LeishMANIAdb
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Methyltransf_11 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Methyltransf_11 domain-containing protein
Gene product:
methyltransferase domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4H8M0_LEIBR
TriTrypDb:
LbrM.16.0970 , LBRM2903_160016200 *
Length:
488

Annotations

LeishMANIAdb annotations

Homologous to yeast mitochondrial OMS1 methyltransferase, but many Kinetoplastid homologs lack the transit signal.. One sub-group of these proteins have an N-terminal membrane anchor, while others might possess an internal Tm segment potentially targeted to mitochondria.. Localization: Mitochondrial (by homology) / Others (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 9
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8M0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8M0

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 2
GO:0032259 methylation 2 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008168 methyltransferase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016741 transferase activity, transferring one-carbon groups 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 247 251 PF00656 0.433
CLV_NRD_NRD_1 213 215 PF00675 0.601
CLV_NRD_NRD_1 296 298 PF00675 0.570
CLV_NRD_NRD_1 437 439 PF00675 0.459
CLV_NRD_NRD_1 478 480 PF00675 0.627
CLV_NRD_NRD_1 71 73 PF00675 0.488
CLV_PCSK_FUR_1 69 73 PF00082 0.489
CLV_PCSK_KEX2_1 215 217 PF00082 0.596
CLV_PCSK_KEX2_1 295 297 PF00082 0.618
CLV_PCSK_KEX2_1 437 439 PF00082 0.449
CLV_PCSK_KEX2_1 71 73 PF00082 0.486
CLV_PCSK_PC1ET2_1 215 217 PF00082 0.596
CLV_PCSK_PC7_1 291 297 PF00082 0.643
CLV_PCSK_SKI1_1 112 116 PF00082 0.612
CLV_PCSK_SKI1_1 210 214 PF00082 0.686
CLV_PCSK_SKI1_1 216 220 PF00082 0.661
CLV_PCSK_SKI1_1 226 230 PF00082 0.649
CLV_PCSK_SKI1_1 328 332 PF00082 0.467
CLV_PCSK_SKI1_1 399 403 PF00082 0.531
CLV_PCSK_SKI1_1 423 427 PF00082 0.470
CLV_PCSK_SKI1_1 72 76 PF00082 0.483
DEG_APCC_DBOX_1 346 354 PF00400 0.282
DEG_APCC_KENBOX_2 142 146 PF00400 0.434
DEG_Nend_UBRbox_1 1 4 PF02207 0.669
DEG_SPOP_SBC_1 131 135 PF00917 0.306
DEG_SPOP_SBC_1 243 247 PF00917 0.365
DOC_CKS1_1 229 234 PF01111 0.389
DOC_CYCLIN_RxL_1 325 333 PF00134 0.181
DOC_MAPK_gen_1 112 120 PF00069 0.284
DOC_MAPK_gen_1 392 402 PF00069 0.236
DOC_MAPK_gen_1 41 50 PF00069 0.373
DOC_MAPK_gen_1 434 442 PF00069 0.239
DOC_MAPK_MEF2A_6 112 120 PF00069 0.284
DOC_PP2B_LxvP_1 28 31 PF13499 0.392
DOC_PP4_FxxP_1 380 383 PF00568 0.249
DOC_USP7_MATH_1 126 130 PF00917 0.521
DOC_USP7_MATH_1 200 204 PF00917 0.399
DOC_USP7_MATH_1 243 247 PF00917 0.543
DOC_USP7_MATH_1 321 325 PF00917 0.245
DOC_USP7_MATH_1 364 368 PF00917 0.292
DOC_USP7_MATH_1 465 469 PF00917 0.340
DOC_USP7_MATH_2 335 341 PF00917 0.181
DOC_USP7_UBL2_3 395 399 PF12436 0.331
DOC_USP7_UBL2_3 449 453 PF12436 0.347
DOC_WW_Pin1_4 171 176 PF00397 0.342
DOC_WW_Pin1_4 228 233 PF00397 0.385
DOC_WW_Pin1_4 26 31 PF00397 0.403
LIG_14-3-3_CanoR_1 307 311 PF00244 0.430
LIG_14-3-3_CanoR_1 41 46 PF00244 0.409
LIG_Actin_WH2_2 323 341 PF00022 0.181
LIG_APCC_ABBAyCdc20_2 216 222 PF00400 0.338
LIG_BRCT_BRCA1_1 451 455 PF00533 0.348
LIG_BRCT_BRCA1_1 59 63 PF00533 0.367
LIG_Clathr_ClatBox_1 400 404 PF01394 0.249
LIG_CtBP_PxDLS_1 335 339 PF00389 0.282
LIG_deltaCOP1_diTrp_1 448 455 PF00928 0.392
LIG_deltaCOP1_diTrp_1 470 475 PF00928 0.374
LIG_DLG_GKlike_1 41 48 PF00625 0.411
LIG_FHA_1 132 138 PF00498 0.327
LIG_FHA_1 321 327 PF00498 0.279
LIG_FHA_1 9 15 PF00498 0.302
LIG_FHA_2 222 228 PF00498 0.427
LIG_FHA_2 234 240 PF00498 0.498
LIG_LIR_Apic_2 174 179 PF02991 0.339
LIG_LIR_Apic_2 379 383 PF02991 0.236
LIG_LIR_Gen_1 365 375 PF02991 0.252
LIG_LIR_Gen_1 44 53 PF02991 0.332
LIG_LIR_Gen_1 470 477 PF02991 0.373
LIG_LIR_Nem_3 365 371 PF02991 0.252
LIG_LIR_Nem_3 44 48 PF02991 0.324
LIG_LIR_Nem_3 470 475 PF02991 0.358
LIG_LIR_Nem_3 62 67 PF02991 0.444
LIG_PCNA_yPIPBox_3 426 440 PF02747 0.236
LIG_PDZ_Class_1 483 488 PF00595 0.487
LIG_PTB_Apo_2 92 99 PF02174 0.327
LIG_PTB_Phospho_1 92 98 PF10480 0.329
LIG_SH2_CRK 45 49 PF00017 0.320
LIG_SH2_NCK_1 181 185 PF00017 0.368
LIG_SH2_NCK_1 318 322 PF00017 0.181
LIG_SH2_SRC 181 184 PF00017 0.349
LIG_SH2_STAT3 136 139 PF00017 0.443
LIG_SH2_STAT5 103 106 PF00017 0.412
LIG_SH2_STAT5 136 139 PF00017 0.394
LIG_SH2_STAT5 173 176 PF00017 0.312
LIG_SH2_STAT5 22 25 PF00017 0.271
LIG_SH2_STAT5 34 37 PF00017 0.357
LIG_SH2_STAT5 460 463 PF00017 0.259
LIG_SH2_STAT5 64 67 PF00017 0.325
LIG_SH3_3 253 259 PF00018 0.429
LIG_SH3_3 329 335 PF00018 0.235
LIG_SH3_3 390 396 PF00018 0.236
LIG_SH3_3 459 465 PF00018 0.227
LIG_SH3_4 395 402 PF00018 0.331
LIG_SUMO_SIM_par_1 399 404 PF11976 0.236
LIG_TRAF2_1 236 239 PF00917 0.439
LIG_TRAF2_1 468 471 PF00917 0.424
LIG_UBA3_1 137 143 PF00899 0.446
LIG_UBA3_1 400 407 PF00899 0.236
LIG_WRC_WIRS_1 377 382 PF05994 0.249
LIG_WW_1 31 34 PF00397 0.392
MOD_CDK_SPxK_1 171 177 PF00069 0.342
MOD_CK1_1 196 202 PF00069 0.411
MOD_CK1_1 443 449 PF00069 0.352
MOD_CK2_1 185 191 PF00069 0.373
MOD_CK2_1 196 202 PF00069 0.390
MOD_CK2_1 221 227 PF00069 0.422
MOD_CK2_1 231 237 PF00069 0.477
MOD_CK2_1 321 327 PF00069 0.348
MOD_CK2_1 338 344 PF00069 0.229
MOD_CK2_1 465 471 PF00069 0.322
MOD_CMANNOS 428 431 PF00535 0.436
MOD_GlcNHglycan 128 131 PF01048 0.678
MOD_GlcNHglycan 154 158 PF01048 0.548
MOD_GlcNHglycan 19 22 PF01048 0.411
MOD_GlcNHglycan 198 201 PF01048 0.591
MOD_GlcNHglycan 202 205 PF01048 0.718
MOD_GlcNHglycan 233 236 PF01048 0.643
MOD_GlcNHglycan 250 253 PF01048 0.606
MOD_GlcNHglycan 318 321 PF01048 0.477
MOD_GlcNHglycan 442 445 PF01048 0.531
MOD_GSK3_1 126 133 PF00069 0.498
MOD_GSK3_1 196 203 PF00069 0.366
MOD_GSK3_1 244 251 PF00069 0.527
MOD_GSK3_1 316 323 PF00069 0.259
MOD_GSK3_1 8 15 PF00069 0.272
MOD_LATS_1 405 411 PF00433 0.331
MOD_N-GLC_1 131 136 PF02516 0.653
MOD_N-GLC_1 316 321 PF02516 0.486
MOD_NEK2_1 159 164 PF00069 0.282
MOD_NEK2_1 17 22 PF00069 0.299
MOD_NEK2_1 242 247 PF00069 0.549
MOD_NEK2_1 338 343 PF00069 0.181
MOD_NEK2_1 455 460 PF00069 0.292
MOD_NEK2_1 65 70 PF00069 0.298
MOD_PIKK_1 193 199 PF00454 0.500
MOD_PIKK_1 244 250 PF00454 0.536
MOD_PIKK_1 57 63 PF00454 0.328
MOD_PK_1 407 413 PF00069 0.246
MOD_PKA_2 186 192 PF00069 0.456
MOD_PKA_2 306 312 PF00069 0.496
MOD_PKA_2 338 344 PF00069 0.263
MOD_PKA_2 440 446 PF00069 0.331
MOD_PKA_2 46 52 PF00069 0.267
MOD_PKB_1 295 303 PF00069 0.336
MOD_Plk_1 131 137 PF00069 0.471
MOD_Plk_1 321 327 PF00069 0.263
MOD_Plk_1 364 370 PF00069 0.262
MOD_Plk_1 388 394 PF00069 0.244
MOD_Plk_2-3 221 227 PF00069 0.500
MOD_Plk_4 12 18 PF00069 0.272
MOD_Plk_4 132 138 PF00069 0.449
MOD_Plk_4 252 258 PF00069 0.365
MOD_Plk_4 306 312 PF00069 0.487
MOD_ProDKin_1 171 177 PF00069 0.342
MOD_ProDKin_1 228 234 PF00069 0.388
MOD_ProDKin_1 26 32 PF00069 0.406
MOD_SUMO_for_1 165 168 PF00179 0.243
MOD_SUMO_rev_2 446 455 PF00179 0.345
MOD_SUMO_rev_2 49 58 PF00179 0.331
TRG_DiLeu_BaEn_1 327 332 PF01217 0.267
TRG_DiLeu_BaEn_2 236 242 PF01217 0.491
TRG_DiLeu_BaEn_3 305 311 PF01217 0.423
TRG_DiLeu_BaEn_4 237 243 PF01217 0.493
TRG_DiLeu_BaLyEn_6 268 273 PF01217 0.403
TRG_ENDOCYTIC_2 45 48 PF00928 0.310
TRG_ENDOCYTIC_2 466 469 PF00928 0.367
TRG_ENDOCYTIC_2 64 67 PF00928 0.312
TRG_ER_diArg_1 213 216 PF00400 0.475
TRG_ER_diArg_1 294 297 PF00400 0.430
TRG_ER_diArg_1 436 438 PF00400 0.249
TRG_ER_diArg_1 70 72 PF00400 0.279
TRG_ER_diArg_1 81 84 PF00400 0.282
TRG_NLS_MonoCore_2 213 218 PF00514 0.477
TRG_NLS_MonoExtN_4 214 219 PF00514 0.481
TRG_Pf-PMV_PEXEL_1 217 221 PF00026 0.539
TRG_Pf-PMV_PEXEL_1 271 276 PF00026 0.528
TRG_Pf-PMV_PEXEL_1 385 389 PF00026 0.436

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8I0 Leptomonas seymouri 73% 100%
A0A1X0NZ02 Trypanosomatidae 46% 100%
A0A3Q8I9F7 Leishmania donovani 86% 100%
A0A3R7NGZ3 Trypanosoma rangeli 47% 100%
A4HWZ1 Leishmania infantum 85% 100%
C9ZW11 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AQQ5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4QES4 Leishmania major 85% 100%
V5ANK2 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS