Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H8P1_LEIBR

TriTrypDb:

LbrM.16.1180 , LBRM2903_160019500

Length:

120

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8P1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8P1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.564
CLV_C14_Caspase3-7	114	118	PF00656	0.643
CLV_MEL_PAP_1	34	40	PF00089	0.304
CLV_NRD_NRD_1	99	101	PF00675	0.704
CLV_PCSK_KEX2_1	101	103	PF00082	0.617
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.597
CLV_PCSK_SKI1_1	10	14	PF00082	0.596
CLV_PCSK_SKI1_1	71	75	PF00082	0.445
DEG_Nend_UBRbox_1	1	4	PF02207	0.468
DOC_CKS1_1	87	92	PF01111	0.417
DOC_CYCLIN_RxL_1	7	17	PF00134	0.519
DOC_MAPK_HePTP_8	24	36	PF00069	0.319
DOC_MAPK_MEF2A_6	27	36	PF00069	0.514
DOC_MAPK_MEF2A_6	45	52	PF00069	0.441
DOC_PP4_FxxP_1	87	90	PF00568	0.401
DOC_USP7_MATH_1	57	61	PF00917	0.623
DOC_USP7_UBL2_3	10	14	PF12436	0.354
DOC_WW_Pin1_4	86	91	PF00397	0.486
LIG_14-3-3_CanoR_1	45	51	PF00244	0.470
LIG_AP2alpha_2	85	87	PF02296	0.424
LIG_BRCT_BRCA1_1	108	112	PF00533	0.624
LIG_BRCT_BRCA1_1	48	52	PF00533	0.477
LIG_FHA_2	101	107	PF00498	0.550
LIG_LIR_Apic_2	85	90	PF02991	0.448
LIG_NRBOX	8	14	PF00104	0.529
LIG_PDZ_Class_1	115	120	PF00595	0.648
LIG_Pex14_1	83	87	PF04695	0.431
LIG_PTB_Apo_2	66	73	PF02174	0.383
LIG_PTB_Phospho_1	66	72	PF10480	0.382
LIG_SH2_STAP1	72	76	PF00017	0.396
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.308
LIG_SUMO_SIM_anti_2	47	52	PF11976	0.407
LIG_TRAF2_1	75	78	PF00917	0.454
LIG_UBA3_1	65	71	PF00899	0.450
MOD_CK1_1	56	62	PF00069	0.520
MOD_CK2_1	27	33	PF00069	0.479
MOD_CK2_1	72	78	PF00069	0.551
MOD_GlcNHglycan	28	32	PF01048	0.501
MOD_GlcNHglycan	55	58	PF01048	0.667
MOD_GSK3_1	100	107	PF00069	0.637
MOD_GSK3_1	111	118	PF00069	0.750
MOD_GSK3_1	52	59	PF00069	0.588
MOD_GSK3_1	88	95	PF00069	0.544
MOD_N-GLC_1	115	120	PF02516	0.558
MOD_N-GLC_1	53	58	PF02516	0.561
MOD_NEK2_1	52	57	PF00069	0.590
MOD_PKA_1	100	106	PF00069	0.495
MOD_PKA_2	44	50	PF00069	0.569
MOD_PKB_1	102	110	PF00069	0.670
MOD_Plk_2-3	106	112	PF00069	0.645
MOD_Plk_4	46	52	PF00069	0.505
MOD_Plk_4	8	14	PF00069	0.389
MOD_ProDKin_1	86	92	PF00069	0.492
MOD_SUMO_rev_2	98	103	PF00179	0.579
TRG_DiLeu_BaEn_4	77	83	PF01217	0.480
TRG_NLS_MonoExtC_3	100	106	PF00514	0.626
TRG_NLS_MonoExtN_4	100	105	PF00514	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAA9	Leptomonas seymouri	64%	94%
A0A3S5H6Y4	Leishmania donovani	81%	100%
A0A422NPT6	Trypanosoma rangeli	29%	77%
C9ZZZ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	75%
E9ACR6	Leishmania major	76%	100%
E9AGP1	Leishmania infantum	81%	100%
E9AQS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%