Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8P2_LEIBR

TriTrypDb:

LbrM.16.1190 , LBRM2903_160019600

Length:

342

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8P2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8P2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	175	177	PF00675	0.495
CLV_NRD_NRD_1	186	188	PF00675	0.506
CLV_NRD_NRD_1	223	225	PF00675	0.376
CLV_NRD_NRD_1	337	339	PF00675	0.432
CLV_NRD_NRD_1	56	58	PF00675	0.617
CLV_NRD_NRD_1	62	64	PF00675	0.656
CLV_PCSK_FUR_1	221	225	PF00082	0.381
CLV_PCSK_KEX2_1	175	177	PF00082	0.495
CLV_PCSK_KEX2_1	223	225	PF00082	0.376
CLV_PCSK_KEX2_1	337	339	PF00082	0.532
CLV_PCSK_KEX2_1	56	58	PF00082	0.617
CLV_PCSK_KEX2_1	61	63	PF00082	0.611
CLV_PCSK_PC7_1	57	63	PF00082	0.525
CLV_PCSK_SKI1_1	126	130	PF00082	0.668
CLV_PCSK_SKI1_1	304	308	PF00082	0.438
CLV_PCSK_SKI1_1	98	102	PF00082	0.430
DEG_Nend_Nbox_1	1	3	PF02207	0.539
DOC_CKS1_1	85	90	PF01111	0.507
DOC_CYCLIN_RxL_1	124	134	PF00134	0.442
DOC_CYCLIN_RxL_1	173	183	PF00134	0.572
DOC_CYCLIN_RxL_1	301	310	PF00134	0.378
DOC_MAPK_gen_1	126	132	PF00069	0.440
DOC_MAPK_gen_1	185	195	PF00069	0.385
DOC_MAPK_MEF2A_6	280	288	PF00069	0.419
DOC_MAPK_RevD_3	162	176	PF00069	0.432
DOC_PP1_RVXF_1	174	181	PF00149	0.538
DOC_PP1_RVXF_1	96	103	PF00149	0.395
DOC_PP4_FxxP_1	55	58	PF00568	0.521
DOC_USP7_MATH_1	29	33	PF00917	0.661
DOC_USP7_MATH_1	46	50	PF00917	0.446
DOC_USP7_MATH_1	74	78	PF00917	0.689
DOC_WW_Pin1_4	42	47	PF00397	0.648
DOC_WW_Pin1_4	84	89	PF00397	0.584
LIG_14-3-3_CanoR_1	137	143	PF00244	0.443
LIG_14-3-3_CanoR_1	175	181	PF00244	0.620
LIG_14-3-3_CanoR_1	61	66	PF00244	0.623
LIG_Actin_WH2_2	121	139	PF00022	0.442
LIG_BRCT_BRCA1_1	176	180	PF00533	0.619
LIG_BRCT_BRCA1_1	48	52	PF00533	0.543
LIG_deltaCOP1_diTrp_1	147	153	PF00928	0.625
LIG_FHA_1	117	123	PF00498	0.434
LIG_FHA_1	139	145	PF00498	0.616
LIG_FHA_1	291	297	PF00498	0.507
LIG_LIR_Gen_1	158	166	PF02991	0.473
LIG_LIR_Gen_1	49	59	PF02991	0.530
LIG_LIR_Nem_3	158	163	PF02991	0.479
LIG_LIR_Nem_3	49	55	PF02991	0.723
LIG_LIR_Nem_3	89	95	PF02991	0.444
LIG_MLH1_MIPbox_1	48	52	PF16413	0.543
LIG_PCNA_yPIPBox_3	112	122	PF02747	0.660
LIG_Pex14_2	55	59	PF04695	0.585
LIG_PTB_Apo_2	154	161	PF02174	0.379
LIG_PTB_Phospho_1	154	160	PF10480	0.381
LIG_SH2_CRK	160	164	PF00017	0.375
LIG_SH2_GRB2like	138	141	PF00017	0.452
LIG_SH2_STAT5	138	141	PF00017	0.518
LIG_SH2_STAT5	326	329	PF00017	0.496
LIG_SH2_STAT5	51	54	PF00017	0.542
LIG_SH3_3	190	196	PF00018	0.372
LIG_TRAF2_1	145	148	PF00917	0.403
LIG_TRAF2_1	216	219	PF00917	0.398
LIG_TRAF2_1	330	333	PF00917	0.627
LIG_TRAF2_1	40	43	PF00917	0.586
LIG_UBA3_1	263	269	PF00899	0.354
MOD_CK1_1	32	38	PF00069	0.761
MOD_CK1_1	77	83	PF00069	0.575
MOD_CK1_1	86	92	PF00069	0.482
MOD_CK2_1	176	182	PF00069	0.517
MOD_CK2_1	259	265	PF00069	0.586
MOD_CK2_1	327	333	PF00069	0.389
MOD_CK2_1	37	43	PF00069	0.594
MOD_GlcNHglycan	212	215	PF01048	0.456
MOD_GlcNHglycan	33	37	PF01048	0.646
MOD_GlcNHglycan	48	51	PF01048	0.469
MOD_GSK3_1	28	35	PF00069	0.674
MOD_GSK3_1	37	44	PF00069	0.556
MOD_GSK3_1	61	68	PF00069	0.573
MOD_GSK3_1	74	81	PF00069	0.594
MOD_GSK3_1	83	90	PF00069	0.492
MOD_LATS_1	174	180	PF00433	0.432
MOD_N-GLC_2	18	20	PF02516	0.549
MOD_NEK2_1	121	126	PF00069	0.629
MOD_NEK2_1	164	169	PF00069	0.483
MOD_NEK2_1	327	332	PF00069	0.388
MOD_NEK2_2	151	156	PF00069	0.394
MOD_PIKK_1	116	122	PF00454	0.429
MOD_PIKK_1	164	170	PF00454	0.362
MOD_PIKK_1	207	213	PF00454	0.567
MOD_PIKK_1	72	78	PF00454	0.535
MOD_PK_1	61	67	PF00069	0.537
MOD_PKA_1	61	67	PF00069	0.537
MOD_PKA_2	151	157	PF00069	0.451
MOD_PKA_2	174	180	PF00069	0.496
MOD_PKA_2	207	213	PF00069	0.614
MOD_PKA_2	61	67	PF00069	0.631
MOD_Plk_1	116	122	PF00069	0.557
MOD_Plk_2-3	34	40	PF00069	0.802
MOD_Plk_4	259	265	PF00069	0.590
MOD_ProDKin_1	42	48	PF00069	0.647
MOD_ProDKin_1	84	90	PF00069	0.577
MOD_SUMO_for_1	216	219	PF00179	0.398
MOD_SUMO_rev_2	182	190	PF00179	0.391
MOD_SUMO_rev_2	9	19	PF00179	0.536
TRG_DiLeu_BaEn_3	116	122	PF01217	0.593
TRG_ENDOCYTIC_2	159	162	PF00928	0.549
TRG_ENDOCYTIC_2	236	239	PF00928	0.460
TRG_ENDOCYTIC_2	271	274	PF00928	0.383
TRG_ENDOCYTIC_2	281	284	PF00928	0.395
TRG_ENDOCYTIC_2	92	95	PF00928	0.487
TRG_ER_diArg_1	223	225	PF00400	0.448
TRG_ER_diArg_1	337	339	PF00400	0.432
TRG_ER_diArg_1	55	57	PF00400	0.558
TRG_ER_diArg_1	61	63	PF00400	0.548
TRG_NES_CRM1_1	120	134	PF08389	0.441
TRG_NES_CRM1_1	265	278	PF08389	0.356
TRG_Pf-PMV_PEXEL_1	104	109	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	294	299	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	304	309	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Q2	Leptomonas seymouri	51%	96%
A0A3S7WU27	Leishmania donovani	71%	100%
A0A422NPU4	Trypanosoma rangeli	39%	99%
A4HX12	Leishmania infantum	71%	100%
E9AQS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QEQ2	Leishmania major	72%	100%