Fe-S_biosyn domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Iron-sulfur assembly protein 1, putative

Species:

Leishmania braziliensis

UniProt:

A4H8K7_LEIBR

TriTrypDb:

LbrM.16.0840 , LBRM2903_160014900

Length:

269

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8K7

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016226	iron-sulfur cluster assembly	4	12
GO:0022607	cellular component assembly	4	12
GO:0031163	metallo-sulfur cluster assembly	5	12
GO:0044237	cellular metabolic process	2	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0006807	nitrogen compound metabolic process	2	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0097428	protein maturation by iron-sulfur cluster transfer	5	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051540	metal cluster binding	2	12
GO:0051537	2 iron, 2 sulfur cluster binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.609
CLV_NRD_NRD_1	102	104	PF00675	0.511
CLV_NRD_NRD_1	110	112	PF00675	0.413
CLV_NRD_NRD_1	129	131	PF00675	0.480
CLV_NRD_NRD_1	169	171	PF00675	0.275
CLV_NRD_NRD_1	196	198	PF00675	0.301
CLV_PCSK_KEX2_1	110	112	PF00082	0.479
CLV_PCSK_KEX2_1	129	131	PF00082	0.366
CLV_PCSK_KEX2_1	168	170	PF00082	0.242
CLV_PCSK_KEX2_1	187	189	PF00082	0.355
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.369
CLV_PCSK_PC7_1	164	170	PF00082	0.264
CLV_PCSK_SKI1_1	118	122	PF00082	0.445
CLV_PCSK_SKI1_1	129	133	PF00082	0.444
CLV_PCSK_SKI1_1	191	195	PF00082	0.279
DEG_SPOP_SBC_1	72	76	PF00917	0.776
DOC_CYCLIN_RxL_1	129	139	PF00134	0.516
DOC_PP1_RVXF_1	109	116	PF00149	0.530
DOC_PP4_FxxP_1	243	246	PF00568	0.439
DOC_USP7_MATH_1	150	154	PF00917	0.683
DOC_USP7_MATH_1	158	162	PF00917	0.502
DOC_USP7_MATH_1	18	22	PF00917	0.728
DOC_USP7_MATH_1	23	27	PF00917	0.711
DOC_USP7_MATH_1	89	93	PF00917	0.654
DOC_USP7_UBL2_3	187	191	PF12436	0.463
DOC_USP7_UBL2_3	240	244	PF12436	0.497
DOC_USP7_UBL2_3	40	44	PF12436	0.622
DOC_WW_Pin1_4	103	108	PF00397	0.501
DOC_WW_Pin1_4	121	126	PF00397	0.451
DOC_WW_Pin1_4	146	151	PF00397	0.678
DOC_WW_Pin1_4	191	196	PF00397	0.537
DOC_WW_Pin1_4	46	51	PF00397	0.734
DOC_WW_Pin1_4	81	86	PF00397	0.666
LIG_14-3-3_CanoR_1	90	100	PF00244	0.594
LIG_BIR_II_1	1	5	PF00653	0.497
LIG_BRCT_BRCA1_1	83	87	PF00533	0.558
LIG_FHA_1	33	39	PF00498	0.617
LIG_FHA_1	46	52	PF00498	0.502
LIG_FHA_1	7	13	PF00498	0.662
LIG_FHA_2	226	232	PF00498	0.439
LIG_FHA_2	233	239	PF00498	0.548
LIG_FHA_2	74	80	PF00498	0.513
LIG_Integrin_RGD_1	188	190	PF01839	0.180
LIG_LIR_Apic_2	242	246	PF02991	0.439
LIG_LIR_LC3C_4	205	208	PF02991	0.474
LIG_LIR_Nem_3	220	226	PF02991	0.501
LIG_LIR_Nem_3	256	261	PF02991	0.389
LIG_SH2_SRC	224	227	PF00017	0.439
LIG_SH2_STAP1	175	179	PF00017	0.439
LIG_SH2_STAT5	177	180	PF00017	0.439
LIG_SH2_STAT5	182	185	PF00017	0.439
LIG_SH2_STAT5	224	227	PF00017	0.456
LIG_SH2_STAT5	232	235	PF00017	0.450
LIG_SH3_3	144	150	PF00018	0.542
LIG_SH3_3	9	15	PF00018	0.638
LIG_TRAF2_1	54	57	PF00917	0.498
LIG_TRFH_1	121	125	PF08558	0.370
LIG_WW_3	194	198	PF00397	0.195
MOD_CDK_SPxK_1	191	197	PF00069	0.390
MOD_CDK_SPxxK_3	103	110	PF00069	0.488
MOD_CDK_SPxxK_3	191	198	PF00069	0.357
MOD_CDK_SPxxK_3	46	53	PF00069	0.642
MOD_CK1_1	149	155	PF00069	0.667
MOD_CK1_1	16	22	PF00069	0.731
MOD_CK1_1	173	179	PF00069	0.239
MOD_CK1_1	26	32	PF00069	0.666
MOD_CK1_1	91	97	PF00069	0.588
MOD_CK2_1	1	7	PF00069	0.492
MOD_CK2_1	232	238	PF00069	0.373
MOD_CK2_1	51	57	PF00069	0.657
MOD_CK2_1	73	79	PF00069	0.512
MOD_CK2_1	89	95	PF00069	0.529
MOD_GlcNHglycan	142	145	PF01048	0.647
MOD_GlcNHglycan	154	158	PF01048	0.516
MOD_GlcNHglycan	160	163	PF01048	0.358
MOD_GlcNHglycan	172	175	PF01048	0.243
MOD_GlcNHglycan	184	187	PF01048	0.298
MOD_GlcNHglycan	20	23	PF01048	0.727
MOD_GlcNHglycan	25	28	PF01048	0.732
MOD_GSK3_1	1	8	PF00069	0.680
MOD_GSK3_1	136	143	PF00069	0.567
MOD_GSK3_1	146	153	PF00069	0.647
MOD_NEK2_1	38	43	PF00069	0.692
MOD_PIKK_1	32	38	PF00454	0.636
MOD_PKA_2	16	22	PF00069	0.764
MOD_PKA_2	89	95	PF00069	0.593
MOD_PKB_1	168	176	PF00069	0.312
MOD_Plk_4	225	231	PF00069	0.195
MOD_Plk_4	254	260	PF00069	0.388
MOD_ProDKin_1	103	109	PF00069	0.498
MOD_ProDKin_1	121	127	PF00069	0.444
MOD_ProDKin_1	146	152	PF00069	0.679
MOD_ProDKin_1	191	197	PF00069	0.414
MOD_ProDKin_1	46	52	PF00069	0.735
MOD_ProDKin_1	81	87	PF00069	0.666
TRG_ER_diArg_1	128	130	PF00400	0.382
TRG_ER_diArg_1	167	170	PF00400	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6U6	Leptomonas seymouri	63%	100%
A0A0S4KJP5	Bodo saltans	52%	100%
A0A1X0NZ22	Trypanosomatidae	48%	100%
A0A3Q8IAJ0	Leishmania donovani	78%	92%
A0A422NDJ9	Trypanosoma rangeli	52%	92%
A4HWY0	Leishmania infantum	78%	92%
C9ZW24	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	99%
E9AQP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	92%
Q4QET6	Leishmania major	76%	100%
V5BHL1	Trypanosoma cruzi	47%	84%