Stealth_CR3 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3184), putative

Species:

Leishmania braziliensis

UniProt:

A4H8M8_LEIBR

TriTrypDb:

LbrM.16.1050 , LBRM2903_160017500

Length:

388

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8M8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8M8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016740	transferase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.504
CLV_NRD_NRD_1	22	24	PF00675	0.658
CLV_NRD_NRD_1	267	269	PF00675	0.675
CLV_NRD_NRD_1	60	62	PF00675	0.778
CLV_PCSK_FUR_1	58	62	PF00082	0.765
CLV_PCSK_KEX2_1	267	269	PF00082	0.675
CLV_PCSK_KEX2_1	60	62	PF00082	0.778
CLV_PCSK_SKI1_1	138	142	PF00082	0.690
CLV_PCSK_SKI1_1	229	233	PF00082	0.724
CLV_PCSK_SKI1_1	26	30	PF00082	0.627
CLV_PCSK_SKI1_1	267	271	PF00082	0.479
CLV_PCSK_SKI1_1	313	317	PF00082	0.668
DEG_APCC_DBOX_1	266	274	PF00400	0.496
DEG_Nend_Nbox_1	1	3	PF02207	0.291
DOC_CKS1_1	145	150	PF01111	0.757
DOC_CYCLIN_yCln2_LP_2	28	34	PF00134	0.468
DOC_MAPK_gen_1	113	122	PF00069	0.703
DOC_MAPK_gen_1	21	30	PF00069	0.468
DOC_MAPK_HePTP_8	141	153	PF00069	0.750
DOC_MAPK_MEF2A_6	144	153	PF00069	0.766
DOC_MAPK_MEF2A_6	210	217	PF00069	0.645
DOC_MAPK_MEF2A_6	23	32	PF00069	0.468
DOC_PP1_RVXF_1	350	357	PF00149	0.636
DOC_PP2B_LxvP_1	28	31	PF13499	0.468
DOC_PP2B_LxvP_1	316	319	PF13499	0.639
DOC_PP4_FxxP_1	145	148	PF00568	0.743
DOC_USP7_MATH_1	305	309	PF00917	0.698
DOC_USP7_MATH_1	360	364	PF00917	0.733
DOC_WW_Pin1_4	144	149	PF00397	0.738
DOC_WW_Pin1_4	43	48	PF00397	0.703
LIG_14-3-3_CanoR_1	214	218	PF00244	0.647
LIG_14-3-3_CanoR_1	384	388	PF00244	0.775
LIG_BIR_III_2	66	70	PF00653	0.735
LIG_BIR_III_4	271	275	PF00653	0.522
LIG_BRCT_BRCA1_1	172	176	PF00533	0.689
LIG_BRCT_BRCA1_1	45	49	PF00533	0.706
LIG_FHA_1	115	121	PF00498	0.499
LIG_FHA_1	299	305	PF00498	0.477
LIG_FHA_1	320	326	PF00498	0.687
LIG_FHA_1	366	372	PF00498	0.731
LIG_FHA_1	69	75	PF00498	0.791
LIG_FHA_2	156	162	PF00498	0.607
LIG_FHA_2	222	228	PF00498	0.564
LIG_FHA_2	244	250	PF00498	0.520
LIG_FHA_2	255	261	PF00498	0.446
LIG_FHA_2	5	11	PF00498	0.406
LIG_LIR_Apic_2	368	372	PF02991	0.724
LIG_LIR_Apic_2	382	388	PF02991	0.586
LIG_LIR_Gen_1	147	157	PF02991	0.724
LIG_LIR_Gen_1	374	383	PF02991	0.730
LIG_LIR_LC3C_4	339	344	PF02991	0.623
LIG_LIR_Nem_3	173	179	PF02991	0.659
LIG_LIR_Nem_3	27	32	PF02991	0.421
LIG_LIR_Nem_3	326	331	PF02991	0.671
LIG_LIR_Nem_3	46	52	PF02991	0.430
LIG_LIR_Nem_3	94	100	PF02991	0.733
LIG_PTB_Apo_2	115	122	PF02174	0.708
LIG_PTB_Phospho_1	115	121	PF10480	0.704
LIG_REV1ctd_RIR_1	2	12	PF16727	0.406
LIG_RPA_C_Fungi	341	353	PF08784	0.600
LIG_SH2_GRB2like	121	124	PF00017	0.717
LIG_SH2_SRC	190	193	PF00017	0.636
LIG_SH2_STAP1	9	13	PF00017	0.308
LIG_SH2_STAT5	121	124	PF00017	0.717
LIG_SH2_STAT5	150	153	PF00017	0.809
LIG_SH2_STAT5	52	55	PF00017	0.734
LIG_SH3_3	274	280	PF00018	0.689
LIG_SH3_3	364	370	PF00018	0.657
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.623
LIG_SUMO_SIM_par_1	321	327	PF11976	0.687
LIG_SUMO_SIM_par_1	339	345	PF11976	0.347
LIG_TRAF2_1	189	192	PF00917	0.630
LIG_WRC_WIRS_1	137	142	PF05994	0.479
MOD_CDK_SPK_2	43	48	PF00069	0.703
MOD_CK1_1	90	96	PF00069	0.677
MOD_CK2_1	126	132	PF00069	0.722
MOD_CK2_1	155	161	PF00069	0.606
MOD_CK2_1	186	192	PF00069	0.609
MOD_CK2_1	221	227	PF00069	0.579
MOD_CK2_1	243	249	PF00069	0.570
MOD_CK2_1	254	260	PF00069	0.586
MOD_CK2_1	4	10	PF00069	0.468
MOD_CK2_1	56	62	PF00069	0.552
MOD_GlcNHglycan	237	240	PF01048	0.783
MOD_GlcNHglycan	307	310	PF01048	0.711
MOD_GlcNHglycan	385	388	PF01048	0.573
MOD_GSK3_1	221	228	PF00069	0.513
MOD_NEK2_1	13	18	PF00069	0.418
MOD_NEK2_1	197	202	PF00069	0.620
MOD_NEK2_1	225	230	PF00069	0.505
MOD_NEK2_1	365	370	PF00069	0.727
MOD_NEK2_1	4	9	PF00069	0.556
MOD_NEK2_1	56	61	PF00069	0.754
MOD_NEK2_2	221	226	PF00069	0.579
MOD_PIKK_1	68	74	PF00454	0.654
MOD_PK_1	87	93	PF00069	0.581
MOD_PKA_2	114	120	PF00069	0.494
MOD_PKA_2	213	219	PF00069	0.658
MOD_PKA_2	225	231	PF00069	0.521
MOD_ProDKin_1	144	150	PF00069	0.746
MOD_ProDKin_1	43	49	PF00069	0.701
MOD_SUMO_rev_2	345	354	PF00179	0.622
TRG_DiLeu_BaEn_1	362	367	PF01217	0.737
TRG_ENDOCYTIC_2	121	124	PF00928	0.717
TRG_ENDOCYTIC_2	150	153	PF00928	0.809
TRG_ENDOCYTIC_2	34	37	PF00928	0.472
TRG_ENDOCYTIC_2	376	379	PF00928	0.692
TRG_ER_diArg_1	18	21	PF00400	0.534
TRG_ER_diArg_1	250	253	PF00400	0.467
TRG_ER_diArg_1	290	293	PF00400	0.563
TRG_ER_diArg_1	58	61	PF00400	0.764

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H8M6	Leishmania braziliensis	96%	100%
E9AGN8	Leishmania infantum	79%	90%