WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WW domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8P0_LEIBR

TriTrypDb:

LbrM.16.1170 , LBRM2903_160019400

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005685	U1 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H8P0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8P0

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	301	305	PF00656	0.692
CLV_NRD_NRD_1	237	239	PF00675	0.612
CLV_NRD_NRD_1	292	294	PF00675	0.778
CLV_NRD_NRD_1	78	80	PF00675	0.450
CLV_PCSK_KEX2_1	292	294	PF00082	0.778
CLV_PCSK_KEX2_1	475	477	PF00082	0.437
CLV_PCSK_KEX2_1	78	80	PF00082	0.450
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.233
CLV_PCSK_SKI1_1	28	32	PF00082	0.540
CLV_PCSK_SKI1_1	280	284	PF00082	0.567
CLV_PCSK_SKI1_1	53	57	PF00082	0.399
DEG_SPOP_SBC_1	365	369	PF00917	0.815
DOC_ANK_TNKS_1	299	306	PF00023	0.553
DOC_CKS1_1	137	142	PF01111	0.538
DOC_CYCLIN_RxL_1	102	110	PF00134	0.547
DOC_CYCLIN_RxL_1	426	438	PF00134	0.667
DOC_CYCLIN_RxL_1	75	84	PF00134	0.440
DOC_CYCLIN_yCln2_LP_2	37	43	PF00134	0.632
DOC_CYCLIN_yCln2_LP_2	511	517	PF00134	0.233
DOC_CYCLIN_yCln2_LP_2	579	585	PF00134	0.485
DOC_PP1_RVXF_1	51	58	PF00149	0.398
DOC_PP1_RVXF_1	76	83	PF00149	0.418
DOC_PP2B_LxvP_1	270	273	PF13499	0.805
DOC_PP2B_LxvP_1	37	40	PF13499	0.341
DOC_PP2B_LxvP_1	511	514	PF13499	0.233
DOC_PP2B_LxvP_1	579	582	PF13499	0.485
DOC_PP4_FxxP_1	271	274	PF00568	0.801
DOC_USP7_MATH_1	265	269	PF00917	0.697
DOC_USP7_MATH_1	365	369	PF00917	0.784
DOC_USP7_MATH_1	381	385	PF00917	0.673
DOC_USP7_MATH_1	388	392	PF00917	0.517
DOC_USP7_MATH_1	497	501	PF00917	0.705
DOC_USP7_MATH_1	503	507	PF00917	0.802
DOC_WW_Pin1_4	136	141	PF00397	0.530
DOC_WW_Pin1_4	285	290	PF00397	0.546
DOC_WW_Pin1_4	346	351	PF00397	0.692
DOC_WW_Pin1_4	355	360	PF00397	0.680
DOC_WW_Pin1_4	367	372	PF00397	0.709
DOC_WW_Pin1_4	447	452	PF00397	0.518
DOC_WW_Pin1_4	93	98	PF00397	0.476
LIG_14-3-3_CanoR_1	15	22	PF00244	0.603
LIG_14-3-3_CanoR_1	28	37	PF00244	0.349
LIG_14-3-3_CanoR_1	280	285	PF00244	0.673
LIG_14-3-3_CanoR_1	419	425	PF00244	0.647
LIG_14-3-3_CanoR_1	545	553	PF00244	0.535
LIG_14-3-3_CanoR_1	565	570	PF00244	0.763
LIG_14-3-3_CanoR_1	81	90	PF00244	0.504
LIG_BIR_III_4	415	419	PF00653	0.550
LIG_BRCT_BRCA1_1	267	271	PF00533	0.547
LIG_EVH1_2	332	336	PF00568	0.525
LIG_FHA_1	102	108	PF00498	0.221
LIG_FHA_1	182	188	PF00498	0.597
LIG_FHA_1	336	342	PF00498	0.786
LIG_FHA_1	367	373	PF00498	0.813
LIG_FHA_1	391	397	PF00498	0.670
LIG_FHA_1	46	52	PF00498	0.580
LIG_FHA_1	475	481	PF00498	0.420
LIG_FHA_1	524	530	PF00498	0.498
LIG_FHA_1	548	554	PF00498	0.759
LIG_FHA_1	592	598	PF00498	0.498
LIG_FHA_1	69	75	PF00498	0.454
LIG_FHA_1	82	88	PF00498	0.414
LIG_FHA_2	144	150	PF00498	0.518
LIG_FHA_2	15	21	PF00498	0.526
LIG_FHA_2	29	35	PF00498	0.478
LIG_FHA_2	485	491	PF00498	0.485
LIG_FHA_2	534	540	PF00498	0.485
LIG_FHA_2	602	608	PF00498	0.424
LIG_FHA_2	94	100	PF00498	0.562
LIG_LIR_Apic_2	268	274	PF02991	0.787
LIG_LIR_Apic_2	422	427	PF02991	0.557
LIG_LIR_Apic_2	486	492	PF02991	0.372
LIG_LIR_Apic_2	535	541	PF02991	0.401
LIG_LIR_Apic_2	567	572	PF02991	0.718
LIG_LIR_Apic_2	603	609	PF02991	0.370
LIG_LIR_Nem_3	158	164	PF02991	0.486
LIG_LIR_Nem_3	397	401	PF02991	0.601
LIG_Pex14_1	398	402	PF04695	0.486
LIG_SH2_GRB2like	528	531	PF00017	0.401
LIG_SH2_GRB2like	559	562	PF00017	0.702
LIG_SH2_GRB2like	596	599	PF00017	0.369
LIG_SH2_NCK_1	402	406	PF00017	0.405
LIG_SH2_SRC	479	482	PF00017	0.444
LIG_SH2_SRC	528	531	PF00017	0.401
LIG_SH2_SRC	596	599	PF00017	0.369
LIG_SH2_STAT5	143	146	PF00017	0.448
LIG_SH2_STAT5	479	482	PF00017	0.369
LIG_SH2_STAT5	528	531	PF00017	0.401
LIG_SH2_STAT5	596	599	PF00017	0.401
LIG_SH2_STAT5	9	12	PF00017	0.418
LIG_SH3_2	427	432	PF14604	0.683
LIG_SH3_3	245	251	PF00018	0.728
LIG_SH3_3	256	262	PF00018	0.699
LIG_SH3_3	271	277	PF00018	0.761
LIG_SH3_3	283	289	PF00018	0.719
LIG_SH3_3	308	314	PF00018	0.766
LIG_SH3_3	324	330	PF00018	0.584
LIG_SH3_3	424	430	PF00018	0.679
LIG_SH3_3	574	580	PF00018	0.746
LIG_TRAF2_1	17	20	PF00917	0.494
LIG_WW_2	262	265	PF00397	0.528
MOD_CDK_SPK_2	346	351	PF00069	0.556
MOD_CDK_SPxxK_3	285	292	PF00069	0.552
MOD_CK1_1	288	294	PF00069	0.708
MOD_CK1_1	295	301	PF00069	0.674
MOD_CK1_1	340	346	PF00069	0.662
MOD_CK1_1	349	355	PF00069	0.749
MOD_CK1_1	358	364	PF00069	0.790
MOD_CK1_1	367	373	PF00069	0.808
MOD_CK1_1	450	456	PF00069	0.772
MOD_CK1_1	484	490	PF00069	0.491
MOD_CK1_1	501	507	PF00069	0.753
MOD_CK2_1	14	20	PF00069	0.471
MOD_CK2_1	143	149	PF00069	0.477
MOD_CK2_1	28	34	PF00069	0.439
MOD_CK2_1	331	337	PF00069	0.752
MOD_CK2_1	381	387	PF00069	0.748
MOD_CK2_1	484	490	PF00069	0.485
MOD_CK2_1	533	539	PF00069	0.485
MOD_CK2_1	601	607	PF00069	0.424
MOD_DYRK1A_RPxSP_1	93	97	PF00069	0.534
MOD_GlcNHglycan	11	14	PF01048	0.462
MOD_GlcNHglycan	122	125	PF01048	0.703
MOD_GlcNHglycan	177	180	PF01048	0.479
MOD_GlcNHglycan	222	225	PF01048	0.650
MOD_GlcNHglycan	274	277	PF01048	0.588
MOD_GlcNHglycan	295	298	PF01048	0.751
MOD_GlcNHglycan	360	363	PF01048	0.814
MOD_GlcNHglycan	372	375	PF01048	0.752
MOD_GlcNHglycan	459	462	PF01048	0.718
MOD_GlcNHglycan	503	506	PF01048	0.798
MOD_GlcNHglycan	573	576	PF01048	0.536
MOD_GlcNHglycan	58	61	PF01048	0.569
MOD_GSK3_1	120	127	PF00069	0.679
MOD_GSK3_1	194	201	PF00069	0.630
MOD_GSK3_1	272	279	PF00069	0.699
MOD_GSK3_1	280	287	PF00069	0.674
MOD_GSK3_1	288	295	PF00069	0.635
MOD_GSK3_1	331	338	PF00069	0.674
MOD_GSK3_1	342	349	PF00069	0.643
MOD_GSK3_1	366	373	PF00069	0.761
MOD_GSK3_1	42	49	PF00069	0.563
MOD_GSK3_1	447	454	PF00069	0.713
MOD_GSK3_1	467	474	PF00069	0.466
MOD_GSK3_1	481	488	PF00069	0.280
MOD_GSK3_1	497	504	PF00069	0.767
MOD_GSK3_1	519	526	PF00069	0.418
MOD_GSK3_1	530	537	PF00069	0.390
MOD_GSK3_1	543	550	PF00069	0.697
MOD_GSK3_1	561	568	PF00069	0.707
MOD_GSK3_1	571	578	PF00069	0.735
MOD_GSK3_1	587	594	PF00069	0.362
MOD_GSK3_1	598	605	PF00069	0.374
MOD_GSK3_1	68	75	PF00069	0.496
MOD_N-GLC_1	118	123	PF02516	0.604
MOD_N-GLC_1	218	223	PF02516	0.672
MOD_N-GLC_1	497	502	PF02516	0.768
MOD_NEK2_1	107	112	PF00069	0.535
MOD_NEK2_1	220	225	PF00069	0.618
MOD_NEK2_1	335	340	PF00069	0.735
MOD_NEK2_1	366	371	PF00069	0.590
MOD_NEK2_1	372	377	PF00069	0.593
MOD_NEK2_1	389	394	PF00069	0.608
MOD_NEK2_1	56	61	PF00069	0.453
MOD_PIKK_1	451	457	PF00454	0.547
MOD_PIKK_1	551	557	PF00454	0.520
MOD_PKA_1	238	244	PF00069	0.494
MOD_PKA_1	292	298	PF00069	0.776
MOD_PKA_2	14	20	PF00069	0.576
MOD_PKA_2	237	243	PF00069	0.546
MOD_PKA_2	291	297	PF00069	0.755
MOD_PKA_2	420	426	PF00069	0.640
MOD_PKA_2	544	550	PF00069	0.713
MOD_PKA_2	564	570	PF00069	0.750
MOD_PKB_1	79	87	PF00069	0.424
MOD_Plk_1	218	224	PF00069	0.666
MOD_Plk_4	107	113	PF00069	0.505
MOD_Plk_4	194	200	PF00069	0.730
MOD_Plk_4	244	250	PF00069	0.776
MOD_Plk_4	331	337	PF00069	0.741
MOD_Plk_4	46	52	PF00069	0.478
MOD_ProDKin_1	136	142	PF00069	0.534
MOD_ProDKin_1	285	291	PF00069	0.548
MOD_ProDKin_1	346	352	PF00069	0.695
MOD_ProDKin_1	355	361	PF00069	0.680
MOD_ProDKin_1	367	373	PF00069	0.711
MOD_ProDKin_1	447	453	PF00069	0.523
MOD_ProDKin_1	93	99	PF00069	0.463
MOD_SUMO_rev_2	18	25	PF00179	0.522
MOD_SUMO_rev_2	221	231	PF00179	0.572
TRG_DiLeu_BaEn_1	34	39	PF01217	0.333
TRG_ER_diArg_1	77	79	PF00400	0.426
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ37	Leptomonas seymouri	50%	100%
A0A3Q8IJ47	Leishmania donovani	72%	95%
A0A3R7LE31	Trypanosoma rangeli	35%	94%
A4HX11	Leishmania infantum	73%	95%
C9ZVZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	99%
E9AQS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	94%
Q4QEQ3	Leishmania major	72%	97%
V5BML0	Trypanosoma cruzi	34%	100%