Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8L3_LEIBR

TriTrypDb:

LbrM.16.0900 , LBRM2903_160015600

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8L3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8L3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.596
CLV_NRD_NRD_1	193	195	PF00675	0.604
CLV_NRD_NRD_1	30	32	PF00675	0.552
CLV_NRD_NRD_1	88	90	PF00675	0.634
CLV_NRD_NRD_1	99	101	PF00675	0.504
CLV_PCSK_KEX2_1	18	20	PF00082	0.586
CLV_PCSK_KEX2_1	192	194	PF00082	0.609
CLV_PCSK_KEX2_1	30	32	PF00082	0.556
CLV_PCSK_KEX2_1	88	90	PF00082	0.750
CLV_PCSK_KEX2_1	99	101	PF00082	0.486
CLV_PCSK_SKI1_1	193	197	PF00082	0.620
CLV_Separin_Metazoa	233	237	PF03568	0.436
DEG_SPOP_SBC_1	268	272	PF00917	0.642
DOC_CKS1_1	254	259	PF01111	0.490
DOC_CKS1_1	287	292	PF01111	0.528
DOC_MAPK_gen_1	30	38	PF00069	0.551
DOC_PP1_RVXF_1	97	104	PF00149	0.528
DOC_USP7_MATH_1	135	139	PF00917	0.558
DOC_USP7_MATH_1	150	154	PF00917	0.514
DOC_USP7_MATH_1	268	272	PF00917	0.648
DOC_USP7_MATH_1	276	280	PF00917	0.581
DOC_USP7_MATH_1	37	41	PF00917	0.551
DOC_USP7_MATH_1	79	83	PF00917	0.591
DOC_USP7_MATH_1	87	91	PF00917	0.565
DOC_WW_Pin1_4	253	258	PF00397	0.542
DOC_WW_Pin1_4	286	291	PF00397	0.664
LIG_14-3-3_CanoR_1	171	177	PF00244	0.501
LIG_14-3-3_CanoR_1	18	22	PF00244	0.592
LIG_14-3-3_CanoR_1	275	285	PF00244	0.686
LIG_14-3-3_CanoR_1	46	54	PF00244	0.678
LIG_14-3-3_CanoR_1	99	104	PF00244	0.538
LIG_BIR_II_1	1	5	PF00653	0.569
LIG_BRCT_BRCA1_1	205	209	PF00533	0.527
LIG_FHA_1	222	228	PF00498	0.556
LIG_FHA_1	248	254	PF00498	0.440
LIG_FHA_1	7	13	PF00498	0.493
LIG_LIR_Gen_1	105	111	PF02991	0.470
LIG_LIR_Gen_1	138	146	PF02991	0.602
LIG_LIR_Gen_1	20	28	PF02991	0.484
LIG_LIR_Nem_3	105	110	PF02991	0.474
LIG_LIR_Nem_3	138	143	PF02991	0.593
LIG_LIR_Nem_3	20	24	PF02991	0.487
LIG_LIR_Nem_3	51	56	PF02991	0.515
LIG_LYPXL_yS_3	53	56	PF13949	0.475
LIG_PDZ_Class_2	293	298	PF00595	0.478
LIG_Pex14_1	103	107	PF04695	0.493
LIG_Rb_LxCxE_1	117	138	PF01857	0.576
LIG_SH2_CRK	167	171	PF00017	0.598
LIG_SH2_CRK	288	292	PF00017	0.493
LIG_SH2_NCK_1	70	74	PF00017	0.500
LIG_SH2_STAT5	288	291	PF00017	0.491
LIG_SH2_STAT5	294	297	PF00017	0.477
LIG_SH3_1	167	173	PF00018	0.596
LIG_SH3_1	281	287	PF00018	0.517
LIG_SH3_3	167	173	PF00018	0.556
LIG_SH3_3	251	257	PF00018	0.465
LIG_SH3_3	281	287	PF00018	0.592
LIG_TYR_ITSM	49	56	PF00017	0.474
MOD_CK1_1	102	108	PF00069	0.520
MOD_CK1_1	203	209	PF00069	0.613
MOD_CK1_1	214	220	PF00069	0.547
MOD_CK1_1	264	270	PF00069	0.616
MOD_CK1_1	71	77	PF00069	0.683
MOD_CK1_1	81	87	PF00069	0.667
MOD_CK2_1	150	156	PF00069	0.500
MOD_Cter_Amidation	16	19	PF01082	0.479
MOD_Cter_Amidation	190	193	PF01082	0.570
MOD_GlcNHglycan	158	161	PF01048	0.607
MOD_GlcNHglycan	202	205	PF01048	0.662
MOD_GlcNHglycan	214	217	PF01048	0.556
MOD_GlcNHglycan	221	224	PF01048	0.478
MOD_GlcNHglycan	266	269	PF01048	0.599
MOD_GlcNHglycan	56	59	PF01048	0.655
MOD_GlcNHglycan	70	73	PF01048	0.532
MOD_GlcNHglycan	83	86	PF01048	0.709
MOD_GSK3_1	105	112	PF00069	0.504
MOD_GSK3_1	141	148	PF00069	0.542
MOD_GSK3_1	156	163	PF00069	0.531
MOD_GSK3_1	199	206	PF00069	0.609
MOD_GSK3_1	264	271	PF00069	0.703
MOD_GSK3_1	45	52	PF00069	0.600
MOD_GSK3_1	64	71	PF00069	0.523
MOD_GSK3_1	95	102	PF00069	0.590
MOD_NEK2_1	266	271	PF00069	0.624
MOD_NEK2_1	6	11	PF00069	0.615
MOD_PIKK_1	105	111	PF00454	0.609
MOD_PKA_1	99	105	PF00069	0.508
MOD_PKA_2	156	162	PF00069	0.492
MOD_PKA_2	17	23	PF00069	0.525
MOD_PKA_2	229	235	PF00069	0.488
MOD_PKA_2	45	51	PF00069	0.485
MOD_PKA_2	87	93	PF00069	0.647
MOD_PKA_2	99	105	PF00069	0.410
MOD_PKB_1	192	200	PF00069	0.569
MOD_PKB_1	66	74	PF00069	0.495
MOD_Plk_1	261	267	PF00069	0.672
MOD_Plk_4	261	267	PF00069	0.530
MOD_ProDKin_1	253	259	PF00069	0.548
MOD_ProDKin_1	286	292	PF00069	0.662
TRG_ENDOCYTIC_2	21	24	PF00928	0.633
TRG_ENDOCYTIC_2	288	291	PF00928	0.491
TRG_ENDOCYTIC_2	53	56	PF00928	0.547
TRG_ER_diArg_1	119	122	PF00400	0.502
TRG_ER_diArg_1	169	172	PF00400	0.471
TRG_ER_diArg_1	192	194	PF00400	0.642
TRG_ER_diArg_1	65	68	PF00400	0.485
TRG_ER_diArg_1	87	89	PF00400	0.614
TRG_ER_diArg_1	99	101	PF00400	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P756	Leptomonas seymouri	33%	96%
A0A3S7WU02	Leishmania donovani	70%	100%
E9AGN6	Leishmania infantum	71%	100%
E9AQP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4QES9	Leishmania major	68%	100%