Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H8L1_LEIBR

TriTrypDb:

LbrM.16.0880 , LBRM2903_160015300

Length:

686

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8L1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8L1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.664
CLV_C14_Caspase3-7	87	91	PF00656	0.562
CLV_NRD_NRD_1	199	201	PF00675	0.561
CLV_NRD_NRD_1	217	219	PF00675	0.577
CLV_NRD_NRD_1	351	353	PF00675	0.623
CLV_NRD_NRD_1	642	644	PF00675	0.401
CLV_PCSK_KEX2_1	199	201	PF00082	0.513
CLV_PCSK_KEX2_1	217	219	PF00082	0.544
CLV_PCSK_KEX2_1	351	353	PF00082	0.623
CLV_PCSK_KEX2_1	664	666	PF00082	0.358
CLV_PCSK_PC1ET2_1	664	666	PF00082	0.391
CLV_PCSK_SKI1_1	200	204	PF00082	0.606
CLV_PCSK_SKI1_1	211	215	PF00082	0.585
CLV_PCSK_SKI1_1	227	231	PF00082	0.612
CLV_PCSK_SKI1_1	399	403	PF00082	0.444
CLV_PCSK_SKI1_1	422	426	PF00082	0.395
CLV_PCSK_SKI1_1	525	529	PF00082	0.461
DEG_SCF_FBW7_1	103	109	PF00400	0.542
DOC_CDC14_PxL_1	59	67	PF14671	0.539
DOC_CKS1_1	103	108	PF01111	0.544
DOC_CKS1_1	155	160	PF01111	0.604
DOC_CYCLIN_yCln2_LP_2	140	143	PF00134	0.484
DOC_MAPK_gen_1	196	204	PF00069	0.582
DOC_MAPK_gen_1	217	224	PF00069	0.485
DOC_MAPK_gen_1	274	284	PF00069	0.559
DOC_MAPK_gen_1	393	402	PF00069	0.240
DOC_PP1_RVXF_1	197	204	PF00149	0.459
DOC_PP1_RVXF_1	266	272	PF00149	0.550
DOC_PP1_RVXF_1	417	424	PF00149	0.438
DOC_PP2B_LxvP_1	140	143	PF13499	0.484
DOC_PP2B_LxvP_1	168	171	PF13499	0.682
DOC_PP4_FxxP_1	124	127	PF00568	0.524
DOC_PP4_FxxP_1	156	159	PF00568	0.428
DOC_PP4_MxPP_1	21	24	PF00568	0.554
DOC_USP7_MATH_1	164	168	PF00917	0.722
DOC_USP7_MATH_1	377	381	PF00917	0.670
DOC_USP7_MATH_1	534	538	PF00917	0.438
DOC_USP7_UBL2_3	399	403	PF12436	0.438
DOC_WW_Pin1_4	102	107	PF00397	0.693
DOC_WW_Pin1_4	123	128	PF00397	0.713
DOC_WW_Pin1_4	154	159	PF00397	0.592
DOC_WW_Pin1_4	175	180	PF00397	0.634
DOC_WW_Pin1_4	19	24	PF00397	0.745
DOC_WW_Pin1_4	346	351	PF00397	0.531
DOC_WW_Pin1_4	644	649	PF00397	0.240
DOC_WW_Pin1_4	91	96	PF00397	0.780
LIG_14-3-3_CanoR_1	132	140	PF00244	0.711
LIG_14-3-3_CanoR_1	163	169	PF00244	0.668
LIG_14-3-3_CanoR_1	227	237	PF00244	0.466
LIG_14-3-3_CanoR_1	277	282	PF00244	0.526
LIG_14-3-3_CanoR_1	422	427	PF00244	0.383
LIG_14-3-3_CanoR_1	618	623	PF00244	0.336
LIG_BIR_II_1	1	5	PF00653	0.736
LIG_BIR_III_4	144	148	PF00653	0.383
LIG_BRCT_BRCA1_1	120	124	PF00533	0.662
LIG_BRCT_BRCA1_1	274	278	PF00533	0.546
LIG_BRCT_BRCA1_1	403	407	PF00533	0.438
LIG_BRCT_BRCA1_1	419	423	PF00533	0.438
LIG_CaM_IQ_9	284	299	PF13499	0.555
LIG_Clathr_ClatBox_1	518	522	PF01394	0.269
LIG_CtBP_PxDLS_1	192	196	PF00389	0.441
LIG_CtBP_PxDLS_1	67	71	PF00389	0.549
LIG_DLG_GKlike_1	277	284	PF00625	0.598
LIG_FHA_1	103	109	PF00498	0.681
LIG_FHA_1	265	271	PF00498	0.484
LIG_FHA_1	369	375	PF00498	0.593
LIG_FHA_1	444	450	PF00498	0.427
LIG_FHA_1	547	553	PF00498	0.438
LIG_FHA_1	583	589	PF00498	0.438
LIG_FHA_1	645	651	PF00498	0.364
LIG_FHA_1	678	684	PF00498	0.481
LIG_FHA_2	327	333	PF00498	0.634
LIG_FHA_2	368	374	PF00498	0.609
LIG_FHA_2	393	399	PF00498	0.413
LIG_FHA_2	596	602	PF00498	0.438
LIG_FHA_2	630	636	PF00498	0.427
LIG_FHA_2	85	91	PF00498	0.564
LIG_FXI_DFP_1	574	578	PF00024	0.391
LIG_GBD_Chelix_1	432	440	PF00786	0.391
LIG_GBD_Chelix_1	650	658	PF00786	0.326
LIG_Integrin_RGD_1	467	469	PF01839	0.454
LIG_LIR_Apic_2	121	127	PF02991	0.531
LIG_LIR_Apic_2	153	159	PF02991	0.631
LIG_LIR_Apic_2	181	187	PF02991	0.653
LIG_LIR_Apic_2	541	547	PF02991	0.357
LIG_LIR_Gen_1	134	145	PF02991	0.502
LIG_LIR_Gen_1	280	287	PF02991	0.597
LIG_LIR_Gen_1	420	430	PF02991	0.430
LIG_LIR_Gen_1	434	442	PF02991	0.277
LIG_LIR_Nem_3	134	140	PF02991	0.576
LIG_LIR_Nem_3	251	256	PF02991	0.559
LIG_LIR_Nem_3	275	281	PF02991	0.623
LIG_LIR_Nem_3	324	328	PF02991	0.641
LIG_LIR_Nem_3	381	387	PF02991	0.645
LIG_LIR_Nem_3	420	426	PF02991	0.430
LIG_LIR_Nem_3	434	438	PF02991	0.277
LIG_LIR_Nem_3	576	580	PF02991	0.357
LIG_LIR_Nem_3	606	612	PF02991	0.346
LIG_LIR_Nem_3	659	663	PF02991	0.417
LIG_LYPXL_yS_3	429	432	PF13949	0.240
LIG_MYND_1	106	110	PF01753	0.536
LIG_MYND_1	63	67	PF01753	0.538
LIG_NRBOX	563	569	PF00104	0.240
LIG_PDZ_Class_2	681	686	PF00595	0.625
LIG_Pex14_2	471	475	PF04695	0.438
LIG_PTB_Apo_2	503	510	PF02174	0.438
LIG_REV1ctd_RIR_1	201	209	PF16727	0.653
LIG_SH2_CRK	165	169	PF00017	0.574
LIG_SH2_CRK	256	260	PF00017	0.534
LIG_SH2_CRK	384	388	PF00017	0.619
LIG_SH2_CRK	660	664	PF00017	0.438
LIG_SH2_PTP2	281	284	PF00017	0.587
LIG_SH2_SRC	128	131	PF00017	0.536
LIG_SH2_SRC	454	457	PF00017	0.438
LIG_SH2_STAP1	137	141	PF00017	0.516
LIG_SH2_STAP1	4	8	PF00017	0.637
LIG_SH2_STAT3	682	685	PF00017	0.366
LIG_SH2_STAT5	128	131	PF00017	0.720
LIG_SH2_STAT5	154	157	PF00017	0.570
LIG_SH2_STAT5	246	249	PF00017	0.730
LIG_SH2_STAT5	253	256	PF00017	0.529
LIG_SH2_STAT5	281	284	PF00017	0.587
LIG_SH2_STAT5	435	438	PF00017	0.357
LIG_SH2_STAT5	569	572	PF00017	0.357
LIG_SH2_STAT5	608	611	PF00017	0.240
LIG_SH2_STAT5	646	649	PF00017	0.448
LIG_SH2_STAT5	682	685	PF00017	0.521
LIG_SH3_2	127	132	PF14604	0.529
LIG_SH3_2	158	163	PF14604	0.642
LIG_SH3_3	100	106	PF00018	0.591
LIG_SH3_3	124	130	PF00018	0.557
LIG_SH3_3	155	161	PF00018	0.532
LIG_SH3_3	171	177	PF00018	0.664
LIG_SH3_3	186	192	PF00018	0.508
LIG_SH3_3	363	369	PF00018	0.541
LIG_SH3_3	5	11	PF00018	0.550
LIG_SH3_3	572	578	PF00018	0.357
LIG_SH3_3	61	67	PF00018	0.804
LIG_SUMO_SIM_par_1	653	659	PF11976	0.438
LIG_TRAF2_1	58	61	PF00917	0.536
LIG_TYR_ITIM	433	438	PF00017	0.381
LIG_TYR_ITIM	658	663	PF00017	0.438
LIG_TYR_ITSM	252	259	PF00017	0.406
LIG_WW_3	22	26	PF00397	0.556
MOD_CDC14_SPxK_1	160	163	PF00782	0.602
MOD_CDC14_SPxK_1	349	352	PF00782	0.629
MOD_CDK_SPK_2	346	351	PF00069	0.616
MOD_CDK_SPK_2	91	96	PF00069	0.742
MOD_CDK_SPxK_1	157	163	PF00069	0.593
MOD_CDK_SPxK_1	19	25	PF00069	0.566
MOD_CDK_SPxK_1	346	352	PF00069	0.617
MOD_CK1_1	113	119	PF00069	0.699
MOD_CK1_1	231	237	PF00069	0.526
MOD_CK1_1	255	261	PF00069	0.466
MOD_CK1_1	280	286	PF00069	0.484
MOD_CK1_1	392	398	PF00069	0.510
MOD_CK1_1	43	49	PF00069	0.651
MOD_CK1_1	538	544	PF00069	0.438
MOD_CK1_1	607	613	PF00069	0.490
MOD_CK1_1	617	623	PF00069	0.331
MOD_CK1_1	629	635	PF00069	0.316
MOD_CK1_1	91	97	PF00069	0.560
MOD_CK2_1	175	181	PF00069	0.734
MOD_CK2_1	318	324	PF00069	0.656
MOD_CK2_1	326	332	PF00069	0.633
MOD_CK2_1	367	373	PF00069	0.605
MOD_CK2_1	392	398	PF00069	0.574
MOD_CK2_1	55	61	PF00069	0.667
MOD_CK2_1	629	635	PF00069	0.427
MOD_Cter_Amidation	197	200	PF01082	0.491
MOD_DYRK1A_RPxSP_1	102	106	PF00069	0.545
MOD_GlcNHglycan	120	123	PF01048	0.715
MOD_GlcNHglycan	14	17	PF01048	0.741
MOD_GlcNHglycan	196	199	PF01048	0.597
MOD_GlcNHglycan	232	236	PF01048	0.687
MOD_GlcNHglycan	293	296	PF01048	0.597
MOD_GlcNHglycan	320	323	PF01048	0.669
MOD_GlcNHglycan	340	343	PF01048	0.520
MOD_GlcNHglycan	37	40	PF01048	0.734
MOD_GlcNHglycan	380	383	PF01048	0.648
MOD_GlcNHglycan	42	45	PF01048	0.790
MOD_GlcNHglycan	48	51	PF01048	0.752
MOD_GlcNHglycan	609	612	PF01048	0.503
MOD_GlcNHglycan	628	631	PF01048	0.462
MOD_GSK3_1	102	109	PF00069	0.699
MOD_GSK3_1	244	251	PF00069	0.648
MOD_GSK3_1	260	267	PF00069	0.379
MOD_GSK3_1	282	289	PF00069	0.545
MOD_GSK3_1	326	333	PF00069	0.686
MOD_GSK3_1	385	392	PF00069	0.509
MOD_GSK3_1	401	408	PF00069	0.337
MOD_GSK3_1	471	478	PF00069	0.438
MOD_GSK3_1	51	58	PF00069	0.711
MOD_GSK3_1	534	541	PF00069	0.415
MOD_GSK3_1	556	563	PF00069	0.391
MOD_GSK3_1	610	617	PF00069	0.356
MOD_GSK3_1	84	91	PF00069	0.615
MOD_N-GLC_1	272	277	PF02516	0.378
MOD_N-GLC_1	345	350	PF02516	0.448
MOD_N-GLC_1	639	644	PF02516	0.492
MOD_NEK2_1	230	235	PF00069	0.702
MOD_NEK2_1	244	249	PF00069	0.696
MOD_NEK2_1	40	45	PF00069	0.762
MOD_NEK2_1	471	476	PF00069	0.400
MOD_NEK2_1	481	486	PF00069	0.324
MOD_NEK2_1	84	89	PF00069	0.568
MOD_NEK2_2	417	422	PF00069	0.364
MOD_NEK2_2	97	102	PF00069	0.590
MOD_PIKK_1	113	119	PF00454	0.628
MOD_PIKK_1	582	588	PF00454	0.438
MOD_PK_1	618	624	PF00069	0.240
MOD_PKA_1	318	324	PF00069	0.656
MOD_PKA_1	664	670	PF00069	0.438
MOD_PKA_2	131	137	PF00069	0.724
MOD_PKA_2	291	297	PF00069	0.586
MOD_PKA_2	392	398	PF00069	0.542
MOD_PKA_2	617	623	PF00069	0.336
MOD_PKA_2	664	670	PF00069	0.438
MOD_Plk_1	330	336	PF00069	0.600
MOD_Plk_1	471	477	PF00069	0.438
MOD_Plk_4	169	175	PF00069	0.645
MOD_Plk_4	255	261	PF00069	0.452
MOD_Plk_4	277	283	PF00069	0.594
MOD_Plk_4	422	428	PF00069	0.387
MOD_Plk_4	471	477	PF00069	0.393
MOD_Plk_4	569	575	PF00069	0.438
MOD_Plk_4	604	610	PF00069	0.413
MOD_Plk_4	84	90	PF00069	0.566
MOD_ProDKin_1	102	108	PF00069	0.694
MOD_ProDKin_1	123	129	PF00069	0.714
MOD_ProDKin_1	154	160	PF00069	0.598
MOD_ProDKin_1	175	181	PF00069	0.636
MOD_ProDKin_1	19	25	PF00069	0.750
MOD_ProDKin_1	346	352	PF00069	0.532
MOD_ProDKin_1	644	650	PF00069	0.240
MOD_ProDKin_1	91	97	PF00069	0.781
MOD_SUMO_for_1	306	309	PF00179	0.582
MOD_SUMO_for_1	502	505	PF00179	0.357
MOD_SUMO_for_1	550	553	PF00179	0.438
MOD_SUMO_rev_2	404	414	PF00179	0.492
TRG_DiLeu_BaEn_1	649	654	PF01217	0.240
TRG_DiLeu_BaEn_4	60	66	PF01217	0.540
TRG_ENDOCYTIC_2	137	140	PF00928	0.525
TRG_ENDOCYTIC_2	165	168	PF00928	0.569
TRG_ENDOCYTIC_2	256	259	PF00928	0.536
TRG_ENDOCYTIC_2	281	284	PF00928	0.587
TRG_ENDOCYTIC_2	325	328	PF00928	0.631
TRG_ENDOCYTIC_2	384	387	PF00928	0.632
TRG_ENDOCYTIC_2	429	432	PF00928	0.371
TRG_ENDOCYTIC_2	435	438	PF00928	0.375
TRG_ENDOCYTIC_2	660	663	PF00928	0.438
TRG_ER_diArg_1	199	201	PF00400	0.513
TRG_ER_diArg_1	217	220	PF00400	0.554
TRG_ER_diArg_1	350	352	PF00400	0.628
TRG_ER_FFAT_2	606	613	PF00635	0.240
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE38	Leptomonas seymouri	75%	100%
A0A0S4JLW5	Bodo saltans	35%	90%
A0A3S5H6X9	Leishmania donovani	75%	100%
A4HWY3	Leishmania infantum	76%	100%
C9ZW20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AQP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QET2	Leishmania major	76%	100%