Putative metallopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COP9 signalosome complex subunit 5, putative

Species:

Leishmania braziliensis

UniProt:

A4H8K9_LEIBR

TriTrypDb:

LbrM.16.0860 , LBRM2903_160015100

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0008180	COP9 signalosome	3	7
GO:0032991	protein-containing complex	1	7
GO:0140513	nuclear protein-containing complex	2	7
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8K9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8K9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0019538	protein metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:0000338	protein deneddylation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0070646	protein modification by small protein removal	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004175	endopeptidase activity	4	7
GO:0004222	metalloendopeptidase activity	5	7
GO:0005488	binding	1	7
GO:0008233	peptidase activity	3	7
GO:0008237	metallopeptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:0019783	ubiquitin-like protein peptidase activity	4	1
GO:0019784	deNEDDylase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.493
CLV_C14_Caspase3-7	373	377	PF00656	0.788
CLV_C14_Caspase3-7	380	384	PF00656	0.532
CLV_NRD_NRD_1	149	151	PF00675	0.381
CLV_NRD_NRD_1	293	295	PF00675	0.358
CLV_NRD_NRD_1	349	351	PF00675	0.661
CLV_NRD_NRD_1	55	57	PF00675	0.468
CLV_PCSK_FUR_1	435	439	PF00082	0.541
CLV_PCSK_KEX2_1	149	151	PF00082	0.381
CLV_PCSK_KEX2_1	293	295	PF00082	0.358
CLV_PCSK_KEX2_1	349	351	PF00082	0.661
CLV_PCSK_KEX2_1	437	439	PF00082	0.755
CLV_PCSK_KEX2_1	55	57	PF00082	0.468
CLV_PCSK_PC1ET2_1	437	439	PF00082	0.755
CLV_PCSK_SKI1_1	79	83	PF00082	0.482
DOC_ANK_TNKS_1	211	218	PF00023	0.463
DOC_CKS1_1	20	25	PF01111	0.795
DOC_CYCLIN_yCln2_LP_2	302	308	PF00134	0.566
DOC_MAPK_gen_1	293	300	PF00069	0.363
DOC_MAPK_HePTP_8	290	302	PF00069	0.626
DOC_MAPK_MEF2A_6	185	193	PF00069	0.344
DOC_MAPK_MEF2A_6	270	278	PF00069	0.455
DOC_MAPK_MEF2A_6	293	302	PF00069	0.627
DOC_PP4_FxxP_1	120	123	PF00568	0.381
DOC_USP7_MATH_1	13	17	PF00917	0.707
DOC_USP7_MATH_1	237	241	PF00917	0.639
DOC_USP7_MATH_1	242	246	PF00917	0.609
DOC_USP7_MATH_1	256	260	PF00917	0.505
DOC_USP7_MATH_1	37	41	PF00917	0.499
DOC_USP7_MATH_1	393	397	PF00917	0.564
DOC_USP7_MATH_1	429	433	PF00917	0.619
DOC_USP7_MATH_1	460	464	PF00917	0.558
DOC_USP7_MATH_1	89	93	PF00917	0.366
DOC_WW_Pin1_4	19	24	PF00397	0.737
DOC_WW_Pin1_4	337	342	PF00397	0.684
DOC_WW_Pin1_4	440	445	PF00397	0.596
DOC_WW_Pin1_4	456	461	PF00397	0.503
DOC_WW_Pin1_4	9	14	PF00397	0.799
LIG_14-3-3_CanoR_1	277	287	PF00244	0.482
LIG_14-3-3_CanoR_1	4	10	PF00244	0.610
LIG_14-3-3_CanoR_1	438	444	PF00244	0.658
LIG_Actin_WH2_2	187	204	PF00022	0.405
LIG_AP2alpha_2	188	190	PF02296	0.442
LIG_BIR_II_1	1	5	PF00653	0.761
LIG_BRCT_BRCA1_1	202	206	PF00533	0.363
LIG_BRCT_BRCA1_1	300	304	PF00533	0.534
LIG_BRCT_BRCA1_1	63	67	PF00533	0.540
LIG_CtBP_PxDLS_1	297	301	PF00389	0.526
LIG_deltaCOP1_diTrp_1	41	48	PF00928	0.587
LIG_EH1_1	98	106	PF00400	0.381
LIG_FHA_1	393	399	PF00498	0.635
LIG_FHA_1	428	434	PF00498	0.476
LIG_FHA_2	211	217	PF00498	0.451
LIG_HP1_1	189	193	PF01393	0.425
LIG_Integrin_RGD_1	350	352	PF01839	0.527
LIG_LIR_Apic_2	117	123	PF02991	0.381
LIG_LIR_Apic_2	251	256	PF02991	0.672
LIG_LIR_Apic_2	40	46	PF02991	0.426
LIG_LIR_Gen_1	188	198	PF02991	0.429
LIG_LIR_Gen_1	404	414	PF02991	0.733
LIG_LIR_Gen_1	47	54	PF02991	0.567
LIG_LIR_Gen_1	64	75	PF02991	0.482
LIG_LIR_Nem_3	188	193	PF02991	0.431
LIG_LIR_Nem_3	247	253	PF02991	0.501
LIG_LIR_Nem_3	404	409	PF02991	0.726
LIG_LIR_Nem_3	64	70	PF02991	0.501
LIG_MLH1_MIPbox_1	63	67	PF16413	0.540
LIG_PAM2_1	397	409	PF00658	0.452
LIG_PCNA_PIPBox_1	102	111	PF02747	0.381
LIG_PDZ_Class_3	468	473	PF00595	0.682
LIG_Pex14_1	44	48	PF04695	0.591
LIG_RPA_C_Fungi	397	409	PF08784	0.452
LIG_SH2_CRK	253	257	PF00017	0.686
LIG_SH2_CRK	33	37	PF00017	0.436
LIG_SH2_STAP1	168	172	PF00017	0.381
LIG_SH2_STAT5	144	147	PF00017	0.381
LIG_SH3_3	191	197	PF00018	0.420
LIG_SH3_3	302	308	PF00018	0.626
LIG_SUMO_SIM_anti_2	71	77	PF11976	0.276
LIG_SUMO_SIM_par_1	296	301	PF11976	0.526
LIG_SUMO_SIM_par_1	390	397	PF11976	0.685
LIG_TRAF2_1	467	470	PF00917	0.764
MOD_CDK_SPxxK_3	337	344	PF00069	0.535
MOD_CK1_1	440	446	PF00069	0.766
MOD_CK1_1	455	461	PF00069	0.576
MOD_CK2_1	124	130	PF00069	0.283
MOD_CK2_1	210	216	PF00069	0.431
MOD_CK2_1	313	319	PF00069	0.442
MOD_CK2_1	464	470	PF00069	0.567
MOD_Cter_Amidation	435	438	PF01082	0.537
MOD_GlcNHglycan	1	4	PF01048	0.646
MOD_GlcNHglycan	172	175	PF01048	0.381
MOD_GlcNHglycan	202	205	PF01048	0.370
MOD_GlcNHglycan	24	27	PF01048	0.580
MOD_GlcNHglycan	240	243	PF01048	0.545
MOD_GlcNHglycan	244	247	PF01048	0.538
MOD_GlcNHglycan	280	283	PF01048	0.583
MOD_GlcNHglycan	316	319	PF01048	0.675
MOD_GlcNHglycan	324	327	PF01048	0.541
MOD_GlcNHglycan	367	370	PF01048	0.723
MOD_GlcNHglycan	372	375	PF01048	0.686
MOD_GlcNHglycan	376	380	PF01048	0.572
MOD_GlcNHglycan	399	402	PF01048	0.424
MOD_GlcNHglycan	445	448	PF01048	0.794
MOD_GSK3_1	114	121	PF00069	0.359
MOD_GSK3_1	166	173	PF00069	0.381
MOD_GSK3_1	176	183	PF00069	0.381
MOD_GSK3_1	18	25	PF00069	0.758
MOD_GSK3_1	200	207	PF00069	0.487
MOD_GSK3_1	221	228	PF00069	0.716
MOD_GSK3_1	238	245	PF00069	0.468
MOD_GSK3_1	296	303	PF00069	0.530
MOD_GSK3_1	393	400	PF00069	0.493
MOD_GSK3_1	439	446	PF00069	0.739
MOD_GSK3_1	452	459	PF00069	0.676
MOD_GSK3_1	460	467	PF00069	0.699
MOD_GSK3_1	5	12	PF00069	0.760
MOD_GSK3_1	66	73	PF00069	0.398
MOD_N-GLC_1	131	136	PF02516	0.235
MOD_N-GLC_1	225	230	PF02516	0.528
MOD_N-GLC_1	242	247	PF02516	0.559
MOD_NEK2_1	116	121	PF00069	0.359
MOD_NEK2_1	298	303	PF00069	0.501
MOD_NEK2_1	32	37	PF00069	0.695
MOD_NEK2_1	359	364	PF00069	0.764
MOD_NEK2_1	66	71	PF00069	0.418
MOD_NEK2_1	74	79	PF00069	0.338
MOD_NEK2_1	82	87	PF00069	0.287
MOD_NEK2_2	166	171	PF00069	0.381
MOD_NEK2_2	197	202	PF00069	0.405
MOD_NEK2_2	204	209	PF00069	0.470
MOD_PIKK_1	134	140	PF00454	0.334
MOD_PIKK_1	176	182	PF00454	0.381
MOD_PIKK_1	221	227	PF00454	0.505
MOD_PIKK_1	307	313	PF00454	0.448
MOD_PIKK_1	328	334	PF00454	0.468
MOD_PIKK_1	89	95	PF00454	0.381
MOD_PKA_1	437	443	PF00069	0.657
MOD_PKA_2	437	443	PF00069	0.677
MOD_Plk_1	134	140	PF00069	0.391
MOD_Plk_1	204	210	PF00069	0.328
MOD_Plk_1	452	458	PF00069	0.790
MOD_Plk_1	464	470	PF00069	0.602
MOD_Plk_4	244	250	PF00069	0.533
MOD_Plk_4	61	67	PF00069	0.458
MOD_Plk_4	70	76	PF00069	0.381
MOD_ProDKin_1	19	25	PF00069	0.733
MOD_ProDKin_1	337	343	PF00069	0.686
MOD_ProDKin_1	440	446	PF00069	0.597
MOD_ProDKin_1	456	462	PF00069	0.505
MOD_ProDKin_1	9	15	PF00069	0.802
MOD_SUMO_for_1	385	388	PF00179	0.628
TRG_DiLeu_BaEn_1	100	105	PF01217	0.381
TRG_DiLeu_BaEn_1	404	409	PF01217	0.626
TRG_DiLeu_BaLyEn_6	387	392	PF01217	0.701
TRG_DiLeu_LyEn_5	354	359	PF01217	0.517
TRG_ENDOCYTIC_2	168	171	PF00928	0.381
TRG_ENDOCYTIC_2	271	274	PF00928	0.377
TRG_ENDOCYTIC_2	33	36	PF00928	0.620
TRG_ER_diArg_1	149	151	PF00400	0.381
TRG_ER_diArg_1	293	295	PF00400	0.358
TRG_ER_diArg_1	344	347	PF00400	0.545
TRG_ER_diArg_1	348	350	PF00400	0.561
TRG_ER_diArg_1	86	89	PF00400	0.235

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD30	Leptomonas seymouri	58%	100%
A0A3Q8IAE8	Leishmania donovani	79%	96%
A4HWY1	Leishmania infantum	79%	100%
E9AQP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QET4	Leishmania major	78%	100%
Q6C703	Yarrowia lipolytica (strain CLIB 122 / E 150)	30%	100%