Ubiquitin-fold modifier 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin fold modifier protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8N2_LEIBR

TriTrypDb:

LbrM.16.1090 , LBRM2903_160018300

Length:

106

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8N2

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0019538	protein metabolic process	3	8
GO:0032446	protein modification by small protein conjugation	6	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044238	primary metabolic process	2	8
GO:0070647	protein modification by small protein conjugation or removal	5	8
GO:0071569	protein ufmylation	7	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	66	70	PF00656	0.434
CLV_PCSK_SKI1_1	22	26	PF00082	0.239
DEG_Nend_UBRbox_1	1	4	PF02207	0.475
DOC_PP1_RVXF_1	16	22	PF00149	0.267
DOC_USP7_MATH_1	14	18	PF00917	0.544
LIG_14-3-3_CanoR_1	22	32	PF00244	0.434
LIG_14-3-3_CanoR_1	97	103	PF00244	0.530
LIG_BRCT_BRCA1_1	29	33	PF00533	0.458
LIG_FHA_1	18	24	PF00498	0.458
LIG_FHA_1	43	49	PF00498	0.434
LIG_FHA_2	64	70	PF00498	0.447
LIG_LIR_Nem_3	20	24	PF02991	0.434
LIG_LIR_Nem_3	30	36	PF02991	0.439
LIG_LIR_Nem_3	81	86	PF02991	0.507
LIG_SUMO_SIM_par_1	101	106	PF11976	0.466
LIG_SUMO_SIM_par_1	34	41	PF11976	0.434
LIG_TRAF2_1	51	54	PF00917	0.434
MOD_CK1_1	17	23	PF00069	0.260
MOD_CK1_1	27	33	PF00069	0.280
MOD_CK1_1	59	65	PF00069	0.270
MOD_CK2_1	34	40	PF00069	0.267
MOD_GlcNHglycan	14	17	PF01048	0.391
MOD_GlcNHglycan	9	12	PF01048	0.690
MOD_GSK3_1	23	30	PF00069	0.272
MOD_GSK3_1	59	66	PF00069	0.270
MOD_NEK2_1	63	68	PF00069	0.276
MOD_PIKK_1	27	33	PF00454	0.267
MOD_PK_1	34	40	PF00069	0.267
MOD_Plk_4	78	84	PF00069	0.360
MOD_Plk_4	98	104	PF00069	0.422
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.267

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HW33	Leptomonas seymouri	98%	100%
A0A0S4JBR9	Bodo saltans	88%	72%
A0A3S5H6Y2	Leishmania donovani	90%	92%
A4HX02	Leishmania infantum	90%	92%
A8D888	Artemia franciscana	62%	100%
A8DYH2	Drosophila melanogaster	57%	100%
A8Q8M5	Brugia malayi	57%	100%
B0G186	Dictyostelium discoideum	57%	100%
B0WK43	Culex quinquefasciatus	60%	100%
B3DL37	Xenopus tropicalis	56%	100%
B4GBR1	Drosophila persimilis	58%	100%
B4JVK9	Drosophila grimshawi	58%	100%
B4KSR4	Drosophila mojavensis	58%	100%
B4LP65	Drosophila virilis	58%	100%
B5E0K3	Drosophila pseudoobscura pseudoobscura	58%	100%
B5LVL2	Columba livia	59%	100%
B9ENM6	Salmo salar	59%	100%
C1BJ98	Osmerus mordax	59%	100%
C9ZW05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	90%	100%
E9AQR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	93%
P34661	Caenorhabditis elegans	55%	100%
P61960	Homo sapiens	56%	100%
P61961	Mus musculus	56%	100%
Q09JK2	Argas monolakensis	55%	100%
Q176V0	Aedes aegypti	60%	100%
Q2KJG2	Bos taurus	58%	100%
Q4N927	Theileria parva	54%	100%
Q4R4I2	Macaca fascicularis	56%	100%
Q5BJP3	Rattus norvegicus	58%	100%
Q5PU89	Chlamydomonas incerta	62%	100%
Q5R4N5	Pongo abelii	56%	100%
Q5RJW4	Xenopus laevis	56%	100%
Q5ZMK7	Gallus gallus	58%	100%
Q61E22	Caenorhabditis briggsae	57%	100%
Q7PXE2	Anopheles gambiae	59%	100%
Q803Y4	Danio rerio	58%	100%
Q94DM8	Oryza sativa subsp. japonica	60%	100%
Q94EY2	Chlamydomonas reinhardtii	60%	100%
Q9CA23	Arabidopsis thaliana	58%	100%