Nucleolar protein, Nop52 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein,Nop52, putative

Species:

Leishmania braziliensis

UniProt:

A4H8L2_LEIBR

TriTrypDb:

LbrM.16.0890 , LBRM2903_160015500

Length:

662

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	11
GO:0030688	preribosome, small subunit precursor	4	11
GO:0032991	protein-containing complex	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8L2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.514
CLV_NRD_NRD_1	129	131	PF00675	0.575
CLV_NRD_NRD_1	144	146	PF00675	0.511
CLV_NRD_NRD_1	277	279	PF00675	0.339
CLV_NRD_NRD_1	361	363	PF00675	0.495
CLV_NRD_NRD_1	455	457	PF00675	0.436
CLV_NRD_NRD_1	557	559	PF00675	0.564
CLV_NRD_NRD_1	619	621	PF00675	0.574
CLV_NRD_NRD_1	631	633	PF00675	0.525
CLV_NRD_NRD_1	639	641	PF00675	0.587
CLV_NRD_NRD_1	8	10	PF00675	0.566
CLV_PCSK_FUR_1	629	633	PF00082	0.678
CLV_PCSK_KEX2_1	10	12	PF00082	0.626
CLV_PCSK_KEX2_1	128	130	PF00082	0.582
CLV_PCSK_KEX2_1	144	146	PF00082	0.491
CLV_PCSK_KEX2_1	277	279	PF00082	0.426
CLV_PCSK_KEX2_1	306	308	PF00082	0.768
CLV_PCSK_KEX2_1	327	329	PF00082	0.759
CLV_PCSK_KEX2_1	437	439	PF00082	0.424
CLV_PCSK_KEX2_1	455	457	PF00082	0.345
CLV_PCSK_KEX2_1	473	475	PF00082	0.632
CLV_PCSK_KEX2_1	477	479	PF00082	0.530
CLV_PCSK_KEX2_1	48	50	PF00082	0.414
CLV_PCSK_KEX2_1	556	558	PF00082	0.547
CLV_PCSK_KEX2_1	631	633	PF00082	0.617
CLV_PCSK_KEX2_1	639	641	PF00082	0.627
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.692
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.803
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.759
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.424
CLV_PCSK_PC1ET2_1	473	475	PF00082	0.627
CLV_PCSK_PC1ET2_1	477	479	PF00082	0.530
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.434
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.628
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.615
CLV_PCSK_PC7_1	125	131	PF00082	0.573
CLV_PCSK_SKI1_1	129	133	PF00082	0.416
CLV_PCSK_SKI1_1	211	215	PF00082	0.257
CLV_PCSK_SKI1_1	246	250	PF00082	0.355
CLV_PCSK_SKI1_1	278	282	PF00082	0.378
CLV_PCSK_SKI1_1	285	289	PF00082	0.378
CLV_PCSK_SKI1_1	384	388	PF00082	0.492
CLV_PCSK_SKI1_1	437	441	PF00082	0.487
CLV_PCSK_SKI1_1	528	532	PF00082	0.461
CLV_PCSK_SKI1_1	581	585	PF00082	0.572
CLV_PCSK_SKI1_1	616	620	PF00082	0.636
CLV_Separin_Metazoa	406	410	PF03568	0.490
DEG_Nend_UBRbox_1	1	4	PF02207	0.606
DOC_CKS1_1	98	103	PF01111	0.702
DOC_CYCLIN_RxL_1	241	252	PF00134	0.358
DOC_CYCLIN_yClb5_NLxxxL_5	105	113	PF00134	0.622
DOC_MAPK_gen_1	241	249	PF00069	0.441
DOC_MAPK_gen_1	266	275	PF00069	0.355
DOC_MAPK_gen_1	9	17	PF00069	0.578
DOC_MAPK_MEF2A_6	105	113	PF00069	0.598
DOC_PP1_RVXF_1	209	216	PF00149	0.257
DOC_PP1_RVXF_1	244	250	PF00149	0.355
DOC_PP2B_LxvP_1	237	240	PF13499	0.408
DOC_PP4_FxxP_1	443	446	PF00568	0.388
DOC_USP7_MATH_1	157	161	PF00917	0.528
DOC_USP7_MATH_1	168	172	PF00917	0.518
DOC_USP7_MATH_1	345	349	PF00917	0.551
DOC_USP7_MATH_1	612	616	PF00917	0.650
DOC_USP7_UBL2_3	2	6	PF12436	0.610
DOC_USP7_UBL2_3	323	327	PF12436	0.800
DOC_USP7_UBL2_3	473	477	PF12436	0.644
DOC_USP7_UBL2_3	593	597	PF12436	0.512
DOC_WW_Pin1_4	152	157	PF00397	0.485
DOC_WW_Pin1_4	314	319	PF00397	0.750
DOC_WW_Pin1_4	484	489	PF00397	0.576
DOC_WW_Pin1_4	97	102	PF00397	0.701
LIG_14-3-3_CanoR_1	128	134	PF00244	0.538
LIG_14-3-3_CanoR_1	191	196	PF00244	0.528
LIG_14-3-3_CanoR_1	384	393	PF00244	0.531
LIG_14-3-3_CanoR_1	528	538	PF00244	0.480
LIG_14-3-3_CanoR_1	539	547	PF00244	0.542
LIG_14-3-3_CanoR_1	71	79	PF00244	0.500
LIG_14-3-3_CanoR_1	91	101	PF00244	0.357
LIG_APCC_ABBAyCdc20_2	648	654	PF00400	0.638
LIG_deltaCOP1_diTrp_1	197	206	PF00928	0.293
LIG_FHA_1	341	347	PF00498	0.697
LIG_FHA_1	36	42	PF00498	0.592
LIG_FHA_1	367	373	PF00498	0.505
LIG_FHA_1	394	400	PF00498	0.428
LIG_FHA_2	119	125	PF00498	0.558
LIG_FHA_2	130	136	PF00498	0.480
LIG_FHA_2	192	198	PF00498	0.569
LIG_FHA_2	645	651	PF00498	0.588
LIG_GBD_Chelix_1	374	382	PF00786	0.523
LIG_IBAR_NPY_1	102	104	PF08397	0.629
LIG_LIR_Apic_2	441	446	PF02991	0.395
LIG_LIR_Apic_2	650	655	PF02991	0.482
LIG_LIR_Gen_1	197	207	PF02991	0.401
LIG_LIR_Gen_1	270	280	PF02991	0.336
LIG_LIR_Gen_1	401	412	PF02991	0.370
LIG_LIR_Gen_1	414	425	PF02991	0.350
LIG_LIR_Nem_3	148	153	PF02991	0.681
LIG_LIR_Nem_3	197	202	PF02991	0.410
LIG_LIR_Nem_3	203	209	PF02991	0.344
LIG_LIR_Nem_3	252	257	PF02991	0.349
LIG_LIR_Nem_3	260	264	PF02991	0.372
LIG_LIR_Nem_3	270	275	PF02991	0.298
LIG_LIR_Nem_3	377	382	PF02991	0.491
LIG_LIR_Nem_3	401	407	PF02991	0.363
LIG_LIR_Nem_3	414	420	PF02991	0.354
LIG_LIR_Nem_3	441	447	PF02991	0.453
LIG_LIR_Nem_3	545	550	PF02991	0.566
LIG_MAD2	438	446	PF02301	0.422
LIG_PCNA_TLS_4	266	273	PF02747	0.447
LIG_PCNA_TLS_4	437	444	PF02747	0.409
LIG_PCNA_yPIPBox_3	351	365	PF02747	0.589
LIG_Pex14_2	214	218	PF04695	0.257
LIG_SH2_CRK	153	157	PF00017	0.741
LIG_SH2_CRK	250	254	PF00017	0.408
LIG_SH2_GRB2like	106	109	PF00017	0.600
LIG_SH2_STAP1	83	87	PF00017	0.585
LIG_SH2_STAT3	182	185	PF00017	0.584
LIG_SH2_STAT3	380	383	PF00017	0.423
LIG_SH2_STAT5	272	275	PF00017	0.402
LIG_SH2_STAT5	283	286	PF00017	0.408
LIG_SH2_STAT5	380	383	PF00017	0.399
LIG_SH2_STAT5	434	437	PF00017	0.456
LIG_SH2_STAT5	68	71	PF00017	0.446
LIG_SH2_STAT5	93	96	PF00017	0.636
LIG_SH3_3	95	101	PF00018	0.668
LIG_SH3_4	222	229	PF00018	0.335
LIG_TRAF2_1	121	124	PF00917	0.589
LIG_TRAF2_1	655	658	PF00917	0.510
LIG_TYR_ITIM	248	253	PF00017	0.447
LIG_UBA3_1	213	222	PF00899	0.266
MOD_CDK_SPxxK_3	314	321	PF00069	0.754
MOD_CK1_1	299	305	PF00069	0.726
MOD_CK1_1	309	315	PF00069	0.762
MOD_CK1_1	319	325	PF00069	0.743
MOD_CK1_1	357	363	PF00069	0.607
MOD_CK1_1	388	394	PF00069	0.542
MOD_CK2_1	118	124	PF00069	0.515
MOD_CK2_1	129	135	PF00069	0.417
MOD_CK2_1	191	197	PF00069	0.580
MOD_CK2_1	314	320	PF00069	0.817
MOD_CK2_1	529	535	PF00069	0.497
MOD_GlcNHglycan	311	314	PF01048	0.662
MOD_GlcNHglycan	420	423	PF01048	0.526
MOD_GlcNHglycan	540	543	PF01048	0.581
MOD_GSK3_1	319	326	PF00069	0.791
MOD_GSK3_1	341	348	PF00069	0.641
MOD_GSK3_1	385	392	PF00069	0.529
MOD_GSK3_1	93	100	PF00069	0.693
MOD_N-GLC_1	309	314	PF02516	0.678
MOD_N-GLC_1	644	649	PF02516	0.487
MOD_NEK2_1	249	254	PF00069	0.240
MOD_NEK2_1	349	354	PF00069	0.686
MOD_NEK2_1	387	392	PF00069	0.500
MOD_NEK2_1	418	423	PF00069	0.525
MOD_NEK2_1	512	517	PF00069	0.467
MOD_NEK2_1	550	555	PF00069	0.643
MOD_PIKK_1	354	360	PF00454	0.575
MOD_PIKK_1	427	433	PF00454	0.495
MOD_PKA_1	129	135	PF00069	0.535
MOD_PKA_1	306	312	PF00069	0.802
MOD_PKA_1	323	329	PF00069	0.700
MOD_PKA_1	473	479	PF00069	0.697
MOD_PKA_2	129	135	PF00069	0.413
MOD_PKA_2	240	246	PF00069	0.441
MOD_PKA_2	306	312	PF00069	0.722
MOD_PKA_2	473	479	PF00069	0.717
MOD_PKA_2	538	544	PF00069	0.582
MOD_PKA_2	70	76	PF00069	0.512
MOD_PKB_1	189	197	PF00069	0.590
MOD_Plk_1	168	174	PF00069	0.492
MOD_Plk_1	341	347	PF00069	0.613
MOD_Plk_2-3	118	124	PF00069	0.553
MOD_Plk_2-3	260	266	PF00069	0.355
MOD_Plk_4	191	197	PF00069	0.580
MOD_Plk_4	249	255	PF00069	0.349
MOD_Plk_4	345	351	PF00069	0.431
MOD_Plk_4	614	620	PF00069	0.621
MOD_ProDKin_1	152	158	PF00069	0.484
MOD_ProDKin_1	314	320	PF00069	0.752
MOD_ProDKin_1	484	490	PF00069	0.568
MOD_ProDKin_1	97	103	PF00069	0.698
MOD_SUMO_rev_2	560	566	PF00179	0.660
MOD_SUMO_rev_2	576	585	PF00179	0.651
TRG_ENDOCYTIC_2	106	109	PF00928	0.567
TRG_ENDOCYTIC_2	250	253	PF00928	0.386
TRG_ENDOCYTIC_2	272	275	PF00928	0.378
TRG_ENDOCYTIC_2	283	286	PF00928	0.378
TRG_ER_diArg_1	128	130	PF00400	0.616
TRG_ER_diArg_1	136	139	PF00400	0.566
TRG_ER_diArg_1	276	278	PF00400	0.434
TRG_ER_diArg_1	556	558	PF00400	0.534
TRG_ER_diArg_1	8	11	PF00400	0.614
TRG_NLS_Bipartite_1	620	635	PF00514	0.585
TRG_NLS_MonoCore_2	638	643	PF00514	0.614
TRG_NLS_MonoExtN_4	629	635	PF00514	0.590
TRG_NLS_MonoExtN_4	639	644	PF00514	0.602
TRG_Pf-PMV_PEXEL_1	255	260	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	557	561	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R2	Leptomonas seymouri	65%	98%
A0A0S4JIU4	Bodo saltans	37%	100%
A0A3S7WTZ9	Leishmania donovani	84%	100%
A0A422NDR1	Trypanosoma rangeli	38%	100%
A4HWY4	Leishmania infantum	84%	100%
C9ZW19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AQP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QET0	Leishmania major	85%	100%
V5BD23	Trypanosoma cruzi	36%	100%