SAC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8N3_LEIBR

TriTrypDb:

LbrM.16.1100 , LBRM2903_160018400

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8N3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8N3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	440	444	PF00656	0.656
CLV_NRD_NRD_1	105	107	PF00675	0.533
CLV_NRD_NRD_1	201	203	PF00675	0.720
CLV_NRD_NRD_1	260	262	PF00675	0.593
CLV_PCSK_KEX2_1	105	107	PF00082	0.537
CLV_PCSK_KEX2_1	201	203	PF00082	0.720
CLV_PCSK_KEX2_1	362	364	PF00082	0.559
CLV_PCSK_KEX2_1	432	434	PF00082	0.448
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.595
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.421
CLV_PCSK_SKI1_1	215	219	PF00082	0.531
CLV_PCSK_SKI1_1	296	300	PF00082	0.426
CLV_PCSK_SKI1_1	429	433	PF00082	0.540
CLV_PCSK_SKI1_1	489	493	PF00082	0.523
CLV_PCSK_SKI1_1	496	500	PF00082	0.527
DEG_APCC_DBOX_1	221	229	PF00400	0.524
DEG_APCC_DBOX_1	295	303	PF00400	0.437
DEG_SCF_TRCP1_1	168	174	PF00400	0.719
DOC_CYCLIN_RxL_1	293	303	PF00134	0.478
DOC_MAPK_gen_1	144	152	PF00069	0.582
DOC_MAPK_gen_1	405	415	PF00069	0.631
DOC_MAPK_MEF2A_6	119	126	PF00069	0.591
DOC_MAPK_MEF2A_6	408	417	PF00069	0.546
DOC_PP4_FxxP_1	87	90	PF00568	0.501
DOC_USP7_MATH_1	109	113	PF00917	0.460
DOC_USP7_MATH_1	180	184	PF00917	0.762
DOC_USP7_MATH_1	2	6	PF00917	0.714
DOC_USP7_MATH_1	318	322	PF00917	0.721
DOC_USP7_UBL2_3	362	366	PF12436	0.502
DOC_WW_Pin1_4	194	199	PF00397	0.744
DOC_WW_Pin1_4	380	385	PF00397	0.578
DOC_WW_Pin1_4	388	393	PF00397	0.507
DOC_WW_Pin1_4	54	59	PF00397	0.692
LIG_14-3-3_CanoR_1	14	22	PF00244	0.678
LIG_14-3-3_CanoR_1	222	226	PF00244	0.558
LIG_14-3-3_CanoR_1	405	411	PF00244	0.647
LIG_14-3-3_CanoR_1	45	52	PF00244	0.656
LIG_Actin_WH2_2	428	444	PF00022	0.443
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BRCT_BRCA1_1	83	87	PF00533	0.600
LIG_CSL_BTD_1	87	90	PF09270	0.521
LIG_eIF4E_1	482	488	PF01652	0.432
LIG_FHA_1	253	259	PF00498	0.635
LIG_FHA_1	301	307	PF00498	0.690
LIG_FHA_1	412	418	PF00498	0.569
LIG_FHA_1	84	90	PF00498	0.514
LIG_FHA_2	15	21	PF00498	0.677
LIG_LIR_Apic_2	381	385	PF02991	0.521
LIG_LIR_Apic_2	479	485	PF02991	0.656
LIG_LIR_Apic_2	84	90	PF02991	0.515
LIG_LIR_Gen_1	242	252	PF02991	0.464
LIG_LIR_Gen_1	329	340	PF02991	0.563
LIG_LIR_Nem_3	230	236	PF02991	0.487
LIG_LIR_Nem_3	242	247	PF02991	0.417
LIG_LIR_Nem_3	321	326	PF02991	0.636
LIG_LIR_Nem_3	329	335	PF02991	0.524
LIG_LIR_Nem_3	338	343	PF02991	0.405
LIG_LIR_Nem_3	424	428	PF02991	0.619
LIG_LIR_Nem_3	478	483	PF02991	0.711
LIG_LYPXL_S_1	189	193	PF13949	0.511
LIG_LYPXL_yS_3	190	193	PF13949	0.508
LIG_NRBOX	342	348	PF00104	0.470
LIG_PCNA_PIPBox_1	400	409	PF02747	0.529
LIG_PCNA_yPIPBox_3	396	407	PF02747	0.521
LIG_SH2_CRK	249	253	PF00017	0.529
LIG_SH2_CRK	332	336	PF00017	0.547
LIG_SH2_CRK	382	386	PF00017	0.605
LIG_SH2_CRK	407	411	PF00017	0.500
LIG_SH2_CRK	428	432	PF00017	0.598
LIG_SH2_NCK_1	382	386	PF00017	0.560
LIG_SH2_SRC	166	169	PF00017	0.679
LIG_SH2_STAP1	241	245	PF00017	0.430
LIG_SH2_STAT3	263	266	PF00017	0.427
LIG_SH2_STAT5	102	105	PF00017	0.600
LIG_SH2_STAT5	234	237	PF00017	0.466
LIG_SH2_STAT5	263	266	PF00017	0.427
LIG_SH2_STAT5	382	385	PF00017	0.508
LIG_SH3_3	21	27	PF00018	0.730
LIG_SH3_3	303	309	PF00018	0.692
LIG_SH3_3	86	92	PF00018	0.525
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.611
LIG_SUMO_SIM_par_1	278	284	PF11976	0.611
LIG_TRAF2_1	227	230	PF00917	0.568
LIG_TRFH_1	501	505	PF08558	0.562
LIG_TYR_ITIM	330	335	PF00017	0.543
LIG_TYR_ITIM	426	431	PF00017	0.581
LIG_UBA3_1	142	147	PF00899	0.597
LIG_UBA3_1	487	496	PF00899	0.629
LIG_WRC_WIRS_1	422	427	PF05994	0.357
MOD_CDK_SPxxK_3	194	201	PF00069	0.519
MOD_CK1_1	129	135	PF00069	0.551
MOD_CK1_1	197	203	PF00069	0.705
MOD_CK1_1	211	217	PF00069	0.582
MOD_CK1_1	224	230	PF00069	0.554
MOD_CK1_1	5	11	PF00069	0.684
MOD_CK1_1	59	65	PF00069	0.573
MOD_CK2_1	14	20	PF00069	0.671
MOD_CK2_1	224	230	PF00069	0.537
MOD_CMANNOS	387	390	PF00535	0.631
MOD_Cter_Amidation	259	262	PF01082	0.539
MOD_GlcNHglycan	107	110	PF01048	0.449
MOD_GlcNHglycan	167	171	PF01048	0.708
MOD_GlcNHglycan	178	181	PF01048	0.635
MOD_GlcNHglycan	204	207	PF01048	0.621
MOD_GlcNHglycan	240	244	PF01048	0.475
MOD_GlcNHglycan	332	335	PF01048	0.588
MOD_GlcNHglycan	450	453	PF01048	0.642
MOD_GlcNHglycan	58	61	PF01048	0.671
MOD_GlcNHglycan	68	71	PF01048	0.744
MOD_GlcNHglycan	78	81	PF01048	0.720
MOD_GSK3_1	1	8	PF00069	0.637
MOD_GSK3_1	105	112	PF00069	0.519
MOD_GSK3_1	171	178	PF00069	0.733
MOD_GSK3_1	193	200	PF00069	0.691
MOD_GSK3_1	217	224	PF00069	0.597
MOD_GSK3_1	248	255	PF00069	0.537
MOD_GSK3_1	72	79	PF00069	0.669
MOD_N-GLC_1	109	114	PF02516	0.568
MOD_N-GLC_1	126	131	PF02516	0.464
MOD_N-GLC_1	28	33	PF02516	0.721
MOD_N-GLC_1	318	323	PF02516	0.687
MOD_N-GLC_1	330	335	PF02516	0.488
MOD_NEK2_1	1	6	PF00069	0.720
MOD_NEK2_1	115	120	PF00069	0.603
MOD_NEK2_1	126	131	PF00069	0.503
MOD_NEK2_1	143	148	PF00069	0.435
MOD_NEK2_1	171	176	PF00069	0.757
MOD_NEK2_1	193	198	PF00069	0.725
MOD_NEK2_1	217	222	PF00069	0.654
MOD_NEK2_1	487	492	PF00069	0.534
MOD_NEK2_1	73	78	PF00069	0.502
MOD_NEK2_2	437	442	PF00069	0.480
MOD_PIKK_1	2	8	PF00454	0.682
MOD_PIKK_1	81	87	PF00454	0.689
MOD_PK_1	248	254	PF00069	0.496
MOD_PKA_1	105	111	PF00069	0.557
MOD_PKA_2	105	111	PF00069	0.458
MOD_PKA_2	13	19	PF00069	0.713
MOD_PKA_2	143	149	PF00069	0.559
MOD_PKA_2	221	227	PF00069	0.599
MOD_PKA_2	448	454	PF00069	0.608
MOD_PKA_2	459	465	PF00069	0.591
MOD_PKA_2	65	71	PF00069	0.771
MOD_Plk_1	109	115	PF00069	0.555
MOD_Plk_1	171	177	PF00069	0.759
MOD_Plk_1	239	245	PF00069	0.425
MOD_Plk_1	318	324	PF00069	0.681
MOD_Plk_1	330	336	PF00069	0.488
MOD_Plk_4	254	260	PF00069	0.600
MOD_Plk_4	421	427	PF00069	0.392
MOD_Plk_4	73	79	PF00069	0.546
MOD_Plk_4	83	89	PF00069	0.587
MOD_ProDKin_1	194	200	PF00069	0.745
MOD_ProDKin_1	380	386	PF00069	0.570
MOD_ProDKin_1	388	394	PF00069	0.496
MOD_ProDKin_1	54	60	PF00069	0.693
MOD_SUMO_rev_2	359	367	PF00179	0.651
TRG_DiLeu_BaEn_1	231	236	PF01217	0.504
TRG_DiLeu_BaEn_1	275	280	PF01217	0.501
TRG_ENDOCYTIC_2	190	193	PF00928	0.508
TRG_ENDOCYTIC_2	233	236	PF00928	0.473
TRG_ENDOCYTIC_2	249	252	PF00928	0.463
TRG_ENDOCYTIC_2	332	335	PF00928	0.537
TRG_ENDOCYTIC_2	407	410	PF00928	0.514
TRG_ENDOCYTIC_2	428	431	PF00928	0.556
TRG_ER_diArg_1	201	203	PF00400	0.707
TRG_ER_diArg_1	372	375	PF00400	0.592
TRG_ER_diArg_1	395	398	PF00400	0.561
TRG_ER_diArg_1	44	47	PF00400	0.624
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	296	301	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM4	Leptomonas seymouri	69%	100%
A0A0S4KPP2	Bodo saltans	33%	100%
A0A1X0NYW7	Trypanosomatidae	44%	100%
A0A3S7WU15	Leishmania donovani	83%	99%
A0A422NAT9	Trypanosoma rangeli	44%	100%
A4HX03	Leishmania infantum	83%	99%
C9ZW04	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AQR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QER0	Leishmania major	80%	100%