LeishMANIAdb
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Stealth_CR3 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Stealth_CR3 domain-containing protein
Gene product:
Protein of unknown function (DUF3184), putative
Species:
Leishmania braziliensis
UniProt:
A4H8M6_LEIBR
TriTrypDb:
LbrM.16.1030 , LBRM2903_160017500
Length:
550

Annotations

LeishMANIAdb annotations

N-acetylglucosamine-1-phosphotransferase homologous protein. Assumed to be a type II TM protein like its distant relatives.. Signal-anchored glycan biogenesis protein essential for mannose 6-P generation (lysosomal signal for the Metazoan hosts). Family only expended in Leishmaniids.. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 35
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 8
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005794 Golgi apparatus 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 5
GO:0016020 membrane 2 3

Expansion

Sequence features

A4H8M6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8M6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 15
GO:0016740 transferase activity 2 15
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 512 516 PF00656 0.378
CLV_C14_Caspase3-7 74 78 PF00656 0.344
CLV_NRD_NRD_1 103 105 PF00675 0.587
CLV_NRD_NRD_1 149 151 PF00675 0.580
CLV_NRD_NRD_1 152 154 PF00675 0.513
CLV_NRD_NRD_1 187 189 PF00675 0.565
CLV_NRD_NRD_1 225 227 PF00675 0.545
CLV_NRD_NRD_1 432 434 PF00675 0.598
CLV_NRD_NRD_1 62 64 PF00675 0.315
CLV_PCSK_FUR_1 150 154 PF00082 0.498
CLV_PCSK_FUR_1 223 227 PF00082 0.560
CLV_PCSK_KEX2_1 149 151 PF00082 0.526
CLV_PCSK_KEX2_1 152 154 PF00082 0.459
CLV_PCSK_KEX2_1 225 227 PF00082 0.577
CLV_PCSK_KEX2_1 432 434 PF00082 0.598
CLV_PCSK_SKI1_1 153 157 PF00082 0.564
CLV_PCSK_SKI1_1 191 195 PF00082 0.488
CLV_PCSK_SKI1_1 22 26 PF00082 0.532
CLV_PCSK_SKI1_1 303 307 PF00082 0.502
CLV_PCSK_SKI1_1 394 398 PF00082 0.583
CLV_PCSK_SKI1_1 432 436 PF00082 0.468
CLV_PCSK_SKI1_1 478 482 PF00082 0.563
CLV_PCSK_SKI1_1 59 63 PF00082 0.502
CLV_PCSK_SKI1_1 64 68 PF00082 0.436
DEG_APCC_DBOX_1 431 439 PF00400 0.363
DOC_CKS1_1 310 315 PF01111 0.605
DOC_CYCLIN_yCln2_LP_2 193 199 PF00134 0.285
DOC_MAPK_gen_1 110 120 PF00069 0.324
DOC_MAPK_gen_1 186 195 PF00069 0.341
DOC_MAPK_gen_1 20 29 PF00069 0.511
DOC_MAPK_gen_1 278 287 PF00069 0.529
DOC_MAPK_HePTP_8 306 318 PF00069 0.605
DOC_MAPK_MEF2A_6 113 122 PF00069 0.318
DOC_MAPK_MEF2A_6 188 197 PF00069 0.370
DOC_MAPK_MEF2A_6 22 31 PF00069 0.504
DOC_MAPK_MEF2A_6 309 318 PF00069 0.643
DOC_MAPK_MEF2A_6 375 382 PF00069 0.565
DOC_PP1_RVXF_1 515 522 PF00149 0.450
DOC_PP1_SILK_1 59 64 PF00149 0.317
DOC_PP2B_LxvP_1 193 196 PF13499 0.339
DOC_PP2B_LxvP_1 481 484 PF13499 0.470
DOC_PP4_FxxP_1 310 313 PF00568 0.509
DOC_USP7_MATH_1 470 474 PF00917 0.551
DOC_USP7_MATH_1 525 529 PF00917 0.562
DOC_WW_Pin1_4 120 125 PF00397 0.306
DOC_WW_Pin1_4 208 213 PF00397 0.476
DOC_WW_Pin1_4 309 314 PF00397 0.581
LIG_14-3-3_CanoR_1 104 111 PF00244 0.549
LIG_14-3-3_CanoR_1 152 162 PF00244 0.354
LIG_14-3-3_CanoR_1 22 31 PF00244 0.470
LIG_14-3-3_CanoR_1 379 383 PF00244 0.594
LIG_14-3-3_CanoR_1 6 10 PF00244 0.498
LIG_14-3-3_CanoR_1 80 88 PF00244 0.518
LIG_BIR_III_2 231 235 PF00653 0.515
LIG_BIR_III_4 436 440 PF00653 0.392
LIG_BRCT_BRCA1_1 210 214 PF00533 0.400
LIG_BRCT_BRCA1_1 337 341 PF00533 0.625
LIG_FHA_1 234 240 PF00498 0.573
LIG_FHA_1 280 286 PF00498 0.515
LIG_FHA_1 464 470 PF00498 0.367
LIG_FHA_1 485 491 PF00498 0.506
LIG_FHA_1 531 537 PF00498 0.491
LIG_FHA_2 268 274 PF00498 0.464
LIG_FHA_2 321 327 PF00498 0.546
LIG_FHA_2 387 393 PF00498 0.499
LIG_FHA_2 409 415 PF00498 0.583
LIG_FHA_2 420 426 PF00498 0.436
LIG_FHA_2 72 78 PF00498 0.524
LIG_LIR_Apic_2 533 537 PF02991 0.485
LIG_LIR_Gen_1 312 322 PF02991 0.662
LIG_LIR_Gen_1 539 548 PF02991 0.675
LIG_LIR_Gen_1 82 93 PF02991 0.351
LIG_LIR_LC3C_4 504 509 PF02991 0.510
LIG_LIR_Nem_3 177 183 PF02991 0.315
LIG_LIR_Nem_3 192 197 PF02991 0.277
LIG_LIR_Nem_3 211 217 PF02991 0.514
LIG_LIR_Nem_3 259 265 PF02991 0.438
LIG_LIR_Nem_3 312 318 PF02991 0.678
LIG_LIR_Nem_3 338 344 PF02991 0.437
LIG_LIR_Nem_3 44 50 PF02991 0.435
LIG_LIR_Nem_3 491 496 PF02991 0.508
LIG_PTB_Apo_2 280 287 PF02174 0.477
LIG_PTB_Apo_2 29 36 PF02174 0.459
LIG_PTB_Phospho_1 280 286 PF10480 0.527
LIG_PTB_Phospho_1 29 35 PF10480 0.463
LIG_RPA_C_Fungi 506 518 PF08784 0.439
LIG_SH2_CRK 180 184 PF00017 0.386
LIG_SH2_GRB2like 286 289 PF00017 0.499
LIG_SH2_GRB2like 30 33 PF00017 0.535
LIG_SH2_NCK_1 135 139 PF00017 0.389
LIG_SH2_SRC 135 138 PF00017 0.396
LIG_SH2_SRC 315 318 PF00017 0.654
LIG_SH2_SRC 355 358 PF00017 0.517
LIG_SH2_SRC 97 100 PF00017 0.270
LIG_SH2_STAP1 154 158 PF00017 0.397
LIG_SH2_STAT5 162 165 PF00017 0.305
LIG_SH2_STAT5 217 220 PF00017 0.422
LIG_SH2_STAT5 286 289 PF00017 0.499
LIG_SH2_STAT5 315 318 PF00017 0.683
LIG_SH2_STAT5 35 38 PF00017 0.388
LIG_SH2_STAT5 97 100 PF00017 0.520
LIG_SH3_3 115 121 PF00018 0.394
LIG_SH3_3 439 445 PF00018 0.471
LIG_SH3_3 529 535 PF00018 0.466
LIG_SH3_3 63 69 PF00018 0.321
LIG_SUMO_SIM_anti_2 504 510 PF11976 0.470
LIG_SUMO_SIM_anti_2 89 96 PF11976 0.470
LIG_SUMO_SIM_par_1 486 492 PF11976 0.524
LIG_SUMO_SIM_par_1 504 510 PF11976 0.476
LIG_TRAF2_1 354 357 PF00917 0.501
LIG_TYR_ITIM 178 183 PF00017 0.375
LIG_WRC_WIRS_1 302 307 PF05994 0.427
MOD_CDK_SPK_2 208 213 PF00069 0.426
MOD_CK1_1 255 261 PF00069 0.399
MOD_CK2_1 221 227 PF00069 0.333
MOD_CK2_1 267 273 PF00069 0.477
MOD_CK2_1 291 297 PF00069 0.561
MOD_CK2_1 320 326 PF00069 0.502
MOD_CK2_1 351 357 PF00069 0.425
MOD_CK2_1 386 392 PF00069 0.545
MOD_CK2_1 408 414 PF00069 0.615
MOD_CK2_1 419 425 PF00069 0.537
MOD_GlcNHglycan 106 109 PF01048 0.483
MOD_GlcNHglycan 115 118 PF01048 0.501
MOD_GlcNHglycan 402 405 PF01048 0.544
MOD_GlcNHglycan 472 475 PF01048 0.555
MOD_GSK3_1 386 393 PF00069 0.630
MOD_GSK3_1 50 57 PF00069 0.384
MOD_LATS_1 151 157 PF00433 0.365
MOD_N-GLC_1 22 27 PF02516 0.485
MOD_N-GLC_1 267 272 PF02516 0.439
MOD_NEK2_1 169 174 PF00069 0.453
MOD_NEK2_1 221 226 PF00069 0.552
MOD_NEK2_1 362 367 PF00069 0.433
MOD_NEK2_1 390 395 PF00069 0.353
MOD_NEK2_1 530 535 PF00069 0.473
MOD_NEK2_2 386 391 PF00069 0.496
MOD_PIKK_1 233 239 PF00454 0.594
MOD_PK_1 252 258 PF00069 0.322
MOD_PKA_1 104 110 PF00069 0.354
MOD_PKA_2 279 285 PF00069 0.482
MOD_PKA_2 378 384 PF00069 0.525
MOD_PKA_2 390 396 PF00069 0.460
MOD_PKA_2 5 11 PF00069 0.548
MOD_PKA_2 79 85 PF00069 0.360
MOD_PKB_1 20 28 PF00069 0.455
MOD_Plk_1 22 28 PF00069 0.452
MOD_Plk_4 142 148 PF00069 0.389
MOD_Plk_4 50 56 PF00069 0.380
MOD_ProDKin_1 120 126 PF00069 0.309
MOD_ProDKin_1 208 214 PF00069 0.473
MOD_ProDKin_1 309 315 PF00069 0.592
MOD_SUMO_rev_2 101 107 PF00179 0.278
MOD_SUMO_rev_2 510 519 PF00179 0.474
TRG_DiLeu_BaEn_1 527 532 PF01217 0.462
TRG_ENDOCYTIC_2 180 183 PF00928 0.368
TRG_ENDOCYTIC_2 199 202 PF00928 0.311
TRG_ENDOCYTIC_2 286 289 PF00928 0.501
TRG_ENDOCYTIC_2 315 318 PF00928 0.681
TRG_ENDOCYTIC_2 541 544 PF00928 0.556
TRG_ER_diArg_1 148 150 PF00400 0.459
TRG_ER_diArg_1 152 154 PF00400 0.404
TRG_ER_diArg_1 183 186 PF00400 0.360
TRG_ER_diArg_1 19 22 PF00400 0.523
TRG_ER_diArg_1 223 226 PF00400 0.556
TRG_ER_diArg_1 415 418 PF00400 0.379
TRG_ER_diArg_1 455 458 PF00400 0.519

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HR00 Leptomonas seymouri 41% 100%
A0A0N1I2Q7 Leptomonas seymouri 46% 93%
A0A1X0NYY7 Trypanosomatidae 44% 70%
A0A3Q8IJ32 Leishmania donovani 81% 66%
A0A422NAR5 Trypanosoma rangeli 46% 69%
A4H8M8 Leishmania braziliensis 96% 100%
A4H8N0 Leishmania braziliensis 51% 70%
A4HX01 Leishmania infantum 54% 70%
A4I0N5 Leishmania infantum 32% 70%
E9AGN8 Leishmania infantum 81% 100%
E9AGP0 Leishmania infantum 75% 89%
Q4QER4 Leishmania major 77% 100%
Q4QES0 Leishmania major 83% 100%
V5ANJ8 Trypanosoma cruzi 46% 69%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS