CDC73_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8M1_LEIBR

TriTrypDb:

LbrM.16.0980 , LBRM2903_160016300

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8M1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8M1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.611
CLV_C14_Caspase3-7	278	282	PF00656	0.441
CLV_C14_Caspase3-7	40	44	PF00656	0.384
CLV_C14_Caspase3-7	507	511	PF00656	0.538
CLV_NRD_NRD_1	164	166	PF00675	0.538
CLV_NRD_NRD_1	172	174	PF00675	0.571
CLV_NRD_NRD_1	309	311	PF00675	0.664
CLV_NRD_NRD_1	56	58	PF00675	0.312
CLV_NRD_NRD_1	605	607	PF00675	0.564
CLV_NRD_NRD_1	646	648	PF00675	0.639
CLV_NRD_NRD_1	742	744	PF00675	0.575
CLV_PCSK_FUR_1	644	648	PF00082	0.628
CLV_PCSK_KEX2_1	121	123	PF00082	0.365
CLV_PCSK_KEX2_1	164	166	PF00082	0.491
CLV_PCSK_KEX2_1	172	174	PF00082	0.514
CLV_PCSK_KEX2_1	495	497	PF00082	0.572
CLV_PCSK_KEX2_1	56	58	PF00082	0.312
CLV_PCSK_KEX2_1	646	648	PF00082	0.635
CLV_PCSK_KEX2_1	742	744	PF00082	0.526
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.365
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.572
CLV_PCSK_PC7_1	491	497	PF00082	0.438
CLV_PCSK_SKI1_1	121	125	PF00082	0.569
CLV_PCSK_SKI1_1	247	251	PF00082	0.604
CLV_PCSK_SKI1_1	427	431	PF00082	0.650
CLV_PCSK_SKI1_1	461	465	PF00082	0.564
CLV_PCSK_SKI1_1	479	483	PF00082	0.480
CLV_PCSK_SKI1_1	57	61	PF00082	0.520
CLV_PCSK_SKI1_1	661	665	PF00082	0.622
CLV_PCSK_SKI1_1	703	707	PF00082	0.483
DEG_APCC_DBOX_1	474	482	PF00400	0.474
DEG_APCC_DBOX_1	56	64	PF00400	0.568
DEG_APCC_DBOX_1	656	664	PF00400	0.676
DOC_CYCLIN_RxL_1	244	253	PF00134	0.618
DOC_CYCLIN_RxL_1	475	485	PF00134	0.479
DOC_MAPK_MEF2A_6	475	484	PF00069	0.476
DOC_MAPK_MEF2A_6	750	758	PF00069	0.557
DOC_PP1_RVXF_1	459	465	PF00149	0.543
DOC_PP1_RVXF_1	564	570	PF00149	0.583
DOC_PP2B_LxvP_1	445	448	PF13499	0.494
DOC_PP2B_LxvP_1	678	681	PF13499	0.704
DOC_PP4_FxxP_1	363	366	PF00568	0.410
DOC_USP7_MATH_1	236	240	PF00917	0.765
DOC_USP7_MATH_1	327	331	PF00917	0.696
DOC_USP7_MATH_1	44	48	PF00917	0.499
DOC_USP7_MATH_1	453	457	PF00917	0.591
DOC_USP7_MATH_1	656	660	PF00917	0.601
DOC_WW_Pin1_4	199	204	PF00397	0.762
DOC_WW_Pin1_4	417	422	PF00397	0.644
DOC_WW_Pin1_4	694	699	PF00397	0.444
LIG_14-3-3_CanoR_1	475	479	PF00244	0.415
LIG_14-3-3_CanoR_1	491	495	PF00244	0.402
LIG_14-3-3_CanoR_1	537	545	PF00244	0.719
LIG_14-3-3_CanoR_1	657	661	PF00244	0.662
LIG_Actin_WH2_2	564	582	PF00022	0.599
LIG_APCC_ABBA_1	430	435	PF00400	0.643
LIG_APCC_ABBA_1	583	588	PF00400	0.293
LIG_BIR_II_1	1	5	PF00653	0.408
LIG_BRCT_BRCA1_1	236	240	PF00533	0.536
LIG_Clathr_ClatBox_1	249	253	PF01394	0.570
LIG_eIF4E_1	386	392	PF01652	0.497
LIG_EVH1_1	518	522	PF00568	0.542
LIG_FHA_1	155	161	PF00498	0.522
LIG_FHA_1	296	302	PF00498	0.523
LIG_FHA_1	334	340	PF00498	0.548
LIG_FHA_1	475	481	PF00498	0.406
LIG_FHA_1	53	59	PF00498	0.448
LIG_FHA_1	611	617	PF00498	0.520
LIG_FHA_1	739	745	PF00498	0.456
LIG_FHA_2	103	109	PF00498	0.711
LIG_FHA_2	124	130	PF00498	0.470
LIG_FHA_2	156	162	PF00498	0.447
LIG_FHA_2	189	195	PF00498	0.525
LIG_FHA_2	20	26	PF00498	0.536
LIG_FHA_2	312	318	PF00498	0.655
LIG_FHA_2	38	44	PF00498	0.284
LIG_FHA_2	398	404	PF00498	0.519
LIG_FHA_2	64	70	PF00498	0.646
LIG_HCF-1_HBM_1	725	728	PF13415	0.324
LIG_LIR_Apic_2	288	294	PF02991	0.581
LIG_LIR_Apic_2	361	366	PF02991	0.406
LIG_LIR_Gen_1	265	274	PF02991	0.405
LIG_LIR_Gen_1	350	360	PF02991	0.473
LIG_LIR_Gen_1	498	505	PF02991	0.481
LIG_LIR_Nem_3	245	249	PF02991	0.582
LIG_LIR_Nem_3	265	269	PF02991	0.184
LIG_LIR_Nem_3	350	356	PF02991	0.407
LIG_LIR_Nem_3	367	371	PF02991	0.399
LIG_LIR_Nem_3	383	388	PF02991	0.214
LIG_LIR_Nem_3	420	425	PF02991	0.584
LIG_LIR_Nem_3	492	497	PF02991	0.481
LIG_LIR_Nem_3	498	504	PF02991	0.499
LIG_LIR_Nem_3	584	589	PF02991	0.425
LIG_LIR_Nem_3	725	731	PF02991	0.510
LIG_LIR_Nem_3	88	93	PF02991	0.650
LIG_LYPXL_S_1	89	93	PF13949	0.700
LIG_LYPXL_yS_3	728	731	PF13949	0.580
LIG_LYPXL_yS_3	90	93	PF13949	0.703
LIG_MAD2	461	469	PF02301	0.542
LIG_NRBOX	477	483	PF00104	0.476
LIG_PCNA_PIPBox_1	707	716	PF02747	0.558
LIG_PCNA_yPIPBox_3	305	316	PF02747	0.474
LIG_PCNA_yPIPBox_3	703	714	PF02747	0.524
LIG_Pex14_2	17	21	PF04695	0.476
LIG_Pex14_2	583	587	PF04695	0.413
LIG_RPA_C_Fungi	504	516	PF08784	0.578
LIG_SH2_CRK	246	250	PF00017	0.576
LIG_SH2_CRK	291	295	PF00017	0.375
LIG_SH2_CRK	501	505	PF00017	0.459
LIG_SH2_NCK_1	291	295	PF00017	0.539
LIG_SH2_STAP1	102	106	PF00017	0.726
LIG_SH2_STAP1	152	156	PF00017	0.425
LIG_SH2_STAP1	353	357	PF00017	0.484
LIG_SH2_STAP1	371	375	PF00017	0.392
LIG_SH2_STAP1	386	390	PF00017	0.286
LIG_SH2_STAP1	497	501	PF00017	0.503
LIG_SH2_STAT3	166	169	PF00017	0.565
LIG_SH2_STAT5	154	157	PF00017	0.510
LIG_SH2_STAT5	166	169	PF00017	0.588
LIG_SH2_STAT5	364	367	PF00017	0.435
LIG_SH3_2	681	686	PF14604	0.662
LIG_SH3_3	230	236	PF00018	0.690
LIG_SH3_3	428	434	PF00018	0.650
LIG_SH3_3	460	466	PF00018	0.483
LIG_SH3_3	516	522	PF00018	0.575
LIG_SH3_3	678	684	PF00018	0.653
LIG_SH3_3	754	760	PF00018	0.589
LIG_SUMO_SIM_anti_2	548	553	PF11976	0.565
LIG_SUMO_SIM_anti_2	625	631	PF11976	0.523
LIG_SUMO_SIM_par_1	248	253	PF11976	0.534
LIG_SUMO_SIM_par_1	480	485	PF11976	0.264
LIG_SUMO_SIM_par_1	548	553	PF11976	0.565
LIG_TRAF2_1	168	171	PF00917	0.382
LIG_TRAF2_1	190	193	PF00917	0.775
LIG_TRAF2_1	22	25	PF00917	0.577
LIG_TRAF2_1	226	229	PF00917	0.603
MOD_CK1_1	610	616	PF00069	0.573
MOD_CK1_1	659	665	PF00069	0.630
MOD_CK2_1	102	108	PF00069	0.742
MOD_CK2_1	156	162	PF00069	0.502
MOD_CK2_1	188	194	PF00069	0.632
MOD_CK2_1	19	25	PF00069	0.587
MOD_CK2_1	218	224	PF00069	0.569
MOD_CK2_1	272	278	PF00069	0.455
MOD_CK2_1	311	317	PF00069	0.626
MOD_CK2_1	397	403	PF00069	0.524
MOD_CK2_1	482	488	PF00069	0.428
MOD_CK2_1	521	527	PF00069	0.542
MOD_CK2_1	63	69	PF00069	0.459
MOD_CK2_1	642	648	PF00069	0.568
MOD_CK2_1	743	749	PF00069	0.615
MOD_GlcNHglycan	139	142	PF01048	0.546
MOD_GlcNHglycan	287	290	PF01048	0.507
MOD_GlcNHglycan	306	309	PF01048	0.441
MOD_GlcNHglycan	329	332	PF01048	0.677
MOD_GlcNHglycan	455	458	PF01048	0.621
MOD_GlcNHglycan	562	565	PF01048	0.566
MOD_GlcNHglycan	571	574	PF01048	0.405
MOD_GSK3_1	102	109	PF00069	0.704
MOD_GSK3_1	137	144	PF00069	0.508
MOD_GSK3_1	15	22	PF00069	0.561
MOD_GSK3_1	188	195	PF00069	0.523
MOD_GSK3_1	252	259	PF00069	0.575
MOD_GSK3_1	295	302	PF00069	0.544
MOD_GSK3_1	321	328	PF00069	0.652
MOD_GSK3_1	393	400	PF00069	0.550
MOD_GSK3_1	59	66	PF00069	0.515
MOD_GSK3_1	592	599	PF00069	0.543
MOD_GSK3_1	661	668	PF00069	0.533
MOD_N-GLC_1	414	419	PF02516	0.418
MOD_NEK2_1	106	111	PF00069	0.594
MOD_NEK2_1	123	128	PF00069	0.551
MOD_NEK2_1	155	160	PF00069	0.475
MOD_NEK2_1	252	257	PF00069	0.601
MOD_NEK2_1	299	304	PF00069	0.515
MOD_NEK2_1	441	446	PF00069	0.490
MOD_NEK2_1	474	479	PF00069	0.365
MOD_NEK2_1	482	487	PF00069	0.368
MOD_NEK2_1	504	509	PF00069	0.519
MOD_NEK2_1	52	57	PF00069	0.464
MOD_NEK2_1	693	698	PF00069	0.515
MOD_NEK2_1	706	711	PF00069	0.398
MOD_NEK2_1	94	99	PF00069	0.643
MOD_NEK2_2	335	340	PF00069	0.591
MOD_NEK2_2	592	597	PF00069	0.540
MOD_NEK2_2	656	661	PF00069	0.672
MOD_NEK2_2	665	670	PF00069	0.572
MOD_PIKK_1	123	129	PF00454	0.598
MOD_PIKK_1	19	25	PF00454	0.582
MOD_PIKK_1	192	198	PF00454	0.789
MOD_PIKK_1	211	217	PF00454	0.535
MOD_PIKK_1	252	258	PF00454	0.578
MOD_PIKK_1	527	533	PF00454	0.485
MOD_PIKK_1	550	556	PF00454	0.372
MOD_PIKK_1	63	69	PF00454	0.459
MOD_PKA_2	304	310	PF00069	0.715
MOD_PKA_2	321	327	PF00069	0.736
MOD_PKA_2	474	480	PF00069	0.380
MOD_PKA_2	490	496	PF00069	0.406
MOD_PKA_2	656	662	PF00069	0.659
MOD_PKA_2	738	744	PF00069	0.521
MOD_Plk_1	102	108	PF00069	0.742
MOD_Plk_1	252	258	PF00069	0.487
MOD_Plk_1	397	403	PF00069	0.574
MOD_Plk_1	414	420	PF00069	0.356
MOD_Plk_1	441	447	PF00069	0.689
MOD_Plk_1	489	495	PF00069	0.399
MOD_Plk_1	701	707	PF00069	0.578
MOD_Plk_1	9	15	PF00069	0.548
MOD_Plk_2-3	218	224	PF00069	0.540
MOD_Plk_2-3	37	43	PF00069	0.417
MOD_Plk_4	141	147	PF00069	0.560
MOD_Plk_4	272	278	PF00069	0.404
MOD_Plk_4	279	285	PF00069	0.401
MOD_Plk_4	311	317	PF00069	0.715
MOD_Plk_4	380	386	PF00069	0.502
MOD_Plk_4	44	50	PF00069	0.454
MOD_Plk_4	521	527	PF00069	0.547
MOD_Plk_4	701	707	PF00069	0.586
MOD_Plk_4	743	749	PF00069	0.526
MOD_Plk_4	85	91	PF00069	0.715
MOD_Plk_4	9	15	PF00069	0.487
MOD_ProDKin_1	199	205	PF00069	0.763
MOD_ProDKin_1	417	423	PF00069	0.636
MOD_ProDKin_1	694	700	PF00069	0.442
MOD_SUMO_rev_2	697	705	PF00179	0.370
TRG_DiLeu_BaEn_1	69	74	PF01217	0.715
TRG_DiLeu_BaEn_1	701	706	PF01217	0.415
TRG_DiLeu_BaEn_4	701	707	PF01217	0.326
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.581
TRG_DiLeu_BaLyEn_6	375	380	PF01217	0.424
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.551
TRG_DiLeu_BaLyEn_6	611	616	PF01217	0.324
TRG_ENDOCYTIC_2	152	155	PF00928	0.515
TRG_ENDOCYTIC_2	246	249	PF00928	0.561
TRG_ENDOCYTIC_2	353	356	PF00928	0.535
TRG_ENDOCYTIC_2	385	388	PF00928	0.408
TRG_ENDOCYTIC_2	497	500	PF00928	0.474
TRG_ENDOCYTIC_2	501	504	PF00928	0.457
TRG_ENDOCYTIC_2	586	589	PF00928	0.460
TRG_ENDOCYTIC_2	728	731	PF00928	0.485
TRG_ENDOCYTIC_2	90	93	PF00928	0.674
TRG_ER_diArg_1	163	165	PF00400	0.555
TRG_ER_diArg_1	183	186	PF00400	0.404
TRG_ER_diArg_1	448	451	PF00400	0.508
TRG_ER_diArg_1	56	58	PF00400	0.312
TRG_ER_diArg_1	576	579	PF00400	0.475
TRG_ER_diArg_1	612	615	PF00400	0.529
TRG_ER_diArg_1	643	646	PF00400	0.645
TRG_ER_diArg_1	737	740	PF00400	0.587
TRG_ER_diArg_1	742	744	PF00400	0.598
TRG_NES_CRM1_1	588	601	PF08389	0.512
TRG_Pf-PMV_PEXEL_1	122	127	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	636	640	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6V3	Leptomonas seymouri	54%	100%
A0A1X0NZ87	Trypanosomatidae	27%	100%
A0A3Q8ICJ8	Leishmania donovani	79%	100%
A0A422NAP0	Trypanosoma rangeli	27%	100%
A4HWZ2	Leishmania infantum	80%	100%
C9ZW10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AQQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QES3	Leishmania major	80%	100%
V5B3X0	Trypanosoma cruzi	24%	100%