	84	PF00069	0.688
MOD_CK2_1	110	116	PF00069	0.511
MOD_CK2_1	139	145	PF00069	0.697
MOD_CK2_1	405	411	PF00069	0.584
MOD_CK2_1	98	104	PF00069	0.584
MOD_GlcNHglycan	141	144	PF01048	0.662
MOD_GlcNHglycan	278	281	PF01048	0.724
MOD_GlcNHglycan	288	291	PF01048	0.714
MOD_GlcNHglycan	299	302	PF01048	0.518
MOD_GlcNHglycan	383	386	PF01048	0.658
MOD_GlcNHglycan	9	12	PF01048	0.534
MOD_GSK3_1	1	8	PF00069	0.530
MOD_GSK3_1	121	128	PF00069	0.654
MOD_GSK3_1	139	146	PF00069	0.517
MOD_GSK3_1	178	185	PF00069	0.701
MOD_GSK3_1	325	332	PF00069	0.668
MOD_GSK3_1	340	347	PF00069	0.473
MOD_GSK3_1	377	384	PF00069	0.565
MOD_GSK3_1	441	448	PF00069	0.527
MOD_GSK3_1	78	85	PF00069	0.644
MOD_N-GLC_1	139	144	PF02516	0.612
MOD_N-GLC_1	332	337	PF02516	0.482
MOD_NEK2_1	236	241	PF00069	0.457
MOD_NEK2_1	329	334	PF00069	0.630
MOD_NEK2_1	344	349	PF00069	0.473
MOD_NEK2_1	456	461	PF00069	0.661
MOD_NEK2_1	98	103	PF00069	0.515
MOD_NEK2_2	325	330	PF00069	0.521
MOD_NEK2_2	83	88	PF00069	0.521
MOD_PIKK_1	274	280	PF00454	0.667
MOD_PIKK_1	320	326	PF00454	0.632
MOD_PKA_2	201	207	PF00069	0.542
MOD_PKA_2	269	275	PF00069	0.554
MOD_PKA_2	329	335	PF00069	0.749
MOD_PKA_2	405	411	PF00069	0.584
MOD_Plk_1	426	432	PF00069	0.543
MOD_Plk_4	332	338	PF00069	0.723
MOD_Plk_4	344	350	PF00069	0.447
MOD_Plk_4	405	411	PF00069	0.584
MOD_Plk_4	98	104	PF00069	0.648
MOD_ProDKin_1	1	7	PF00069	0.651
MOD_ProDKin_1	123	129	PF00069	0.500
MOD_ProDKin_1	203	209	PF00069	0.671
MOD_ProDKin_1	210	216	PF00069	0.493
MOD_ProDKin_1	418	424	PF00069	0.493
MOD_ProDKin_1	441	447	PF00069	0.513
MOD_ProDKin_1	75	81	PF00069	0.687
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.536
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.556
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.660
TRG_DiLeu_BaLyEn_6	243	248	PF01217	0.487
TRG_ENDOCYTIC_2	220	223	PF00928	0.666
TRG_ENDOCYTIC_2	415	418	PF00928	0.550
TRG_ER_diArg_1	475	477	PF00400	0.456
TRG_NLS_Bipartite_1	413	435	PF00514	0.533
TRG_NLS_MonoCore_2	318	323	PF00514	0.614
TRG_NLS_MonoCore_2	430	435	PF00514	0.711
TRG_NLS_MonoExtC_3	430	436	PF00514	0.710
TRG_NLS_MonoExtN_4	428	435	PF00514	0.713

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Q0	Leptomonas seymouri	30%	100%
A0A3Q8IAM2	Leishmania donovani	72%	99%
A4HX13	Leishmania infantum	72%	99%
E9AQS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	98%
Q4QEQ1	Leishmania major	73%	100%