Stealth_CR3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF3184), putative

Species:

Leishmania braziliensis

UniProt:

A4H8M4_LEIBR

TriTrypDb:

LbrM.16.1010 , LBRM2903_160017500

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8M4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8M4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.337
CLV_NRD_NRD_1	103	105	PF00675	0.339
CLV_NRD_NRD_1	149	151	PF00675	0.386
CLV_NRD_NRD_1	152	154	PF00675	0.285
CLV_NRD_NRD_1	187	189	PF00675	0.431
CLV_NRD_NRD_1	225	227	PF00675	0.387
CLV_NRD_NRD_1	354	356	PF00675	0.488
CLV_NRD_NRD_1	62	64	PF00675	0.353
CLV_PCSK_FUR_1	150	154	PF00082	0.345
CLV_PCSK_FUR_1	223	227	PF00082	0.376
CLV_PCSK_KEX2_1	149	151	PF00082	0.386
CLV_PCSK_KEX2_1	152	154	PF00082	0.285
CLV_PCSK_KEX2_1	225	227	PF00082	0.392
CLV_PCSK_KEX2_1	354	356	PF00082	0.488
CLV_PCSK_SKI1_1	153	157	PF00082	0.330
CLV_PCSK_SKI1_1	191	195	PF00082	0.482
CLV_PCSK_SKI1_1	22	26	PF00082	0.369
CLV_PCSK_SKI1_1	303	307	PF00082	0.345
CLV_PCSK_SKI1_1	59	63	PF00082	0.359
CLV_PCSK_SKI1_1	64	68	PF00082	0.312
DOC_CKS1_1	310	315	PF01111	0.405
DOC_CYCLIN_yCln2_LP_2	193	199	PF00134	0.227
DOC_MAPK_gen_1	110	120	PF00069	0.378
DOC_MAPK_gen_1	186	195	PF00069	0.230
DOC_MAPK_gen_1	20	29	PF00069	0.434
DOC_MAPK_gen_1	278	287	PF00069	0.344
DOC_MAPK_HePTP_8	306	318	PF00069	0.411
DOC_MAPK_MEF2A_6	113	122	PF00069	0.372
DOC_MAPK_MEF2A_6	188	197	PF00069	0.231
DOC_MAPK_MEF2A_6	22	31	PF00069	0.338
DOC_MAPK_MEF2A_6	309	318	PF00069	0.437
DOC_PP1_SILK_1	59	64	PF00149	0.359
DOC_PP2B_LxvP_1	193	196	PF13499	0.227
DOC_PP4_FxxP_1	310	313	PF00568	0.381
DOC_WW_Pin1_4	120	125	PF00397	0.343
DOC_WW_Pin1_4	208	213	PF00397	0.457
DOC_WW_Pin1_4	309	314	PF00397	0.383
LIG_14-3-3_CanoR_1	104	111	PF00244	0.350
LIG_14-3-3_CanoR_1	152	162	PF00244	0.334
LIG_14-3-3_CanoR_1	22	31	PF00244	0.303
LIG_14-3-3_CanoR_1	6	10	PF00244	0.399
LIG_14-3-3_CanoR_1	80	88	PF00244	0.349
LIG_BIR_III_2	231	235	PF00653	0.451
LIG_BRCT_BRCA1_1	210	214	PF00533	0.300
LIG_BRCT_BRCA1_1	337	341	PF00533	0.436
LIG_FHA_1	234	240	PF00498	0.415
LIG_FHA_1	280	286	PF00498	0.574
LIG_FHA_2	268	274	PF00498	0.338
LIG_FHA_2	321	327	PF00498	0.528
LIG_FHA_2	72	78	PF00498	0.564
LIG_LIR_Gen_1	312	322	PF02991	0.589
LIG_LIR_Gen_1	82	93	PF02991	0.306
LIG_LIR_Nem_3	177	183	PF02991	0.265
LIG_LIR_Nem_3	192	197	PF02991	0.243
LIG_LIR_Nem_3	211	217	PF02991	0.300
LIG_LIR_Nem_3	259	265	PF02991	0.317
LIG_LIR_Nem_3	312	318	PF02991	0.575
LIG_LIR_Nem_3	338	344	PF02991	0.429
LIG_LIR_Nem_3	44	50	PF02991	0.461
LIG_PTB_Apo_2	280	287	PF02174	0.328
LIG_PTB_Apo_2	29	36	PF02174	0.330
LIG_PTB_Phospho_1	280	286	PF10480	0.332
LIG_PTB_Phospho_1	29	35	PF10480	0.331
LIG_SH2_CRK	180	184	PF00017	0.231
LIG_SH2_GRB2like	286	289	PF00017	0.302
LIG_SH2_GRB2like	30	33	PF00017	0.331
LIG_SH2_NCK_1	135	139	PF00017	0.372
LIG_SH2_SRC	135	138	PF00017	0.380
LIG_SH2_SRC	315	318	PF00017	0.720
LIG_SH2_SRC	97	100	PF00017	0.324
LIG_SH2_STAP1	154	158	PF00017	0.314
LIG_SH2_STAT5	162	165	PF00017	0.227
LIG_SH2_STAT5	217	220	PF00017	0.314
LIG_SH2_STAT5	286	289	PF00017	0.302
LIG_SH2_STAT5	315	318	PF00017	0.772
LIG_SH2_STAT5	35	38	PF00017	0.313
LIG_SH2_STAT5	97	100	PF00017	0.324
LIG_SH3_3	115	121	PF00018	0.373
LIG_SH3_3	63	69	PF00018	0.337
LIG_SUMO_SIM_anti_2	89	96	PF11976	0.304
LIG_TYR_ITIM	178	183	PF00017	0.231
LIG_WRC_WIRS_1	302	307	PF05994	0.344
MOD_CDK_SPK_2	208	213	PF00069	0.301
MOD_CK1_1	255	261	PF00069	0.348
MOD_CK2_1	221	227	PF00069	0.359
MOD_CK2_1	267	273	PF00069	0.334
MOD_CK2_1	291	297	PF00069	0.365
MOD_CK2_1	320	326	PF00069	0.524
MOD_Cter_Amidation	352	355	PF01082	0.482
MOD_GlcNHglycan	106	109	PF01048	0.339
MOD_GlcNHglycan	115	118	PF01048	0.369
MOD_GlcNHglycan	351	354	PF01048	0.475
MOD_GSK3_1	50	57	PF00069	0.437
MOD_LATS_1	151	157	PF00433	0.335
MOD_N-GLC_1	22	27	PF02516	0.359
MOD_N-GLC_1	267	272	PF02516	0.331
MOD_NEK2_1	169	174	PF00069	0.282
MOD_NEK2_1	221	226	PF00069	0.354
MOD_PIKK_1	233	239	PF00454	0.416
MOD_PK_1	252	258	PF00069	0.346
MOD_PKA_1	104	110	PF00069	0.343
MOD_PKA_2	279	285	PF00069	0.578
MOD_PKA_2	5	11	PF00069	0.384
MOD_PKA_2	79	85	PF00069	0.281
MOD_PKB_1	20	28	PF00069	0.354
MOD_Plk_1	22	28	PF00069	0.350
MOD_Plk_4	142	148	PF00069	0.405
MOD_Plk_4	50	56	PF00069	0.418
MOD_ProDKin_1	120	126	PF00069	0.344
MOD_ProDKin_1	208	214	PF00069	0.455
MOD_ProDKin_1	309	315	PF00069	0.393
MOD_SUMO_rev_2	101	107	PF00179	0.406
TRG_ENDOCYTIC_2	180	183	PF00928	0.378
TRG_ENDOCYTIC_2	199	202	PF00928	0.201
TRG_ENDOCYTIC_2	286	289	PF00928	0.302
TRG_ENDOCYTIC_2	315	318	PF00928	0.488
TRG_ER_diArg_1	148	150	PF00400	0.384
TRG_ER_diArg_1	152	154	PF00400	0.411
TRG_ER_diArg_1	183	186	PF00400	0.227
TRG_ER_diArg_1	19	22	PF00400	0.371
TRG_ER_diArg_1	223	226	PF00400	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HR00	Leptomonas seymouri	41%	95%