Polyketide_cyc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Polyketide cyclase / dehydrase and lipid transport, putative

Species:

Leishmania braziliensis

UniProt:

A4H8N7_LEIBR

TriTrypDb:

LbrM.16.1140 , LBRM2903_160019000

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8N7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8N7

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	2
GO:0006743	ubiquinone metabolic process	5	2
GO:0006744	ubiquinone biosynthetic process	6	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0015980	energy derivation by oxidation of organic compounds	4	2
GO:0042180	cellular ketone metabolic process	3	2
GO:0042181	ketone biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0045333	cellular respiration	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901661	quinone metabolic process	4	2
GO:1901663	quinone biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0048038	quinone binding	2	2
GO:0048039	ubiquinone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.840
CLV_C14_Caspase3-7	232	236	PF00656	0.855
CLV_C14_Caspase3-7	449	453	PF00656	0.549
CLV_C14_Caspase3-7	491	495	PF00656	0.549
CLV_NRD_NRD_1	109	111	PF00675	0.773
CLV_NRD_NRD_1	139	141	PF00675	0.815
CLV_NRD_NRD_1	162	164	PF00675	0.821
CLV_NRD_NRD_1	219	221	PF00675	0.840
CLV_NRD_NRD_1	269	271	PF00675	0.852
CLV_NRD_NRD_1	416	418	PF00675	0.549
CLV_NRD_NRD_1	480	482	PF00675	0.549
CLV_NRD_NRD_1	601	603	PF00675	0.632
CLV_PCSK_KEX2_1	109	111	PF00082	0.773
CLV_PCSK_KEX2_1	139	141	PF00082	0.815
CLV_PCSK_KEX2_1	162	164	PF00082	0.821
CLV_PCSK_KEX2_1	219	221	PF00082	0.840
CLV_PCSK_KEX2_1	269	271	PF00082	0.852
CLV_PCSK_KEX2_1	320	322	PF00082	0.815
CLV_PCSK_KEX2_1	416	418	PF00082	0.549
CLV_PCSK_KEX2_1	545	547	PF00082	0.549
CLV_PCSK_KEX2_1	601	603	PF00082	0.632
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.815
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.549
CLV_PCSK_SKI1_1	139	143	PF00082	0.810
CLV_PCSK_SKI1_1	163	167	PF00082	0.814
CLV_PCSK_SKI1_1	173	177	PF00082	0.638
CLV_PCSK_SKI1_1	438	442	PF00082	0.549
CLV_PCSK_SKI1_1	546	550	PF00082	0.549
DEG_APCC_DBOX_1	260	268	PF00400	0.863
DEG_APCC_DBOX_1	545	553	PF00400	0.549
DEG_Nend_UBRbox_3	1	3	PF02207	0.742
DEG_SCF_FBW7_1	141	146	PF00400	0.822
DEG_SCF_FBW7_1	46	53	PF00400	0.710
DEG_SPOP_SBC_1	150	154	PF00917	0.835
DEG_SPOP_SBC_1	245	249	PF00917	0.851
DEG_SPOP_SBC_1	27	31	PF00917	0.698
DEG_SPOP_SBC_1	609	613	PF00917	0.665
DOC_CKS1_1	158	163	PF01111	0.822
DOC_CKS1_1	47	52	PF01111	0.709
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.825
DOC_MAPK_MEF2A_6	564	572	PF00069	0.549
DOC_PP2B_LxvP_1	195	198	PF13499	0.827
DOC_PP2B_LxvP_1	34	37	PF13499	0.693
DOC_PP4_FxxP_1	578	581	PF00568	0.549
DOC_SPAK_OSR1_1	62	66	PF12202	0.667
DOC_USP7_MATH_1	191	195	PF00917	0.838
DOC_USP7_MATH_1	201	205	PF00917	0.661
DOC_USP7_MATH_1	208	212	PF00917	0.553
DOC_USP7_MATH_1	227	231	PF00917	0.511
DOC_USP7_MATH_1	245	249	PF00917	0.536
DOC_USP7_MATH_1	27	31	PF00917	0.698
DOC_USP7_MATH_1	355	359	PF00917	0.846
DOC_USP7_MATH_1	428	432	PF00917	0.549
DOC_USP7_MATH_1	544	548	PF00917	0.549
DOC_WW_Pin1_4	116	121	PF00397	0.826
DOC_WW_Pin1_4	139	144	PF00397	0.815
DOC_WW_Pin1_4	157	162	PF00397	0.492
DOC_WW_Pin1_4	187	192	PF00397	0.840
DOC_WW_Pin1_4	246	251	PF00397	0.848
DOC_WW_Pin1_4	345	350	PF00397	0.867
DOC_WW_Pin1_4	383	388	PF00397	0.599
DOC_WW_Pin1_4	433	438	PF00397	0.549
DOC_WW_Pin1_4	46	51	PF00397	0.709
DOC_WW_Pin1_4	516	521	PF00397	0.549
DOC_WW_Pin1_4	86	91	PF00397	0.713
LIG_14-3-3_CanoR_1	321	329	PF00244	0.825
LIG_14-3-3_CanoR_1	474	478	PF00244	0.549
LIG_14-3-3_CanoR_1	504	512	PF00244	0.549
LIG_14-3-3_CanoR_1	85	90	PF00244	0.711
LIG_Actin_WH2_2	95	111	PF00022	0.667
LIG_APCC_ABBA_1	374	379	PF00400	0.663
LIG_BIR_III_2	205	209	PF00653	0.855
LIG_BRCT_BRCA1_1	34	38	PF00533	0.698
LIG_BRCT_BRCA1_1	572	576	PF00533	0.549
LIG_CtBP_PxDLS_1	90	94	PF00389	0.702
LIG_deltaCOP1_diTrp_1	555	558	PF00928	0.549
LIG_FHA_1	123	129	PF00498	0.812
LIG_FHA_1	140	146	PF00498	0.523
LIG_FHA_1	153	159	PF00498	0.603
LIG_FHA_1	184	190	PF00498	0.832
LIG_FHA_1	213	219	PF00498	0.833
LIG_FHA_1	31	37	PF00498	0.694
LIG_FHA_1	324	330	PF00498	0.838
LIG_FHA_1	341	347	PF00498	0.582
LIG_FHA_1	413	419	PF00498	0.549
LIG_FHA_1	422	428	PF00498	0.392
LIG_FHA_1	43	49	PF00498	0.549
LIG_FHA_1	455	461	PF00498	0.549
LIG_FHA_1	470	476	PF00498	0.287
LIG_FHA_1	565	571	PF00498	0.549
LIG_FHA_1	610	616	PF00498	0.660
LIG_FHA_2	119	125	PF00498	0.818
LIG_FHA_2	286	292	PF00498	0.891
LIG_FHA_2	439	445	PF00498	0.549
LIG_LIR_Apic_2	575	581	PF02991	0.549
LIG_LIR_Apic_2	604	610	PF02991	0.659
LIG_LIR_Gen_1	398	408	PF02991	0.549
LIG_LIR_Gen_1	461	471	PF02991	0.549
LIG_LIR_Nem_3	35	41	PF02991	0.699
LIG_LIR_Nem_3	388	394	PF02991	0.549
LIG_LIR_Nem_3	398	403	PF02991	0.375
LIG_LIR_Nem_3	461	467	PF02991	0.549
LIG_LIR_Nem_3	555	561	PF02991	0.549
LIG_NRBOX	263	269	PF00104	0.868
LIG_Pex14_2	175	179	PF04695	0.826
LIG_Pex14_2	572	576	PF04695	0.549
LIG_PTB_Apo_2	20	27	PF02174	0.701
LIG_REV1ctd_RIR_1	530	539	PF16727	0.549
LIG_SH2_CRK	105	109	PF00017	0.663
LIG_SH2_CRK	391	395	PF00017	0.549
LIG_SH2_CRK	607	611	PF00017	0.658
LIG_SH2_GRB2like	221	224	PF00017	0.835
LIG_SH2_PTP2	221	224	PF00017	0.835
LIG_SH2_SRC	221	224	PF00017	0.835
LIG_SH2_STAP1	400	404	PF00017	0.549
LIG_SH2_STAP1	471	475	PF00017	0.549
LIG_SH2_STAT5	105	108	PF00017	0.659
LIG_SH2_STAT5	133	136	PF00017	0.813
LIG_SH2_STAT5	221	224	PF00017	0.835
LIG_SH2_STAT5	471	474	PF00017	0.549
LIG_SH3_3	155	161	PF00018	0.824
LIG_SH3_3	185	191	PF00018	0.796
LIG_SH3_3	194	200	PF00018	0.707
LIG_SH3_3	343	349	PF00018	0.874
LIG_SH3_3	415	421	PF00018	0.549
LIG_SH3_3	612	618	PF00018	0.668
LIG_SH3_3	92	98	PF00018	0.686
LIG_SUMO_SIM_anti_2	447	452	PF11976	0.549
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.549
LIG_SUMO_SIM_par_1	40	45	PF11976	0.707
LIG_SUMO_SIM_par_1	589	596	PF11976	0.686
LIG_SUMO_SIM_par_1	88	94	PF11976	0.707
LIG_TRAF2_1	386	389	PF00917	0.549
LIG_TYR_ITIM	103	108	PF00017	0.657
LIG_WRC_WIRS_1	529	534	PF05994	0.549
LIG_WW_3	258	262	PF00397	0.843
MOD_CDK_SPK_2	157	162	PF00069	0.824
MOD_CDK_SPK_2	433	438	PF00069	0.549
MOD_CDK_SPxK_1	116	122	PF00069	0.825
MOD_CDK_SPxK_1	157	163	PF00069	0.824
MOD_CDK_SPxxK_3	345	352	PF00069	0.864
MOD_CK1_1	168	174	PF00069	0.799
MOD_CK1_1	183	189	PF00069	0.567
MOD_CK1_1	244	250	PF00069	0.846
MOD_CK1_1	279	285	PF00069	0.881
MOD_CK1_1	28	34	PF00069	0.701
MOD_CK1_1	332	338	PF00069	0.865
MOD_CK1_1	353	359	PF00069	0.849
MOD_CK1_1	362	368	PF00069	0.650
MOD_CK1_1	430	436	PF00069	0.549
MOD_CK1_1	473	479	PF00069	0.549
MOD_CK1_1	513	519	PF00069	0.549
MOD_CK1_1	593	599	PF00069	0.645
MOD_CK1_1	89	95	PF00069	0.701
MOD_CK2_1	118	124	PF00069	0.821
MOD_CK2_1	187	193	PF00069	0.838
MOD_CK2_1	285	291	PF00069	0.889
MOD_CK2_1	353	359	PF00069	0.849
MOD_CK2_1	383	389	PF00069	0.549
MOD_CK2_1	438	444	PF00069	0.549
MOD_CK2_1	503	509	PF00069	0.549
MOD_Cter_Amidation	137	140	PF01082	0.812
MOD_Cter_Amidation	479	482	PF01082	0.549
MOD_GlcNHglycan	111	114	PF01048	0.790
MOD_GlcNHglycan	146	149	PF01048	0.835
MOD_GlcNHglycan	167	170	PF01048	0.804
MOD_GlcNHglycan	182	185	PF01048	0.561
MOD_GlcNHglycan	201	204	PF01048	0.502
MOD_GlcNHglycan	243	246	PF01048	0.853
MOD_GlcNHglycan	272	275	PF01048	0.857
MOD_GlcNHglycan	278	281	PF01048	0.773
MOD_GlcNHglycan	329	332	PF01048	0.860
MOD_GlcNHglycan	335	338	PF01048	0.756
MOD_GlcNHglycan	361	364	PF01048	0.824
MOD_GlcNHglycan	400	403	PF01048	0.549
MOD_GlcNHglycan	432	435	PF01048	0.549
MOD_GSK3_1	118	125	PF00069	0.820
MOD_GSK3_1	139	146	PF00069	0.821
MOD_GSK3_1	149	156	PF00069	0.659
MOD_GSK3_1	179	186	PF00069	0.826
MOD_GSK3_1	187	194	PF00069	0.698
MOD_GSK3_1	208	215	PF00069	0.846
MOD_GSK3_1	21	28	PF00069	0.701
MOD_GSK3_1	223	230	PF00069	0.576
MOD_GSK3_1	233	240	PF00069	0.679
MOD_GSK3_1	241	248	PF00069	0.534
MOD_GSK3_1	272	279	PF00069	0.867
MOD_GSK3_1	323	330	PF00069	0.833
MOD_GSK3_1	355	362	PF00069	0.843
MOD_GSK3_1	379	386	PF00069	0.604
MOD_GSK3_1	407	414	PF00069	0.549
MOD_GSK3_1	42	49	PF00069	0.707
MOD_GSK3_1	454	461	PF00069	0.549
MOD_GSK3_1	469	476	PF00069	0.287
MOD_GSK3_1	499	506	PF00069	0.549
MOD_GSK3_1	510	517	PF00069	0.357
MOD_GSK3_1	586	593	PF00069	0.711
MOD_GSK3_1	609	616	PF00069	0.664
MOD_GSK3_1	81	88	PF00069	0.710
MOD_GSK3_1	89	96	PF00069	0.594
MOD_LATS_1	83	89	PF00433	0.715
MOD_N-GLC_1	212	217	PF02516	0.834
MOD_N-GLC_1	302	307	PF02516	0.816
MOD_N-GLC_1	323	328	PF02516	0.824
MOD_N-GLC_1	332	337	PF02516	0.709
MOD_NEK2_1	103	108	PF00069	0.657
MOD_NEK2_1	165	170	PF00069	0.806
MOD_NEK2_1	212	217	PF00069	0.834
MOD_NEK2_1	25	30	PF00069	0.701
MOD_NEK2_1	262	267	PF00069	0.867
MOD_NEK2_1	276	281	PF00069	0.628
MOD_NEK2_1	329	334	PF00069	0.865
MOD_NEK2_1	350	355	PF00069	0.856
MOD_NEK2_1	427	432	PF00069	0.549
MOD_NEK2_1	456	461	PF00069	0.549
MOD_NEK2_1	499	504	PF00069	0.549
MOD_NEK2_1	528	533	PF00069	0.549
MOD_NEK2_1	586	591	PF00069	0.721
MOD_NEK2_1	70	75	PF00069	0.658
MOD_NEK2_2	191	196	PF00069	0.835
MOD_PIKK_1	4	10	PF00454	0.708
MOD_PIKK_1	56	62	PF00454	0.686
MOD_PK_1	214	220	PF00069	0.834
MOD_PKA_1	109	115	PF00069	0.789
MOD_PKA_2	109	115	PF00069	0.789
MOD_PKA_2	379	385	PF00069	0.606
MOD_PKA_2	473	479	PF00069	0.549
MOD_PKA_2	503	509	PF00069	0.549
MOD_Plk_1	238	244	PF00069	0.848
MOD_Plk_1	262	268	PF00069	0.868
MOD_Plk_1	302	308	PF00069	0.817
MOD_Plk_4	103	109	PF00069	0.659
MOD_Plk_4	21	27	PF00069	0.701
MOD_Plk_4	473	479	PF00069	0.549
MOD_Plk_4	528	534	PF00069	0.549
MOD_Plk_4	590	596	PF00069	0.677
MOD_Plk_4	602	608	PF00069	0.434
MOD_Plk_4	70	76	PF00069	0.660
MOD_ProDKin_1	116	122	PF00069	0.825
MOD_ProDKin_1	139	145	PF00069	0.819
MOD_ProDKin_1	157	163	PF00069	0.491
MOD_ProDKin_1	187	193	PF00069	0.838
MOD_ProDKin_1	246	252	PF00069	0.847
MOD_ProDKin_1	345	351	PF00069	0.865
MOD_ProDKin_1	383	389	PF00069	0.549
MOD_ProDKin_1	433	439	PF00069	0.549
MOD_ProDKin_1	46	52	PF00069	0.709
MOD_ProDKin_1	516	522	PF00069	0.549
MOD_ProDKin_1	86	92	PF00069	0.712
MOD_SUMO_rev_2	353	363	PF00179	0.842
MOD_SUMO_rev_2	557	565	PF00179	0.549
MOD_SUMO_rev_2	573	581	PF00179	0.269
TRG_DiLeu_BaEn_1	263	268	PF01217	0.869
TRG_DiLeu_LyEn_5	263	268	PF01217	0.869
TRG_ENDOCYTIC_2	105	108	PF00928	0.659
TRG_ENDOCYTIC_2	221	224	PF00928	0.835
TRG_ENDOCYTIC_2	391	394	PF00928	0.549
TRG_ENDOCYTIC_2	400	403	PF00928	0.392
TRG_ER_diArg_1	108	110	PF00400	0.769
TRG_ER_diArg_1	139	141	PF00400	0.815
TRG_ER_diArg_1	161	163	PF00400	0.818
TRG_ER_diArg_1	218	220	PF00400	0.833
TRG_ER_diArg_1	268	270	PF00400	0.866
TRG_ER_diArg_1	416	419	PF00400	0.549
TRG_Pf-PMV_PEXEL_1	546	550	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q6DFA6	XENLA	26%	100%