Charged multivesicular body protein 6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Snf7, putative

Species:

Leishmania braziliensis

UniProt:

A4H8L7_LEIBR

TriTrypDb:

LbrM.16.0940 , LBRM2903_160015900

Length:

223

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0000815	ESCRT III complex	3	1
GO:0005768	endosome	7	1
GO:0005770	late endosome	8	1
GO:0005771	multivesicular body	9	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	1
GO:0036452	ESCRT complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098796	membrane protein complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8L7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	13
GO:0007034	vacuolar transport	4	13
GO:0009987	cellular process	1	13
GO:0046907	intracellular transport	3	13
GO:0051179	localization	1	13
GO:0051234	establishment of localization	2	13
GO:0051641	cellular localization	2	13
GO:0051649	establishment of localization in cell	3	13
GO:0006900	vesicle budding from membrane	5	1
GO:0006996	organelle organization	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0061024	membrane organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0071985	multivesicular body sorting pathway	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.474
CLV_C14_Caspase3-7	88	92	PF00656	0.399
CLV_NRD_NRD_1	43	45	PF00675	0.287
CLV_NRD_NRD_1	66	68	PF00675	0.310
CLV_PCSK_KEX2_1	202	204	PF00082	0.703
CLV_PCSK_KEX2_1	66	68	PF00082	0.285
CLV_PCSK_KEX2_1	74	76	PF00082	0.308
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.703
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.272
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.311
CLV_PCSK_PC7_1	62	68	PF00082	0.317
CLV_PCSK_SKI1_1	67	71	PF00082	0.287
DEG_APCC_DBOX_1	66	74	PF00400	0.317
DOC_CKS1_1	21	26	PF01111	0.484
DOC_MAPK_DCC_7	178	188	PF00069	0.399
DOC_MAPK_gen_1	27	34	PF00069	0.395
DOC_MAPK_MEF2A_6	27	34	PF00069	0.317
DOC_MAPK_NFAT4_5	27	35	PF00069	0.317
DOC_PP2B_LxvP_1	186	189	PF13499	0.560
DOC_USP7_MATH_1	139	143	PF00917	0.287
DOC_USP7_MATH_1	17	21	PF00917	0.585
DOC_USP7_MATH_1	189	193	PF00917	0.529
DOC_USP7_MATH_1	78	82	PF00917	0.351
DOC_WW_Pin1_4	20	25	PF00397	0.604
LIG_14-3-3_CanoR_1	48	53	PF00244	0.167
LIG_Clathr_ClatBox_1	167	171	PF01394	0.167
LIG_FHA_1	174	180	PF00498	0.259
LIG_FHA_1	85	91	PF00498	0.278
LIG_FHA_2	21	27	PF00498	0.491
LIG_LIR_Gen_1	99	110	PF02991	0.277
LIG_LIR_Nem_3	99	105	PF02991	0.277
LIG_SH2_NCK_1	46	50	PF00017	0.291
LIG_SH2_STAP1	46	50	PF00017	0.272
LIG_SH2_STAT5	71	74	PF00017	0.291
LIG_SUMO_SIM_anti_2	81	88	PF11976	0.399
LIG_TRAF2_1	142	145	PF00917	0.317
MOD_CDK_SPxxK_3	20	27	PF00069	0.623
MOD_CK1_1	11	17	PF00069	0.602
MOD_CK1_1	20	26	PF00069	0.557
MOD_CK1_1	81	87	PF00069	0.317
MOD_CK2_1	139	145	PF00069	0.299
MOD_GlcNHglycan	197	200	PF01048	0.461
MOD_GSK3_1	96	103	PF00069	0.356
MOD_N-GLC_1	184	189	PF02516	0.317
MOD_NEK2_1	173	178	PF00069	0.419
MOD_NEK2_1	3	8	PF00069	0.661
MOD_NMyristoyl	1	7	PF02799	0.526
MOD_PIKK_1	100	106	PF00454	0.351
MOD_PIKK_1	151	157	PF00454	0.396
MOD_PIKK_1	17	23	PF00454	0.466
MOD_PIKK_1	173	179	PF00454	0.389
MOD_PIKK_1	78	84	PF00454	0.325
MOD_PIKK_1	8	14	PF00454	0.580
MOD_Plk_1	100	106	PF00069	0.341
MOD_Plk_1	17	23	PF00069	0.638
MOD_Plk_1	184	190	PF00069	0.423
MOD_ProDKin_1	20	26	PF00069	0.597
MOD_SUMO_for_1	168	171	PF00179	0.167
MOD_SUMO_for_1	201	204	PF00179	0.489
MOD_SUMO_for_1	73	76	PF00179	0.317
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.286
TRG_ENDOCYTIC_2	46	49	PF00928	0.317
TRG_NES_CRM1_1	104	119	PF08389	0.326

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5W8	Leptomonas seymouri	36%	99%
A0A0N1ILA5	Leptomonas seymouri	66%	100%
A0A1X0NZJ9	Trypanosomatidae	56%	100%
A0A3Q8IJN8	Leishmania donovani	34%	99%
A0A3R7NQB4	Trypanosoma rangeli	30%	98%
A0A3S7WU01	Leishmania donovani	83%	100%
A0A422NAN8	Trypanosoma rangeli	58%	100%
A4HPQ2	Leishmania braziliensis	35%	99%
A4HWY8	Leishmania infantum	83%	100%
A4ID11	Leishmania infantum	34%	99%
C9ZW12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
D0A8G1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	98%
E9AQQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9ATG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	99%
P0C0A3	Mus musculus	29%	100%
Q04272	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q4Q130	Leishmania major	33%	100%
Q4QES7	Leishmania major	81%	99%
Q503V0	Danio rerio	32%	100%
Q54KZ4	Dictyostelium discoideum	34%	100%
Q5R861	Pongo abelii	31%	100%
Q5ZL55	Gallus gallus	30%	100%
Q6GMA4	Xenopus laevis	33%	100%
Q6NU11	Xenopus laevis	32%	100%
Q8GXN6	Arabidopsis thaliana	28%	100%
Q96FZ7	Homo sapiens	31%	100%
Q9FY89	Arabidopsis thaliana	28%	100%
Q9VVI9	Drosophila melanogaster	28%	99%