Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H8M3_LEIBR

TriTrypDb:

LbrM.16.1000 , LBRM2903_160016500

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0016592	mediator complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H8M3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8M3

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6
GO:0004693	cyclin-dependent protein serine/threonine kinase activity	5	1
GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	5	1
GO:0097472	cyclin-dependent protein kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_FUR_1	97	101	PF00082	0.506
CLV_PCSK_KEX2_1	358	360	PF00082	0.506
CLV_PCSK_KEX2_1	36	38	PF00082	0.506
CLV_PCSK_KEX2_1	91	93	PF00082	0.506
CLV_PCSK_KEX2_1	99	101	PF00082	0.374
CLV_PCSK_PC1ET2_1	358	360	PF00082	0.506
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.506
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.506
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.374
CLV_PCSK_SKI1_1	109	113	PF00082	0.341
CLV_PCSK_SKI1_1	130	134	PF00082	0.371
CLV_PCSK_SKI1_1	272	276	PF00082	0.492
CLV_PCSK_SKI1_1	391	395	PF00082	0.346
CLV_PCSK_SKI1_1	99	103	PF00082	0.506
CLV_Separin_Metazoa	413	417	PF03568	0.253
DEG_APCC_DBOX_1	108	116	PF00400	0.506
DOC_CYCLIN_RxL_1	96	105	PF00134	0.506
DOC_MAPK_gen_1	130	139	PF00069	0.506
DOC_MAPK_gen_1	358	366	PF00069	0.253
DOC_MAPK_gen_1	59	69	PF00069	0.413
DOC_MAPK_gen_1	6	13	PF00069	0.506
DOC_MAPK_JIP1_4	207	213	PF00069	0.376
DOC_MAPK_MEF2A_6	133	141	PF00069	0.506
DOC_MAPK_MEF2A_6	207	215	PF00069	0.358
DOC_PP1_RVXF_1	270	276	PF00149	0.506
DOC_PP1_RVXF_1	29	36	PF00149	0.506
DOC_PP4_FxxP_1	389	392	PF00568	0.506
DOC_PP4_FxxP_1	74	77	PF00568	0.506
DOC_USP7_MATH_1	151	155	PF00917	0.643
DOC_USP7_MATH_1	179	183	PF00917	0.750
DOC_USP7_MATH_1	374	378	PF00917	0.506
DOC_USP7_MATH_2	181	187	PF00917	0.542
DOC_USP7_UBL2_3	8	12	PF12436	0.506
DOC_WW_Pin1_4	149	154	PF00397	0.754
DOC_WW_Pin1_4	192	197	PF00397	0.580
DOC_WW_Pin1_4	239	244	PF00397	0.506
DOC_WW_Pin1_4	290	295	PF00397	0.506
LIG_14-3-3_CanoR_1	184	188	PF00244	0.541
LIG_14-3-3_CanoR_1	359	365	PF00244	0.506
LIG_14-3-3_CanoR_1	37	47	PF00244	0.506
LIG_14-3-3_CanoR_1	375	383	PF00244	0.311
LIG_14-3-3_CanoR_1	426	433	PF00244	0.506
LIG_APCC_ABBAyCdc20_2	125	131	PF00400	0.506
LIG_BIR_II_1	1	5	PF00653	0.502
LIG_BRCT_BRCA1_1	184	188	PF00533	0.541
LIG_deltaCOP1_diTrp_1	257	266	PF00928	0.506
LIG_deltaCOP1_diTrp_1	386	394	PF00928	0.506
LIG_FAT_LD_1	449	457	PF03623	0.680
LIG_FHA_1	268	274	PF00498	0.506
LIG_FHA_1	27	33	PF00498	0.506
LIG_FHA_1	378	384	PF00498	0.506
LIG_FHA_1	452	458	PF00498	0.675
LIG_FHA_2	39	45	PF00498	0.506
LIG_LIR_Apic_2	237	243	PF02991	0.506
LIG_LIR_Apic_2	249	255	PF02991	0.308
LIG_LIR_Apic_2	380	384	PF02991	0.495
LIG_LIR_Apic_2	386	392	PF02991	0.395
LIG_LIR_Apic_2	71	77	PF02991	0.506
LIG_LIR_Gen_1	145	153	PF02991	0.728
LIG_LIR_Gen_1	68	77	PF02991	0.506
LIG_LIR_Nem_3	145	149	PF02991	0.712
LIG_LIR_Nem_3	15	21	PF02991	0.506
LIG_LIR_Nem_3	68	73	PF02991	0.506
LIG_Pex14_2	70	74	PF04695	0.506
LIG_SH2_CRK	18	22	PF00017	0.506
LIG_SH2_CRK	252	256	PF00017	0.506
LIG_SH2_CRK	361	365	PF00017	0.506
LIG_SH2_CRK	381	385	PF00017	0.176
LIG_SH2_SRC	121	124	PF00017	0.506
LIG_SH2_SRC	421	424	PF00017	0.253
LIG_SH2_SRC	437	440	PF00017	0.578
LIG_SH2_STAP1	231	235	PF00017	0.506
LIG_SH2_STAT5	121	124	PF00017	0.506
LIG_SH2_STAT5	437	440	PF00017	0.578
LIG_SH3_3	138	144	PF00018	0.506
LIG_SH3_3	156	162	PF00018	0.496
LIG_SH3_3	438	444	PF00018	0.598
LIG_SUMO_SIM_anti_2	410	416	PF11976	0.386
LIG_SUMO_SIM_par_1	253	260	PF11976	0.506
LIG_SUMO_SIM_par_1	64	71	PF11976	0.506
LIG_UBA3_1	264	272	PF00899	0.506
LIG_UBA3_1	351	358	PF00899	0.506
LIG_UBA3_1	69	78	PF00899	0.506
MOD_CAAXbox	463	466	PF01239	0.684
MOD_CDC14_SPxK_1	293	296	PF00782	0.506
MOD_CDK_SPxK_1	290	296	PF00069	0.506
MOD_CK1_1	182	188	PF00069	0.543
MOD_CK1_1	301	307	PF00069	0.506
MOD_CK1_1	337	343	PF00069	0.460
MOD_CK1_1	373	379	PF00069	0.458
MOD_CK1_1	405	411	PF00069	0.431
MOD_CK2_1	192	198	PF00069	0.558
MOD_CK2_1	39	45	PF00069	0.506
MOD_GlcNHglycan	164	167	PF01048	0.669
MOD_GlcNHglycan	248	251	PF01048	0.506
MOD_GlcNHglycan	371	375	PF01048	0.506
MOD_GlcNHglycan	376	379	PF01048	0.424
MOD_GlcNHglycan	398	401	PF01048	0.506
MOD_GSK3_1	147	154	PF00069	0.746
MOD_GSK3_1	162	169	PF00069	0.542
MOD_GSK3_1	175	182	PF00069	0.588
MOD_GSK3_1	22	29	PF00069	0.506
MOD_GSK3_1	246	253	PF00069	0.506
MOD_GSK3_1	301	308	PF00069	0.390
MOD_GSK3_1	335	342	PF00069	0.420
MOD_GSK3_1	370	377	PF00069	0.506
MOD_GSK3_1	421	428	PF00069	0.260
MOD_GSK3_1	452	459	PF00069	0.517
MOD_N-GLC_1	343	348	PF02516	0.253
MOD_NEK2_1	246	251	PF00069	0.492
MOD_NEK2_1	268	273	PF00069	0.365
MOD_NEK2_1	360	365	PF00069	0.506
MOD_NEK2_1	452	457	PF00069	0.530
MOD_NEK2_1	93	98	PF00069	0.431
MOD_PIKK_1	337	343	PF00454	0.506
MOD_PIKK_1	350	356	PF00454	0.291
MOD_PKA_1	229	235	PF00069	0.508
MOD_PKA_2	183	189	PF00069	0.544
MOD_PKA_2	295	301	PF00069	0.506
MOD_PKA_2	313	319	PF00069	0.176
MOD_PKA_2	374	380	PF00069	0.506
MOD_PKA_2	425	431	PF00069	0.506
MOD_Plk_1	182	188	PF00069	0.543
MOD_Plk_4	17	23	PF00069	0.506
MOD_Plk_4	183	189	PF00069	0.544
MOD_Plk_4	234	240	PF00069	0.390
MOD_Plk_4	298	304	PF00069	0.467
MOD_Plk_4	452	458	PF00069	0.675
MOD_ProDKin_1	149	155	PF00069	0.760
MOD_ProDKin_1	192	198	PF00069	0.577
MOD_ProDKin_1	239	245	PF00069	0.506
MOD_ProDKin_1	290	296	PF00069	0.506
MOD_SUMO_rev_2	84	93	PF00179	0.506
TRG_DiLeu_BaEn_1	280	285	PF01217	0.409
TRG_DiLeu_BaEn_1	410	415	PF01217	0.506
TRG_DiLeu_BaEn_1	461	466	PF01217	0.685
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.506
TRG_ENDOCYTIC_2	18	21	PF00928	0.325
TRG_ENDOCYTIC_2	361	364	PF00928	0.506
TRG_ENDOCYTIC_2	7	10	PF00928	0.506
TRG_NES_CRM1_1	210	224	PF08389	0.506
TRG_Pf-PMV_PEXEL_1	100	105	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	391	396	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P759	Leptomonas seymouri	72%	99%
A0A0S4KIN4	Bodo saltans	24%	68%
A0A1X0NYA7	Trypanosomatidae	23%	71%
A0A1X0NZD5	Trypanosomatidae	40%	93%
A0A1X0P018	Trypanosomatidae	28%	84%
A0A3R7NBN7	Trypanosoma rangeli	31%	100%
A0A3S5H6Y0	Leishmania donovani	89%	99%
A0A3S5IQV1	Trypanosoma rangeli	42%	99%
A0A422NT89	Trypanosoma rangeli	23%	71%
A3LUB9	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	24%	100%
A4H9U7	Leishmania braziliensis	23%	92%
A4HWZ4	Leishmania infantum	90%	99%
C9ZLG9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZW07	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A5Q8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AQQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
O61125	Dictyostelium discoideum	25%	100%
P0C661	Caenorhabditis briggsae	28%	76%
P23293	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	71%
P32581	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	72%
P97377	Mus musculus	29%	100%
Q00646	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	30%	100%
Q01917	Crithidia fasciculata	73%	98%
Q0CQK1	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	24%	100%
Q4I5U9	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	26%	86%
Q4QES1	Leishmania major	90%	100%
Q6BV06	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	26%	77%
Q6CRA9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	72%
Q6FQ83	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	25%	70%
Q871M9	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	83%
Q96VK3	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	86%
V5B752	Trypanosoma cruzi	25%	74%
V5D488	Trypanosoma cruzi	42%	100%
V5DCN7	Trypanosoma cruzi	29%	78%