SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8K8_LEIBR

TriTrypDb:

LbrM.16.0850 , LBRM2903_160015000

Length:

788

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H8K8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8K8

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018026	peptidyl-lysine monomethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.350
CLV_C14_Caspase3-7	244	248	PF00656	0.686
CLV_C14_Caspase3-7	770	774	PF00656	0.580
CLV_NRD_NRD_1	175	177	PF00675	0.618
CLV_NRD_NRD_1	290	292	PF00675	0.540
CLV_NRD_NRD_1	305	307	PF00675	0.498
CLV_NRD_NRD_1	447	449	PF00675	0.707
CLV_NRD_NRD_1	565	567	PF00675	0.646
CLV_NRD_NRD_1	62	64	PF00675	0.445
CLV_PCSK_KEX2_1	175	177	PF00082	0.672
CLV_PCSK_KEX2_1	290	292	PF00082	0.603
CLV_PCSK_KEX2_1	305	307	PF00082	0.527
CLV_PCSK_KEX2_1	446	448	PF00082	0.698
CLV_PCSK_KEX2_1	565	567	PF00082	0.512
CLV_PCSK_SKI1_1	306	310	PF00082	0.485
CLV_PCSK_SKI1_1	548	552	PF00082	0.438
CLV_Separin_Metazoa	624	628	PF03568	0.299
DEG_APCC_DBOX_1	504	512	PF00400	0.390
DEG_APCC_DBOX_1	547	555	PF00400	0.493
DEG_APCC_DBOX_1	598	606	PF00400	0.497
DEG_Nend_UBRbox_2	1	3	PF02207	0.447
DEG_SCF_FBW7_1	613	620	PF00400	0.566
DEG_SPOP_SBC_1	727	731	PF00917	0.319
DOC_CKS1_1	698	703	PF01111	0.623
DOC_CYCLIN_RxL_1	762	773	PF00134	0.443
DOC_MAPK_FxFP_2	385	388	PF00069	0.502
DOC_MAPK_gen_1	455	463	PF00069	0.661
DOC_MAPK_gen_1	522	528	PF00069	0.638
DOC_MAPK_JIP1_4	505	511	PF00069	0.389
DOC_PP1_RVXF_1	716	723	PF00149	0.325
DOC_PP2B_LxvP_1	509	512	PF13499	0.572
DOC_PP4_FxxP_1	385	388	PF00568	0.519
DOC_PP4_FxxP_1	698	701	PF00568	0.575
DOC_USP7_MATH_1	112	116	PF00917	0.550
DOC_USP7_MATH_1	271	275	PF00917	0.637
DOC_USP7_MATH_1	277	281	PF00917	0.600
DOC_USP7_MATH_1	29	33	PF00917	0.455
DOC_USP7_MATH_1	327	331	PF00917	0.638
DOC_USP7_MATH_1	404	408	PF00917	0.419
DOC_USP7_MATH_1	437	441	PF00917	0.550
DOC_USP7_MATH_1	454	458	PF00917	0.470
DOC_USP7_MATH_1	536	540	PF00917	0.564
DOC_USP7_MATH_1	55	59	PF00917	0.377
DOC_USP7_MATH_1	608	612	PF00917	0.406
DOC_USP7_MATH_1	693	697	PF00917	0.446
DOC_USP7_MATH_1	768	772	PF00917	0.502
DOC_USP7_MATH_1	86	90	PF00917	0.683
DOC_USP7_MATH_2	191	197	PF00917	0.481
DOC_WW_Pin1_4	232	237	PF00397	0.630
DOC_WW_Pin1_4	261	266	PF00397	0.682
DOC_WW_Pin1_4	476	481	PF00397	0.352
DOC_WW_Pin1_4	600	605	PF00397	0.442
DOC_WW_Pin1_4	613	618	PF00397	0.512
DOC_WW_Pin1_4	629	634	PF00397	0.393
DOC_WW_Pin1_4	697	702	PF00397	0.455
LIG_14-3-3_CanoR_1	166	174	PF00244	0.451
LIG_14-3-3_CanoR_1	284	290	PF00244	0.665
LIG_14-3-3_CanoR_1	291	297	PF00244	0.396
LIG_14-3-3_CanoR_1	560	564	PF00244	0.316
LIG_14-3-3_CanoR_1	57	63	PF00244	0.357
LIG_14-3-3_CanoR_1	754	759	PF00244	0.550
LIG_Actin_WH2_2	120	135	PF00022	0.449
LIG_Actin_WH2_2	490	507	PF00022	0.526
LIG_Actin_WH2_2	96	111	PF00022	0.405
LIG_AP2alpha_1	397	401	PF02296	0.463
LIG_APCC_ABBA_1	394	399	PF00400	0.456
LIG_BIR_III_2	641	645	PF00653	0.378
LIG_BIR_III_4	535	539	PF00653	0.582
LIG_BRCT_BRCA1_1	381	385	PF00533	0.375
LIG_CSL_BTD_1	698	701	PF09270	0.575
LIG_deltaCOP1_diTrp_1	207	214	PF00928	0.395
LIG_deltaCOP1_diTrp_1	389	397	PF00928	0.345
LIG_deltaCOP1_diTrp_1	653	659	PF00928	0.469
LIG_deltaCOP1_diTrp_1	662	667	PF00928	0.511
LIG_deltaCOP1_diTrp_1	759	766	PF00928	0.509
LIG_eIF4E_1	491	497	PF01652	0.382
LIG_FHA_1	148	154	PF00498	0.424
LIG_FHA_1	40	46	PF00498	0.439
LIG_FHA_1	423	429	PF00498	0.603
LIG_FHA_1	451	457	PF00498	0.554
LIG_FHA_1	630	636	PF00498	0.512
LIG_FHA_1	753	759	PF00498	0.562
LIG_FHA_2	242	248	PF00498	0.743
LIG_FHA_2	477	483	PF00498	0.403
LIG_FHA_2	488	494	PF00498	0.302
LIG_FHA_2	618	624	PF00498	0.606
LIG_LIR_Apic_2	382	388	PF02991	0.500
LIG_LIR_Apic_2	696	701	PF02991	0.586
LIG_LIR_Gen_1	207	218	PF02991	0.461
LIG_LIR_Gen_1	285	294	PF02991	0.578
LIG_LIR_Gen_1	389	400	PF02991	0.343
LIG_LIR_Gen_1	490	498	PF02991	0.400
LIG_LIR_Gen_1	759	769	PF02991	0.500
LIG_LIR_LC3C_4	712	717	PF02991	0.427
LIG_LIR_Nem_3	285	289	PF02991	0.579
LIG_LIR_Nem_3	399	403	PF02991	0.385
LIG_LIR_Nem_3	468	474	PF02991	0.490
LIG_LIR_Nem_3	490	494	PF02991	0.376
LIG_LIR_Nem_3	661	667	PF02991	0.541
LIG_LIR_Nem_3	670	675	PF02991	0.540
LIG_LIR_Nem_3	759	764	PF02991	0.461
LIG_LIR_Nem_3	777	782	PF02991	0.510
LIG_MYND_1	506	510	PF01753	0.470
LIG_NRBOX	621	627	PF00104	0.462
LIG_NRBOX	9	15	PF00104	0.376
LIG_PCNA_PIPBox_1	760	769	PF02747	0.496
LIG_PCNA_yPIPBox_3	754	767	PF02747	0.536
LIG_Pex14_1	282	286	PF04695	0.580
LIG_Pex14_1	722	726	PF04695	0.384
LIG_Pex14_2	373	377	PF04695	0.435
LIG_Pex14_2	397	401	PF04695	0.419
LIG_SH2_CRK	222	226	PF00017	0.382
LIG_SH2_CRK	598	602	PF00017	0.572
LIG_SH2_GRB2like	222	225	PF00017	0.399
LIG_SH2_GRB2like	400	403	PF00017	0.333
LIG_SH2_GRB2like	726	729	PF00017	0.508
LIG_SH2_NCK_1	491	495	PF00017	0.528
LIG_SH2_PTP2	156	159	PF00017	0.373
LIG_SH2_PTP2	286	289	PF00017	0.574
LIG_SH2_STAP1	222	226	PF00017	0.396
LIG_SH2_STAP1	469	473	PF00017	0.414
LIG_SH2_STAT3	469	472	PF00017	0.472
LIG_SH2_STAT5	156	159	PF00017	0.338
LIG_SH2_STAT5	204	207	PF00017	0.498
LIG_SH2_STAT5	286	289	PF00017	0.544
LIG_SH2_STAT5	307	310	PF00017	0.372
LIG_SH2_STAT5	386	389	PF00017	0.511
LIG_SH2_STAT5	400	403	PF00017	0.268
LIG_SH2_STAT5	532	535	PF00017	0.454
LIG_SH2_STAT5	726	729	PF00017	0.502
LIG_SH2_STAT5	779	782	PF00017	0.447
LIG_SH3_1	598	604	PF00018	0.575
LIG_SH3_3	260	266	PF00018	0.684
LIG_SH3_3	415	421	PF00018	0.594
LIG_SH3_3	524	530	PF00018	0.640
LIG_SH3_3	552	558	PF00018	0.492
LIG_SH3_3	598	604	PF00018	0.554
LIG_SH3_5	396	400	PF00018	0.333
LIG_SUMO_SIM_anti_2	492	498	PF11976	0.448
LIG_SUMO_SIM_anti_2	712	718	PF11976	0.479
LIG_SUMO_SIM_par_1	754	759	PF11976	0.402
LIG_TRAF2_1	178	181	PF00917	0.581
LIG_TRAF2_1	230	233	PF00917	0.578
LIG_TRAF2_1	581	584	PF00917	0.564
LIG_TRAF2_1	709	712	PF00917	0.540
LIG_TRAF2_1	775	778	PF00917	0.457
LIG_TRFH_1	502	506	PF08558	0.437
LIG_TYR_ITIM	154	159	PF00017	0.337
MOD_CDK_SPK_2	476	481	PF00069	0.352
MOD_CDK_SPxxK_3	697	704	PF00069	0.438
MOD_CK1_1	149	155	PF00069	0.423
MOD_CK1_1	285	291	PF00069	0.666
MOD_CK1_1	351	357	PF00069	0.721
MOD_CK1_1	407	413	PF00069	0.413
MOD_CK1_1	432	438	PF00069	0.626
MOD_CK1_1	476	482	PF00069	0.345
MOD_CK1_1	5	11	PF00069	0.500
MOD_CK1_1	515	521	PF00069	0.488
MOD_CK1_1	556	562	PF00069	0.496
MOD_CK1_1	58	64	PF00069	0.323
MOD_CK1_1	697	703	PF00069	0.521
MOD_CK1_1	89	95	PF00069	0.578
MOD_CK2_1	116	122	PF00069	0.608
MOD_CK2_1	325	331	PF00069	0.488
MOD_CK2_1	476	482	PF00069	0.457
MOD_CK2_1	489	495	PF00069	0.392
MOD_CK2_1	578	584	PF00069	0.561
MOD_CK2_1	608	614	PF00069	0.452
MOD_CK2_1	706	712	PF00069	0.524
MOD_CMANNOS	655	658	PF00535	0.257
MOD_GlcNHglycan	118	121	PF01048	0.538
MOD_GlcNHglycan	179	185	PF01048	0.652
MOD_GlcNHglycan	22	25	PF01048	0.472
MOD_GlcNHglycan	247	250	PF01048	0.656
MOD_GlcNHglycan	256	259	PF01048	0.741
MOD_GlcNHglycan	341	344	PF01048	0.754
MOD_GlcNHglycan	358	362	PF01048	0.496
MOD_GlcNHglycan	434	437	PF01048	0.478
MOD_GlcNHglycan	439	442	PF01048	0.479
MOD_GlcNHglycan	514	517	PF01048	0.564
MOD_GlcNHglycan	555	558	PF01048	0.513
MOD_GlcNHglycan	669	672	PF01048	0.518
MOD_GlcNHglycan	7	10	PF01048	0.475
MOD_GlcNHglycan	741	744	PF01048	0.613
MOD_GlcNHglycan	88	91	PF01048	0.479
MOD_GSK3_1	112	119	PF00069	0.521
MOD_GSK3_1	122	129	PF00069	0.488
MOD_GSK3_1	180	187	PF00069	0.689
MOD_GSK3_1	189	196	PF00069	0.720
MOD_GSK3_1	198	205	PF00069	0.490
MOD_GSK3_1	232	239	PF00069	0.575
MOD_GSK3_1	241	248	PF00069	0.611
MOD_GSK3_1	254	261	PF00069	0.686
MOD_GSK3_1	348	355	PF00069	0.727
MOD_GSK3_1	432	439	PF00069	0.659
MOD_GSK3_1	446	453	PF00069	0.694
MOD_GSK3_1	500	507	PF00069	0.489
MOD_GSK3_1	608	615	PF00069	0.540
MOD_GSK3_1	693	700	PF00069	0.474
MOD_GSK3_1	739	746	PF00069	0.608
MOD_GSK3_1	78	85	PF00069	0.515
MOD_N-GLC_1	407	412	PF02516	0.395
MOD_N-GLC_1	432	437	PF02516	0.468
MOD_N-GLC_1	727	732	PF02516	0.482
MOD_NEK2_1	159	164	PF00069	0.428
MOD_NEK2_1	292	297	PF00069	0.539
MOD_NEK2_1	352	357	PF00069	0.682
MOD_NEK2_1	429	434	PF00069	0.513
MOD_NEK2_1	473	478	PF00069	0.427
MOD_NEK2_1	667	672	PF00069	0.535
MOD_NEK2_1	684	689	PF00069	0.538
MOD_NEK2_1	694	699	PF00069	0.315
MOD_NEK2_1	738	743	PF00069	0.745
MOD_NEK2_1	752	757	PF00069	0.519
MOD_NEK2_2	500	505	PF00069	0.523
MOD_PIKK_1	126	132	PF00454	0.382
MOD_PIKK_1	352	358	PF00454	0.639
MOD_PIKK_1	78	84	PF00454	0.469
MOD_PK_1	754	760	PF00069	0.544
MOD_PKA_1	446	452	PF00069	0.488
MOD_PKA_2	165	171	PF00069	0.449
MOD_PKA_2	271	277	PF00069	0.733
MOD_PKA_2	446	452	PF00069	0.585
MOD_PKA_2	454	460	PF00069	0.501
MOD_PKA_2	504	510	PF00069	0.548
MOD_PKA_2	559	565	PF00069	0.582
MOD_Plk_1	180	186	PF00069	0.644
MOD_Plk_1	388	394	PF00069	0.462
MOD_Plk_1	780	786	PF00069	0.369
MOD_Plk_2-3	325	331	PF00069	0.420
MOD_Plk_2-3	578	584	PF00069	0.388
MOD_Plk_4	149	155	PF00069	0.305
MOD_Plk_4	159	165	PF00069	0.308
MOD_Plk_4	241	247	PF00069	0.584
MOD_Plk_4	292	298	PF00069	0.495
MOD_Plk_4	376	382	PF00069	0.307
MOD_Plk_4	407	413	PF00069	0.553
MOD_Plk_4	46	52	PF00069	0.323
MOD_Plk_4	504	510	PF00069	0.500
MOD_Plk_4	536	542	PF00069	0.684
MOD_Plk_4	559	565	PF00069	0.325
MOD_Plk_4	617	623	PF00069	0.452
MOD_Plk_4	685	691	PF00069	0.379
MOD_Plk_4	694	700	PF00069	0.450
MOD_ProDKin_1	232	238	PF00069	0.633
MOD_ProDKin_1	261	267	PF00069	0.683
MOD_ProDKin_1	476	482	PF00069	0.345
MOD_ProDKin_1	600	606	PF00069	0.445
MOD_ProDKin_1	613	619	PF00069	0.500
MOD_ProDKin_1	629	635	PF00069	0.389
MOD_ProDKin_1	697	703	PF00069	0.463
MOD_SUMO_for_1	138	141	PF00179	0.508
TRG_DiLeu_BaEn_3	389	395	PF01217	0.289
TRG_DiLeu_BaEn_4	180	186	PF01217	0.503
TRG_DiLeu_BaLyEn_6	710	715	PF01217	0.458
TRG_ENDOCYTIC_2	156	159	PF00928	0.338
TRG_ENDOCYTIC_2	222	225	PF00928	0.389
TRG_ENDOCYTIC_2	286	289	PF00928	0.487
TRG_ENDOCYTIC_2	491	494	PF00928	0.402
TRG_ER_diArg_1	174	176	PF00400	0.607
TRG_ER_diArg_1	289	291	PF00400	0.595
TRG_ER_diArg_1	305	307	PF00400	0.521
TRG_ER_diArg_1	446	448	PF00400	0.616
TRG_ER_diArg_1	564	566	PF00400	0.502
TRG_Pf-PMV_PEXEL_1	765	770	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I059	Leptomonas seymouri	50%	97%
A0A1X0NQD9	Trypanosomatidae	26%	100%
A0A3R7NAY7	Trypanosoma rangeli	28%	100%
A0A3S7WTX8	Leishmania donovani	74%	98%
C9ZPM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AGN5	Leishmania infantum	74%	98%
E9AQP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	98%
Q4QET5	Leishmania major	74%	100%
V5BLP9	Trypanosoma cruzi	26%	100%