Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H8K5_LEIBR

TriTrypDb:

LbrM.16.0820 , LBRM2903_160014700

Length:

599

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H8K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H8K5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	409	413	PF00656	0.295
CLV_C14_Caspase3-7	594	598	PF00656	0.638
CLV_MEL_PAP_1	310	316	PF00089	0.688
CLV_NRD_NRD_1	127	129	PF00675	0.582
CLV_NRD_NRD_1	15	17	PF00675	0.417
CLV_NRD_NRD_1	289	291	PF00675	0.500
CLV_NRD_NRD_1	312	314	PF00675	0.696
CLV_NRD_NRD_1	361	363	PF00675	0.454
CLV_NRD_NRD_1	384	386	PF00675	0.558
CLV_NRD_NRD_1	431	433	PF00675	0.594
CLV_NRD_NRD_1	571	573	PF00675	0.392
CLV_NRD_NRD_1	581	583	PF00675	0.387
CLV_PCSK_FUR_1	569	573	PF00082	0.287
CLV_PCSK_KEX2_1	127	129	PF00082	0.568
CLV_PCSK_KEX2_1	15	17	PF00082	0.392
CLV_PCSK_KEX2_1	312	314	PF00082	0.696
CLV_PCSK_KEX2_1	361	363	PF00082	0.505
CLV_PCSK_KEX2_1	384	386	PF00082	0.581
CLV_PCSK_KEX2_1	431	433	PF00082	0.594
CLV_PCSK_KEX2_1	571	573	PF00082	0.394
CLV_PCSK_KEX2_1	581	583	PF00082	0.444
CLV_PCSK_SKI1_1	24	28	PF00082	0.376
CLV_PCSK_SKI1_1	269	273	PF00082	0.551
CLV_PCSK_SKI1_1	291	295	PF00082	0.494
CLV_PCSK_SKI1_1	303	307	PF00082	0.580
CLV_PCSK_SKI1_1	361	365	PF00082	0.530
CLV_PCSK_SKI1_1	581	585	PF00082	0.458
CLV_Separin_Metazoa	333	337	PF03568	0.314
DEG_SPOP_SBC_1	186	190	PF00917	0.547
DEG_SPOP_SBC_1	244	248	PF00917	0.442
DOC_CYCLIN_RxL_1	287	295	PF00134	0.389
DOC_CYCLIN_RxL_1	358	370	PF00134	0.338
DOC_MAPK_DCC_7	291	301	PF00069	0.318
DOC_MAPK_gen_1	127	133	PF00069	0.447
DOC_MAPK_gen_1	290	296	PF00069	0.298
DOC_MAPK_gen_1	358	366	PF00069	0.290
DOC_MAPK_JIP1_4	401	407	PF00069	0.383
DOC_MAPK_MEF2A_6	32	41	PF00069	0.475
DOC_PP1_RVXF_1	360	367	PF00149	0.325
DOC_PP1_RVXF_1	421	427	PF00149	0.313
DOC_PP1_RVXF_1	517	523	PF00149	0.609
DOC_PP2B_LxvP_1	112	115	PF13499	0.527
DOC_PP4_FxxP_1	34	37	PF00568	0.430
DOC_USP7_MATH_1	185	189	PF00917	0.540
DOC_USP7_MATH_1	229	233	PF00917	0.508
DOC_USP7_MATH_1	93	97	PF00917	0.543
DOC_WW_Pin1_4	10	15	PF00397	0.620
DOC_WW_Pin1_4	160	165	PF00397	0.477
DOC_WW_Pin1_4	231	236	PF00397	0.539
DOC_WW_Pin1_4	33	38	PF00397	0.350
DOC_WW_Pin1_4	473	478	PF00397	0.325
DOC_WW_Pin1_4	586	591	PF00397	0.548
LIG_14-3-3_CanoR_1	207	216	PF00244	0.502
LIG_14-3-3_CanoR_1	312	317	PF00244	0.477
LIG_14-3-3_CanoR_1	336	345	PF00244	0.328
LIG_14-3-3_CanoR_1	416	424	PF00244	0.357
LIG_14-3-3_CanoR_1	431	440	PF00244	0.289
LIG_14-3-3_CanoR_1	569	579	PF00244	0.625
LIG_Actin_WH2_2	289	305	PF00022	0.349
LIG_APCC_ABBA_1	372	377	PF00400	0.335
LIG_BRCT_BRCA1_1	109	113	PF00533	0.533
LIG_BRCT_BRCA1_1	22	26	PF00533	0.588
LIG_BRCT_BRCA1_1	4	8	PF00533	0.726
LIG_BRCT_BRCA1_1	42	46	PF00533	0.150
LIG_CaM_NSCaTE_8	579	586	PF13499	0.514
LIG_Clathr_ClatBox_1	405	409	PF01394	0.274
LIG_FHA_1	246	252	PF00498	0.451
LIG_FHA_1	304	310	PF00498	0.449
LIG_FHA_1	322	328	PF00498	0.372
LIG_FHA_1	371	377	PF00498	0.363
LIG_FHA_1	523	529	PF00498	0.582
LIG_FHA_2	235	241	PF00498	0.525
LIG_FHA_2	481	487	PF00498	0.363
LIG_Integrin_RGD_1	101	103	PF01839	0.592
LIG_LIR_Apic_2	31	37	PF02991	0.550
LIG_LIR_Apic_2	56	61	PF02991	0.377
LIG_LIR_Gen_1	247	255	PF02991	0.476
LIG_LIR_Gen_1	36	46	PF02991	0.349
LIG_LIR_Gen_1	450	461	PF02991	0.341
LIG_LIR_Gen_1	502	512	PF02991	0.605
LIG_LIR_Nem_3	169	175	PF02991	0.320
LIG_LIR_Nem_3	247	253	PF02991	0.479
LIG_LIR_Nem_3	339	345	PF02991	0.303
LIG_LIR_Nem_3	36	41	PF02991	0.370
LIG_LIR_Nem_3	418	424	PF02991	0.323
LIG_LIR_Nem_3	43	49	PF02991	0.391
LIG_LIR_Nem_3	450	456	PF02991	0.341
LIG_LIR_Nem_3	502	507	PF02991	0.530
LIG_MLH1_MIPbox_1	22	26	PF16413	0.581
LIG_PCNA_yPIPBox_3	312	326	PF02747	0.438
LIG_Pex14_1	459	463	PF04695	0.302
LIG_Rb_LxCxE_1	149	169	PF01857	0.343
LIG_SH2_CRK	172	176	PF00017	0.315
LIG_SH2_GRB2like	18	21	PF00017	0.513
LIG_SH2_PTP2	38	41	PF00017	0.430
LIG_SH2_PTP2	58	61	PF00017	0.239
LIG_SH2_SRC	177	180	PF00017	0.378
LIG_SH2_SRC	547	550	PF00017	0.525
LIG_SH2_STAP1	288	292	PF00017	0.323
LIG_SH2_STAP1	403	407	PF00017	0.280
LIG_SH2_STAT5	177	180	PF00017	0.336
LIG_SH2_STAT5	18	21	PF00017	0.537
LIG_SH2_STAT5	250	253	PF00017	0.389
LIG_SH2_STAT5	38	41	PF00017	0.403
LIG_SH2_STAT5	382	385	PF00017	0.391
LIG_SH2_STAT5	49	52	PF00017	0.299
LIG_SH2_STAT5	547	550	PF00017	0.525
LIG_SH2_STAT5	58	61	PF00017	0.239
LIG_SH3_3	11	17	PF00018	0.629
LIG_SH3_3	439	445	PF00018	0.370
LIG_SH3_3	471	477	PF00018	0.357
LIG_SH3_3	532	538	PF00018	0.546
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.414
LIG_SUMO_SIM_anti_2	404	409	PF11976	0.333
LIG_SUMO_SIM_par_1	404	409	PF11976	0.278
LIG_TRAF2_1	61	64	PF00917	0.460
LIG_TRAF2_2	590	595	PF00917	0.570
LIG_TYR_ITIM	170	175	PF00017	0.388
LIG_WRC_WIRS_1	481	486	PF05994	0.368
MOD_CDC14_SPxK_1	13	16	PF00782	0.378
MOD_CDK_SPK_2	10	15	PF00069	0.454
MOD_CDK_SPK_2	160	165	PF00069	0.333
MOD_CDK_SPxK_1	10	16	PF00069	0.396
MOD_CDK_SPxxK_3	160	167	PF00069	0.556
MOD_CDK_SPxxK_3	586	593	PF00069	0.433
MOD_CK1_1	134	140	PF00069	0.443
MOD_CK1_1	160	166	PF00069	0.591
MOD_CK1_1	195	201	PF00069	0.766
MOD_CK1_1	205	211	PF00069	0.701
MOD_CK1_1	234	240	PF00069	0.668
MOD_CK1_1	370	376	PF00069	0.497
MOD_CK1_1	476	482	PF00069	0.325
MOD_CK1_1	591	597	PF00069	0.682
MOD_CK2_1	234	240	PF00069	0.701
MOD_CMANNOS	576	579	PF00535	0.465
MOD_GlcNHglycan	143	146	PF01048	0.560
MOD_GlcNHglycan	148	151	PF01048	0.506
MOD_GlcNHglycan	183	186	PF01048	0.751
MOD_GlcNHglycan	207	210	PF01048	0.734
MOD_GlcNHglycan	330	333	PF01048	0.356
MOD_GlcNHglycan	4	7	PF01048	0.461
MOD_GlcNHglycan	42	45	PF01048	0.403
MOD_GlcNHglycan	527	531	PF01048	0.536
MOD_GSK3_1	181	188	PF00069	0.609
MOD_GSK3_1	193	200	PF00069	0.634
MOD_GSK3_1	201	208	PF00069	0.793
MOD_GSK3_1	231	238	PF00069	0.695
MOD_GSK3_1	366	373	PF00069	0.495
MOD_GSK3_1	472	479	PF00069	0.313
MOD_GSK3_1	480	487	PF00069	0.347
MOD_GSK3_1	522	529	PF00069	0.447
MOD_GSK3_1	93	100	PF00069	0.492
MOD_N-GLC_1	370	375	PF02516	0.492
MOD_N-GLC_1	393	398	PF02516	0.609
MOD_N-GLC_1	531	536	PF02516	0.502
MOD_N-GLC_2	275	277	PF02516	0.375
MOD_N-GLC_2	437	439	PF02516	0.481
MOD_NEK2_1	197	202	PF00069	0.739
MOD_NEK2_1	292	297	PF00069	0.481
MOD_NEK2_1	366	371	PF00069	0.396
MOD_NEK2_1	40	45	PF00069	0.384
MOD_NEK2_1	461	466	PF00069	0.286
MOD_NEK2_1	484	489	PF00069	0.475
MOD_NEK2_1	583	588	PF00069	0.465
MOD_NEK2_1	77	82	PF00069	0.520
MOD_NEK2_2	171	176	PF00069	0.445
MOD_NEK2_2	337	342	PF00069	0.476
MOD_PIKK_1	208	214	PF00454	0.680
MOD_PIKK_1	270	276	PF00454	0.484
MOD_PIKK_1	303	309	PF00454	0.601
MOD_PIKK_1	416	422	PF00454	0.399
MOD_PIKK_1	570	576	PF00454	0.606
MOD_PIKK_1	588	594	PF00454	0.384
MOD_PK_1	494	500	PF00069	0.347
MOD_PKA_1	312	318	PF00069	0.623
MOD_PKA_1	581	587	PF00069	0.619
MOD_PKA_2	20	26	PF00069	0.533
MOD_PKA_2	312	318	PF00069	0.518
MOD_PKA_2	415	421	PF00069	0.447
MOD_PKA_2	570	576	PF00069	0.548
MOD_PKA_2	581	587	PF00069	0.574
MOD_Plk_1	370	376	PF00069	0.456
MOD_Plk_1	393	399	PF00069	0.420
MOD_Plk_1	531	537	PF00069	0.468
MOD_Plk_4	305	311	PF00069	0.614
MOD_Plk_4	321	327	PF00069	0.389
MOD_Plk_4	352	358	PF00069	0.463
MOD_Plk_4	476	482	PF00069	0.350
MOD_ProDKin_1	10	16	PF00069	0.518
MOD_ProDKin_1	160	166	PF00069	0.610
MOD_ProDKin_1	231	237	PF00069	0.692
MOD_ProDKin_1	33	39	PF00069	0.350
MOD_ProDKin_1	473	479	PF00069	0.325
MOD_ProDKin_1	586	592	PF00069	0.430
MOD_SUMO_for_1	499	502	PF00179	0.532
TRG_ENDOCYTIC_2	172	175	PF00928	0.382
TRG_ENDOCYTIC_2	250	253	PF00928	0.592
TRG_ENDOCYTIC_2	342	345	PF00928	0.484
TRG_ENDOCYTIC_2	38	41	PF00928	0.350
TRG_ENDOCYTIC_2	403	406	PF00928	0.335
TRG_ENDOCYTIC_2	421	424	PF00928	0.364
TRG_ER_diArg_1	126	128	PF00400	0.501
TRG_ER_diArg_1	14	16	PF00400	0.529
TRG_ER_diArg_1	311	313	PF00400	0.626
TRG_ER_diArg_1	361	363	PF00400	0.277
TRG_ER_diArg_1	383	385	PF00400	0.463
TRG_ER_diArg_1	430	432	PF00400	0.491
TRG_ER_diArg_1	568	571	PF00400	0.531
TRG_ER_diArg_1	580	582	PF00400	0.528
TRG_ER_diArg_1	59	62	PF00400	0.476
TRG_Pf-PMV_PEXEL_1	362	367	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6R7	Leptomonas seymouri	63%	100%
A0A0S4IJV1	Bodo saltans	32%	100%
A0A1X0NZ16	Trypanosomatidae	44%	100%
A0A3Q8IJ17	Leishmania donovani	82%	100%
A4HWX8	Leishmania infantum	82%	100%
C9ZW26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AQP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QET8	Leishmania major	82%	100%
V5D930	Trypanosoma cruzi	46%	100%