Putative flagellar calcium-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar calcium-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8L6_LEIBR

TriTrypDb:

LbrM.16.0930 , LBRM2903_160015800

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	18
GO:0031514	motile cilium	5	18
GO:0042995	cell projection	2	18
GO:0043226	organelle	2	18
GO:0043227	membrane-bounded organelle	3	18
GO:0110165	cellular anatomical entity	1	18
GO:0120025	plasma membrane bounded cell projection	3	18
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H8L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8L6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	19
GO:0005509	calcium ion binding	5	19
GO:0043167	ion binding	2	19
GO:0043169	cation binding	3	19
GO:0046872	metal ion binding	4	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.390
CLV_NRD_NRD_1	20	22	PF00675	0.440
CLV_PCSK_SKI1_1	115	119	PF00082	0.386
CLV_PCSK_SKI1_1	145	149	PF00082	0.415
CLV_PCSK_SKI1_1	166	170	PF00082	0.411
CLV_PCSK_SKI1_1	43	47	PF00082	0.520
DEG_APCC_DBOX_1	114	122	PF00400	0.384
DOC_CKS1_1	35	40	PF01111	0.517
DOC_MAPK_gen_1	41	48	PF00069	0.545
DOC_USP7_MATH_1	199	203	PF00917	0.621
DOC_USP7_UBL2_3	7	11	PF12436	0.776
DOC_WW_Pin1_4	34	39	PF00397	0.539
LIG_14-3-3_CanoR_1	29	33	PF00244	0.560
LIG_Actin_WH2_2	67	84	PF00022	0.473
LIG_FHA_1	174	180	PF00498	0.529
LIG_FHA_1	76	82	PF00498	0.447
LIG_FHA_2	15	21	PF00498	0.587
LIG_FHA_2	178	184	PF00498	0.310
LIG_FHA_2	35	41	PF00498	0.321
LIG_FHA_2	58	64	PF00498	0.455
LIG_FHA_2	96	102	PF00498	0.598
LIG_LIR_Gen_1	105	116	PF02991	0.457
LIG_LIR_Gen_1	128	135	PF02991	0.362
LIG_LIR_Gen_1	180	188	PF02991	0.373
LIG_LIR_Nem_3	105	111	PF02991	0.477
LIG_LIR_Nem_3	123	127	PF02991	0.337
LIG_LIR_Nem_3	128	134	PF02991	0.414
LIG_LIR_Nem_3	165	171	PF02991	0.344
LIG_LIR_Nem_3	180	184	PF02991	0.347
LIG_Rb_pABgroove_1	125	133	PF01858	0.365
LIG_SH2_PTP2	108	111	PF00017	0.383
LIG_SH2_STAT5	108	111	PF00017	0.448
LIG_SH2_STAT5	120	123	PF00017	0.363
LIG_SH2_STAT5	124	127	PF00017	0.369
LIG_SUMO_SIM_anti_2	104	113	PF11976	0.422
LIG_SUMO_SIM_anti_2	126	133	PF11976	0.356
LIG_TRAF2_1	60	63	PF00917	0.562
MOD_CDK_SPxxK_3	34	41	PF00069	0.528
MOD_CK2_1	14	20	PF00069	0.586
MOD_CK2_1	140	146	PF00069	0.311
MOD_CK2_1	177	183	PF00069	0.358
MOD_CK2_1	57	63	PF00069	0.412
MOD_GlcNHglycan	11	14	PF01048	0.678
MOD_GlcNHglycan	135	139	PF01048	0.398
MOD_GlcNHglycan	142	145	PF01048	0.398
MOD_GlcNHglycan	55	58	PF01048	0.416
MOD_GSK3_1	173	180	PF00069	0.374
MOD_GSK3_1	53	60	PF00069	0.475
MOD_GSK3_1	87	94	PF00069	0.524
MOD_N-GLC_1	173	178	PF02516	0.398
MOD_N-GLC_1	3	8	PF02516	0.787
MOD_NEK2_1	125	130	PF00069	0.421
MOD_NEK2_1	140	145	PF00069	0.386
MOD_NMyristoyl	1	7	PF02799	0.653
MOD_PKA_2	28	34	PF00069	0.551
MOD_Plk_1	125	131	PF00069	0.366
MOD_Plk_4	125	131	PF00069	0.386
MOD_ProDKin_1	34	40	PF00069	0.530
MOD_SPalmitoyl_4	1	7	PF01529	0.674
MOD_SUMO_for_1	200	203	PF00179	0.412
MOD_SUMO_rev_2	14	24	PF00179	0.514
MOD_SUMO_rev_2	143	150	PF00179	0.395
TRG_DiLeu_BaEn_1	42	47	PF01217	0.361
TRG_ENDOCYTIC_2	108	111	PF00928	0.472
TRG_ENDOCYTIC_2	122	125	PF00928	0.358
TRG_ER_diArg_1	33	36	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	82	86	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S0	Leptomonas seymouri	64%	99%
A0A0S4J8L5	Bodo saltans	37%	100%
A0A0S4KMR0	Bodo saltans	40%	100%
A0A1X0NZ95	Trypanosomatidae	62%	99%
A0A1X0P0A5	Trypanosomatidae	59%	100%
A0A1X0P0I3	Trypanosomatidae	61%	93%
A0A3R7KL32	Trypanosoma rangeli	61%	100%
A0A3S7WTZ3	Leishmania donovani	74%	100%
A0A422NDP3	Trypanosoma rangeli	58%	99%
A4H8L5	Leishmania braziliensis	97%	100%
A4HWY6	Leishmania infantum	78%	100%
A4HWY7	Leishmania infantum	73%	100%
C9ZW14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	93%
C9ZW16	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	87%
E9AQQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
E9AQQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
P07749	Trypanosoma cruzi	56%	96%
P17882	Trypanosoma brucei brucei	55%	87%
Q26677	Trypanosoma brucei brucei	57%	89%
Q26680	Trypanosoma brucei brucei	56%	93%
Q27052	Trypanosoma rangeli	57%	100%
V5D941	Trypanosoma cruzi	56%	82%