Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8L0_LEIBR

TriTrypDb:

LbrM.16.0870 , LBRM2903_160015200

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8L0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	61	65	PF00656	0.556
CLV_NRD_NRD_1	133	135	PF00675	0.509
CLV_NRD_NRD_1	199	201	PF00675	0.566
CLV_PCSK_KEX2_1	133	135	PF00082	0.509
CLV_PCSK_KEX2_1	193	195	PF00082	0.553
CLV_PCSK_KEX2_1	199	201	PF00082	0.566
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.553
CLV_PCSK_PC7_1	189	195	PF00082	0.487
CLV_PCSK_SKI1_1	106	110	PF00082	0.582
DEG_SCF_FBW7_1	24	30	PF00400	0.513
DEG_SCF_TRCP1_1	64	69	PF00400	0.513
DEG_SPOP_SBC_1	27	31	PF00917	0.667
DOC_CKS1_1	24	29	PF01111	0.513
DOC_CKS1_1	4	9	PF01111	0.499
DOC_MAPK_gen_1	196	205	PF00069	0.570
DOC_MAPK_MEF2A_6	80	88	PF00069	0.622
DOC_PP2B_LxvP_1	142	145	PF13499	0.508
DOC_PP4_FxxP_1	157	160	PF00568	0.557
DOC_SPAK_OSR1_1	200	204	PF12202	0.564
DOC_USP7_MATH_1	27	31	PF00917	0.704
DOC_USP7_MATH_1	50	54	PF00917	0.630
DOC_USP7_MATH_1	62	66	PF00917	0.739
DOC_USP7_UBL2_3	76	80	PF12436	0.630
DOC_WW_Pin1_4	117	122	PF00397	0.736
DOC_WW_Pin1_4	156	161	PF00397	0.590
DOC_WW_Pin1_4	23	28	PF00397	0.580
DOC_WW_Pin1_4	3	8	PF00397	0.497
DOC_WW_Pin1_4	96	101	PF00397	0.611
LIG_14-3-3_CanoR_1	106	111	PF00244	0.494
LIG_14-3-3_CanoR_1	85	89	PF00244	0.634
LIG_Actin_WH2_2	5	21	PF00022	0.529
LIG_BRCT_BRCA1_1	111	115	PF00533	0.603
LIG_BRCT_BRCA1_1	197	201	PF00533	0.488
LIG_BRCT_BRCA1_1	32	36	PF00533	0.515
LIG_FHA_1	105	111	PF00498	0.582
LIG_FHA_1	139	145	PF00498	0.510
LIG_FHA_1	38	44	PF00498	0.495
LIG_FHA_1	4	10	PF00498	0.426
LIG_FHA_2	147	153	PF00498	0.656
LIG_LIR_Apic_2	154	160	PF02991	0.557
LIG_SH3_3	21	27	PF00018	0.616
LIG_SH3_3	71	77	PF00018	0.507
LIG_SH3_4	76	83	PF00018	0.628
LIG_SUMO_SIM_anti_2	171	178	PF11976	0.569
LIG_SUMO_SIM_anti_2	216	222	PF11976	0.453
LIG_SUMO_SIM_par_1	106	112	PF11976	0.597
LIG_SUMO_SIM_par_1	139	147	PF11976	0.512
LIG_SUMO_SIM_par_1	216	222	PF11976	0.493
LIG_TRAF2_1	14	17	PF00917	0.597
MOD_CDC14_SPxK_1	99	102	PF00782	0.515
MOD_CDK_SPxK_1	96	102	PF00069	0.517
MOD_CK1_1	117	123	PF00069	0.568
MOD_CK1_1	140	146	PF00069	0.645
MOD_CK1_1	165	171	PF00069	0.548
MOD_CK1_1	185	191	PF00069	0.576
MOD_CK1_1	29	35	PF00069	0.602
MOD_CK1_1	37	43	PF00069	0.578
MOD_CK2_1	146	152	PF00069	0.662
MOD_GlcNHglycan	165	168	PF01048	0.633
MOD_GlcNHglycan	52	55	PF01048	0.606
MOD_GlcNHglycan	64	67	PF01048	0.593
MOD_GSK3_1	109	116	PF00069	0.595
MOD_GSK3_1	134	141	PF00069	0.704
MOD_GSK3_1	146	153	PF00069	0.685
MOD_GSK3_1	179	186	PF00069	0.557
MOD_GSK3_1	22	29	PF00069	0.647
MOD_GSK3_1	30	37	PF00069	0.600
MOD_GSK3_1	62	69	PF00069	0.577
MOD_N-GLC_1	113	118	PF02516	0.593
MOD_N-GLC_1	62	67	PF02516	0.542
MOD_NEK2_1	104	109	PF00069	0.606
MOD_NEK2_1	162	167	PF00069	0.611
MOD_NEK2_1	179	184	PF00069	0.484
MOD_NEK2_1	219	224	PF00069	0.479
MOD_NEK2_1	28	33	PF00069	0.609
MOD_NEK2_1	36	41	PF00069	0.536
MOD_NEK2_2	70	75	PF00069	0.511
MOD_PKA_2	188	194	PF00069	0.489
MOD_PKA_2	84	90	PF00069	0.598
MOD_Plk_1	138	144	PF00069	0.569
MOD_Plk_1	151	157	PF00069	0.607
MOD_Plk_4	170	176	PF00069	0.571
MOD_Plk_4	208	214	PF00069	0.511
MOD_Plk_4	70	76	PF00069	0.510
MOD_Plk_4	79	85	PF00069	0.576
MOD_ProDKin_1	117	123	PF00069	0.737
MOD_ProDKin_1	156	162	PF00069	0.587
MOD_ProDKin_1	23	29	PF00069	0.580
MOD_ProDKin_1	3	9	PF00069	0.498
MOD_ProDKin_1	96	102	PF00069	0.613
TRG_DiLeu_BaEn_1	216	221	PF01217	0.566
TRG_DiLeu_BaLyEn_6	157	162	PF01217	0.494
TRG_ER_diArg_1	199	201	PF00400	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5G6	Leptomonas seymouri	49%	100%
A0A3Q8IAC4	Leishmania donovani	74%	98%
A4HWY2	Leishmania infantum	74%	98%
E9AQP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	70%
Q4QET3	Leishmania major	74%	100%