SH2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8N4_LEIBR

TriTrypDb:

LbrM.16.1110 , LBRM2903_160018600

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8N4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8N4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.601
CLV_C14_Caspase3-7	123	127	PF00656	0.599
CLV_C14_Caspase3-7	195	199	PF00656	0.715
CLV_C14_Caspase3-7	360	364	PF00656	0.824
CLV_C14_Caspase3-7	79	83	PF00656	0.727
CLV_NRD_NRD_1	247	249	PF00675	0.728
CLV_NRD_NRD_1	469	471	PF00675	0.619
CLV_NRD_NRD_1	479	481	PF00675	0.534
CLV_NRD_NRD_1	51	53	PF00675	0.818
CLV_NRD_NRD_1	559	561	PF00675	0.734
CLV_NRD_NRD_1	589	591	PF00675	0.650
CLV_NRD_NRD_1	93	95	PF00675	0.584
CLV_PCSK_FUR_1	258	262	PF00082	0.813
CLV_PCSK_FUR_1	48	52	PF00082	0.813
CLV_PCSK_KEX2_1	220	222	PF00082	0.586
CLV_PCSK_KEX2_1	247	249	PF00082	0.773
CLV_PCSK_KEX2_1	260	262	PF00082	0.731
CLV_PCSK_KEX2_1	469	471	PF00082	0.700
CLV_PCSK_KEX2_1	478	480	PF00082	0.649
CLV_PCSK_KEX2_1	50	52	PF00082	0.813
CLV_PCSK_KEX2_1	559	561	PF00082	0.717
CLV_PCSK_KEX2_1	589	591	PF00082	0.560
CLV_PCSK_KEX2_1	93	95	PF00082	0.584
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.586
CLV_PCSK_PC1ET2_1	260	262	PF00082	0.826
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.685
CLV_PCSK_SKI1_1	248	252	PF00082	0.601
CLV_PCSK_SKI1_1	425	429	PF00082	0.583
DEG_SPOP_SBC_1	570	574	PF00917	0.567
DOC_ANK_TNKS_1	386	393	PF00023	0.569
DOC_CYCLIN_yCln2_LP_2	458	464	PF00134	0.577
DOC_MAPK_gen_1	559	565	PF00069	0.714
DOC_PP1_RVXF_1	444	451	PF00149	0.569
DOC_PP2B_LxvP_1	458	461	PF13499	0.575
DOC_PP4_FxxP_1	540	543	PF00568	0.571
DOC_PP4_MxPP_1	1	4	PF00568	0.571
DOC_PP4_MxPP_1	506	509	PF00568	0.549
DOC_USP7_MATH_1	108	112	PF00917	0.849
DOC_USP7_MATH_1	120	124	PF00917	0.551
DOC_USP7_MATH_1	242	246	PF00917	0.704
DOC_USP7_MATH_1	249	253	PF00917	0.620
DOC_USP7_MATH_1	268	272	PF00917	0.774
DOC_USP7_MATH_1	393	397	PF00917	0.593
DOC_USP7_MATH_1	412	416	PF00917	0.651
DOC_USP7_MATH_1	453	457	PF00917	0.572
DOC_USP7_MATH_1	570	574	PF00917	0.567
DOC_USP7_MATH_2	17	23	PF00917	0.587
DOC_USP7_MATH_2	231	237	PF00917	0.748
DOC_USP7_UBL2_3	478	482	PF12436	0.681
DOC_WW_Pin1_4	118	123	PF00397	0.704
DOC_WW_Pin1_4	13	18	PF00397	0.629
DOC_WW_Pin1_4	149	154	PF00397	0.611
DOC_WW_Pin1_4	168	173	PF00397	0.717
DOC_WW_Pin1_4	220	225	PF00397	0.578
DOC_WW_Pin1_4	408	413	PF00397	0.589
DOC_WW_Pin1_4	538	543	PF00397	0.786
LIG_14-3-3_CanoR_1	273	282	PF00244	0.685
LIG_14-3-3_CanoR_1	491	497	PF00244	0.815
LIG_14-3-3_CanoR_1	559	566	PF00244	0.788
LIG_deltaCOP1_diTrp_1	530	540	PF00928	0.571
LIG_FHA_1	23	29	PF00498	0.567
LIG_FHA_1	443	449	PF00498	0.825
LIG_FHA_1	497	503	PF00498	0.761
LIG_FHA_1	509	515	PF00498	0.644
LIG_FHA_1	57	63	PF00498	0.552
LIG_FHA_1	574	580	PF00498	0.569
LIG_FHA_2	14	20	PF00498	0.676
LIG_FHA_2	252	258	PF00498	0.866
LIG_FHA_2	399	405	PF00498	0.584
LIG_Integrin_RGD_1	101	103	PF01839	0.609
LIG_Integrin_RGD_1	389	391	PF01839	0.571
LIG_LIR_Apic_2	530	536	PF02991	0.573
LIG_LIR_Gen_1	33	40	PF02991	0.507
LIG_LIR_Gen_1	404	412	PF02991	0.583
LIG_LIR_Gen_1	492	502	PF02991	0.549
LIG_LIR_Nem_3	33	37	PF02991	0.506
LIG_LIR_Nem_3	404	410	PF02991	0.585
LIG_LIR_Nem_3	492	497	PF02991	0.556
LIG_LIR_Nem_3	64	70	PF02991	0.798
LIG_PROFILIN_1	2	8	PF00235	0.567
LIG_SH2_CRK	407	411	PF00017	0.590
LIG_SH2_STAP1	207	211	PF00017	0.586
LIG_SH2_STAP1	234	238	PF00017	0.821
LIG_SH2_STAP1	88	92	PF00017	0.595
LIG_SH2_STAT3	421	424	PF00017	0.582
LIG_SH2_STAT3	75	78	PF00017	0.552
LIG_SH2_STAT5	494	497	PF00017	0.559
LIG_SH2_STAT5	586	589	PF00017	0.559
LIG_SH2_STAT5	67	70	PF00017	0.580
LIG_SH3_1	221	227	PF00018	0.849
LIG_SH3_2	585	590	PF14604	0.816
LIG_SH3_3	1	7	PF00018	0.826
LIG_SH3_3	114	120	PF00018	0.628
LIG_SH3_3	151	157	PF00018	0.829
LIG_SH3_3	221	227	PF00018	0.798
LIG_SH3_3	297	303	PF00018	0.586
LIG_SH3_3	432	438	PF00018	0.799
LIG_SH3_3	502	508	PF00018	0.802
LIG_SH3_3	512	518	PF00018	0.643
LIG_SH3_3	539	545	PF00018	0.606
LIG_SH3_3	582	588	PF00018	0.817
LIG_SUMO_SIM_par_1	16	22	PF11976	0.590
LIG_TRAF2_1	176	179	PF00917	0.591
LIG_TYR_ITSM	490	497	PF00017	0.559
LIG_WRC_WIRS_1	57	62	PF05994	0.555
MOD_CDC14_SPxK_1	171	174	PF00782	0.710
MOD_CDK_SPxK_1	168	174	PF00069	0.705
MOD_CK1_1	111	117	PF00069	0.711
MOD_CK1_1	22	28	PF00069	0.690
MOD_CK1_1	30	36	PF00069	0.578
MOD_CK1_1	411	417	PF00069	0.721
MOD_CK1_1	498	504	PF00069	0.798
MOD_CK1_1	541	547	PF00069	0.785
MOD_CK1_1	549	555	PF00069	0.741
MOD_CK1_1	569	575	PF00069	0.716
MOD_CK2_1	13	19	PF00069	0.597
MOD_CK2_1	251	257	PF00069	0.723
MOD_CK2_1	398	404	PF00069	0.586
MOD_CK2_1	469	475	PF00069	0.582
MOD_CK2_1	558	564	PF00069	0.827
MOD_CK2_1	58	64	PF00069	0.551
MOD_GlcNHglycan	113	116	PF01048	0.776
MOD_GlcNHglycan	122	125	PF01048	0.712
MOD_GlcNHglycan	186	189	PF01048	0.819
MOD_GlcNHglycan	198	201	PF01048	0.698
MOD_GlcNHglycan	240	243	PF01048	0.666
MOD_GlcNHglycan	283	286	PF01048	0.785
MOD_GlcNHglycan	341	344	PF01048	0.650
MOD_GlcNHglycan	431	435	PF01048	0.572
MOD_GlcNHglycan	553	556	PF01048	0.629
MOD_GlcNHglycan	567	571	PF01048	0.780
MOD_GlcNHglycan	89	93	PF01048	0.738
MOD_GSK3_1	216	223	PF00069	0.624
MOD_GSK3_1	22	29	PF00069	0.716
MOD_GSK3_1	234	241	PF00069	0.690
MOD_GSK3_1	268	275	PF00069	0.601
MOD_GSK3_1	408	415	PF00069	0.692
MOD_GSK3_1	492	499	PF00069	0.810
MOD_GSK3_1	516	523	PF00069	0.562
MOD_GSK3_1	544	551	PF00069	0.574
MOD_GSK3_1	566	573	PF00069	0.572
MOD_N-GLC_1	243	248	PF02516	0.857
MOD_N-GLC_1	453	458	PF02516	0.575
MOD_N-GLC_1	489	494	PF02516	0.817
MOD_NEK2_1	548	553	PF00069	0.610
MOD_NEK2_2	108	113	PF00069	0.594
MOD_PIKK_1	27	33	PF00454	0.532
MOD_PIKK_1	558	564	PF00454	0.686
MOD_PKA_1	469	475	PF00069	0.698
MOD_PKA_1	478	484	PF00069	0.726
MOD_PKA_2	161	167	PF00069	0.808
MOD_PKA_2	272	278	PF00069	0.737
MOD_PKA_2	442	448	PF00069	0.593
MOD_PKA_2	469	475	PF00069	0.586
MOD_PKA_2	478	484	PF00069	0.619
MOD_PKA_2	490	496	PF00069	0.642
MOD_PKA_2	558	564	PF00069	0.827
MOD_Plk_1	102	108	PF00069	0.602
MOD_Plk_1	182	188	PF00069	0.590
MOD_Plk_1	453	459	PF00069	0.688
MOD_Plk_1	489	495	PF00069	0.558
MOD_Plk_2-3	398	404	PF00069	0.586
MOD_Plk_2-3	525	531	PF00069	0.566
MOD_Plk_2-3	58	64	PF00069	0.587
MOD_Plk_4	492	498	PF00069	0.813
MOD_Plk_4	501	507	PF00069	0.653
MOD_ProDKin_1	118	124	PF00069	0.703
MOD_ProDKin_1	13	19	PF00069	0.628
MOD_ProDKin_1	149	155	PF00069	0.610
MOD_ProDKin_1	168	174	PF00069	0.722
MOD_ProDKin_1	220	226	PF00069	0.580
MOD_ProDKin_1	408	414	PF00069	0.591
MOD_ProDKin_1	538	544	PF00069	0.785
TRG_DiLeu_BaEn_1	35	40	PF01217	0.652
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.569
TRG_DiLeu_LyEn_5	35	40	PF01217	0.505
TRG_ENDOCYTIC_2	329	332	PF00928	0.762
TRG_ENDOCYTIC_2	407	410	PF00928	0.596
TRG_ENDOCYTIC_2	494	497	PF00928	0.559
TRG_ENDOCYTIC_2	599	602	PF00928	0.551
TRG_ER_diArg_1	247	249	PF00400	0.721
TRG_ER_diArg_1	386	389	PF00400	0.590
TRG_ER_diArg_1	469	471	PF00400	0.582
TRG_ER_diArg_1	48	51	PF00400	0.796
TRG_ER_diArg_1	588	590	PF00400	0.559
TRG_NLS_MonoCore_2	476	481	PF00514	0.578
TRG_NLS_MonoExtC_3	477	482	PF00514	0.672
TRG_NLS_MonoExtN_4	477	482	PF00514	0.755

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDQ3	Leishmania donovani	51%	95%
A4HX04	Leishmania infantum	52%	96%
E9AQR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	94%
Q4QEQ9	Leishmania major	51%	100%