Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8N6_LEIBR

TriTrypDb:

LbrM.16.1130 , LBRM2903_160018900

Length:

912

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8N6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8N6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.557
CLV_C14_Caspase3-7	252	256	PF00656	0.533
CLV_C14_Caspase3-7	398	402	PF00656	0.555
CLV_C14_Caspase3-7	48	52	PF00656	0.555
CLV_NRD_NRD_1	189	191	PF00675	0.565
CLV_NRD_NRD_1	247	249	PF00675	0.544
CLV_NRD_NRD_1	374	376	PF00675	0.434
CLV_NRD_NRD_1	425	427	PF00675	0.510
CLV_NRD_NRD_1	462	464	PF00675	0.476
CLV_NRD_NRD_1	648	650	PF00675	0.568
CLV_NRD_NRD_1	775	777	PF00675	0.445
CLV_NRD_NRD_1	797	799	PF00675	0.434
CLV_NRD_NRD_1	827	829	PF00675	0.436
CLV_NRD_NRD_1	833	835	PF00675	0.439
CLV_PCSK_KEX2_1	189	191	PF00082	0.571
CLV_PCSK_KEX2_1	247	249	PF00082	0.546
CLV_PCSK_KEX2_1	374	376	PF00082	0.431
CLV_PCSK_KEX2_1	424	426	PF00082	0.514
CLV_PCSK_KEX2_1	648	650	PF00082	0.577
CLV_PCSK_KEX2_1	775	777	PF00082	0.445
CLV_PCSK_KEX2_1	827	829	PF00082	0.445
CLV_PCSK_KEX2_1	833	835	PF00082	0.398
CLV_PCSK_KEX2_1	862	864	PF00082	0.420
CLV_PCSK_PC1ET2_1	862	864	PF00082	0.439
CLV_PCSK_PC7_1	644	650	PF00082	0.536
CLV_PCSK_PC7_1	858	864	PF00082	0.421
CLV_PCSK_SKI1_1	236	240	PF00082	0.537
CLV_PCSK_SKI1_1	24	28	PF00082	0.550
CLV_PCSK_SKI1_1	285	289	PF00082	0.545
CLV_PCSK_SKI1_1	521	525	PF00082	0.563
CLV_PCSK_SKI1_1	722	726	PF00082	0.557
CLV_PCSK_SKI1_1	729	733	PF00082	0.519
CLV_PCSK_SKI1_1	791	795	PF00082	0.388
CLV_PCSK_SKI1_1	799	803	PF00082	0.404
DEG_APCC_DBOX_1	228	236	PF00400	0.541
DEG_APCC_DBOX_1	428	436	PF00400	0.464
DEG_Nend_UBRbox_3	1	3	PF02207	0.551
DEG_SCF_FBW7_1	43	48	PF00400	0.550
DEG_SPOP_SBC_1	55	59	PF00917	0.569
DEG_SPOP_SBC_1	93	97	PF00917	0.571
DOC_CDC14_PxL_1	412	420	PF14671	0.550
DOC_CKS1_1	346	351	PF01111	0.512
DOC_CKS1_1	723	728	PF01111	0.558
DOC_CKS1_1	730	735	PF01111	0.519
DOC_CYCLIN_RxL_1	21	30	PF00134	0.547
DOC_CYCLIN_yCln2_LP_2	188	194	PF00134	0.545
DOC_MAPK_gen_1	226	234	PF00069	0.541
DOC_MAPK_gen_1	424	432	PF00069	0.460
DOC_MAPK_gen_1	463	472	PF00069	0.431
DOC_MIT_MIM_1	455	466	PF04212	0.436
DOC_PP1_RVXF_1	234	241	PF00149	0.538
DOC_PP1_RVXF_1	809	816	PF00149	0.409
DOC_PP2B_LxvP_1	320	323	PF13499	0.527
DOC_PP4_FxxP_1	759	762	PF00568	0.448
DOC_USP7_MATH_1	118	122	PF00917	0.604
DOC_USP7_MATH_1	199	203	PF00917	0.544
DOC_USP7_MATH_1	38	42	PF00917	0.584
DOC_USP7_MATH_1	400	404	PF00917	0.626
DOC_USP7_MATH_1	45	49	PF00917	0.587
DOC_USP7_MATH_1	482	486	PF00917	0.473
DOC_USP7_MATH_1	506	510	PF00917	0.773
DOC_USP7_MATH_1	55	59	PF00917	0.573
DOC_USP7_MATH_1	677	681	PF00917	0.579
DOC_USP7_MATH_1	682	686	PF00917	0.637
DOC_USP7_MATH_1	94	98	PF00917	0.647
DOC_USP7_UBL2_3	24	28	PF12436	0.550
DOC_WW_Pin1_4	121	126	PF00397	0.596
DOC_WW_Pin1_4	13	18	PF00397	0.784
DOC_WW_Pin1_4	295	300	PF00397	0.598
DOC_WW_Pin1_4	345	350	PF00397	0.566
DOC_WW_Pin1_4	351	356	PF00397	0.539
DOC_WW_Pin1_4	41	46	PF00397	0.613
DOC_WW_Pin1_4	678	683	PF00397	0.571
DOC_WW_Pin1_4	687	692	PF00397	0.591
DOC_WW_Pin1_4	700	705	PF00397	0.560
DOC_WW_Pin1_4	722	727	PF00397	0.589
DOC_WW_Pin1_4	729	734	PF00397	0.521
DOC_WW_Pin1_4	758	763	PF00397	0.452
LIG_14-3-3_CanoR_1	229	235	PF00244	0.540
LIG_14-3-3_CanoR_1	236	241	PF00244	0.478
LIG_14-3-3_CanoR_1	292	300	PF00244	0.578
LIG_14-3-3_CanoR_1	311	317	PF00244	0.472
LIG_14-3-3_CanoR_1	439	447	PF00244	0.463
LIG_14-3-3_CanoR_1	478	482	PF00244	0.486
LIG_14-3-3_CanoR_1	678	682	PF00244	0.570
LIG_14-3-3_CanoR_1	834	842	PF00244	0.429
LIG_14-3-3_CanoR_1	870	877	PF00244	0.410
LIG_14-3-3_CanoR_1	900	904	PF00244	0.410
LIG_Actin_WH2_1	884	902	PF00022	0.382
LIG_BRCT_BRCA1_1	744	748	PF00533	0.512
LIG_BRCT_BRCA1_1	755	759	PF00533	0.509
LIG_eIF4E_1	453	459	PF01652	0.441
LIG_FHA_1	274	280	PF00498	0.557
LIG_FHA_1	415	421	PF00498	0.590
LIG_FHA_1	442	448	PF00498	0.463
LIG_FHA_1	48	54	PF00498	0.596
LIG_FHA_1	691	697	PF00498	0.573
LIG_FHA_1	723	729	PF00498	0.743
LIG_FHA_1	730	736	PF00498	0.599
LIG_FHA_1	800	806	PF00498	0.419
LIG_FHA_1	872	878	PF00498	0.402
LIG_FHA_1	94	100	PF00498	0.567
LIG_FHA_2	107	113	PF00498	0.594
LIG_FHA_2	122	128	PF00498	0.513
LIG_FHA_2	137	143	PF00498	0.500
LIG_FHA_2	181	187	PF00498	0.558
LIG_FHA_2	28	34	PF00498	0.534
LIG_FHA_2	396	402	PF00498	0.557
LIG_FHA_2	450	456	PF00498	0.448
LIG_FHA_2	478	484	PF00498	0.455
LIG_FHA_2	836	842	PF00498	0.427
LIG_LIR_Apic_2	480	484	PF02991	0.452
LIG_LIR_Apic_2	502	506	PF02991	0.555
LIG_LIR_Apic_2	756	762	PF02991	0.445
LIG_LIR_Gen_1	183	192	PF02991	0.672
LIG_LIR_Gen_1	258	264	PF02991	0.579
LIG_LIR_Nem_3	183	188	PF02991	0.608
LIG_LIR_Nem_3	249	254	PF02991	0.564
LIG_LIR_Nem_3	258	262	PF02991	0.536
LIG_LIR_Nem_3	381	386	PF02991	0.472
LIG_LIR_Nem_3	616	621	PF02991	0.433
LIG_LIR_Nem_3	66	71	PF02991	0.545
LIG_LIR_Nem_3	746	752	PF02991	0.504
LIG_MYND_1	733	737	PF01753	0.551
LIG_Pex14_1	569	573	PF04695	0.521
LIG_Pex14_1	755	759	PF04695	0.445
LIG_PTB_Apo_2	258	265	PF02174	0.517
LIG_REV1ctd_RIR_1	260	269	PF16727	0.512
LIG_SH2_CRK	352	356	PF00017	0.552
LIG_SH2_GRB2like	259	262	PF00017	0.519
LIG_SH2_NCK_1	352	356	PF00017	0.495
LIG_SH2_STAP1	259	263	PF00017	0.518
LIG_SH2_STAP1	453	457	PF00017	0.443
LIG_SH2_STAP1	490	494	PF00017	0.628
LIG_SH2_STAP1	618	622	PF00017	0.412
LIG_SH2_STAP1	892	896	PF00017	0.376
LIG_SH2_STAT3	621	624	PF00017	0.423
LIG_SH2_STAT5	347	350	PF00017	0.512
LIG_SH2_STAT5	352	355	PF00017	0.440
LIG_SH2_STAT5	476	479	PF00017	0.446
LIG_SH2_STAT5	515	518	PF00017	0.751
LIG_SH2_STAT5	573	576	PF00017	0.409
LIG_SH3_3	14	20	PF00018	0.552
LIG_SH3_3	467	473	PF00018	0.517
LIG_SH3_3	637	643	PF00018	0.566
LIG_SH3_3	676	682	PF00018	0.570
LIG_SH3_3	685	691	PF00018	0.630
LIG_SH3_3	703	709	PF00018	0.600
LIG_SH3_3	720	726	PF00018	0.586
LIG_SH3_3	727	733	PF00018	0.522
LIG_SH3_3	737	743	PF00018	0.451
LIG_TRAF2_1	452	455	PF00917	0.449
LIG_TRAF2_1	594	597	PF00917	0.440
LIG_TRAF2_1	622	625	PF00917	0.402
LIG_UBA3_1	458	464	PF00899	0.431
MOD_CDK_SPxxK_3	722	729	PF00069	0.560
MOD_CK1_1	121	127	PF00069	0.595
MOD_CK1_1	143	149	PF00069	0.743
MOD_CK1_1	16	22	PF00069	0.546
MOD_CK1_1	216	222	PF00069	0.559
MOD_CK1_1	266	272	PF00069	0.518
MOD_CK1_1	29	35	PF00069	0.534
MOD_CK1_1	291	297	PF00069	0.598
MOD_CK1_1	298	304	PF00069	0.532
MOD_CK1_1	387	393	PF00069	0.570
MOD_CK1_1	41	47	PF00069	0.683
MOD_CK1_1	485	491	PF00069	0.512
MOD_CK1_1	57	63	PF00069	0.532
MOD_CK1_1	681	687	PF00069	0.632
MOD_CK1_1	690	696	PF00069	0.655
MOD_CK1_1	904	910	PF00069	0.453
MOD_CK2_1	114	120	PF00069	0.776
MOD_CK2_1	121	127	PF00069	0.551
MOD_CK2_1	136	142	PF00069	0.621
MOD_CK2_1	149	155	PF00069	0.490
MOD_CK2_1	180	186	PF00069	0.561
MOD_CK2_1	27	33	PF00069	0.536
MOD_CK2_1	449	455	PF00069	0.453
MOD_CK2_1	55	61	PF00069	0.566
MOD_CK2_1	573	579	PF00069	0.610
MOD_Cter_Amidation	713	716	PF01082	0.550
MOD_DYRK1A_RPxSP_1	678	682	PF00069	0.570
MOD_DYRK1A_RPxSP_1	722	726	PF00069	0.557
MOD_DYRK1A_RPxSP_1	729	733	PF00069	0.519
MOD_GlcNHglycan	116	119	PF01048	0.574
MOD_GlcNHglycan	142	145	PF01048	0.566
MOD_GlcNHglycan	168	171	PF01048	0.779
MOD_GlcNHglycan	195	198	PF01048	0.553
MOD_GlcNHglycan	201	204	PF01048	0.537
MOD_GlcNHglycan	215	218	PF01048	0.629
MOD_GlcNHglycan	222	225	PF01048	0.610
MOD_GlcNHglycan	251	254	PF01048	0.608
MOD_GlcNHglycan	300	303	PF01048	0.574
MOD_GlcNHglycan	314	317	PF01048	0.679
MOD_GlcNHglycan	328	331	PF01048	0.559
MOD_GlcNHglycan	389	392	PF01048	0.747
MOD_GlcNHglycan	404	407	PF01048	0.512
MOD_GlcNHglycan	47	50	PF01048	0.551
MOD_GlcNHglycan	512	515	PF01048	0.707
MOD_GlcNHglycan	527	530	PF01048	0.502
MOD_GlcNHglycan	651	654	PF01048	0.543
MOD_GlcNHglycan	684	687	PF01048	0.657
MOD_GlcNHglycan	716	719	PF01048	0.644
MOD_GlcNHglycan	814	818	PF01048	0.411
MOD_GlcNHglycan	904	907	PF01048	0.412
MOD_GlcNHglycan	96	99	PF01048	0.644
MOD_GSK3_1	114	121	PF00069	0.780
MOD_GSK3_1	136	143	PF00069	0.652
MOD_GSK3_1	145	152	PF00069	0.638
MOD_GSK3_1	176	183	PF00069	0.655
MOD_GSK3_1	193	200	PF00069	0.462
MOD_GSK3_1	216	223	PF00069	0.762
MOD_GSK3_1	288	295	PF00069	0.582
MOD_GSK3_1	312	319	PF00069	0.749
MOD_GSK3_1	32	39	PF00069	0.739
MOD_GSK3_1	322	329	PF00069	0.616
MOD_GSK3_1	41	48	PF00069	0.549
MOD_GSK3_1	414	421	PF00069	0.507
MOD_GSK3_1	437	444	PF00069	0.462
MOD_GSK3_1	506	513	PF00069	0.557
MOD_GSK3_1	649	656	PF00069	0.613
MOD_GSK3_1	677	684	PF00069	0.571
MOD_GSK3_1	81	88	PF00069	0.633
MOD_GSK3_1	865	872	PF00069	0.412
MOD_N-GLC_1	249	254	PF02516	0.547
MOD_N-GLC_1	499	504	PF02516	0.556
MOD_N-GLC_1	606	611	PF02516	0.431
MOD_N-GLC_1	835	840	PF02516	0.429
MOD_NEK2_1	1	6	PF00069	0.787
MOD_NEK2_1	100	105	PF00069	0.558
MOD_NEK2_1	26	31	PF00069	0.633
MOD_NEK2_1	279	284	PF00069	0.564
MOD_NEK2_1	331	336	PF00069	0.530
MOD_NEK2_1	378	383	PF00069	0.450
MOD_NEK2_1	477	482	PF00069	0.468
MOD_NEK2_1	606	611	PF00069	0.583
MOD_NEK2_1	75	80	PF00069	0.548
MOD_NEK2_1	813	818	PF00069	0.413
MOD_NEK2_1	899	904	PF00069	0.392
MOD_OFUCOSY	321	326	PF10250	0.522
MOD_PIKK_1	607	613	PF00454	0.446
MOD_PIKK_1	620	626	PF00454	0.356
MOD_PIKK_1	735	741	PF00454	0.524
MOD_PIKK_1	791	797	PF00454	0.413
MOD_PIKK_1	8	14	PF00454	0.541
MOD_PIKK_1	835	841	PF00454	0.427
MOD_PIKK_1	85	91	PF00454	0.634
MOD_PIKK_1	871	877	PF00454	0.419
MOD_PKA_2	118	124	PF00069	0.583
MOD_PKA_2	220	226	PF00069	0.557
MOD_PKA_2	291	297	PF00069	0.585
MOD_PKA_2	326	332	PF00069	0.528
MOD_PKA_2	384	390	PF00069	0.515
MOD_PKA_2	441	447	PF00069	0.459
MOD_PKA_2	477	483	PF00069	0.466
MOD_PKA_2	582	588	PF00069	0.518
MOD_PKA_2	607	613	PF00069	0.552
MOD_PKA_2	677	683	PF00069	0.570
MOD_PKA_2	869	875	PF00069	0.411
MOD_PKA_2	899	905	PF00069	0.411
MOD_Plk_1	266	272	PF00069	0.506
MOD_Plk_1	499	505	PF00069	0.556
MOD_Plk_2-3	255	261	PF00069	0.521
MOD_Plk_2-3	449	455	PF00069	0.453
MOD_Plk_2-3	599	605	PF00069	0.472
MOD_Plk_4	230	236	PF00069	0.540
MOD_Plk_4	379	385	PF00069	0.545
MOD_Plk_4	573	579	PF00069	0.402
MOD_ProDKin_1	121	127	PF00069	0.598
MOD_ProDKin_1	13	19	PF00069	0.782
MOD_ProDKin_1	295	301	PF00069	0.599
MOD_ProDKin_1	345	351	PF00069	0.563
MOD_ProDKin_1	41	47	PF00069	0.613
MOD_ProDKin_1	678	684	PF00069	0.572
MOD_ProDKin_1	687	693	PF00069	0.594
MOD_ProDKin_1	700	706	PF00069	0.558
MOD_ProDKin_1	722	728	PF00069	0.590
MOD_ProDKin_1	729	735	PF00069	0.522
MOD_ProDKin_1	758	764	PF00069	0.451
TRG_DiLeu_BaEn_1	454	459	PF01217	0.438
TRG_DiLeu_BaEn_4	454	460	PF01217	0.434
TRG_DiLeu_BaEn_4	894	900	PF01217	0.364
TRG_ENDOCYTIC_2	259	262	PF00928	0.519
TRG_ENDOCYTIC_2	383	386	PF00928	0.482
TRG_ER_diArg_1	188	190	PF00400	0.593
TRG_ER_diArg_1	373	375	PF00400	0.453
TRG_ER_diArg_1	424	426	PF00400	0.516
TRG_ER_diArg_1	429	432	PF00400	0.474
TRG_ER_diArg_1	581	584	PF00400	0.479
TRG_ER_diArg_1	774	776	PF00400	0.406
TRG_ER_diArg_1	832	834	PF00400	0.442
TRG_NLS_MonoExtC_3	462	468	PF00514	0.423
TRG_NLS_MonoExtN_4	461	467	PF00514	0.425
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	433	438	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	463	468	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	566	570	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	601	605	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	889	894	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4L6	Leptomonas seymouri	38%	100%