Putative flagellar calcium-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar calcium-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H8L5_LEIBR

TriTrypDb:

LbrM.16.0920 , LBRM2903_160015800

Length:

144

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	15
GO:0031514	motile cilium	5	15
GO:0042995	cell projection	2	15
GO:0043226	organelle	2	15
GO:0043227	membrane-bounded organelle	3	15
GO:0110165	cellular anatomical entity	1	15
GO:0120025	plasma membrane bounded cell projection	3	15

Expansion

Sequence features

A4H8L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8L5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	16
GO:0005509	calcium ion binding	5	16
GO:0043167	ion binding	2	16
GO:0043169	cation binding	3	16
GO:0046872	metal ion binding	4	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.666
CLV_PCSK_SKI1_1	106	110	PF00082	0.438
CLV_PCSK_SKI1_1	55	59	PF00082	0.416
CLV_PCSK_SKI1_1	85	89	PF00082	0.418
DEG_APCC_DBOX_1	54	62	PF00400	0.412
DEG_Nend_UBRbox_2	1	3	PF02207	0.356
DOC_USP7_UBL2_3	132	136	PF12436	0.431
LIG_Actin_WH2_2	7	24	PF00022	0.455
LIG_FHA_1	114	120	PF00498	0.511
LIG_FHA_1	16	22	PF00498	0.479
LIG_FHA_2	118	124	PF00498	0.289
LIG_FHA_2	133	139	PF00498	0.505
LIG_FHA_2	36	42	PF00498	0.536
LIG_LIR_Gen_1	120	128	PF02991	0.359
LIG_LIR_Gen_1	45	56	PF02991	0.483
LIG_LIR_Gen_1	68	75	PF02991	0.335
LIG_LIR_Nem_3	105	111	PF02991	0.358
LIG_LIR_Nem_3	120	124	PF02991	0.379
LIG_LIR_Nem_3	45	51	PF02991	0.495
LIG_LIR_Nem_3	63	67	PF02991	0.453
LIG_LIR_Nem_3	68	74	PF02991	0.409
LIG_Rb_pABgroove_1	65	73	PF01858	0.391
LIG_SH2_PTP2	48	51	PF00017	0.391
LIG_SH2_STAT5	48	51	PF00017	0.488
LIG_SH2_STAT5	60	63	PF00017	0.436
LIG_SH2_STAT5	64	67	PF00017	0.418
LIG_SUMO_SIM_anti_2	44	53	PF11976	0.410
LIG_SUMO_SIM_anti_2	66	73	PF11976	0.333
MOD_CK2_1	117	123	PF00069	0.330
MOD_CK2_1	80	86	PF00069	0.275
MOD_GlcNHglycan	75	79	PF01048	0.369
MOD_GlcNHglycan	82	85	PF01048	0.275
MOD_GSK3_1	113	120	PF00069	0.342
MOD_GSK3_1	27	34	PF00069	0.446
MOD_N-GLC_1	113	118	PF02516	0.369
MOD_NEK2_1	65	70	PF00069	0.427
MOD_NEK2_1	80	85	PF00069	0.369
MOD_Plk_1	65	71	PF00069	0.349
MOD_Plk_4	65	71	PF00069	0.369
MOD_SUMO_rev_2	83	90	PF00179	0.427
TRG_ENDOCYTIC_2	48	51	PF00928	0.503
TRG_ENDOCYTIC_2	62	65	PF00928	0.431
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S0	Leptomonas seymouri	70%	70%
A0A0S4J8L5	Bodo saltans	39%	79%
A0A0S4KMR0	Bodo saltans	40%	79%
A0A1X0NZ95	Trypanosomatidae	66%	70%
A0A1X0P0A5	Trypanosomatidae	63%	88%
A0A3R7KL32	Trypanosoma rangeli	64%	85%
A0A3S7WTZ3	Leishmania donovani	78%	74%
A0A422NDP3	Trypanosoma rangeli	64%	70%
A4H8L6	Leishmania braziliensis	97%	71%
A4HWY6	Leishmania infantum	78%	100%
A4HWY7	Leishmania infantum	74%	71%
C9ZW14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	66%
E9AQQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	90%
E9AQQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	71%
P07749	Trypanosoma cruzi	61%	68%
Q26680	Trypanosoma brucei brucei	61%	66%
Q27052	Trypanosoma rangeli	62%	71%