Myosin_tail_1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8M2_LEIBR

TriTrypDb:

LbrM.16.0990 , LBRM2903_160016400

Length:

830

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8M2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.659
CLV_C14_Caspase3-7	747	751	PF00656	0.638
CLV_NRD_NRD_1	118	120	PF00675	0.486
CLV_NRD_NRD_1	278	280	PF00675	0.618
CLV_NRD_NRD_1	311	313	PF00675	0.699
CLV_NRD_NRD_1	373	375	PF00675	0.522
CLV_NRD_NRD_1	541	543	PF00675	0.527
CLV_NRD_NRD_1	549	551	PF00675	0.521
CLV_NRD_NRD_1	604	606	PF00675	0.569
CLV_NRD_NRD_1	701	703	PF00675	0.525
CLV_NRD_NRD_1	711	713	PF00675	0.524
CLV_NRD_NRD_1	789	791	PF00675	0.584
CLV_NRD_NRD_1	810	812	PF00675	0.596
CLV_PCSK_KEX2_1	118	120	PF00082	0.591
CLV_PCSK_KEX2_1	278	280	PF00082	0.598
CLV_PCSK_KEX2_1	311	313	PF00082	0.697
CLV_PCSK_KEX2_1	461	463	PF00082	0.584
CLV_PCSK_KEX2_1	541	543	PF00082	0.527
CLV_PCSK_KEX2_1	549	551	PF00082	0.521
CLV_PCSK_KEX2_1	579	581	PF00082	0.563
CLV_PCSK_KEX2_1	701	703	PF00082	0.525
CLV_PCSK_KEX2_1	711	713	PF00082	0.524
CLV_PCSK_KEX2_1	789	791	PF00082	0.584
CLV_PCSK_KEX2_1	800	802	PF00082	0.583
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.620
CLV_PCSK_PC1ET2_1	579	581	PF00082	0.632
CLV_PCSK_PC1ET2_1	800	802	PF00082	0.689
CLV_PCSK_SKI1_1	121	125	PF00082	0.588
CLV_PCSK_SKI1_1	154	158	PF00082	0.477
CLV_PCSK_SKI1_1	160	164	PF00082	0.467
CLV_PCSK_SKI1_1	236	240	PF00082	0.627
CLV_PCSK_SKI1_1	321	325	PF00082	0.638
CLV_PCSK_SKI1_1	342	346	PF00082	0.614
CLV_PCSK_SKI1_1	432	436	PF00082	0.622
CLV_PCSK_SKI1_1	521	525	PF00082	0.494
CLV_PCSK_SKI1_1	812	816	PF00082	0.574
CLV_Separin_Metazoa	382	386	PF03568	0.600
CLV_Separin_Metazoa	649	653	PF03568	0.393
DEG_APCC_DBOX_1	159	167	PF00400	0.545
DEG_APCC_DBOX_1	223	231	PF00400	0.397
DEG_APCC_DBOX_1	284	292	PF00400	0.682
DEG_APCC_DBOX_1	431	439	PF00400	0.613
DEG_APCC_DBOX_1	592	600	PF00400	0.370
DEG_APCC_DBOX_1	91	99	PF00400	0.577
DOC_CKS1_1	1	6	PF01111	0.601
DOC_CYCLIN_RxL_1	118	128	PF00134	0.585
DOC_MAPK_gen_1	118	126	PF00069	0.482
DOC_MAPK_gen_1	61	68	PF00069	0.383
DOC_MAPK_gen_1	89	97	PF00069	0.580
DOC_MAPK_MEF2A_6	208	216	PF00069	0.525
DOC_USP7_MATH_1	107	111	PF00917	0.604
DOC_USP7_MATH_1	12	16	PF00917	0.608
DOC_USP7_MATH_1	825	829	PF00917	0.738
DOC_WW_Pin1_4	17	22	PF00397	0.615
LIG_14-3-3_CanoR_1	258	266	PF00244	0.699
LIG_14-3-3_CanoR_1	432	441	PF00244	0.545
LIG_14-3-3_CanoR_1	541	545	PF00244	0.581
LIG_14-3-3_CanoR_1	780	788	PF00244	0.586
LIG_BIR_II_1	1	5	PF00653	0.457
LIG_BIR_III_1	1	5	PF00653	0.457
LIG_BIR_III_3	1	5	PF00653	0.457
LIG_FHA_1	143	149	PF00498	0.475
LIG_FHA_1	193	199	PF00498	0.617
LIG_FHA_1	207	213	PF00498	0.496
LIG_FHA_1	247	253	PF00498	0.628
LIG_FHA_1	279	285	PF00498	0.654
LIG_FHA_1	379	385	PF00498	0.566
LIG_FHA_1	402	408	PF00498	0.434
LIG_FHA_1	461	467	PF00498	0.615
LIG_FHA_1	471	477	PF00498	0.633
LIG_FHA_1	771	777	PF00498	0.551
LIG_FHA_1	86	92	PF00498	0.509
LIG_FHA_2	11	17	PF00498	0.655
LIG_FHA_2	477	483	PF00498	0.555
LIG_FHA_2	508	514	PF00498	0.565
LIG_FHA_2	780	786	PF00498	0.602
LIG_LIR_Gen_1	169	174	PF02991	0.594
LIG_LIR_Nem_3	169	173	PF02991	0.557
LIG_NRBOX	122	128	PF00104	0.467
LIG_NRP_CendR_1	829	830	PF00754	0.516
LIG_RPA_C_Fungi	550	562	PF08784	0.634
LIG_SH2_STAP1	170	174	PF00017	0.553
LIG_SH2_STAT3	141	144	PF00017	0.479
LIG_SH2_STAT3	762	765	PF00017	0.599
LIG_SH2_STAT5	136	139	PF00017	0.547
LIG_SH2_STAT5	440	443	PF00017	0.384
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.611
LIG_SUMO_SIM_par_1	122	128	PF11976	0.509
LIG_TRAF2_1	112	115	PF00917	0.509
LIG_TRAF2_1	179	182	PF00917	0.501
LIG_TRAF2_1	229	232	PF00917	0.649
LIG_TRAF2_1	262	265	PF00917	0.617
LIG_TRAF2_1	296	299	PF00917	0.734
LIG_TRAF2_1	327	330	PF00917	0.661
LIG_TRAF2_1	515	518	PF00917	0.570
LIG_TRAF2_1	543	546	PF00917	0.579
LIG_TRAF2_1	575	578	PF00917	0.640
LIG_TRAF2_1	663	666	PF00917	0.538
LIG_TRAF2_1	783	786	PF00917	0.598
LIG_TRAF2_1	80	83	PF00917	0.590
MOD_CDC14_SPxK_1	20	23	PF00782	0.584
MOD_CDK_SPxK_1	17	23	PF00069	0.643
MOD_CK1_1	110	116	PF00069	0.508
MOD_CK1_1	316	322	PF00069	0.712
MOD_CK1_1	717	723	PF00069	0.669
MOD_CK1_1	779	785	PF00069	0.629
MOD_CK2_1	109	115	PF00069	0.470
MOD_CK2_1	259	265	PF00069	0.602
MOD_CK2_1	280	286	PF00069	0.662
MOD_CK2_1	293	299	PF00069	0.719
MOD_CK2_1	461	467	PF00069	0.587
MOD_CK2_1	507	513	PF00069	0.558
MOD_CK2_1	540	546	PF00069	0.636
MOD_CK2_1	737	743	PF00069	0.637
MOD_CK2_1	779	785	PF00069	0.629
MOD_Cter_Amidation	809	812	PF01082	0.586
MOD_GlcNHglycan	10	13	PF01048	0.512
MOD_GlcNHglycan	463	466	PF01048	0.618
MOD_GlcNHglycan	488	491	PF01048	0.644
MOD_GlcNHglycan	734	737	PF01048	0.697
MOD_GSK3_1	202	209	PF00069	0.597
MOD_GSK3_1	426	433	PF00069	0.496
MOD_GSK3_1	443	450	PF00069	0.472
MOD_GSK3_1	482	489	PF00069	0.618
MOD_GSK3_1	500	507	PF00069	0.577
MOD_GSK3_1	775	782	PF00069	0.583
MOD_GSK3_1	795	802	PF00069	0.395
MOD_GSK3_1	8	15	PF00069	0.631
MOD_N-GLC_1	206	211	PF02516	0.445
MOD_NEK2_1	234	239	PF00069	0.410
MOD_NEK2_1	476	481	PF00069	0.519
MOD_NEK2_1	505	510	PF00069	0.592
MOD_NEK2_1	770	775	PF00069	0.547
MOD_NEK2_1	776	781	PF00069	0.563
MOD_NEK2_1	795	800	PF00069	0.579
MOD_PIKK_1	236	242	PF00454	0.616
MOD_PIKK_1	443	449	PF00454	0.639
MOD_PIKK_1	500	506	PF00454	0.580
MOD_PIKK_1	507	513	PF00454	0.508
MOD_PIKK_1	714	720	PF00454	0.571
MOD_PIKK_1	799	805	PF00454	0.737
MOD_PK_1	331	337	PF00069	0.679
MOD_PKA_1	278	284	PF00069	0.659
MOD_PKA_1	311	317	PF00069	0.719
MOD_PKA_1	461	467	PF00069	0.621
MOD_PKA_2	259	265	PF00069	0.700
MOD_PKA_2	278	284	PF00069	0.411
MOD_PKA_2	311	317	PF00069	0.695
MOD_PKA_2	396	402	PF00069	0.526
MOD_PKA_2	413	419	PF00069	0.526
MOD_PKA_2	461	467	PF00069	0.623
MOD_PKA_2	505	511	PF00069	0.635
MOD_PKA_2	540	546	PF00069	0.543
MOD_PKA_2	570	576	PF00069	0.592
MOD_PKA_2	779	785	PF00069	0.629
MOD_Plk_1	132	138	PF00069	0.494
MOD_Plk_1	154	160	PF00069	0.497
MOD_Plk_1	286	292	PF00069	0.470
MOD_Plk_1	331	337	PF00069	0.631
MOD_Plk_1	470	476	PF00069	0.416
MOD_Plk_1	726	732	PF00069	0.669
MOD_Plk_1	749	755	PF00069	0.433
MOD_Plk_1	812	818	PF00069	0.573
MOD_Plk_2-3	280	286	PF00069	0.662
MOD_Plk_2-3	313	319	PF00069	0.673
MOD_Plk_2-3	540	546	PF00069	0.614
MOD_Plk_4	132	138	PF00069	0.554
MOD_Plk_4	144	150	PF00069	0.446
MOD_Plk_4	804	810	PF00069	0.583
MOD_ProDKin_1	17	23	PF00069	0.610
MOD_SUMO_for_1	166	169	PF00179	0.617
MOD_SUMO_rev_2	128	135	PF00179	0.486
MOD_SUMO_rev_2	307	317	PF00179	0.682
MOD_SUMO_rev_2	583	591	PF00179	0.587
TRG_DiLeu_BaEn_1	122	127	PF01217	0.562
TRG_DiLeu_BaEn_3	132	138	PF01217	0.508
TRG_DiLeu_BaEn_4	182	188	PF01217	0.629
TRG_DiLeu_BaEn_4	539	545	PF01217	0.578
TRG_DiLeu_BaEn_4	577	583	PF01217	0.383
TRG_DiLeu_BaEn_4	669	675	PF01217	0.548
TRG_DiLeu_BaEn_4	687	693	PF01217	0.554
TRG_DiLeu_BaLyEn_6	772	777	PF01217	0.594
TRG_ENDOCYTIC_2	170	173	PF00928	0.594
TRG_ER_diArg_1	258	261	PF00400	0.472
TRG_ER_diArg_1	277	279	PF00400	0.706
TRG_ER_diArg_1	310	312	PF00400	0.654
TRG_ER_diArg_1	384	387	PF00400	0.601
TRG_ER_diArg_1	549	551	PF00400	0.622
TRG_ER_diArg_1	651	654	PF00400	0.593
TRG_ER_diArg_1	700	702	PF00400	0.524
TRG_ER_diArg_1	710	712	PF00400	0.529
TRG_ER_diArg_1	788	790	PF00400	0.586
TRG_NES_CRM1_1	90	103	PF08389	0.575
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	331	336	PF00026	0.429
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	521	525	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	542	546	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	549	553	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	580	585	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	605	609	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R5	Leptomonas seymouri	68%	72%
A0A0S4JQ17	Bodo saltans	32%	94%
A0A3R7LSL7	Trypanosoma rangeli	41%	88%
A0A3S7WU05	Leishmania donovani	87%	72%
A4HWZ3	Leishmania infantum	87%	85%
C9ZW08	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	88%
E9AQQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QES2	Leishmania major	87%	100%
V5B8F4	Trypanosoma cruzi	40%	88%