Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8N8_LEIBR

TriTrypDb:

LbrM.16.1150 , LBRM2903_160019100

Length:

156

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8N8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8N8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	81	85	PF00656	0.647
CLV_NRD_NRD_1	66	68	PF00675	0.547
CLV_NRD_NRD_1	70	72	PF00675	0.310
CLV_PCSK_FUR_1	67	71	PF00082	0.521
CLV_PCSK_KEX2_1	122	124	PF00082	0.501
CLV_PCSK_KEX2_1	66	68	PF00082	0.543
CLV_PCSK_KEX2_1	69	71	PF00082	0.346
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.531
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.543
CLV_PCSK_PC7_1	66	72	PF00082	0.556
CLV_PCSK_SKI1_1	109	113	PF00082	0.491
CLV_PCSK_SKI1_1	66	70	PF00082	0.560
DEG_Nend_UBRbox_3	1	3	PF02207	0.556
DOC_CYCLIN_yCln2_LP_2	135	141	PF00134	0.511
DOC_PP2B_LxvP_1	111	114	PF13499	0.482
DOC_PP2B_LxvP_1	135	138	PF13499	0.520
DOC_USP7_MATH_1	90	94	PF00917	0.630
DOC_WW_Pin1_4	4	9	PF00397	0.662
LIG_BIR_III_4	97	101	PF00653	0.621
LIG_BRCT_BRCA1_1	35	39	PF00533	0.526
LIG_eIF4E_1	59	65	PF01652	0.520
LIG_FHA_1	124	130	PF00498	0.447
LIG_LIR_Gen_1	36	47	PF02991	0.498
LIG_LIR_Nem_3	130	135	PF02991	0.512
LIG_LIR_Nem_3	36	42	PF02991	0.434
LIG_Pex14_1	132	136	PF04695	0.515
LIG_Pex14_2	39	43	PF04695	0.505
LIG_SH2_SRC	136	139	PF00017	0.519
LIG_SH2_STAT5	136	139	PF00017	0.519
LIG_SH2_STAT5	44	47	PF00017	0.490
LIG_SH2_STAT5	59	62	PF00017	0.495
LIG_SH3_3	49	55	PF00018	0.447
LIG_SUMO_SIM_par_1	115	121	PF11976	0.297
LIG_TYR_ITIM	42	47	PF00017	0.479
MOD_CK1_1	127	133	PF00069	0.622
MOD_CK1_1	75	81	PF00069	0.577
MOD_CK2_1	9	15	PF00069	0.710
MOD_GlcNHglycan	104	107	PF01048	0.391
MOD_GlcNHglycan	11	14	PF01048	0.665
MOD_GlcNHglycan	74	77	PF01048	0.668
MOD_GlcNHglycan	80	83	PF01048	0.690
MOD_GSK3_1	123	130	PF00069	0.546
MOD_GSK3_1	2	9	PF00069	0.684
MOD_GSK3_1	72	79	PF00069	0.652
MOD_NEK2_1	150	155	PF00069	0.421
MOD_PIKK_1	150	156	PF00454	0.435
MOD_PKA_2	150	156	PF00069	0.435
MOD_PKA_2	2	8	PF00069	0.698
MOD_Plk_1	124	130	PF00069	0.595
MOD_Plk_1	33	39	PF00069	0.519
MOD_Plk_4	38	44	PF00069	0.402
MOD_Plk_4	60	66	PF00069	0.482
MOD_ProDKin_1	4	10	PF00069	0.662
TRG_DiLeu_BaLyEn_6	130	135	PF01217	0.508
TRG_ENDOCYTIC_2	44	47	PF00928	0.468
TRG_ENDOCYTIC_2	59	62	PF00928	0.270
TRG_ER_diArg_1	65	67	PF00400	0.559
TRG_ER_diArg_1	70	72	PF00400	0.309
TRG_NLS_MonoExtN_4	66	73	PF00514	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJB6	Leptomonas seymouri	60%	92%
A0A1X0NYY4	Trypanosomatidae	37%	100%
A0A3S7WU10	Leishmania donovani	79%	99%
A0A422MWL5	Trypanosoma rangeli	37%	100%
A4HX09	Leishmania infantum	79%	99%
C9ZVZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%